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Protein

Calcium-binding protein 39

Gene

CAB39

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.1 Publication

GO - Molecular functioni

  • kinase binding Source: BHF-UCL
  • protein kinase activator activity Source: UniProtKB
  • protein serine/threonine kinase activator activity Source: ParkinsonsUK-UCL
  • protein serine/threonine kinase activity Source: Ensembl

GO - Biological processi

  • cell cycle arrest Source: Reactome
  • cellular hypotonic response Source: ParkinsonsUK-UCL
  • intracellular signal transduction Source: ParkinsonsUK-UCL
  • negative regulation of potassium ion transmembrane transport Source: ParkinsonsUK-UCL
  • negative regulation of potassium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
  • negative regulation of rubidium ion transmembrane transporter activity Source: ParkinsonsUK-UCL
  • negative regulation of rubidium ion transport Source: ParkinsonsUK-UCL
  • peptidyl-serine phosphorylation Source: ParkinsonsUK-UCL
  • positive regulation of peptidyl-threonine phosphorylation Source: ParkinsonsUK-UCL
  • positive regulation of protein serine/threonine kinase activity Source: ParkinsonsUK-UCL
  • protein heterooligomerization Source: Ensembl
  • signal transduction by protein phosphorylation Source: ParkinsonsUK-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135932-MONOMER.
ReactomeiR-HSA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-binding protein 39
Alternative name(s):
MO25alpha
Protein Mo25
Gene namesi
Name:CAB39
Synonyms:MO25
ORF Names:CGI-66
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:20292. CAB39.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • protein complex Source: Ensembl
  • serine/threonine protein kinase complex Source: ParkinsonsUK-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi240R → A: Abolishes activation of STK11/LKB1; when associated with A-243. 1 Publication1
Mutagenesisi243F → A: Abolishes activation of STK11/LKB1; when associated with A-240. 1 Publication1

Organism-specific databases

DisGeNETi51719.
OpenTargetsiENSG00000135932.
PharmGKBiPA128394663.

Polymorphism and mutation databases

BioMutaiCAB39.
DMDMi15214082.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002098241 – 341Calcium-binding protein 39Add BLAST341

Proteomic databases

EPDiQ9Y376.
MaxQBiQ9Y376.
PaxDbiQ9Y376.
PeptideAtlasiQ9Y376.
PRIDEiQ9Y376.

PTM databases

iPTMnetiQ9Y376.
PhosphoSitePlusiQ9Y376.

Expressioni

Gene expression databases

BgeeiENSG00000135932.
CleanExiHS_CAB39.
ExpressionAtlasiQ9Y376. baseline and differential.
GenevisibleiQ9Y376. HS.

Organism-specific databases

HPAiCAB037112.

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
OXSR1O957473EBI-306905,EBI-620853
STK11Q158317EBI-306905,EBI-306838
STK25O005063EBI-306905,EBI-618295
STK26Q9P2896EBI-306905,EBI-618239
STK39Q9UEW84EBI-306905,EBI-2680974
STRADAQ7RTN63EBI-306905,EBI-1109114
STRADBQ9C0K75EBI-306905,EBI-306893

GO - Molecular functioni

  • kinase binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi119696. 38 interactors.
DIPiDIP-31316N.
IntActiQ9Y376. 13 interactors.
MINTiMINT-5000103.
STRINGi9606.ENSP00000258418.

Structurei

Secondary structure

1341
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi12 – 27Combined sources16
Beta strandi29 – 31Combined sources3
Helixi34 – 54Combined sources21
Beta strandi58 – 61Combined sources4
Helixi64 – 77Combined sources14
Helixi79 – 85Combined sources7
Helixi87 – 89Combined sources3
Helixi92 – 106Combined sources15
Helixi115 – 121Combined sources7
Helixi125 – 132Combined sources8
Helixi133 – 135Combined sources3
Turni137 – 139Combined sources3
Helixi140 – 151Combined sources12
Helixi154 – 162Combined sources9
Helixi164 – 167Combined sources4
Helixi168 – 172Combined sources5
Helixi178 – 193Combined sources16
Helixi196 – 205Combined sources10
Helixi207 – 217Combined sources11
Helixi223 – 238Combined sources16
Helixi240 – 242Combined sources3
Helixi243 – 249Combined sources7
Helixi253 – 262Combined sources10
Helixi268 – 283Combined sources16
Helixi289 – 297Combined sources9
Helixi299 – 308Combined sources10
Turni309 – 312Combined sources4
Helixi314 – 316Combined sources3
Helixi318 – 331Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UPKX-ray1.85A1-341[»]
1UPLX-ray2.60A/B1-341[»]
2WTKX-ray2.65A/D1-341[»]
3GNIX-ray2.35A1-341[»]
4FZAX-ray3.15A11-334[»]
4FZDX-ray3.25A11-334[»]
4FZFX-ray3.64A11-334[»]
4NZWX-ray3.58A8-334[»]
4O27X-ray3.18A11-333[»]
ProteinModelPortaliQ9Y376.
SMRiQ9Y376.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y376.

