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Q9Y336

- SIGL9_HUMAN

UniProt

Q9Y336 - SIGL9_HUMAN

Protein

Sialic acid-binding Ig-like lectin 9

Gene

SIGLEC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 135 (01 Oct 2014)
      Sequence version 2 (01 May 2000)
      Previous versions | rss
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    Functioni

    Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201Sialic acidBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cell surface receptor signaling pathway Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sialic acid-binding Ig-like lectin 9
    Short name:
    Siglec-9
    Alternative name(s):
    CDw329
    Protein FOAP-9
    CD_antigen: CD329
    Gene namesi
    Name:SIGLEC9
    ORF Names:UNQ668/PRO1302
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:10878. SIGLEC9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi120 – 1201R → K: Loss of sialic acid binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA35779.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 463446Sialic acid-binding Ig-like lectin 9PRO_0000014949Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi36 ↔ 170PROSITE-ProRule annotation
    Disulfide bondi41 ↔ 102PROSITE-ProRule annotation
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi164 ↔ 213PROSITE-ProRule annotation
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi272 ↔ 320PROSITE-ProRule annotation
    Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ9Y336.
    PRIDEiQ9Y336.

    PTM databases

    PhosphoSiteiQ9Y336.

    Expressioni

    Tissue specificityi

    Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.

    Gene expression databases

    BgeeiQ9Y336.
    CleanExiHS_SIGLEC9.
    GenevestigatoriQ9Y336.

    Organism-specific databases

    HPAiHPA010682.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000250360.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y336.
    SMRiQ9Y336. Positions 23-233.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini18 – 348331ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini370 – 46394CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei349 – 36921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 140121Ig-like V-typeAdd
    BLAST
    Domaini146 – 22984Ig-like C2-type 1Add
    BLAST
    Domaini236 – 336101Ig-like C2-type 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi431 – 4366ITIM motif
    Motifi454 – 4596SLAM-like motif

    Domaini

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG147919.
    HOGENOMiHOG000236324.
    HOVERGENiHBG036161.
    InParanoidiQ9Y336.
    KOiK06740.
    OMAiFREKANI.
    PhylomeDBiQ9Y336.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y336-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MLLLLLPLLW GRERAEGQTS KLLTMQSSVT VQEGLCVHVP CSFSYPSHGW    50
    IYPGPVVHGY WFREGANTDQ DAPVATNNPA RAVWEETRDR FHLLGDPHTK 100
    NCTLSIRDAR RSDAGRYFFR MEKGSIKWNY KHHRLSVNVT ALTHRPNILI 150
    PGTLESGCPQ NLTCSVPWAC EQGTPPMISW IGTSVSPLDP STTRSSVLTL 200
    IPQPQDHGTS LTCQVTFPGA SVTTNKTVHL NVSYPPQNLT MTVFQGDGTV 250
    STVLGNGSSL SLPEGQSLRL VCAVDAVDSN PPARLSLSWR GLTLCPSQPS 300
    NPGVLELPWV HLRDAAEFTC RAQNPLGSQQ VYLNVSLQSK ATSGVTQGVV 350
    GGAGATALVF LSFCVIFVVV RSCRKKSARP AAGVGDTGIE DANAVRGSAS 400
    QGPLTEPWAE DSPPDQPPPA SARSSVGEGE LQYASLSFQM VKPWDSRGQE 450
    ATDTEYSEIK IHR 463
    Length:463
    Mass (Da):50,082
    Last modified:May 1, 2000 - v2
    Checksum:i807BDCE0D18191F2
    GO
    Isoform 2 (identifier: Q9Y336-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         402-463: GPLTEPWAED...TEYSEIKIHR → ILNHFIGFPT...FHWFFLICVG

    Show »
    Length:479
    Mass (Da):52,492
    Checksum:iBA36ABD3025CFC13
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti269 – 2691R → H in AAF87223. (PubMed:10801862)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti100 – 1001K → E.1 Publication
    Corresponds to variant rs2075803 [ dbSNP | Ensembl ].
    VAR_014254
    Natural varianti125 – 1251S → N.
    Corresponds to variant rs200658 [ dbSNP | Ensembl ].
    VAR_014255
    Natural varianti131 – 1311K → Q.
    Corresponds to variant rs16988910 [ dbSNP | Ensembl ].
    VAR_033621
    Natural varianti147 – 1471N → K.
    Corresponds to variant rs273687 [ dbSNP | Ensembl ].
    VAR_014256
    Natural varianti315 – 3151A → E.2 Publications
    Corresponds to variant rs2258983 [ dbSNP | Ensembl ].
    VAR_014257
    Natural varianti316 – 3161A → D.
    Corresponds to variant rs273688 [ dbSNP | Ensembl ].
    VAR_014258
    Natural varianti349 – 3491V → A.
    Corresponds to variant rs273690 [ dbSNP | Ensembl ].
    VAR_033622

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei402 – 46362GPLTE…IKIHR → ILNHFIGFPTFLGLGFEFLL NLRDLCCHPDSEFYVYHFSH FRLIKNIAGEIVWSLEGKIL WLLDVSDFFHWFFLICVG in isoform 2. 1 PublicationVSP_054106Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135027 Genomic DNA. Translation: AAD26428.2.
    AF247180 mRNA. Translation: AAF87223.1.
    AF227924 mRNA. Translation: AAF71455.1.
    AB026265 mRNA. Translation: BAB41100.1.
    AY358913 mRNA. Translation: AAQ89272.1.
    AK297043 mRNA. Translation: BAG59570.1.
    AC011473 Genomic DNA. Translation: AAG23261.1.
    BC035365 mRNA. Translation: AAH35365.2.
    CCDSiCCDS12825.1. [Q9Y336-1]
    CCDS56100.1. [Q9Y336-2]
    RefSeqiNP_001185487.1. NM_001198558.1. [Q9Y336-2]
    NP_055256.1. NM_014441.2. [Q9Y336-1]
    UniGeneiHs.245828.

    Genome annotation databases

    EnsembliENST00000250360; ENSP00000250360; ENSG00000129450. [Q9Y336-1]
    ENST00000440804; ENSP00000413861; ENSG00000129450. [Q9Y336-2]
    GeneIDi27180.
    KEGGihsa:27180.
    UCSCiuc002pvu.3. human. [Q9Y336-1]

    Polymorphism databases

    DMDMi25009270.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Siglec-9

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF135027 Genomic DNA. Translation: AAD26428.2 .
    AF247180 mRNA. Translation: AAF87223.1 .
    AF227924 mRNA. Translation: AAF71455.1 .
    AB026265 mRNA. Translation: BAB41100.1 .
    AY358913 mRNA. Translation: AAQ89272.1 .
    AK297043 mRNA. Translation: BAG59570.1 .
    AC011473 Genomic DNA. Translation: AAG23261.1 .
    BC035365 mRNA. Translation: AAH35365.2 .
    CCDSi CCDS12825.1. [Q9Y336-1 ]
    CCDS56100.1. [Q9Y336-2 ]
    RefSeqi NP_001185487.1. NM_001198558.1. [Q9Y336-2 ]
    NP_055256.1. NM_014441.2. [Q9Y336-1 ]
    UniGenei Hs.245828.

    3D structure databases

    ProteinModelPortali Q9Y336.
    SMRi Q9Y336. Positions 23-233.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000250360.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei Q9Y336.

    Polymorphism databases

    DMDMi 25009270.

    Proteomic databases

    PaxDbi Q9Y336.
    PRIDEi Q9Y336.

    Protocols and materials databases

    DNASUi 27180.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250360 ; ENSP00000250360 ; ENSG00000129450 . [Q9Y336-1 ]
    ENST00000440804 ; ENSP00000413861 ; ENSG00000129450 . [Q9Y336-2 ]
    GeneIDi 27180.
    KEGGi hsa:27180.
    UCSCi uc002pvu.3. human. [Q9Y336-1 ]

    Organism-specific databases

    CTDi 27180.
    GeneCardsi GC19P051628.
    HGNCi HGNC:10878. SIGLEC9.
    HPAi HPA010682.
    MIMi 605640. gene.
    neXtProti NX_Q9Y336.
    PharmGKBi PA35779.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147919.
    HOGENOMi HOG000236324.
    HOVERGENi HBG036161.
    InParanoidi Q9Y336.
    KOi K06740.
    OMAi FREKANI.
    PhylomeDBi Q9Y336.

    Miscellaneous databases

    GeneWikii SIGLEC9.
    GenomeRNAii 27180.
    NextBioi 50008.
    PROi Q9Y336.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y336.
    CleanExi HS_SIGLEC9.
    Genevestigatori Q9Y336.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)."
      Foussias G., Yousef G.M., Diamandis E.P.
      Genomics 67:171-178(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Tissue: Bone marrow.
    2. "Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes."
      Zhang J.Q., Nicoll G., Jones C., Crocker P.R.
      J. Biol. Chem. 275:22121-22126(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways."
      Angata T., Varki A.
      J. Biol. Chem. 275:22127-22135(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF ARG-120.
      Tissue: Peripheral blood.
    4. "Molecular cloning of a novel gene, FOAP-9, which are induced by oxydized LDL in human macrophages."
      Takayama K., Fujii Y., Turitani K., Naitou K., Kawaguchi A., Ukai Y., Amemiya C., Yajima Y., Yazaki M.
      Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-315.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    7. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-100 AND GLU-315.
      Tissue: Brain.

    Entry informationi

    Entry nameiSIGL9_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y336
    Secondary accession number(s): Q6GTU4, Q9BYI9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 135 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3