Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y365

- PCTL_HUMAN

UniProt

Q9Y365 - PCTL_HUMAN

Protein

PCTP-like protein

Gene

STARD10

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (15 Nov 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May play metabolic roles in sperm maturation or fertilization By similarity. Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.By similarity1 Publication

    GO - Molecular functioni

    1. lipid binding Source: UniProtKB-KW
    2. protein binding Source: IntAct

    GO - Biological processi

    1. lipid transport Source: UniProtKB-KW

    Keywords - Biological processi

    Lipid transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    PCTP-like protein
    Short name:
    PCTP-L
    Alternative name(s):
    Antigen NY-CO-28
    START domain-containing protein 10
    Short name:
    StARD10
    Serologically defined colon cancer antigen 28
    StAR-related lipid transfer protein 10
    Gene namesi
    Name:STARD10
    Synonyms:SDCCAG28
    ORF Names:CGI-52
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:10666. STARD10.

    Subcellular locationi

    Cell projectionciliumflagellum By similarity. Cytoplasm 1 Publication. Membrane 1 Publication
    Note: In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm By similarity. Mainly cytosolic.By similarity

    GO - Cellular componenti

    1. cell projection Source: UniProtKB-KW
    2. cytoplasm Source: UniProtKB-SubCell
    3. membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell projection, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35596.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 291291PCTP-like proteinPRO_0000220661Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei94 – 941N6-succinyllysineBy similarity
    Modified residuei197 – 1971N6-succinyllysineBy similarity
    Modified residuei202 – 2021N6-succinyllysineBy similarity
    Modified residuei284 – 2841Phosphoserine; by CK21 Publication

    Post-translational modificationi

    Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y365.
    PaxDbiQ9Y365.
    PRIDEiQ9Y365.

    PTM databases

    PhosphoSiteiQ9Y365.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y365.
    BgeeiQ9Y365.
    CleanExiHS_STARD10.
    GenevestigatoriQ9Y365.

    Organism-specific databases

    HPAiHPA026661.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PRMT6Q96LA82EBI-4289836,EBI-912440

    Protein-protein interaction databases

    BioGridi116023. 4 interactions.
    IntActiQ9Y365. 1 interaction.
    MINTiMINT-5000159.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y365.
    SMRiQ9Y365. Positions 42-198.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini14 – 224211STARTPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 START domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG292439.
    HOGENOMiHOG000019919.
    HOVERGENiHBG031807.
    InParanoidiQ9Y365.
    OMAiASFKAEC.
    PhylomeDBiQ9Y365.
    TreeFamiTF354285.

    Family and domain databases

    Gene3Di3.30.530.20. 1 hit.
    InterProiIPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view]
    PfamiPF01852. START. 1 hit.
    [Graphical view]
    SMARTiSM00234. START. 1 hit.
    [Graphical view]
    PROSITEiPS50848. START. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y365-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLAASTEP QGPRPVLGRE SVQVPDDQDF RSFRSECEAE VGWNLTYSRA    50
    GVSVWVQAVE MDRTLHKIKC RMECCDVPAE TLYDVLHDIE YRKKWDSNVI 100
    ETFDIARLTV NADVGYYSWR CPKPLKNRDV ITLRSWLPMG ADYIIMNYSV 150
    KHPKYPPRKD LVRAVSIQTG YLIQSTGPKS CVITYLAQVD PKGSLPKWVV 200
    NKSSQFLAPK AMKKMYKACL KYPEWKQKHL PHFKPWLHPE QSPLPSLALS 250
    ELSVQHADSL ENIDESAVAE SREERMGGAG GEGSDDDTSL T 291
    Length:291
    Mass (Da):33,049
    Last modified:November 15, 2002 - v2
    Checksum:i26D6D3AF8C300EA6
    GO

    Sequence cautioni

    The sequence AAC18045.1 differs from that shown. Reason: Various sequencing problems as well as a translation in a wrong frame.
    The sequence AAD34047.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151810 mRNA. Translation: AAD34047.1. Different initiation.
    BC007919 mRNA. Translation: AAH07919.1.
    BC014033 mRNA. Translation: AAH14033.1.
    AF039696 mRNA. Translation: AAC18045.1. Sequence problems.
    CCDSiCCDS41688.1.
    RefSeqiNP_006636.2. NM_006645.2.
    UniGeneiHs.188606.

