Sorting nexin-24 - Homo sapiens (Human)

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Sequences

References

Cross-references

Entry information

Relevant documents

Molecule processing

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Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

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Molecule processing

Regions

Sites

Natural variations

Secondary structure

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

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Q9Y343 (SNX24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 95. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Protein names

Recommended name:
Sorting nexin-24

Gene names

Name:	SNX24
ORF Names:	SBBI31, UNQ654/PRO1284

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Sequence length	169 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

Function	May be involved in several stages of intracellular trafficking By similarity.
Subcellular location	Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity.
Domain	The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) By similarity.
Sequence similarities	Belongs to the sorting nexin family. Contains 1 PX (phox homology) domain.

Keywords
Biological process	Protein transport Transport
Cellular component	Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing
Ligand	Lipid-binding
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell communication Inferred from electronic annotation. Source: InterPro protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasmic vesicle membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	phosphatidylinositol binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Chain

1 – 169

169

Sorting nexin-24

PRO_0000213872

Domain

1 – 125

125

Binding site

Phosphatidylinositol 3-phosphate By similarity

Binding site

Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity

Binding site

Phosphatidylinositol 3-phosphate By similarity

Binding site

Phosphatidylinositol 3-phosphate By similarity

Alternative sequence

148 – 169

DFPNV…HLQPR → GNQTCHLLTALY in isoform 2.

VSP_012034

169

Helix Strand Turn

Details...

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 651B3964493AFE5D Show »	FASTA	169	19,818
10 20 30 40 50 60 MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK KCIKTPEIPS 70 80 90 100 110 120 KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL NVRHLPSLPK AESCGSFDET 130 140 150 160 ESEESSKLSH QPVLLFLRDP YVLPAASDFP NVVIEGVLHG IFYPHLQPR « Hide
Isoform 2 [UniParc]. Checksum: 82D317A42D081AB7 Show »	FASTA	159	18,603
10 20 30 40 50 60 MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK KCIKTPEIPS 70 80 90 100 110 120 KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL NVRHLPSLPK AESCGSFDET 130 140 150 ESEESSKLSH QPVLLFLRDP YVLPAASGNQ TCHLLTALY « Hide

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hypothetical human protein SBBI31." Zhang W., Wan T., Cao X. Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"SBBI31 as a new member (SNX24) of the sorting nexin family." Hong W. Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Kidney and Lung.
+	Additional computationally mapped references.

EMBL
GenBank
DDBJ

AF139461 mRNA. Translation: AAD32668.1.
AY044655 mRNA. Translation: AAK98769.1.
AY358098 mRNA. Translation: AAQ88465.1.
BC069012 mRNA. Translation: AAH69012.1.
BC010886 mRNA. Translation: AAH10886.1.

IPI

IPI00022302.
IPI00432714.

RefSeq

NP_054754.1. NM_014035.2.

UniGene

Hs.483200.

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4AZ9	X-ray	1.75	A/B	1-107	[»]

ProteinModelPortal

Q9Y343.

ModBase

Search...

IntAct

Q9Y343. 4 interactions.

MINT

MINT-1398929.

STRING

9606.ENSP00000261369.

PhosphoSite

Q9Y343.

DMDM

20140349.

PaxDb

Q9Y343.

PRIDE

Q9Y343.

DNASU

28966.

StructuralBiologyKnowledgebase

Search...

Ensembl

ENST00000261369; ENSP00000261369; ENSG00000064652.
ENST00000506996; ENSP00000422535; ENSG00000064652.
ENST00000513881; ENSP00000424149; ENSG00000064652.

GeneID

28966.

KEGG

hsa:28966.

UCSC

uc003ktf.2. human.
uc011cwo.2. human.

CTD

28966.

GeneCards

GC05P122209.

HGNC

HGNC:21533. SNX24.

HPA

HPA044566.

neXtProt

NX_Q9Y343.

PharmGKB

PA134980773.

GenAtlas

Search...

eggNOG

NOG284786.

HOGENOM

HOG000253944.

HOVERGEN

HBG064936.

OrthoDB

EOG4HDSVM.

PhylomeDB

Q9Y343.

ArrayExpress

Q9Y343.

Bgee

Q9Y343.

CleanEx

HS_SNX24.

Genevestigator

Q9Y343.

GermOnline

ENSG00000064652. Homo sapiens.

Gene3D

3.30.1520.10. 1 hit.

InterPro

IPR001683. Phox.
[Graphical view]

Pfam

PF00787. PX. 1 hit.
[Graphical view]

SMART

SM00312. PX. 1 hit.
[Graphical view]

SUPFAM

SSF64268. PX. 1 hit.

PROSITE

PS50195. PX. 1 hit.
[Graphical view]

ProtoNet

Search...

GenomeRNAi

28966.

NextBio

51819.

Entry name

SNX24_HUMAN

Accession

Primary (citable) accession number: Q9Y343
Secondary accession number(s): Q6UY33

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 27, 2002
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 95 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y343-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y343-2)

The sequence of this isoform differs from the canonical sequence as follows:
148-169: DFPNVVIEGVLHGIFYPHLQPR → GNQTCHLLTALY