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Q9Y376

- CAB39_HUMAN

UniProt

Q9Y376 - CAB39_HUMAN

Protein

Calcium-binding protein 39

Gene

CAB39

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.1 Publication

    GO - Molecular functioni

    1. kinase binding Source: BHF-UCL
    2. protein binding Source: UniProtKB
    3. protein kinase activator activity Source: UniProtKB
    4. protein serine/threonine kinase activator activity Source: BHF-UCL

    GO - Biological processi

    1. activation of protein kinase activity Source: Ensembl
    2. cell cycle arrest Source: Reactome
    3. cellular hypotonic response Source: BHF-UCL
    4. insulin receptor signaling pathway Source: Reactome
    5. intracellular signal transduction Source: BHF-UCL
    6. negative regulation of potassium ion transmembrane transport Source: BHF-UCL
    7. negative regulation of potassium ion transmembrane transporter activity Source: BHF-UCL
    8. negative regulation of rubidium ion transmembrane transporter activity Source: BHF-UCL
    9. negative regulation of rubidium ion transport Source: BHF-UCL
    10. peptidyl-serine phosphorylation Source: BHF-UCL
    11. peptidyl-threonine phosphorylation Source: BHF-UCL
    12. positive regulation of protein serine/threonine kinase activity Source: BHF-UCL
    13. protein heterooligomerization Source: Ensembl
    14. signal transduction by phosphorylation Source: BHF-UCL

    Enzyme and pathway databases

    ReactomeiREACT_21285. Regulation of AMPK activity via LKB1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcium-binding protein 39
    Alternative name(s):
    MO25alpha
    Protein Mo25
    Gene namesi
    Name:CAB39
    Synonyms:MO25
    ORF Names:CGI-66
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:20292. CAB39.

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. extracellular vesicular exosome Source: UniProt
    3. protein complex Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi240 – 2401R → A: Abolishes activation of STK11/LKB1; when associated with A-243. 1 Publication
    Mutagenesisi243 – 2431F → A: Abolishes activation of STK11/LKB1; when associated with A-240. 1 Publication

    Organism-specific databases

    PharmGKBiPA128394663.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 341341Calcium-binding protein 39PRO_0000209824Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y376.
    PaxDbiQ9Y376.
    PeptideAtlasiQ9Y376.
    PRIDEiQ9Y376.

    PTM databases

    PhosphoSiteiQ9Y376.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y376.
    BgeeiQ9Y376.
    CleanExiHS_CAB39.
    GenevestigatoriQ9Y376.

    Organism-specific databases

    HPAiCAB037112.

    Interactioni

    Subunit structurei

    Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MST4Q9P2896EBI-306905,EBI-618239
    OXSR1O957473EBI-306905,EBI-620853
    STK11Q158315EBI-306905,EBI-306838
    STK25O005063EBI-306905,EBI-618295
    STK39Q9UEW84EBI-306905,EBI-2680974
    STRADAQ7RTN63EBI-306905,EBI-1109114
    STRADBQ9C0K75EBI-306905,EBI-306893

    Protein-protein interaction databases

    BioGridi119696. 15 interactions.
    DIPiDIP-31316N.
    IntActiQ9Y376. 11 interactions.
    MINTiMINT-5000103.
    STRINGi9606.ENSP00000258418.

    Structurei

    Secondary structure

    1
    341
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi12 – 2716
    Beta strandi29 – 313
    Helixi34 – 5421
    Beta strandi58 – 614
    Helixi64 – 7714
    Helixi79 – 857
    Helixi87 – 893
    Helixi92 – 10615
    Helixi115 – 1217
    Helixi125 – 1328
    Helixi133 – 1353
    Turni137 – 1393
    Helixi140 – 15112
    Helixi154 – 1629
    Helixi164 – 1674
    Helixi168 – 1725
    Helixi178 – 19316
    Helixi196 – 20510
    Helixi207 – 21711
    Helixi223 – 23816
    Helixi240 – 2423
    Helixi243 – 2497
    Helixi253 – 26210
    Helixi268 – 28316
    Helixi289 – 2979
    Helixi299 – 30810
    Turni309 – 3124
    Helixi314 – 3163
    Helixi318 – 33114

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UPKX-ray1.85A1-341[»]
    1UPLX-ray2.60A/B1-341[»]
    2WTKX-ray2.65A/D1-341[»]
    3GNIX-ray2.35A1-341[»]
    4FZAX-ray3.15A11-334[»]
    4FZDX-ray3.25A11-334[»]
    4FZFX-ray3.64A11-334[»]
    ProteinModelPortaliQ9Y376.
    SMRiQ9Y376. Positions 2-336.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y376.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Mo25 family.Curated

