Calcium-binding protein 39 - Homo sapiens (Human)

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Q9Y376 (CAB39_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 111. History...

Clusters with 100%, 90%, 50% identity |

Documents (4) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Calcium-binding protein 39

Alternative name(s):
MO25alpha
Protein Mo25

Gene names

Name:	CAB39
Synonyms:	MO25
ORF Names:	CGI-66

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	341 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. Ref.6
Subunit structure	Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Ref.6
Subcellular location	Cytoplasm Potential.
Sequence similarities	Belongs to the Mo25 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell cycle arrest Traceable author statement. Source: Reactome insulin receptor signaling pathway Traceable author statement. Source: Reactome regulation of fatty acid oxidation Traceable author statement. Source: Reactome
Cellular_component	cytosol Traceable author statement. Source: Reactome
Molecular_function	protein kinase activator activity Inferred from direct assay Ref.6. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
STK11	Q15831	4	EBI-306905,EBI-306838
STRADB	Q9C0K7	5	EBI-306905,EBI-306893

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 341

341

Calcium-binding protein 39

PRO_0000209824

Experimental info

Mutagenesis

240

R → A: Abolishes activation of STK11/LKB1; when associated with A-243. Ref.6

Mutagenesis

243

F → A: Abolishes activation of STK11/LKB1; when associated with A-240. Ref.6

Secondary structure

341

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y376 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: EC710A528B6F9811
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FASTA

341

39,869

        10         20         30         40         50         60 
MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK 

        70         80         90        100        110        120 
EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI 

       130        140        150        160        170        180 
CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI 

       190        200        210        220        230        240 
ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR 

       250        260        270        280        290        300 
HNFTIMTKYI SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA 

       310        320        330        340 
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"A novel gene expressed in the human hypothalamus." Jin W., Shi J., Ren S., Gu J., Fu S., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hypothalamus.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Duodenum.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[5]	"Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor." Milburn C.C., Boudeau J., Deak M., Alessi D.R., van Aalten D.M. Nat. Struct. Mol. Biol. 11:193-200(2004) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 10-339.
[6]	"Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation." Zeqiraj E., Filippi B.M., Deak M., Alessi D.R., van Aalten D.M. Science 326:1707-1711(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 1-341 IN COMPLEX WITH STK11/LKB1 AND STRADA, IDENTIFICATION IN A COMPLEX WITH STK11/LKB1 AND STRADA, FUNCTION, MUTAGENESIS OF ARG-240 AND PHE-243.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF151824 mRNA. Translation: AAD34061.1.
AF113536 mRNA. Translation: AAF14873.1.
BC020570 mRNA. Translation: AAH20570.1.

IPI

IPI00032561.

RefSeq

NP_001124321.1. NM_001130849.1.
NP_001124322.1. NM_001130850.1.
NP_057373.1. NM_016289.3.

UniGene

Hs.603930.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UPK	X-ray	1.85	A	1-341	[»]
1UPL	X-ray	2.60	A/B	1-341	[»]
2WTK	X-ray	2.65	A/D	1-341	[»]
3GNI	X-ray	2.35	A	1-341	[»]
4FZA	X-ray	3.15	A	11-334	[»]
4FZD	X-ray	3.25	A	11-334	[»]
4FZF	X-ray	3.64	A	11-334	[»]

ProteinModelPortal

Q9Y376.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-31316N.

IntAct

Q9Y376. 6 interactions.

MINT

MINT-5000103.

STRING

9606.ENSP00000258418.

PTM databases

PhosphoSite

Q9Y376.

Polymorphism databases

DMDM

15214082.

Proteomic databases

PaxDb

Q9Y376.

PeptideAtlas

Q9Y376.

PRIDE

Q9Y376.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000258418; ENSP00000258418; ENSG00000135932.
ENST00000409788; ENSP00000386238; ENSG00000135932.
ENST00000410084; ENSP00000386642; ENSG00000135932.

GeneID

51719.

KEGG

hsa:51719.

UCSC

uc002vqx.3. human.

Organism-specific databases

CTD

51719.

GeneCards

GC02P231577.

HGNC

HGNC:20292. CAB39.

HPA

CAB037112.

MIM

612174. gene.

neXtProt

NX_Q9Y376.

PharmGKB

PA128394663.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG307443.

HOGENOM

HOG000234711.

HOVERGEN

HBG050757.

InParanoid

Q9Y376.

K08272.

OMA

TVEYLCT.

OrthoDB

EOG4JDH72.

PhylomeDB

Q9Y376.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.
REACT_11163. Activated AMPK stimulates fatty-acid oxidation in muscle.

Gene expression databases

ArrayExpress

Q9Y376.

Bgee

Q9Y376.

CleanEx

HS_CAB39.

Genevestigator

Q9Y376.

Family and domain databases

Gene3D

1.25.10.10. 1 hit.

InterPro

IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]

PANTHER

PTHR10182. PTHR10182. 1 hit.

Pfam

PF08569. Mo25. 1 hit.
[Graphical view]

SUPFAM

SSF48371. ARM-type_fold. 1 hit.

ProtoNet

Search...

Other

EvolutionaryTrace

Q9Y376.

GenomeRNAi

51719.

NextBio

55768.

SOURCE

Search...

Entry information

Entry name

CAB39_HUMAN

Accession

Primary (citable) accession number: Q9Y376

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 14, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Experimental info

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents