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Protein

Kallikrein-5

Gene

KLK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in desquamation.

Enzyme regulationi

Inhibited by Zn2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Charge relay system1 Publication1
Sitei150Major binding site for inhibitory zinc1
Active sitei153Charge relay system1 Publication1
Active sitei245Charge relay system1 Publication1

GO - Molecular functioni

  • endopeptidase activity Source: Reactome
  • peptidase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB
  • serine-type peptidase activity Source: ProtInc

GO - Biological processi

  • cornification Source: Reactome
  • epidermis development Source: ProtInc
  • positive regulation of antibacterial peptide production Source: UniProtKB
  • positive regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protease, Serine protease

Enzyme and pathway databases

BRENDAi3.4.21.B39 2681
ReactomeiR-HSA-6809371 Formation of the cornified envelope

Protein family/group databases

MEROPSiS01.017

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-5Imported (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 2
Short name:
KLK-L2
Stratum corneum tryptic enzyme
Gene namesi
Name:KLK5Imported
Synonyms:SCTEImported
ORF Names:UNQ570/PRO1132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167754.12
HGNCiHGNC:6366 KLK5
MIMi605643 gene
neXtProtiNX_Q9Y337

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi25818
OpenTargetsiENSG00000167754
PharmGKBiPA30155

Chemistry databases

ChEMBLiCHEMBL4447
GuidetoPHARMACOLOGYi2375

Polymorphism and mutation databases

BioMutaiKLK5
DMDMi296434569

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002793923 – 293Kallikrein-5Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi73 ↔ 206PROSITE-ProRule annotation1 Publication
Disulfide bondi93 ↔ 109PROSITE-ProRule annotation1 Publication
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi178 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi185 ↔ 251PROSITE-ProRule annotation1 Publication
Glycosylationi208N-linked (GlcNAc...) asparagine1 Publication1
Disulfide bondi217 ↔ 231PROSITE-ProRule annotation1 Publication
Disulfide bondi241 ↔ 266PROSITE-ProRule annotation1 Publication
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y337
PeptideAtlasiQ9Y337
PRIDEiQ9Y337

PTM databases

iPTMnetiQ9Y337
PhosphoSitePlusiQ9Y337

Miscellaneous databases

PMAP-CutDBQ9Y337

Expressioni

Tissue specificityi

Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.1 Publication

Gene expression databases

BgeeiENSG00000167754
CleanExiHS_KLK5
ExpressionAtlasiQ9Y337 baseline and differential
GenevisibleiQ9Y337 HS

Organism-specific databases

HPAiCAB025503
CAB026341
HPA014343

Interactioni

Subunit structurei

Interacts with SPINK9.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLGP209304EBI-9057524,EBI-1058782

Protein-protein interaction databases

BioGridi117346, 53 interactors
IntActiQ9Y337, 10 interactors
MINTiQ9Y337
STRINGi9606.ENSP00000337733

Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi81 – 86Combined sources6
Turni87 – 89Combined sources3
Beta strandi90 – 99Combined sources10
Beta strandi102 – 105Combined sources4
Helixi107 – 109Combined sources3
Beta strandi115 – 119Combined sources5
Beta strandi122 – 124Combined sources3
Beta strandi132 – 141Combined sources10
Beta strandi147 – 149Combined sources3
Beta strandi155 – 161Combined sources7
Beta strandi167 – 169Combined sources3
Beta strandi184 – 191Combined sources8
Beta strandi193 – 197Combined sources5
Beta strandi205 – 211Combined sources7
Helixi214 – 220Combined sources7
Turni222 – 224Combined sources3
Beta strandi229 – 232Combined sources4
Beta strandi248 – 251Combined sources4
Beta strandi254 – 261Combined sources8
Beta strandi273 – 277Combined sources5
Helixi278 – 280Combined sources3
Helixi282 – 291Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PSXX-ray2.30A67-293[»]
2PSYX-ray2.30A67-293[»]
ProteinModelPortaliQ9Y337
SMRiQ9Y337
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y337

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 290Peptidase S1PROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627 Eukaryota
COG5640 LUCA
GeneTreeiENSGT00910000144067
HOGENOMiHOG000251820
HOVERGENiHBG013304
InParanoidiQ9Y337
KOiK09617
OMAiYESGQQM
OrthoDBiEOG091G0DF7
PhylomeDBiQ9Y337
TreeFamiTF331065

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF00089 Trypsin, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATARPPWMW VLCALITALL LGVTEHVLAN NDVSCDHPSN TVPSGSNQDL
60 70 80 90 100
GAGAGEDARS DDSSSRIING SDCDMHTQPW QAALLLRPNQ LYCGAVLVHP
110 120 130 140 150
QWLLTAAHCR KKVFRVRLGH YSLSPVYESG QQMFQGVKSI PHPGYSHPGH
160 170 180 190 200
SNDLMLIKLN RRIRPTKDVR PINVSSHCPS AGTKCLVSGW GTTKSPQVHF
210 220 230 240 250
PKVLQCLNIS VLSQKRCEDA YPRQIDDTMF CAGDKAGRDS CQGDSGGPVV
260 270 280 290
CNGSLQGLVS WGDYPCARPN RPGVYTNLCK FTKWIQETIQ ANS
Length:293
Mass (Da):32,020
Last modified:October 25, 2017 - v3
Checksum:iD92C92F5609E5946
GO

Sequence cautioni

The sequence AAG33358 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAG33358 differs from that shown. Reason: Erroneous gene model prediction.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05185355G → R. Corresponds to variant dbSNP:rs2232532Ensembl.1
Natural variantiVAR_051854153D → N. Corresponds to variant dbSNP:rs183854Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168768 mRNA Translation: AAF03101.1
AF135028 Genomic DNA Translation: AAD26429.1
AF243527 Genomic DNA Translation: AAG33358.1 Sequence problems.
AY279380 mRNA Translation: AAP42275.1
AY279381 mRNA Translation: AAP42276.1
LT631554 Genomic DNA Translation: SFW93201.1
AY359010 mRNA Translation: AAQ89369.1
BT006867 mRNA Translation: AAP35513.1
AC011483 Genomic DNA No translation available.
CH471135 Genomic DNA Translation: EAW71946.1
CH471135 Genomic DNA Translation: EAW71948.1
CH471135 Genomic DNA Translation: EAW71949.1
CH471135 Genomic DNA Translation: EAW71950.1
CH471135 Genomic DNA Translation: EAW71952.1
BC008036 mRNA Translation: AAH08036.1
CCDSiCCDS12810.1
RefSeqiNP_001070959.1, NM_001077491.1
NP_001070960.1, NM_001077492.1
NP_036559.1, NM_012427.4
XP_011525004.1, XM_011526702.1
XP_011525005.1, XM_011526703.2
UniGeneiHs.50915

Genome annotation databases

EnsembliENST00000336334; ENSP00000337733; ENSG00000167754
ENST00000391809; ENSP00000375685; ENSG00000167754
ENST00000593428; ENSP00000471966; ENSG00000167754
GeneIDi25818
KEGGihsa:25818
UCSCiuc002pue.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiKLK5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y337
Secondary accession number(s): A0A024R4G4, Q53ZR3, Q9HBG8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: October 25, 2017
Last modified: May 23, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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