Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y343

- SNX24_HUMAN

UniProt

Q9Y343 - SNX24_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Sorting nexin-24

Gene

SNX24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei38 – 381Phosphatidylinositol 3-phosphateBy similarity
Binding sitei40 – 401Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
Binding sitei61 – 611Phosphatidylinositol 3-phosphateBy similarity
Binding sitei74 – 741Phosphatidylinositol 3-phosphateBy similarity

GO - Molecular functioni

  1. phosphatidylinositol binding Source: InterPro

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-24
Gene namesi
Name:SNX24
ORF Names:SBBI31, UNQ654/PRO1284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:21533. SNX24.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134980773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 169169Sorting nexin-24PRO_0000213872Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei116 – 1161PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y343.
PaxDbiQ9Y343.
PRIDEiQ9Y343.

PTM databases

PhosphoSiteiQ9Y343.

Expressioni

Gene expression databases

BgeeiQ9Y343.
CleanExiHS_SNX24.
ExpressionAtlasiQ9Y343. baseline and differential.
GenevestigatoriQ9Y343.

Organism-specific databases

HPAiHPA044566.

Interactioni

Protein-protein interaction databases

BioGridi118791. 14 interactions.
IntActiQ9Y343. 6 interactions.
MINTiMINT-1398929.
STRINGi9606.ENSP00000261369.

Structurei

Secondary structure

1
169
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi2 – 1110Combined sources
Beta strandi19 – 2810Combined sources
Beta strandi31 – 388Combined sources
Helixi39 – 4911Combined sources
Turni50 – 523Combined sources
Helixi68 – 8821Combined sources
Helixi94 – 996Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AZ9X-ray1.75A/B1-107[»]
ProteinModelPortaliQ9Y343.
SMRiQ9Y343. Positions 1-115.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 125125PXPROSITE-ProRule annotationAdd
BLAST

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG284786.
GeneTreeiENSGT00390000001280.
HOGENOMiHOG000253944.
HOVERGENiHBG064936.
InParanoidiQ9Y343.
KOiK17941.
OrthoDBiEOG7QVM42.
PhylomeDBiQ9Y343.
TreeFamiTF332414.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y343-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK
60 70 80 90 100
KCIKTPEIPS KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL
110 120 130 140 150
NVRHLPSLPK AESCGSFDET ESEESSKLSH QPVLLFLRDP YVLPAASDFP
160
NVVIEGVLHG IFYPHLQPR
Length:169
Mass (Da):19,818
Last modified:November 1, 1999 - v1
Checksum:i651B3964493AFE5D
GO
Isoform 2 (identifier: Q9Y343-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-169: DFPNVVIEGVLHGIFYPHLQPR → GNQTCHLLTALY

Show »
Length:159
Mass (Da):18,603
Checksum:i82D317A42D081AB7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei148 – 16922DFPNV…HLQPR → GNQTCHLLTALY in isoform 2. 2 PublicationsVSP_012034Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139461 mRNA. Translation: AAD32668.1.
AY044655 mRNA. Translation: AAK98769.1.
AY358098 mRNA. Translation: AAQ88465.1.
BC069012 mRNA. Translation: AAH69012.1.
BC010886 mRNA. Translation: AAH10886.1.
CCDSiCCDS4132.1. [Q9Y343-1]
RefSeqiNP_054754.1. NM_014035.2. [Q9Y343-1]
UniGeneiHs.483200.

Genome annotation databases

EnsembliENST00000261369; ENSP00000261369; ENSG00000064652. [Q9Y343-1]
ENST00000506996; ENSP00000422535; ENSG00000064652. [Q9Y343-2]
ENST00000513881; ENSP00000424149; ENSG00000064652. [Q9Y343-2]
GeneIDi28966.
KEGGihsa:28966.
UCSCiuc003ktf.2. human. [Q9Y343-2]
uc011cwo.2. human. [Q9Y343-1]

Polymorphism databases

DMDMi20140349.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139461 mRNA. Translation: AAD32668.1 .
AY044655 mRNA. Translation: AAK98769.1 .
AY358098 mRNA. Translation: AAQ88465.1 .
BC069012 mRNA. Translation: AAH69012.1 .
BC010886 mRNA. Translation: AAH10886.1 .
CCDSi CCDS4132.1. [Q9Y343-1 ]
RefSeqi NP_054754.1. NM_014035.2. [Q9Y343-1 ]
UniGenei Hs.483200.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AZ9 X-ray 1.75 A/B 1-107 [» ]
ProteinModelPortali Q9Y343.
SMRi Q9Y343. Positions 1-115.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118791. 14 interactions.
IntActi Q9Y343. 6 interactions.
MINTi MINT-1398929.
STRINGi 9606.ENSP00000261369.

PTM databases

PhosphoSitei Q9Y343.

Polymorphism databases

DMDMi 20140349.

Proteomic databases

MaxQBi Q9Y343.
PaxDbi Q9Y343.
PRIDEi Q9Y343.

Protocols and materials databases

DNASUi 28966.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261369 ; ENSP00000261369 ; ENSG00000064652 . [Q9Y343-1 ]
ENST00000506996 ; ENSP00000422535 ; ENSG00000064652 . [Q9Y343-2 ]
ENST00000513881 ; ENSP00000424149 ; ENSG00000064652 . [Q9Y343-2 ]
GeneIDi 28966.
KEGGi hsa:28966.
UCSCi uc003ktf.2. human. [Q9Y343-2 ]
uc011cwo.2. human. [Q9Y343-1 ]

Organism-specific databases

CTDi 28966.
GeneCardsi GC05P122209.
HGNCi HGNC:21533. SNX24.
HPAi HPA044566.
neXtProti NX_Q9Y343.
PharmGKBi PA134980773.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284786.
GeneTreei ENSGT00390000001280.
HOGENOMi HOG000253944.
HOVERGENi HBG064936.
InParanoidi Q9Y343.
KOi K17941.
OrthoDBi EOG7QVM42.
PhylomeDBi Q9Y343.
TreeFami TF332414.

Miscellaneous databases

GenomeRNAii 28966.
NextBioi 51819.
PROi Q9Y343.

Gene expression databases

Bgeei Q9Y343.
CleanExi HS_SNX24.
ExpressionAtlasi Q9Y343. baseline and differential.
Genevestigatori Q9Y343.

Family and domain databases

Gene3Di 3.30.1520.10. 1 hit.
InterProi IPR001683. Phox.
[Graphical view ]
Pfami PF00787. PX. 1 hit.
[Graphical view ]
SMARTi SM00312. PX. 1 hit.
[Graphical view ]
SUPFAMi SSF64268. SSF64268. 1 hit.
PROSITEi PS50195. PX. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Hypothetical human protein SBBI31."
    Zhang W., Wan T., Cao X.
    Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "SBBI31 as a new member (SNX24) of the sorting nexin family."
    Hong W.
    Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Kidney and Lung.
  5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSNX24_HUMAN
AccessioniPrimary (citable) accession number: Q9Y343
Secondary accession number(s): Q6UY33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1999
Last modified: November 26, 2014
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3