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Protein

Sorting nexin-24

Gene

SNX24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei40Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei61Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei74Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-24
Gene namesi
Name:SNX24
ORF Names:SBBI31, UNQ654/PRO1284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000064652.10
HGNCiHGNC:21533 SNX24
neXtProtiNX_Q9Y343

Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000064652
PharmGKBiPA134980773

Polymorphism and mutation databases

BioMutaiSNX24
DMDMi20140349

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138721 – 169Sorting nexin-24Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei113PhosphoserineBy similarity1
Modified residuei116PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y343
PaxDbiQ9Y343
PeptideAtlasiQ9Y343
PRIDEiQ9Y343
ProteomicsDBi85973
85974 [Q9Y343-2]

PTM databases

iPTMnetiQ9Y343
PhosphoSitePlusiQ9Y343

Expressioni

Gene expression databases

BgeeiENSG00000064652
CleanExiHS_SNX24
ExpressionAtlasiQ9Y343 baseline and differential
GenevisibleiQ9Y343 HS

Organism-specific databases

HPAiHPA044566
HPA073934

Interactioni

Protein-protein interaction databases

BioGridi118791, 26 interactors
IntActiQ9Y343, 8 interactors
MINTiQ9Y343
STRINGi9606.ENSP00000261369

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 11Combined sources10
Beta strandi19 – 28Combined sources10
Beta strandi31 – 38Combined sources8
Helixi39 – 49Combined sources11
Turni50 – 52Combined sources3
Helixi68 – 88Combined sources21
Helixi94 – 99Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AZ9X-ray1.75A/B1-107[»]
ProteinModelPortaliQ9Y343
SMRiQ9Y343
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 125PXPROSITE-ProRule annotationAdd BLAST125

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiENOG410IMHV Eukaryota
ENOG41123R8 LUCA
GeneTreeiENSGT00390000001280
HOGENOMiHOG000253944
HOVERGENiHBG064936
InParanoidiQ9Y343
KOiK17941
PhylomeDBiQ9Y343
TreeFamiTF332414

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK
60 70 80 90 100
KCIKTPEIPS KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL
110 120 130 140 150
NVRHLPSLPK AESCGSFDET ESEESSKLSH QPVLLFLRDP YVLPAASDFP
160
NVVIEGVLHG IFYPHLQPR
Length:169
Mass (Da):19,818
Last modified:November 1, 1999 - v1
Checksum:i651B3964493AFE5D
GO
Isoform 2 (identifier: Q9Y343-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-169: DFPNVVIEGVLHGIFYPHLQPR → GNQTCHLLTALY

Show »
Length:159
Mass (Da):18,603
Checksum:i82D317A42D081AB7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012034148 – 169DFPNV…HLQPR → GNQTCHLLTALY in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139461 mRNA Translation: AAD32668.1
AY044655 mRNA Translation: AAK98769.1
AY358098 mRNA Translation: AAQ88465.1
BC069012 mRNA Translation: AAH69012.1
BC010886 mRNA Translation: AAH10886.1
CCDSiCCDS4132.1 [Q9Y343-1]
RefSeqiNP_054754.1, NM_014035.2 [Q9Y343-1]
UniGeneiHs.483200

Genome annotation databases

EnsembliENST00000261369; ENSP00000261369; ENSG00000064652 [Q9Y343-1]
ENST00000506996; ENSP00000422535; ENSG00000064652 [Q9Y343-2]
ENST00000513881; ENSP00000424149; ENSG00000064652 [Q9Y343-2]
GeneIDi28966
KEGGihsa:28966
UCSCiuc003ktf.3 human [Q9Y343-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNX24_HUMAN
AccessioniPrimary (citable) accession number: Q9Y343
Secondary accession number(s): Q6UY33
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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