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Q9Y343

- SNX24_HUMAN

UniProt

Q9Y343 - SNX24_HUMAN

Protein

Sorting nexin-24

Gene

SNX24

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    May be involved in several stages of intracellular trafficking.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei38 – 381Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei40 – 401Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity
    Binding sitei61 – 611Phosphatidylinositol 3-phosphateBy similarity
    Binding sitei74 – 741Phosphatidylinositol 3-phosphateBy similarity

    GO - Molecular functioni

    1. phosphatidylinositol binding Source: InterPro

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    Lipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sorting nexin-24
    Gene namesi
    Name:SNX24
    ORF Names:SBBI31, UNQ654/PRO1284
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:21533. SNX24.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasmic vesicle membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134980773.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 169169Sorting nexin-24PRO_0000213872Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei116 – 1161PhosphoserineBy similarity

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y343.
    PaxDbiQ9Y343.
    PRIDEiQ9Y343.

    PTM databases

    PhosphoSiteiQ9Y343.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y343.
    BgeeiQ9Y343.
    CleanExiHS_SNX24.
    GenevestigatoriQ9Y343.

    Organism-specific databases

    HPAiHPA044566.

    Interactioni

    Protein-protein interaction databases

    BioGridi118791. 7 interactions.
    IntActiQ9Y343. 6 interactions.
    MINTiMINT-1398929.
    STRINGi9606.ENSP00000261369.

    Structurei

    Secondary structure

    1
    169
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi2 – 1110
    Beta strandi19 – 2810
    Beta strandi31 – 388
    Helixi39 – 4911
    Turni50 – 523
    Helixi68 – 8821
    Helixi94 – 996

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AZ9X-ray1.75A/B1-107[»]
    ProteinModelPortaliQ9Y343.
    SMRiQ9Y343. Positions 1-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 125125PXPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).By similarity

    Sequence similaritiesi

    Belongs to the sorting nexin family.Curated
    Contains 1 PX (phox homology) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG284786.
    HOGENOMiHOG000253944.
    HOVERGENiHBG064936.
    KOiK17941.
    OrthoDBiEOG7QVM42.
    PhylomeDBiQ9Y343.
    TreeFamiTF332414.

    Family and domain databases

    Gene3Di3.30.1520.10. 1 hit.
    InterProiIPR001683. Phox.
    [Graphical view]
    PfamiPF00787. PX. 1 hit.
    [Graphical view]
    SMARTiSM00312. PX. 1 hit.
    [Graphical view]
    SUPFAMiSSF64268. SSF64268. 1 hit.
    PROSITEiPS50195. PX. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y343-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK    50
    KCIKTPEIPS KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL 100
    NVRHLPSLPK AESCGSFDET ESEESSKLSH QPVLLFLRDP YVLPAASDFP 150
    NVVIEGVLHG IFYPHLQPR 169
    Length:169
    Mass (Da):19,818
    Last modified:November 1, 1999 - v1
    Checksum:i651B3964493AFE5D
    GO
    Isoform 2 (identifier: Q9Y343-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         148-169: DFPNVVIEGVLHGIFYPHLQPR → GNQTCHLLTALY

    Show »
    Length:159
    Mass (Da):18,603
    Checksum:i82D317A42D081AB7
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei148 – 16922DFPNV…HLQPR → GNQTCHLLTALY in isoform 2. 2 PublicationsVSP_012034Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139461 mRNA. Translation: AAD32668.1.
    AY044655 mRNA. Translation: AAK98769.1.
    AY358098 mRNA. Translation: AAQ88465.1.
    BC069012 mRNA. Translation: AAH69012.1.
    BC010886 mRNA. Translation: AAH10886.1.
    CCDSiCCDS4132.1. [Q9Y343-1]
    RefSeqiNP_054754.1. NM_014035.2. [Q9Y343-1]
    UniGeneiHs.483200.

    Genome annotation databases

    EnsembliENST00000261369; ENSP00000261369; ENSG00000064652. [Q9Y343-1]
    ENST00000506996; ENSP00000422535; ENSG00000064652. [Q9Y343-2]
    ENST00000513881; ENSP00000424149; ENSG00000064652. [Q9Y343-2]
    GeneIDi28966.
    KEGGihsa:28966.
    UCSCiuc003ktf.2. human. [Q9Y343-2]
    uc011cwo.2. human. [Q9Y343-1]

    Polymorphism databases

    DMDMi20140349.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF139461 mRNA. Translation: AAD32668.1 .
    AY044655 mRNA. Translation: AAK98769.1 .
    AY358098 mRNA. Translation: AAQ88465.1 .
    BC069012 mRNA. Translation: AAH69012.1 .
    BC010886 mRNA. Translation: AAH10886.1 .
    CCDSi CCDS4132.1. [Q9Y343-1 ]
    RefSeqi NP_054754.1. NM_014035.2. [Q9Y343-1 ]
    UniGenei Hs.483200.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AZ9 X-ray 1.75 A/B 1-107 [» ]
    ProteinModelPortali Q9Y343.
    SMRi Q9Y343. Positions 1-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118791. 7 interactions.
    IntActi Q9Y343. 6 interactions.
    MINTi MINT-1398929.
    STRINGi 9606.ENSP00000261369.

    PTM databases

    PhosphoSitei Q9Y343.

    Polymorphism databases

    DMDMi 20140349.

    Proteomic databases

    MaxQBi Q9Y343.
    PaxDbi Q9Y343.
    PRIDEi Q9Y343.

    Protocols and materials databases

    DNASUi 28966.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261369 ; ENSP00000261369 ; ENSG00000064652 . [Q9Y343-1 ]
    ENST00000506996 ; ENSP00000422535 ; ENSG00000064652 . [Q9Y343-2 ]
    ENST00000513881 ; ENSP00000424149 ; ENSG00000064652 . [Q9Y343-2 ]
    GeneIDi 28966.
    KEGGi hsa:28966.
    UCSCi uc003ktf.2. human. [Q9Y343-2 ]
    uc011cwo.2. human. [Q9Y343-1 ]

    Organism-specific databases

    CTDi 28966.
    GeneCardsi GC05P122209.
    HGNCi HGNC:21533. SNX24.
    HPAi HPA044566.
    neXtProti NX_Q9Y343.
    PharmGKBi PA134980773.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284786.
    HOGENOMi HOG000253944.
    HOVERGENi HBG064936.
    KOi K17941.
    OrthoDBi EOG7QVM42.
    PhylomeDBi Q9Y343.
    TreeFami TF332414.

    Miscellaneous databases

    GenomeRNAii 28966.
    NextBioi 51819.
    PROi Q9Y343.

    Gene expression databases

    ArrayExpressi Q9Y343.
    Bgeei Q9Y343.
    CleanExi HS_SNX24.
    Genevestigatori Q9Y343.

    Family and domain databases

    Gene3Di 3.30.1520.10. 1 hit.
    InterProi IPR001683. Phox.
    [Graphical view ]
    Pfami PF00787. PX. 1 hit.
    [Graphical view ]
    SMARTi SM00312. PX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF64268. SSF64268. 1 hit.
    PROSITEi PS50195. PX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hypothetical human protein SBBI31."
      Zhang W., Wan T., Cao X.
      Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "SBBI31 as a new member (SNX24) of the sorting nexin family."
      Hong W.
      Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Kidney and Lung.
    5. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    6. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSNX24_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y343
    Secondary accession number(s): Q6UY33
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 27, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 105 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3