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Protein

Plasmolipin

Gene

PLLP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmolipin
Alternative name(s):
Plasma membrane proteolipid
Gene namesi
Name:PLLP
Synonyms:PMLP, TM4SF11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102934.9
HGNCiHGNC:18553 PLLP
MIMi600340 gene
neXtProtiNX_Q9Y342

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 68ExtracellularSequence analysisAdd BLAST12
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 99CytoplasmicSequence analysis10
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 141ExtracellularSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 182CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51090
OpenTargetsiENSG00000102934
PharmGKBiPA38572

Polymorphism and mutation databases

BioMutaiPLLP
DMDMi12229882

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568131 – 182PlasmolipinAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y342
PaxDbiQ9Y342
PeptideAtlasiQ9Y342
PRIDEiQ9Y342

PTM databases

iPTMnetiQ9Y342
PhosphoSitePlusiQ9Y342

Expressioni

Gene expression databases

BgeeiENSG00000102934
CleanExiHS_PLLP
ExpressionAtlasiQ9Y342 baseline and differential
GenevisibleiQ9Y342 HS

Organism-specific databases

HPAiHPA041862

Interactioni

Subunit structurei

Hexamer arranged as a trimer of two plasmolipin subunits.By similarity

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi119279, 6 interactors
IntActiQ9Y342, 18 interactors
MINTiQ9Y342
STRINGi9606.ENSP00000219207

Structurei

3D structure databases

ProteinModelPortaliQ9Y342
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 166MARVELPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00730000110954
HOGENOMiHOG000247057
HOVERGENiHBG108271
InParanoidiQ9Y342
OMAiVLMIFNV
OrthoDBiEOG091G0RE7
PhylomeDBiQ9Y342
TreeFamiTF316174

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y342-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAEFPSKVST RTSSPAQGAE ASVSALRPDL GFVRSRLGAL MLLQLVLGLL
60 70 80 90 100
VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVLFNLYLFQ LHMKLYMVPW
110 120 130 140 150
PLVLMIFNIS ATVLYITAFI ACSAAVDLTS LRGTRPYNQR AAASFFACLV
160 170 180
MIAYGVSAFF SYQAWRGVGS NAATSQMAGG YA
Length:182
Mass (Da):19,987
Last modified:November 1, 1999 - v1
Checksum:i6F09AA080E2F67E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF137386 mRNA Translation: AAD33060.1
AK313910 mRNA Translation: BAG36633.1
CH471092 Genomic DNA Translation: EAW82915.1
BC002760 mRNA Translation: AAH02760.1
CCDSiCCDS10777.1
RefSeqiNP_057077.1, NM_015993.2
UniGeneiHs.632215

Genome annotation databases

EnsembliENST00000219207; ENSP00000219207; ENSG00000102934
GeneIDi51090
KEGGihsa:51090
UCSCiuc002elg.3 human

Similar proteinsi

Entry informationi

Entry nameiPLLP_HUMAN
AccessioniPrimary (citable) accession number: Q9Y342
Secondary accession number(s): B2R9T6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: April 25, 2018
This is version 130 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health