Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y337

- KLK5_HUMAN

UniProt

Q9Y337 - KLK5_HUMAN

Protein

Kallikrein-5

Gene

KLK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    May be involved in desquamation.

    Enzyme regulationi

    Inhibited by Zn2+.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei108 – 1081Charge relay system1 Publication
    Sitei150 – 1501Major binding site for inhibitory zinc
    Active sitei153 – 1531Charge relay system1 Publication
    Active sitei245 – 2451Charge relay system1 Publication

    GO - Molecular functioni

    1. peptidase activity Source: ProtInc
    2. protein binding Source: UniProtKB
    3. serine-type endopeptidase activity Source: UniProtKB
    4. serine-type peptidase activity Source: ProtInc

    GO - Biological processi

    1. epidermis development Source: ProtInc
    2. positive regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Protein family/group databases

    MEROPSiS01.017.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kallikrein-5 (EC:3.4.21.-)
    Alternative name(s):
    Kallikrein-like protein 2
    Short name:
    KLK-L2
    Stratum corneum tryptic enzyme
    Gene namesi
    Name:KLK5
    Synonyms:SCTE
    ORF Names:UNQ570/PRO1132
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:6366. KLK5.

    Subcellular locationi

    GO - Cellular componenti

    1. epidermal lamellar body Source: UniProtKB
    2. extracellular space Source: ProtInc

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30155.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 293271Kallikrein-5PRO_0000027939Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi69 – 691N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi73 ↔ 2061 PublicationPROSITE-ProRule annotation
    Disulfide bondi93 ↔ 1091 PublicationPROSITE-ProRule annotation
    Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi178 ↔ 2791 PublicationPROSITE-ProRule annotation
    Disulfide bondi185 ↔ 2511 PublicationPROSITE-ProRule annotation
    Glycosylationi208 – 2081N-linked (GlcNAc...)1 Publication
    Disulfide bondi217 ↔ 2311 PublicationPROSITE-ProRule annotation
    Disulfide bondi241 ↔ 2661 PublicationPROSITE-ProRule annotation
    Glycosylationi252 – 2521N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y337.
    PRIDEiQ9Y337.

    PTM databases

    PhosphoSiteiQ9Y337.

    Miscellaneous databases

    PMAP-CutDBQ9Y337.

    Expressioni

    Tissue specificityi

    Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y337.
    BgeeiQ9Y337.
    CleanExiHS_KLK5.
    GenevestigatoriQ9Y337.

    Organism-specific databases

    HPAiCAB025503.
    CAB026341.
    HPA014343.

    Interactioni

    Subunit structurei

    Interacts with SPINK9.2 Publications

    Protein-protein interaction databases

    BioGridi117346. 1 interaction.
    STRINGi9606.ENSP00000337733.

    Structurei

    Secondary structure

    1
    293
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi81 – 866
    Turni87 – 893
    Beta strandi90 – 9910
    Beta strandi102 – 1054
    Helixi107 – 1093
    Beta strandi115 – 1195
    Beta strandi122 – 1243
    Beta strandi132 – 14110
    Beta strandi147 – 1493
    Beta strandi155 – 1617
    Beta strandi167 – 1693
    Beta strandi184 – 1918
    Beta strandi193 – 1975
    Beta strandi205 – 2117
    Helixi214 – 2207
    Turni222 – 2243
    Beta strandi229 – 2324
    Beta strandi248 – 2514
    Beta strandi254 – 2618
    Beta strandi273 – 2775
    Helixi278 – 2803
    Helixi282 – 29110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2PSXX-ray2.30A67-293[»]
    2PSYX-ray2.30A67-293[»]
    ProteinModelPortaliQ9Y337.
    SMRiQ9Y337. Positions 35-293.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y337.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 290224Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiQ9Y337.
    KOiK09617.
    OMAiAAHCRKK.
    OrthoDBiEOG75B84T.
    PhylomeDBiQ9Y337.
    TreeFamiTF331065.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y337-1 [UniParc]FASTAAdd to Basket

    « Hide

    MATARPPWMW VLCALITALL LGVTEHVLAN NDVSCDHPSN TVPSGSNQDL    50
    GAGAGEDARS DDSSSRIING SDCDMHTQPW QAALLLRPNQ LYCGAVLVHP 100
    QWLLTAAHCR KKVFRVRLGH YSLSPVYESG QQMFQGVKSI PHPGYSHPGH 150
    SNNLMLIKLN RRIRPTKDVR PINVSSHCPS AGTKCLVSGW GTTKSPQVHF 200
    PKVLQCLNIS VLSQKRCEDA YPRQIDDTMF CAGDKAGRDS CQGDSGGPVV 250
    CNGSLQGLVS WGDYPCARPN RPGVYTNLCK FTKWIQETIQ ANS 293
    Length:293
    Mass (Da):32,019
    Last modified:May 18, 2010 - v2
    Checksum:iD92C9F98055131E4
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 5632Missing in AAG33358. (PubMed:11054574)CuratedAdd
    BLAST

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551G → R.
    Corresponds to variant rs2232532 [ dbSNP | Ensembl ].
    VAR_051853
    Natural varianti153 – 1531N → D.8 Publications
    Corresponds to variant rs183854 [ dbSNP | Ensembl ].
    VAR_051854

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF168768 mRNA. Translation: AAF03101.1.
    AF135028 Genomic DNA. Translation: AAD26429.1.
    AF243527 Genomic DNA. Translation: AAG33358.1.
    AY279380 mRNA. Translation: AAP42275.1.
    AY279381 mRNA. Translation: AAP42276.1.
    AY359010 mRNA. Translation: AAQ89369.1.
    BT006867 mRNA. Translation: AAP35513.1.
    AC011483 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW71946.1.
    BC008036 mRNA. Translation: AAH08036.1.
    CCDSiCCDS12810.1.
    RefSeqiNP_001070959.1. NM_001077491.1.
    NP_001070960.1. NM_001077492.1.
    NP_036559.1. NM_012427.4.
    UniGeneiHs.50915.

