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Protein

Plasmolipin

Gene

PLLP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmolipin
Alternative name(s):
Plasma membrane proteolipid
Gene namesi
Name:PLLP
Synonyms:PMLP, TM4SF11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:18553. PLLP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3535CytoplasmicSequence analysisAdd
BLAST
Transmembranei36 – 5621HelicalSequence analysisAdd
BLAST
Topological domaini57 – 6812ExtracellularSequence analysisAdd
BLAST
Transmembranei69 – 8921HelicalSequence analysisAdd
BLAST
Topological domaini90 – 9910CytoplasmicSequence analysis
Transmembranei100 – 12021HelicalSequence analysisAdd
BLAST
Topological domaini121 – 14121ExtracellularSequence analysisAdd
BLAST
Transmembranei142 – 16221HelicalSequence analysisAdd
BLAST
Topological domaini163 – 18220CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • compact myelin Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • membrane raft Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA38572.

Polymorphism and mutation databases

BioMutaiPLLP.
DMDMi12229882.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 182182PlasmolipinPRO_0000156813Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei9 – 91PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y342.
PaxDbiQ9Y342.
PeptideAtlasiQ9Y342.
PRIDEiQ9Y342.

PTM databases

iPTMnetiQ9Y342.
PhosphoSiteiQ9Y342.

Expressioni

Gene expression databases

BgeeiENSG00000102934.
CleanExiHS_PLLP.
ExpressionAtlasiQ9Y342. baseline and differential.
GenevisibleiQ9Y342. HS.

Organism-specific databases

HPAiHPA041862.

Interactioni

Subunit structurei

Hexamer arranged as a trimer of two plasmolipin subunits.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BCL2L13Q9BXK53EBI-3919291,EBI-747430
MS4A12Q9NXJ03EBI-3919291,EBI-10227644

Protein-protein interaction databases

BioGridi119279. 5 interactions.
IntActiQ9Y342. 4 interactions.
MINTiMINT-5005766.
STRINGi9606.ENSP00000219207.

Structurei

3D structure databases

ProteinModelPortaliQ9Y342.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 166135MARVELPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the MAL family.Curated
Contains 1 MARVEL domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiQ9Y342.
OMAiVLMIFNV.
OrthoDBiEOG091G0RE7.
PhylomeDBiQ9Y342.
TreeFamiTF316174.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFPSKVST RTSSPAQGAE ASVSALRPDL GFVRSRLGAL MLLQLVLGLL
60 70 80 90 100
VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVLFNLYLFQ LHMKLYMVPW
110 120 130 140 150
PLVLMIFNIS ATVLYITAFI ACSAAVDLTS LRGTRPYNQR AAASFFACLV
160 170 180
MIAYGVSAFF SYQAWRGVGS NAATSQMAGG YA
Length:182
Mass (Da):19,987
Last modified:November 1, 1999 - v1
Checksum:i6F09AA080E2F67E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137386 mRNA. Translation: AAD33060.1.
AK313910 mRNA. Translation: BAG36633.1.
CH471092 Genomic DNA. Translation: EAW82915.1.
BC002760 mRNA. Translation: AAH02760.1.
CCDSiCCDS10777.1.
RefSeqiNP_057077.1. NM_015993.2.
UniGeneiHs.632215.

Genome annotation databases

EnsembliENST00000219207; ENSP00000219207; ENSG00000102934.
GeneIDi51090.
KEGGihsa:51090.
UCSCiuc002elg.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137386 mRNA. Translation: AAD33060.1.
AK313910 mRNA. Translation: BAG36633.1.
CH471092 Genomic DNA. Translation: EAW82915.1.
BC002760 mRNA. Translation: AAH02760.1.
CCDSiCCDS10777.1.
RefSeqiNP_057077.1. NM_015993.2.
UniGeneiHs.632215.

3D structure databases

ProteinModelPortaliQ9Y342.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119279. 5 interactions.
IntActiQ9Y342. 4 interactions.
MINTiMINT-5005766.
STRINGi9606.ENSP00000219207.

PTM databases

iPTMnetiQ9Y342.
PhosphoSiteiQ9Y342.

Polymorphism and mutation databases

BioMutaiPLLP.
DMDMi12229882.

Proteomic databases

MaxQBiQ9Y342.
PaxDbiQ9Y342.
PeptideAtlasiQ9Y342.
PRIDEiQ9Y342.

Protocols and materials databases

DNASUi51090.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219207; ENSP00000219207; ENSG00000102934.
GeneIDi51090.
KEGGihsa:51090.
UCSCiuc002elg.3. human.

Organism-specific databases

CTDi51090.
GeneCardsiPLLP.
HGNCiHGNC:18553. PLLP.
HPAiHPA041862.
MIMi600340. gene.
neXtProtiNX_Q9Y342.
PharmGKBiPA38572.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4788. Eukaryota.
ENOG4111IAF. LUCA.
GeneTreeiENSGT00730000110954.
HOGENOMiHOG000247057.
HOVERGENiHBG108271.
InParanoidiQ9Y342.
OMAiVLMIFNV.
OrthoDBiEOG091G0RE7.
PhylomeDBiQ9Y342.
TreeFamiTF316174.

Miscellaneous databases

GenomeRNAii51090.
PROiQ9Y342.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102934.
CleanExiHS_PLLP.
ExpressionAtlasiQ9Y342. baseline and differential.
GenevisibleiQ9Y342. HS.

Family and domain databases

InterProiIPR013295. MAL.
IPR008253. Marvel.
[Graphical view]
PfamiPF01284. MARVEL. 1 hit.
[Graphical view]
PRINTSiPR01884. MALPROTEIN.
PROSITEiPS51225. MARVEL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPLLP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y342
Secondary accession number(s): B2R9T6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 7, 2016
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.