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Q9Y365

- PCTL_HUMAN

UniProt

Q9Y365 - PCTL_HUMAN

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Protein

PCTP-like protein

Gene
STARD10, SDCCAG28, CGI-52
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

May play metabolic roles in sperm maturation or fertilization By similarity. Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.1 Publication

GO - Molecular functioni

  1. lipid binding Source: UniProtKB-KW
  2. protein binding Source: IntAct

GO - Biological processi

  1. lipid transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
PCTP-like protein
Short name:
PCTP-L
Alternative name(s):
Antigen NY-CO-28
START domain-containing protein 10
Short name:
StARD10
Serologically defined colon cancer antigen 28
StAR-related lipid transfer protein 10
Gene namesi
Name:STARD10
Synonyms:SDCCAG28
ORF Names:CGI-52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:10666. STARD10.

Subcellular locationi

Cell projectionciliumflagellum By similarity. Cytoplasm. Membrane
Note: In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm By similarity. Mainly cytosolic.1 Publication

GO - Cellular componenti

  1. cell projection Source: UniProtKB-KW
  2. cytoplasm Source: UniProtKB-SubCell
  3. membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35596.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 291291PCTP-like proteinPRO_0000220661Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei94 – 941N6-succinyllysine By similarity
Modified residuei197 – 1971N6-succinyllysine By similarity
Modified residuei202 – 2021N6-succinyllysine By similarity
Modified residuei284 – 2841Phosphoserine; by CK21 Publication

Post-translational modificationi

Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y365.
PaxDbiQ9Y365.
PRIDEiQ9Y365.

PTM databases

PhosphoSiteiQ9Y365.

Expressioni

Gene expression databases

ArrayExpressiQ9Y365.
BgeeiQ9Y365.
CleanExiHS_STARD10.
GenevestigatoriQ9Y365.

Organism-specific databases

HPAiHPA026661.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PRMT6Q96LA82EBI-4289836,EBI-912440

Protein-protein interaction databases

BioGridi116023. 4 interactions.
IntActiQ9Y365. 1 interaction.
MINTiMINT-5000159.

Structurei

3D structure databases

ProteinModelPortaliQ9Y365.
SMRiQ9Y365. Positions 42-198.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 224211STARTAdd
BLAST

Sequence similaritiesi

Contains 1 START domain.

Phylogenomic databases

eggNOGiNOG292439.
HOGENOMiHOG000019919.
HOVERGENiHBG031807.
InParanoidiQ9Y365.
OMAiASFKAEC.
PhylomeDBiQ9Y365.
TreeFamiTF354285.

Family and domain databases

Gene3Di3.30.530.20. 1 hit.
InterProiIPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view]
PfamiPF01852. START. 1 hit.
[Graphical view]
SMARTiSM00234. START. 1 hit.
[Graphical view]
PROSITEiPS50848. START. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y365-1 [UniParc]FASTAAdd to Basket

« Hide

MEKLAASTEP QGPRPVLGRE SVQVPDDQDF RSFRSECEAE VGWNLTYSRA    50
GVSVWVQAVE MDRTLHKIKC RMECCDVPAE TLYDVLHDIE YRKKWDSNVI 100
ETFDIARLTV NADVGYYSWR CPKPLKNRDV ITLRSWLPMG ADYIIMNYSV 150
KHPKYPPRKD LVRAVSIQTG YLIQSTGPKS CVITYLAQVD PKGSLPKWVV 200
NKSSQFLAPK AMKKMYKACL KYPEWKQKHL PHFKPWLHPE QSPLPSLALS 250
ELSVQHADSL ENIDESAVAE SREERMGGAG GEGSDDDTSL T 291
Length:291
Mass (Da):33,049
Last modified:November 15, 2002 - v2
Checksum:i26D6D3AF8C300EA6
GO

Sequence cautioni

The sequence AAC18045.1 differs from that shown. Reason: Various sequencing problems as well as a translation in a wrong frame.
The sequence AAD34047.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151810 mRNA. Translation: AAD34047.1. Different initiation.
BC007919 mRNA. Translation: AAH07919.1.
BC014033 mRNA. Translation: AAH14033.1.
AF039696 mRNA. Translation: AAC18045.1. Sequence problems.
CCDSiCCDS41688.1.
RefSeqiNP_006636.2. NM_006645.2.
UniGeneiHs.188606.