    Genome annotation databases

    EnsembliENST00000336334; ENSP00000337733; ENSG00000167754.
    ENST00000391809; ENSP00000375685; ENSG00000167754.
    ENST00000593428; ENSP00000471966; ENSG00000167754.
    GeneIDi25818.
    KEGGihsa:25818.
    UCSCiuc002pue.3. human.

    Polymorphism databases

    DMDMi296434569.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF168768 mRNA. Translation: AAF03101.1 .
    AF135028 Genomic DNA. Translation: AAD26429.1 .
    AF243527 Genomic DNA. Translation: AAG33358.1 .
    AY279380 mRNA. Translation: AAP42275.1 .
    AY279381 mRNA. Translation: AAP42276.1 .
    AY359010 mRNA. Translation: AAQ89369.1 .
    BT006867 mRNA. Translation: AAP35513.1 .
    AC011483 Genomic DNA. No translation available.
    CH471135 Genomic DNA. Translation: EAW71946.1 .
    BC008036 mRNA. Translation: AAH08036.1 .
    CCDSi CCDS12810.1.
    RefSeqi NP_001070959.1. NM_001077491.1.
    NP_001070960.1. NM_001077492.1.
    NP_036559.1. NM_012427.4.
    UniGenei Hs.50915.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2PSX X-ray 2.30 A 67-293 [» ]
    2PSY X-ray 2.30 A 67-293 [» ]
    ProteinModelPortali Q9Y337.
    SMRi Q9Y337. Positions 35-293.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117346. 1 interaction.
    STRINGi 9606.ENSP00000337733.

    Chemistry

    ChEMBLi CHEMBL4447.

    Protein family/group databases

    MEROPSi S01.017.

    PTM databases

    PhosphoSitei Q9Y337.

    Polymorphism databases

    DMDMi 296434569.

    Proteomic databases

    PaxDbi Q9Y337.
    PRIDEi Q9Y337.

    Protocols and materials databases

    DNASUi 25818.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000336334 ; ENSP00000337733 ; ENSG00000167754 .
    ENST00000391809 ; ENSP00000375685 ; ENSG00000167754 .
    ENST00000593428 ; ENSP00000471966 ; ENSG00000167754 .
    GeneIDi 25818.
    KEGGi hsa:25818.
    UCSCi uc002pue.3. human.

    Organism-specific databases

    CTDi 25818.
    GeneCardsi GC19M051446.
    HGNCi HGNC:6366. KLK5.
    HPAi CAB025503.
    CAB026341.
    HPA014343.
    MIMi 605643. gene.
    neXtProti NX_Q9Y337.
    PharmGKBi PA30155.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi Q9Y337.
    KOi K09617.
    OMAi AAHCRKK.
    OrthoDBi EOG75B84T.
    PhylomeDBi Q9Y337.
    TreeFami TF331065.

    Miscellaneous databases

    EvolutionaryTracei Q9Y337.
    GeneWikii KLK5.
    GenomeRNAii 25818.
    NextBioi 47059.
    PMAP-CutDB Q9Y337.
    PROi Q9Y337.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y337.
    Bgeei Q9Y337.
    CleanExi HS_KLK5.
    Genevestigatori Q9Y337.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation."
      Brattsand M., Egelrud T.
      J. Biol. Chem. 274:30033-30040(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-153.
      Tissue: Stratum corneum.
    2. "Identification of novel human kallikrein-like genes on chromosome 19q13.3-q13.4."
      Yousef G.M., Luo L.-Y., Diamandis E.P.
      Anticancer Res. 19:2843-2852(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-153.
    3. "Sequencing and expression analysis of the serine protease gene cluster located in chromosome 19q13 region."
      Gan L., Lee I., Smith R., Argonza-Barrett R., Lei H., McCuaig J., Moss P., Paeper B., Wang K.
      Gene 257:119-130(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ASP-153.
    4. "Differential expression of a human kallikrein 5 (KLK5) splice variant in ovarian and prostate cancer."
      Kurlender L., Yousef G.M., Memari N., Robb J.D., Michael I.P., Borgono C., Katsaros D., Stephan C., Jung K., Diamandis E.P.
      Tumor Biol. 25:149-156(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-153.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-153.
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-153.
    7. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ASP-153.
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ASP-153.
      Tissue: Ovary.
    10. "SPINK9: a selective, skin-specific Kazal-type serine protease inhibitor."
      Brattsand M., Stefansson K., Hubiche T., Nilsson S.K., Egelrud T.
      J. Invest. Dermatol. 129:1656-1665(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SPINK9.
    11. "Identification of lympho-epithelial Kazal-type inhibitor 2 in human skin as a kallikrein-related peptidase 5-specific protease inhibitor."
      Meyer-Hoffert U., Wu Z., Schroeder J.M.
      PLoS ONE 4:E4372-E4372(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    12. "Structural basis of the zinc inhibition of human tissue kallikrein 5."
      Debela M., Goettig P., Magdolen V., Huber R., Schechter N.M., Bode W.
      J. Mol. Biol. 373:1017-1031(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 67-293 ALONE AND IN COMPLEX WITH ZINC, ENZYME REGULATION, ACTIVE SITE, GLYCOSYLATION AT ASN-208, DISULFIDE BONDS.

    Entry informationi

    Entry nameiKLK5_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y337
    Secondary accession number(s): Q53ZR3, Q9HBG8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Peptidase families
      Classification of peptidase families and list of entries
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3