    Genome annotation databases

    EnsembliENST00000334805; ENSP00000335247; ENSG00000214530.
    ENST00000543304; ENSP00000438792; ENSG00000214530.
    GeneIDi10809.
    KEGGihsa:10809.
    UCSCiuc001osy.3. human.

    Polymorphism databases

    DMDMi25090873.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF151810 mRNA. Translation: AAD34047.1 . Different initiation.
    BC007919 mRNA. Translation: AAH07919.1 .
    BC014033 mRNA. Translation: AAH14033.1 .
    AF039696 mRNA. Translation: AAC18045.1 . Sequence problems.
    CCDSi CCDS41688.1.
    RefSeqi NP_006636.2. NM_006645.2.
    UniGenei Hs.188606.

    3D structure databases

    ProteinModelPortali Q9Y365.
    SMRi Q9Y365. Positions 42-198.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 116023. 4 interactions.
    IntActi Q9Y365. 1 interaction.
    MINTi MINT-5000159.

    PTM databases

    PhosphoSitei Q9Y365.

    Polymorphism databases

    DMDMi 25090873.

    Proteomic databases

    MaxQBi Q9Y365.
    PaxDbi Q9Y365.
    PRIDEi Q9Y365.

    Protocols and materials databases

    DNASUi 10809.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000334805 ; ENSP00000335247 ; ENSG00000214530 .
    ENST00000543304 ; ENSP00000438792 ; ENSG00000214530 .
    GeneIDi 10809.
    KEGGi hsa:10809.
    UCSCi uc001osy.3. human.

    Organism-specific databases

    CTDi 10809.
    GeneCardsi GC11M072465.
    HGNCi HGNC:10666. STARD10.
    HPAi HPA026661.
    neXtProti NX_Q9Y365.
    PharmGKBi PA35596.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG292439.
    HOGENOMi HOG000019919.
    HOVERGENi HBG031807.
    InParanoidi Q9Y365.
    OMAi ASFKAEC.
    PhylomeDBi Q9Y365.
    TreeFami TF354285.

    Miscellaneous databases

    GeneWikii STARD10.
    GenomeRNAii 10809.
    NextBioi 41063.
    PROi Q9Y365.

    Gene expression databases

    ArrayExpressi Q9Y365.
    Bgeei Q9Y365.
    CleanExi HS_STARD10.
    Genevestigatori Q9Y365.

    Family and domain databases

    Gene3Di 3.30.530.20. 1 hit.
    InterProi IPR023393. START-like_dom.
    IPR002913. START_lipid-bd_dom.
    [Graphical view ]
    Pfami PF01852. START. 1 hit.
    [Graphical view ]
    SMARTi SM00234. START. 1 hit.
    [Graphical view ]
    PROSITEi PS50848. START. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    3. "Characterization of human colon cancer antigens recognized by autologous antibodies."
      Scanlan M.J., Chen Y.-T., Williamson B., Gure A.O., Stockert E., Gordan J.D., Tuereci O., Sahin U., Pfreundschuh M., Old L.J.
      Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Colon carcinoma.
    4. "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein."
      Olayioye M.A., Vehring S., Muller P., Herrmann A., Schiller J., Thiele C., Lindeman G.J., Visvader J.E., Pomorski T.
      J. Biol. Chem. 280:27436-27442(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, LIPID-BINDING.
    5. "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity."
      Olayioye M.A., Buchholz M., Schmid S., Schoffler P., Hoffmann P., Pomorski T.
      J. Biol. Chem. 282:22492-22498(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-284, SUBCELLULAR LOCATION.
    6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPCTL_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y365
    Secondary accession number(s): O60532
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: November 15, 2002
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3