Family & Domainsi

Sequence similaritiesi

Belongs to the Mo25 family.Curated

Phylogenomic databases

eggNOGiKOG1566. Eukaryota.
ENOG410XP4S. LUCA.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9Y376.
KOiK08272.
OMAiKVFSHYQ.
OrthoDBiEOG091G0DTL.
PhylomeDBiQ9Y376.
TreeFamiTF314910.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y376-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM
60 70 80 90 100
KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ
110 120 130 140 150
IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC
160 170 180 190 200
IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA
210 220 230 240 250
EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI
260 270 280 290 300
SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA
310 320 330 340
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A
Length:341
Mass (Da):39,869
Last modified:November 1, 1999 - v1
Checksum:iEC710A528B6F9811
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151824 mRNA. Translation: AAD34061.1.
AF113536 mRNA. Translation: AAF14873.1.
AK292382 mRNA. Translation: BAF85071.1.
AK315692 mRNA. Translation: BAG38055.1.
CH471063 Genomic DNA. Translation: EAW70932.1.
BC020570 mRNA. Translation: AAH20570.1.
CCDSiCCDS2478.1.
RefSeqiNP_001124321.1. NM_001130849.1.
NP_001124322.1. NM_001130850.1.
NP_057373.1. NM_016289.3.
UniGeneiHs.603930.

Genome annotation databases

EnsembliENST00000258418; ENSP00000258418; ENSG00000135932.
ENST00000409788; ENSP00000386238; ENSG00000135932.
ENST00000410084; ENSP00000386642; ENSG00000135932.
GeneIDi51719.
KEGGihsa:51719.
UCSCiuc002vqx.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF151824 mRNA. Translation: AAD34061.1.
AF113536 mRNA. Translation: AAF14873.1.
AK292382 mRNA. Translation: BAF85071.1.
AK315692 mRNA. Translation: BAG38055.1.
CH471063 Genomic DNA. Translation: EAW70932.1.
BC020570 mRNA. Translation: AAH20570.1.
CCDSiCCDS2478.1.
RefSeqiNP_001124321.1. NM_001130849.1.
NP_001124322.1. NM_001130850.1.
NP_057373.1. NM_016289.3.
UniGeneiHs.603930.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UPKX-ray1.85A1-341[»]
1UPLX-ray2.60A/B1-341[»]
2WTKX-ray2.65A/D1-341[»]
3GNIX-ray2.35A1-341[»]
4FZAX-ray3.15A11-334[»]
4FZDX-ray3.25A11-334[»]
4FZFX-ray3.64A11-334[»]
4NZWX-ray3.58A8-334[»]
4O27X-ray3.18A11-333[»]
ProteinModelPortaliQ9Y376.
SMRiQ9Y376.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119696. 38 interactors.
DIPiDIP-31316N.
IntActiQ9Y376. 13 interactors.
MINTiMINT-5000103.
STRINGi9606.ENSP00000258418.

PTM databases

iPTMnetiQ9Y376.
PhosphoSitePlusiQ9Y376.

Polymorphism and mutation databases

BioMutaiCAB39.
DMDMi15214082.

Proteomic databases

EPDiQ9Y376.
MaxQBiQ9Y376.
PaxDbiQ9Y376.
PeptideAtlasiQ9Y376.
PRIDEiQ9Y376.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258418; ENSP00000258418; ENSG00000135932.
ENST00000409788; ENSP00000386238; ENSG00000135932.
ENST00000410084; ENSP00000386642; ENSG00000135932.
GeneIDi51719.
KEGGihsa:51719.
UCSCiuc002vqx.4. human.

Organism-specific databases

CTDi51719.
DisGeNETi51719.
GeneCardsiCAB39.
HGNCiHGNC:20292. CAB39.
HPAiCAB037112.
MIMi612174. gene.
neXtProtiNX_Q9Y376.
OpenTargetsiENSG00000135932.
PharmGKBiPA128394663.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1566. Eukaryota.
ENOG410XP4S. LUCA.
GeneTreeiENSGT00390000004360.
HOGENOMiHOG000234711.
HOVERGENiHBG050757.
InParanoidiQ9Y376.
KOiK08272.
OMAiKVFSHYQ.
OrthoDBiEOG091G0DTL.
PhylomeDBiQ9Y376.
TreeFamiTF314910.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000135932-MONOMER.
ReactomeiR-HSA-380972. Energy dependent regulation of mTOR by LKB1-AMPK.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

ChiTaRSiCAB39. human.
EvolutionaryTraceiQ9Y376.
GeneWikiiCAB39.
GenomeRNAii51719.
PROiQ9Y376.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000135932.
CleanExiHS_CAB39.
ExpressionAtlasiQ9Y376. baseline and differential.
GenevisibleiQ9Y376. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERiPTHR10182. PTHR10182. 1 hit.
PfamiPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCAB39_HUMAN
AccessioniPrimary (citable) accession number: Q9Y376
Secondary accession number(s): A8K8L7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.