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Protein

Sorting nexin-24

Gene

SNX24

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in several stages of intracellular trafficking.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei40Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei61Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei74Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Keywords - Ligandi

Lipid-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064652-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-24
Gene namesi
Name:SNX24
ORF Names:SBBI31, UNQ654/PRO1284
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:21533. SNX24.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi28966.
OpenTargetsiENSG00000064652.
PharmGKBiPA134980773.

Polymorphism and mutation databases

BioMutaiSNX24.
DMDMi20140349.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002138721 – 169Sorting nexin-24Add BLAST169

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei113PhosphoserineBy similarity1
Modified residuei116PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y343.
PaxDbiQ9Y343.
PeptideAtlasiQ9Y343.
PRIDEiQ9Y343.

PTM databases

iPTMnetiQ9Y343.
PhosphoSitePlusiQ9Y343.

Expressioni

Gene expression databases

BgeeiENSG00000064652.
CleanExiHS_SNX24.
ExpressionAtlasiQ9Y343. baseline and differential.
GenevisibleiQ9Y343. HS.

Organism-specific databases

HPAiHPA044566.

Interactioni

Protein-protein interaction databases

BioGridi118791. 27 interactors.
IntActiQ9Y343. 8 interactors.
MINTiMINT-1398929.
STRINGi9606.ENSP00000261369.

Structurei

Secondary structure

1169
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi2 – 11Combined sources10
Beta strandi19 – 28Combined sources10
Beta strandi31 – 38Combined sources8
Helixi39 – 49Combined sources11
Turni50 – 52Combined sources3
Helixi68 – 88Combined sources21
Helixi94 – 99Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AZ9X-ray1.75A/B1-107[»]
ProteinModelPortaliQ9Y343.
SMRiQ9Y343.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 125PXPROSITE-ProRule annotationAdd BLAST125

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

Sequence similaritiesi

Belongs to the sorting nexin family.Curated
Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IMHV. Eukaryota.
ENOG41123R8. LUCA.
GeneTreeiENSGT00390000001280.
HOGENOMiHOG000253944.
HOVERGENiHBG064936.
InParanoidiQ9Y343.
KOiK17941.
PhylomeDBiQ9Y343.
TreeFamiTF332414.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y343-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK
60 70 80 90 100
KCIKTPEIPS KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL
110 120 130 140 150
NVRHLPSLPK AESCGSFDET ESEESSKLSH QPVLLFLRDP YVLPAASDFP
160
NVVIEGVLHG IFYPHLQPR
Length:169
Mass (Da):19,818
Last modified:November 1, 1999 - v1
Checksum:i651B3964493AFE5D
GO
Isoform 2 (identifier: Q9Y343-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     148-169: DFPNVVIEGVLHGIFYPHLQPR → GNQTCHLLTALY

Show »
Length:159
Mass (Da):18,603
Checksum:i82D317A42D081AB7
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012034148 – 169DFPNV…HLQPR → GNQTCHLLTALY in isoform 2. 2 PublicationsAdd BLAST22

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139461 mRNA. Translation: AAD32668.1.
AY044655 mRNA. Translation: AAK98769.1.
AY358098 mRNA. Translation: AAQ88465.1.
BC069012 mRNA. Translation: AAH69012.1.
BC010886 mRNA. Translation: AAH10886.1.
CCDSiCCDS4132.1. [Q9Y343-1]
RefSeqiNP_054754.1. NM_014035.2. [Q9Y343-1]
UniGeneiHs.483200.

Genome annotation databases

EnsembliENST00000261369; ENSP00000261369; ENSG00000064652. [Q9Y343-1]
ENST00000506996; ENSP00000422535; ENSG00000064652. [Q9Y343-2]
ENST00000513881; ENSP00000424149; ENSG00000064652. [Q9Y343-2]
GeneIDi28966.
KEGGihsa:28966.
UCSCiuc003ktf.3. human. [Q9Y343-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF139461 mRNA. Translation: AAD32668.1.
AY044655 mRNA. Translation: AAK98769.1.
AY358098 mRNA. Translation: AAQ88465.1.
BC069012 mRNA. Translation: AAH69012.1.
BC010886 mRNA. Translation: AAH10886.1.
CCDSiCCDS4132.1. [Q9Y343-1]
RefSeqiNP_054754.1. NM_014035.2. [Q9Y343-1]
UniGeneiHs.483200.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AZ9X-ray1.75A/B1-107[»]
ProteinModelPortaliQ9Y343.
SMRiQ9Y343.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118791. 27 interactors.
IntActiQ9Y343. 8 interactors.
MINTiMINT-1398929.
STRINGi9606.ENSP00000261369.

PTM databases

iPTMnetiQ9Y343.
PhosphoSitePlusiQ9Y343.

Polymorphism and mutation databases

BioMutaiSNX24.
DMDMi20140349.

Proteomic databases

EPDiQ9Y343.
PaxDbiQ9Y343.
PeptideAtlasiQ9Y343.
PRIDEiQ9Y343.

Protocols and materials databases

DNASUi28966.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261369; ENSP00000261369; ENSG00000064652. [Q9Y343-1]
ENST00000506996; ENSP00000422535; ENSG00000064652. [Q9Y343-2]
ENST00000513881; ENSP00000424149; ENSG00000064652. [Q9Y343-2]
GeneIDi28966.
KEGGihsa:28966.
UCSCiuc003ktf.3. human. [Q9Y343-1]

Organism-specific databases

CTDi28966.
DisGeNETi28966.
GeneCardsiSNX24.
HGNCiHGNC:21533. SNX24.
HPAiHPA044566.
neXtProtiNX_Q9Y343.
OpenTargetsiENSG00000064652.
PharmGKBiPA134980773.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IMHV. Eukaryota.
ENOG41123R8. LUCA.
GeneTreeiENSGT00390000001280.
HOGENOMiHOG000253944.
HOVERGENiHBG064936.
InParanoidiQ9Y343.
KOiK17941.
PhylomeDBiQ9Y343.
TreeFamiTF332414.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000064652-MONOMER.

Miscellaneous databases

GenomeRNAii28966.
PROiQ9Y343.

Gene expression databases

BgeeiENSG00000064652.
CleanExiHS_SNX24.
ExpressionAtlasiQ9Y343. baseline and differential.
GenevisibleiQ9Y343. HS.

Family and domain databases

Gene3Di3.30.1520.10. 1 hit.
InterProiIPR001683. Phox.
[Graphical view]
PfamiPF00787. PX. 1 hit.
[Graphical view]
SMARTiSM00312. PX. 1 hit.
[Graphical view]
SUPFAMiSSF64268. SSF64268. 1 hit.
PROSITEiPS50195. PX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSNX24_HUMAN
AccessioniPrimary (citable) accession number: Q9Y343
Secondary accession number(s): Q6UY33
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.