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Q9Y343 (SNX24_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 104. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sorting nexin-24
Gene names
Name:SNX24
ORF Names:SBBI31, UNQ654/PRO1284
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length169 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in several stages of intracellular trafficking By similarity.

Subcellular location

Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side By similarity.

Domain

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) By similarity.

Sequence similarities

Belongs to the sorting nexin family.

Contains 1 PX (phox homology) domain.

Ontologies

Keywords
   Biological processProtein transport
Transport
   Cellular componentCytoplasmic vesicle
Membrane
   Coding sequence diversityAlternative splicing
   LigandLipid-binding
   PTMAcetylation
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processprotein transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasmic vesicle membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionphosphatidylinositol binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y343-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y343-2)

The sequence of this isoform differs from the canonical sequence as follows:
     148-169: DFPNVVIEGVLHGIFYPHLQPR → GNQTCHLLTALY

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 169169Sorting nexin-24
PRO_0000213872

Regions

Domain1 – 125125PX

Sites

Binding site381Phosphatidylinositol 3-phosphate By similarity
Binding site401Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygen By similarity
Binding site611Phosphatidylinositol 3-phosphate By similarity
Binding site741Phosphatidylinositol 3-phosphate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.6
Modified residue1161Phosphoserine By similarity

Natural variations

Alternative sequence148 – 16922DFPNV…HLQPR → GNQTCHLLTALY in isoform 2.
VSP_012034

Secondary structure

............. 169
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 651B3964493AFE5D

FASTA16919,818
        10         20         30         40         50         60 
MEVYIPSFRY EESDLERGYT VFKIEVLMNG RKHFVEKRYS EFHALHKKLK KCIKTPEIPS 

        70         80         90        100        110        120 
KHVRNWVPKV LEQRRQGLET YLQAVILENE ELPKLFLDFL NVRHLPSLPK AESCGSFDET 

       130        140        150        160 
ESEESSKLSH QPVLLFLRDP YVLPAASDFP NVVIEGVLHG IFYPHLQPR 

« Hide

Isoform 2 [UniParc].

Checksum: 82D317A42D081AB7
Show »

FASTA15918,603

References

« Hide 'large scale' references
[1]"Hypothetical human protein SBBI31."
Zhang W., Wan T., Cao X.
Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]"SBBI31 as a new member (SNX24) of the sorting nexin family."
Hong W.
Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Tissue: Kidney and Lung.
[5]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[6]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF139461 mRNA. Translation: AAD32668.1.
AY044655 mRNA. Translation: AAK98769.1.
AY358098 mRNA. Translation: AAQ88465.1.
BC069012 mRNA. Translation: AAH69012.1.
BC010886 mRNA. Translation: AAH10886.1.
CCDSCCDS4132.1. [Q9Y343-1]
RefSeqNP_054754.1. NM_014035.2. [Q9Y343-1]
UniGeneHs.483200.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4AZ9X-ray1.75A/B1-107[»]
ProteinModelPortalQ9Y343.
SMRQ9Y343. Positions 1-105.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118791. 7 interactions.
IntActQ9Y343. 6 interactions.
MINTMINT-1398929.
STRING9606.ENSP00000261369.

PTM databases

PhosphoSiteQ9Y343.

Polymorphism databases

DMDM20140349.

Proteomic databases

MaxQBQ9Y343.
PaxDbQ9Y343.
PRIDEQ9Y343.

Protocols and materials databases

DNASU28966.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000261369; ENSP00000261369; ENSG00000064652. [Q9Y343-1]
ENST00000506996; ENSP00000422535; ENSG00000064652. [Q9Y343-2]
ENST00000513881; ENSP00000424149; ENSG00000064652. [Q9Y343-2]
GeneID28966.
KEGGhsa:28966.
UCSCuc003ktf.2. human. [Q9Y343-2]
uc011cwo.2. human. [Q9Y343-1]

Organism-specific databases

CTD28966.
GeneCardsGC05P122209.
HGNCHGNC:21533. SNX24.
HPAHPA044566.
neXtProtNX_Q9Y343.
PharmGKBPA134980773.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284786.
HOGENOMHOG000253944.
HOVERGENHBG064936.
KOK17941.
OrthoDBEOG7QVM42.
PhylomeDBQ9Y343.
TreeFamTF332414.

Gene expression databases

ArrayExpressQ9Y343.
BgeeQ9Y343.
CleanExHS_SNX24.
GenevestigatorQ9Y343.

Family and domain databases

Gene3D3.30.1520.10. 1 hit.
InterProIPR001683. Phox.
[Graphical view]
PfamPF00787. PX. 1 hit.
[Graphical view]
SMARTSM00312. PX. 1 hit.
[Graphical view]
SUPFAMSSF64268. SSF64268. 1 hit.
PROSITEPS50195. PX. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi28966.
NextBio51819.
PROQ9Y343.

Entry information

Entry nameSNX24_HUMAN
AccessionPrimary (citable) accession number: Q9Y343
Secondary accession number(s): Q6UY33
Entry history
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM