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Q9Y376 (CAB39_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Calcium-binding protein 39
Alternative name(s):
MO25alpha
Protein Mo25
Gene names
Name:CAB39
Synonyms:MO25
ORF Names:CGI-66
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1. Ref.8

Subunit structure

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Ref.8

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the Mo25 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 341341Calcium-binding protein 39
PRO_0000209824

Experimental info

Mutagenesis2401R → A: Abolishes activation of STK11/LKB1; when associated with A-243. Ref.8
Mutagenesis2431F → A: Abolishes activation of STK11/LKB1; when associated with A-240. Ref.8

Secondary structure

...................................................... 341
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9Y376 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: EC710A528B6F9811

FASTA34139,869
        10         20         30         40         50         60 
MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM KEILYGTNEK 

        70         80         90        100        110        120 
EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ IFNNILRRQI GTRTPTVEYI 

       130        140        150        160        170        180 
CTQQNILFML LKGYESPEIA LNCGIMLREC IRHEPLAKII LWSEQFYDFF RYVEMSTFDI 

       190        200        210        220        230        240 
ASDAFATFKD LLTRHKLLSA EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR 

       250        260        270        280        290        300 
HNFTIMTKYI SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA 

       310        320        330        340 
KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A 

« Hide

References

« Hide 'large scale' references
[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"A novel gene expressed in the human hypothalamus."
Jin W., Shi J., Ren S., Gu J., Fu S., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Hypothalamus.
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Duodenum.
[6]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor."
Milburn C.C., Boudeau J., Deak M., Alessi D.R., van Aalten D.M.
Nat. Struct. Mol. Biol. 11:193-200(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 10-339.
[8]"Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation."
Zeqiraj E., Filippi B.M., Deak M., Alessi D.R., van Aalten D.M.
Science 326:1707-1711(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 1-341 IN COMPLEX WITH STK11/LKB1 AND STRADA, IDENTIFICATION IN A COMPLEX WITH STK11/LKB1 AND STRADA, FUNCTION, MUTAGENESIS OF ARG-240 AND PHE-243.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF151824 mRNA. Translation: AAD34061.1.
AF113536 mRNA. Translation: AAF14873.1.
AK292382 mRNA. Translation: BAF85071.1.
AK315692 mRNA. Translation: BAG38055.1.
CH471063 Genomic DNA. Translation: EAW70932.1.
BC020570 mRNA. Translation: AAH20570.1.
CCDSCCDS2478.1.
RefSeqNP_001124321.1. NM_001130849.1.
NP_001124322.1. NM_001130850.1.
NP_057373.1. NM_016289.3.
UniGeneHs.603930.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UPKX-ray1.85A1-341[»]
1UPLX-ray2.60A/B1-341[»]
2WTKX-ray2.65A/D1-341[»]
3GNIX-ray2.35A1-341[»]
4FZAX-ray3.15A11-334[»]
4FZDX-ray3.25A11-334[»]
4FZFX-ray3.64A11-334[»]
ProteinModelPortalQ9Y376.
SMRQ9Y376. Positions 2-336.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119696. 15 interactions.
DIPDIP-31316N.
IntActQ9Y376. 11 interactions.
MINTMINT-5000103.
STRING9606.ENSP00000258418.

PTM databases

PhosphoSiteQ9Y376.

Polymorphism databases

DMDM15214082.

Proteomic databases

MaxQBQ9Y376.
PaxDbQ9Y376.
PeptideAtlasQ9Y376.
PRIDEQ9Y376.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000258418; ENSP00000258418; ENSG00000135932.
ENST00000409788; ENSP00000386238; ENSG00000135932.
ENST00000410084; ENSP00000386642; ENSG00000135932.
GeneID51719.
KEGGhsa:51719.
UCSCuc002vqx.3. human.

Organism-specific databases

CTD51719.
GeneCardsGC02P231577.
HGNCHGNC:20292. CAB39.
HPACAB037112.
MIM612174. gene.
neXtProtNX_Q9Y376.
PharmGKBPA128394663.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG307443.
HOGENOMHOG000234711.
HOVERGENHBG050757.
InParanoidQ9Y376.
KOK08272.
OMACKGYEHS.
OrthoDBEOG7CK371.
PhylomeDBQ9Y376.
TreeFamTF314910.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9Y376.
BgeeQ9Y376.
CleanExHS_CAB39.
GenevestigatorQ9Y376.

Family and domain databases

Gene3D1.25.10.10. 1 hit.
InterProIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR013878. Mo25.
[Graphical view]
PANTHERPTHR10182. PTHR10182. 1 hit.
PfamPF08569. Mo25. 1 hit.
[Graphical view]
SUPFAMSSF48371. SSF48371. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9Y376.
GeneWikiCAB39.
GenomeRNAi51719.
NextBio55768.
PROQ9Y376.
SOURCESearch...

Entry information

Entry nameCAB39_HUMAN
AccessionPrimary (citable) accession number: Q9Y376
Secondary accession number(s): A8K8L7
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM