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Protein

Kallikrein-5

Gene

KLK5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in desquamation.

Enzyme regulationi

Inhibited by Zn2+.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei108Charge relay system1 Publication1
Sitei150Major binding site for inhibitory zinc1
Active sitei153Charge relay system1 Publication1
Active sitei245Charge relay system1 Publication1

GO - Molecular functioni

  • peptidase activity Source: UniProtKB
  • serine-type endopeptidase activity Source: UniProtKB
  • serine-type peptidase activity Source: ProtInc

GO - Biological processi

  • epidermis development Source: ProtInc
  • positive regulation of antibacterial peptide production Source: UniProtKB
  • positive regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167754-MONOMER.
BRENDAi3.4.21.B39. 2681.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Protein family/group databases

MEROPSiS01.017.

Names & Taxonomyi

Protein namesi
Recommended name:
Kallikrein-5 (EC:3.4.21.-)
Alternative name(s):
Kallikrein-like protein 2
Short name:
KLK-L2
Stratum corneum tryptic enzyme
Gene namesi
Name:KLK5
Synonyms:SCTE
ORF Names:UNQ570/PRO1132
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:6366. KLK5.

Subcellular locationi

GO - Cellular componenti

  • epidermal lamellar body Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi25818.
PharmGKBiPA30155.

Chemistry databases

ChEMBLiCHEMBL4447.
GuidetoPHARMACOLOGYi2375.

Polymorphism and mutation databases

BioMutaiKLK5.
DMDMi296434569.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000002793923 – 293Kallikrein-5Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi69N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi73 ↔ 206PROSITE-ProRule annotation1 Publication
Disulfide bondi93 ↔ 109PROSITE-ProRule annotation1 Publication
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi178 ↔ 279PROSITE-ProRule annotation1 Publication
Disulfide bondi185 ↔ 251PROSITE-ProRule annotation1 Publication
Glycosylationi208N-linked (GlcNAc...)1 Publication1
Disulfide bondi217 ↔ 231PROSITE-ProRule annotation1 Publication
Disulfide bondi241 ↔ 266PROSITE-ProRule annotation1 Publication
Glycosylationi252N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y337.
PeptideAtlasiQ9Y337.
PRIDEiQ9Y337.

PTM databases

iPTMnetiQ9Y337.
PhosphoSitePlusiQ9Y337.

Miscellaneous databases

PMAP-CutDBQ9Y337.

Expressioni

Tissue specificityi

Expressed in skin, breast, brain and testis. Expressed at the stratum granulosum of palmar skin.1 Publication

Gene expression databases

BgeeiENSG00000167754.
CleanExiHS_KLK5.
ExpressionAtlasiQ9Y337. baseline and differential.
GenevisibleiQ9Y337. HS.

Organism-specific databases

HPAiCAB025503.
CAB026341.
HPA014343.

Interactioni

Subunit structurei

Interacts with SPINK9.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FLGP209304EBI-9057524,EBI-1058782

Protein-protein interaction databases

BioGridi117346. 49 interactors.
IntActiQ9Y337. 10 interactors.
STRINGi9606.ENSP00000337733.

Chemistry databases

BindingDBiQ9Y337.

Structurei

Secondary structure

1293
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi81 – 86Combined sources6
Turni87 – 89Combined sources3
Beta strandi90 – 99Combined sources10
Beta strandi102 – 105Combined sources4
Helixi107 – 109Combined sources3
Beta strandi115 – 119Combined sources5
Beta strandi122 – 124Combined sources3
Beta strandi132 – 141Combined sources10
Beta strandi147 – 149Combined sources3
Beta strandi155 – 161Combined sources7
Beta strandi167 – 169Combined sources3
Beta strandi184 – 191Combined sources8
Beta strandi193 – 197Combined sources5
Beta strandi205 – 211Combined sources7
Helixi214 – 220Combined sources7
Turni222 – 224Combined sources3
Beta strandi229 – 232Combined sources4
Beta strandi248 – 251Combined sources4
Beta strandi254 – 261Combined sources8
Beta strandi273 – 277Combined sources5
Helixi278 – 280Combined sources3
Helixi282 – 291Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PSXX-ray2.30A67-293[»]
2PSYX-ray2.30A67-293[»]
ProteinModelPortaliQ9Y337.
SMRiQ9Y337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 290Peptidase S1PROSITE-ProRule annotationAdd BLAST224

Sequence similaritiesi

Belongs to the peptidase S1 family. Kallikrein subfamily.PROSITE-ProRule annotation
Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9Y337.
KOiK09617.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9Y337.
TreeFamiTF331065.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y337-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATARPPWMW VLCALITALL LGVTEHVLAN NDVSCDHPSN TVPSGSNQDL
60 70 80 90 100
GAGAGEDARS DDSSSRIING SDCDMHTQPW QAALLLRPNQ LYCGAVLVHP
110 120 130 140 150
QWLLTAAHCR KKVFRVRLGH YSLSPVYESG QQMFQGVKSI PHPGYSHPGH
160 170 180 190 200
SNNLMLIKLN RRIRPTKDVR PINVSSHCPS AGTKCLVSGW GTTKSPQVHF
210 220 230 240 250
PKVLQCLNIS VLSQKRCEDA YPRQIDDTMF CAGDKAGRDS CQGDSGGPVV
260 270 280 290
CNGSLQGLVS WGDYPCARPN RPGVYTNLCK FTKWIQETIQ ANS
Length:293
Mass (Da):32,019
Last modified:May 18, 2010 - v2
Checksum:iD92C9F98055131E4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25 – 56Missing in AAG33358 (PubMed:11054574).CuratedAdd BLAST32

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05185355G → R.Corresponds to variant rs2232532dbSNPEnsembl.1
Natural variantiVAR_051854153N → D.8 PublicationsCorresponds to variant rs183854dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168768 mRNA. Translation: AAF03101.1.
AF135028 Genomic DNA. Translation: AAD26429.1.
AF243527 Genomic DNA. Translation: AAG33358.1.
AY279380 mRNA. Translation: AAP42275.1.
AY279381 mRNA. Translation: AAP42276.1.
AY359010 mRNA. Translation: AAQ89369.1.
BT006867 mRNA. Translation: AAP35513.1.
AC011483 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71946.1.
BC008036 mRNA. Translation: AAH08036.1.
CCDSiCCDS12810.1.
RefSeqiNP_001070959.1. NM_001077491.1.
NP_001070960.1. NM_001077492.1.
NP_036559.1. NM_012427.4.
XP_011525004.1. XM_011526702.1.
XP_011525005.1. XM_011526703.2.
UniGeneiHs.50915.

Genome annotation databases

EnsembliENST00000336334; ENSP00000337733; ENSG00000167754.
ENST00000391809; ENSP00000375685; ENSG00000167754.
ENST00000593428; ENSP00000471966; ENSG00000167754.
GeneIDi25818.
KEGGihsa:25818.
UCSCiuc002pue.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF168768 mRNA. Translation: AAF03101.1.
AF135028 Genomic DNA. Translation: AAD26429.1.
AF243527 Genomic DNA. Translation: AAG33358.1.
AY279380 mRNA. Translation: AAP42275.1.
AY279381 mRNA. Translation: AAP42276.1.
AY359010 mRNA. Translation: AAQ89369.1.
BT006867 mRNA. Translation: AAP35513.1.
AC011483 Genomic DNA. No translation available.
CH471135 Genomic DNA. Translation: EAW71946.1.
BC008036 mRNA. Translation: AAH08036.1.
CCDSiCCDS12810.1.
RefSeqiNP_001070959.1. NM_001077491.1.
NP_001070960.1. NM_001077492.1.
NP_036559.1. NM_012427.4.
XP_011525004.1. XM_011526702.1.
XP_011525005.1. XM_011526703.2.
UniGeneiHs.50915.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2PSXX-ray2.30A67-293[»]
2PSYX-ray2.30A67-293[»]
ProteinModelPortaliQ9Y337.
SMRiQ9Y337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117346. 49 interactors.
IntActiQ9Y337. 10 interactors.
STRINGi9606.ENSP00000337733.

Chemistry databases

BindingDBiQ9Y337.
ChEMBLiCHEMBL4447.
GuidetoPHARMACOLOGYi2375.

Protein family/group databases

MEROPSiS01.017.

PTM databases

iPTMnetiQ9Y337.
PhosphoSitePlusiQ9Y337.

Polymorphism and mutation databases

BioMutaiKLK5.
DMDMi296434569.

Proteomic databases

PaxDbiQ9Y337.
PeptideAtlasiQ9Y337.
PRIDEiQ9Y337.

Protocols and materials databases

DNASUi25818.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336334; ENSP00000337733; ENSG00000167754.
ENST00000391809; ENSP00000375685; ENSG00000167754.
ENST00000593428; ENSP00000471966; ENSG00000167754.
GeneIDi25818.
KEGGihsa:25818.
UCSCiuc002pue.4. human.

Organism-specific databases

CTDi25818.
DisGeNETi25818.
GeneCardsiKLK5.
HGNCiHGNC:6366. KLK5.
HPAiCAB025503.
CAB026341.
HPA014343.
MIMi605643. gene.
neXtProtiNX_Q9Y337.
PharmGKBiPA30155.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3627. Eukaryota.
COG5640. LUCA.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiQ9Y337.
KOiK09617.
OrthoDBiEOG091G0DF7.
PhylomeDBiQ9Y337.
TreeFamiTF331065.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000167754-MONOMER.
BRENDAi3.4.21.B39. 2681.
ReactomeiR-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

EvolutionaryTraceiQ9Y337.
GeneWikiiKLK5.
GenomeRNAii25818.
PMAP-CutDBQ9Y337.
PROiQ9Y337.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167754.
CleanExiHS_KLK5.
ExpressionAtlasiQ9Y337. baseline and differential.
GenevisibleiQ9Y337. HS.

Family and domain databases

CDDicd00190. Tryp_SPc. 1 hit.
InterProiIPR009003. Peptidase_S1_PA.
IPR001314. Peptidase_S1A.
IPR001254. Trypsin_dom.
IPR018114. TRYPSIN_HIS.
IPR033116. TRYPSIN_SER.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLK5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y337
Secondary accession number(s): Q53ZR3, Q9HBG8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 148 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Peptidase families
    Classification of peptidase families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.