Genome annotation databases

EnsembliENST00000334805; ENSP00000335247; ENSG00000214530.
ENST00000543304; ENSP00000438792; ENSG00000214530.
GeneIDi10809.
KEGGihsa:10809.
UCSCiuc001osy.3. human.

Polymorphism databases

DMDMi25090873.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF151810 mRNA. Translation: AAD34047.1 . Different initiation.
BC007919 mRNA. Translation: AAH07919.1 .
BC014033 mRNA. Translation: AAH14033.1 .
AF039696 mRNA. Translation: AAC18045.1 . Sequence problems.
CCDSi CCDS41688.1.
RefSeqi NP_006636.2. NM_006645.2.
UniGenei Hs.188606.

3D structure databases

ProteinModelPortali Q9Y365.
SMRi Q9Y365. Positions 42-198.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 116023. 4 interactions.
IntActi Q9Y365. 1 interaction.
MINTi MINT-5000159.

PTM databases

PhosphoSitei Q9Y365.

Polymorphism databases

DMDMi 25090873.

Proteomic databases

MaxQBi Q9Y365.
PaxDbi Q9Y365.
PRIDEi Q9Y365.

Protocols and materials databases

DNASUi 10809.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000334805 ; ENSP00000335247 ; ENSG00000214530 .
ENST00000543304 ; ENSP00000438792 ; ENSG00000214530 .
GeneIDi 10809.
KEGGi hsa:10809.
UCSCi uc001osy.3. human.

Organism-specific databases

CTDi 10809.
GeneCardsi GC11M072465.
HGNCi HGNC:10666. STARD10.
HPAi HPA026661.
neXtProti NX_Q9Y365.
PharmGKBi PA35596.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG292439.
HOGENOMi HOG000019919.
HOVERGENi HBG031807.
InParanoidi Q9Y365.
OMAi ASFKAEC.
PhylomeDBi Q9Y365.
TreeFami TF354285.

Miscellaneous databases

GeneWikii STARD10.
GenomeRNAii 10809.
NextBioi 41063.
PROi Q9Y365.

Gene expression databases

ArrayExpressi Q9Y365.
Bgeei Q9Y365.
CleanExi HS_STARD10.
Genevestigatori Q9Y365.

Family and domain databases

Gene3Di 3.30.530.20. 1 hit.
InterProi IPR023393. START-like_dom.
IPR002913. START_lipid-bd_dom.
[Graphical view ]
Pfami PF01852. START. 1 hit.
[Graphical view ]
SMARTi SM00234. START. 1 hit.
[Graphical view ]
PROSITEi PS50848. START. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  3. "Characterization of human colon cancer antigens recognized by autologous antibodies."
    Scanlan M.J., Chen Y.-T., Williamson B., Gure A.O., Stockert E., Gordan J.D., Tuereci O., Sahin U., Pfreundschuh M., Old L.J.
    Int. J. Cancer 76:652-658(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Colon carcinoma.
  4. "StarD10, a START domain protein overexpressed in breast cancer, functions as a phospholipid transfer protein."
    Olayioye M.A., Vehring S., Muller P., Herrmann A., Schiller J., Thiele C., Lindeman G.J., Visvader J.E., Pomorski T.
    J. Biol. Chem. 280:27436-27442(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, LIPID-BINDING.
  5. "Phosphorylation of StarD10 on serine 284 by casein kinase II modulates its lipid transfer activity."
    Olayioye M.A., Buchholz M., Schmid S., Schoffler P., Hoffmann P., Pomorski T.
    J. Biol. Chem. 282:22492-22498(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-284, SUBCELLULAR LOCATION.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPCTL_HUMAN
AccessioniPrimary (citable) accession number: Q9Y365
Secondary accession number(s): O60532
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: November 15, 2002
Last modified: July 9, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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