    Phylogenomic databases

    eggNOGiNOG307443.
    HOGENOMiHOG000234711.
    HOVERGENiHBG050757.
    InParanoidiQ9Y376.
    KOiK08272.
    OMAiCKGYEHS.
    OrthoDBiEOG7CK371.
    PhylomeDBiQ9Y376.
    TreeFamiTF314910.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013878. Mo25.
    [Graphical view]
    PANTHERiPTHR10182. PTHR10182. 1 hit.
    PfamiPF08569. Mo25. 1 hit.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y376-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPFPFGKSHK SPADIVKNLK ESMAVLEKQD ISDKKAEKAT EEVSKNLVAM    50
    KEILYGTNEK EPQTEAVAQL AQELYNSGLL STLVADLQLI DFEGKKDVAQ 100
    IFNNILRRQI GTRTPTVEYI CTQQNILFML LKGYESPEIA LNCGIMLREC 150
    IRHEPLAKII LWSEQFYDFF RYVEMSTFDI ASDAFATFKD LLTRHKLLSA 200
    EFLEQHYDRF FSEYEKLLHS ENYVTKRQSL KLLGELLLDR HNFTIMTKYI 250
    SKPENLKLMM NLLRDKSRNI QFEAFHVFKV FVANPNKTQP ILDILLKNQA 300
    KLIEFLSKFQ NDRTEDEQFN DEKTYLVKQI RDLKRPAQQE A 341
    Length:341
    Mass (Da):39,869
    Last modified:November 1, 1999 - v1
    Checksum:iEC710A528B6F9811
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151824 mRNA. Translation: AAD34061.1.
    AF113536 mRNA. Translation: AAF14873.1.
    AK292382 mRNA. Translation: BAF85071.1.
    AK315692 mRNA. Translation: BAG38055.1.
    CH471063 Genomic DNA. Translation: EAW70932.1.
    BC020570 mRNA. Translation: AAH20570.1.
    CCDSiCCDS2478.1.
    RefSeqiNP_001124321.1. NM_001130849.1.
    NP_001124322.1. NM_001130850.1.
    NP_057373.1. NM_016289.3.
    UniGeneiHs.603930.

    Genome annotation databases

    EnsembliENST00000258418; ENSP00000258418; ENSG00000135932.
    ENST00000409788; ENSP00000386238; ENSG00000135932.
    ENST00000410084; ENSP00000386642; ENSG00000135932.
    GeneIDi51719.
    KEGGihsa:51719.
    UCSCiuc002vqx.3. human.

    Polymorphism databases

    DMDMi15214082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151824 mRNA. Translation: AAD34061.1 .
    AF113536 mRNA. Translation: AAF14873.1 .
    AK292382 mRNA. Translation: BAF85071.1 .
    AK315692 mRNA. Translation: BAG38055.1 .
    CH471063 Genomic DNA. Translation: EAW70932.1 .
    BC020570 mRNA. Translation: AAH20570.1 .
    CCDSi CCDS2478.1.
    RefSeqi NP_001124321.1. NM_001130849.1.
    NP_001124322.1. NM_001130850.1.
    NP_057373.1. NM_016289.3.
    UniGenei Hs.603930.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UPK X-ray 1.85 A 1-341 [» ]
    1UPL X-ray 2.60 A/B 1-341 [» ]
    2WTK X-ray 2.65 A/D 1-341 [» ]
    3GNI X-ray 2.35 A 1-341 [» ]
    4FZA X-ray 3.15 A 11-334 [» ]
    4FZD X-ray 3.25 A 11-334 [» ]
    4FZF X-ray 3.64 A 11-334 [» ]
    ProteinModelPortali Q9Y376.
    SMRi Q9Y376. Positions 2-336.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119696. 15 interactions.
    DIPi DIP-31316N.
    IntActi Q9Y376. 11 interactions.
    MINTi MINT-5000103.
    STRINGi 9606.ENSP00000258418.

    PTM databases

    PhosphoSitei Q9Y376.

    Polymorphism databases

    DMDMi 15214082.

    Proteomic databases

    MaxQBi Q9Y376.
    PaxDbi Q9Y376.
    PeptideAtlasi Q9Y376.
    PRIDEi Q9Y376.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000258418 ; ENSP00000258418 ; ENSG00000135932 .
    ENST00000409788 ; ENSP00000386238 ; ENSG00000135932 .
    ENST00000410084 ; ENSP00000386642 ; ENSG00000135932 .
    GeneIDi 51719.
    KEGGi hsa:51719.
    UCSCi uc002vqx.3. human.

    Organism-specific databases

    CTDi 51719.
    GeneCardsi GC02P231577.
    HGNCi HGNC:20292. CAB39.
    HPAi CAB037112.
    MIMi 612174. gene.
    neXtProti NX_Q9Y376.
    PharmGKBi PA128394663.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG307443.
    HOGENOMi HOG000234711.
    HOVERGENi HBG050757.
    InParanoidi Q9Y376.
    KOi K08272.
    OMAi CKGYEHS.
    OrthoDBi EOG7CK371.
    PhylomeDBi Q9Y376.
    TreeFami TF314910.

    Enzyme and pathway databases

    Reactomei REACT_21285. Regulation of AMPK activity via LKB1.

    Miscellaneous databases

    EvolutionaryTracei Q9Y376.
    GeneWikii CAB39.
    GenomeRNAii 51719.
    NextBioi 55768.
    PROi Q9Y376.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y376.
    Bgeei Q9Y376.
    CleanExi HS_CAB39.
    Genevestigatori Q9Y376.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR013878. Mo25.
    [Graphical view ]
    PANTHERi PTHR10182. PTHR10182. 1 hit.
    Pfami PF08569. Mo25. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "A novel gene expressed in the human hypothalamus."
      Jin W., Shi J., Ren S., Gu J., Fu S., Huang Q., Dong H., Yu Y., Fu G., Wang Y., Chen Z., Han Z.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Hypothalamus.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Duodenum.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Crystal structure of MO25 alpha in complex with the C-terminus of the pseudo kinase STE20-related adaptor."
      Milburn C.C., Boudeau J., Deak M., Alessi D.R., van Aalten D.M.
      Nat. Struct. Mol. Biol. 11:193-200(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) OF 10-339.
    8. "Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation."
      Zeqiraj E., Filippi B.M., Deak M., Alessi D.R., van Aalten D.M.
      Science 326:1707-1711(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 1-341 IN COMPLEX WITH STK11/LKB1 AND STRADA, IDENTIFICATION IN A COMPLEX WITH STK11/LKB1 AND STRADA, FUNCTION, MUTAGENESIS OF ARG-240 AND PHE-243.

    Entry informationi

    Entry nameiCAB39_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y376
    Secondary accession number(s): A8K8L7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 14, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 125 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3