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Q9Y336

- SIGL9_HUMAN

UniProt

Q9Y336 - SIGL9_HUMAN

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Protein

Sialic acid-binding Ig-like lectin 9

Gene

SIGLEC9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201Sialic acidBy similarity

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cell surface receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Sialic acid-binding Ig-like lectin 9
Short name:
Siglec-9
Alternative name(s):
CDw329
Protein FOAP-9
CD_antigen: CD329
Gene namesi
Name:SIGLEC9
ORF Names:UNQ668/PRO1302
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:10878. SIGLEC9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini18 – 348331ExtracellularSequence AnalysisAdd
BLAST
Transmembranei349 – 36921HelicalSequence AnalysisAdd
BLAST
Topological domaini370 – 46394CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi120 – 1201R → K: Loss of sialic acid binding. 1 Publication

Organism-specific databases

PharmGKBiPA35779.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 463446Sialic acid-binding Ig-like lectin 9PRO_0000014949Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 170PROSITE-ProRule annotation
Disulfide bondi41 ↔ 102PROSITE-ProRule annotation
Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
Glycosylationi138 – 1381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi164 ↔ 213PROSITE-ProRule annotation
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi231 – 2311N-linked (GlcNAc...)Sequence Analysis
Glycosylationi238 – 2381N-linked (GlcNAc...)Sequence Analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi272 ↔ 320PROSITE-ProRule annotation
Glycosylationi334 – 3341N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y336.
PRIDEiQ9Y336.

PTM databases

PhosphoSiteiQ9Y336.

Expressioni

Tissue specificityi

Expressed by peripheral blood leukocytes (neutrophils and monocytes but not eosinophils). Found in liver, fetal liver, bone marrow, placenta, spleen and in lower levels in skeletal muscle, fetal brain, stomach, lung, thymus, prostate, brain, mammary, adrenal gland, colon, trachea, cerebellum, testis, small intestine and spinal cordon.

Gene expression databases

BgeeiQ9Y336.
CleanExiHS_SIGLEC9.
GenevestigatoriQ9Y336.

Organism-specific databases

HPAiHPA010682.

Interactioni

Protein-protein interaction databases

BioGridi118056. 1 interaction.
STRINGi9606.ENSP00000250360.

Structurei

3D structure databases

ProteinModelPortaliQ9Y336.
SMRiQ9Y336. Positions 23-233.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 140121Ig-like V-typeAdd
BLAST
Domaini146 – 22984Ig-like C2-type 1Add
BLAST
Domaini236 – 336101Ig-like C2-type 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi431 – 4366ITIM motif
Motifi454 – 4596SLAM-like motif

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG147919.
GeneTreeiENSGT00760000119139.
HOGENOMiHOG000236324.
HOVERGENiHBG036161.
InParanoidiQ9Y336.
KOiK06740.
OMAiFREKANI.
PhylomeDBiQ9Y336.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y336-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLLLLPLLW GRERAEGQTS KLLTMQSSVT VQEGLCVHVP CSFSYPSHGW
60 70 80 90 100
IYPGPVVHGY WFREGANTDQ DAPVATNNPA RAVWEETRDR FHLLGDPHTK
110 120 130 140 150
NCTLSIRDAR RSDAGRYFFR MEKGSIKWNY KHHRLSVNVT ALTHRPNILI
160 170 180 190 200
PGTLESGCPQ NLTCSVPWAC EQGTPPMISW IGTSVSPLDP STTRSSVLTL
210 220 230 240 250
IPQPQDHGTS LTCQVTFPGA SVTTNKTVHL NVSYPPQNLT MTVFQGDGTV
260 270 280 290 300
STVLGNGSSL SLPEGQSLRL VCAVDAVDSN PPARLSLSWR GLTLCPSQPS
310 320 330 340 350
NPGVLELPWV HLRDAAEFTC RAQNPLGSQQ VYLNVSLQSK ATSGVTQGVV
360 370 380 390 400
GGAGATALVF LSFCVIFVVV RSCRKKSARP AAGVGDTGIE DANAVRGSAS
410 420 430 440 450
QGPLTEPWAE DSPPDQPPPA SARSSVGEGE LQYASLSFQM VKPWDSRGQE
460
ATDTEYSEIK IHR
Length:463
Mass (Da):50,082
Last modified:May 1, 2000 - v2
Checksum:i807BDCE0D18191F2
GO
Isoform 2 (identifier: Q9Y336-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     402-463: GPLTEPWAED...TEYSEIKIHR → ILNHFIGFPT...FHWFFLICVG

Show »
Length:479
Mass (Da):52,492
Checksum:iBA36ABD3025CFC13
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti269 – 2691R → H in AAF87223. (PubMed:10801862)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti100 – 1001K → E.1 Publication
Corresponds to variant rs2075803 [ dbSNP | Ensembl ].
VAR_014254
Natural varianti125 – 1251S → N.
Corresponds to variant rs200658 [ dbSNP | Ensembl ].
VAR_014255
Natural varianti131 – 1311K → Q.
Corresponds to variant rs16988910 [ dbSNP | Ensembl ].
VAR_033621
Natural varianti147 – 1471N → K.
Corresponds to variant rs273687 [ dbSNP | Ensembl ].
VAR_014256
Natural varianti315 – 3151A → E.2 Publications
Corresponds to variant rs2258983 [ dbSNP | Ensembl ].
VAR_014257
Natural varianti316 – 3161A → D.
Corresponds to variant rs273688 [ dbSNP | Ensembl ].
VAR_014258
Natural varianti349 – 3491V → A.
Corresponds to variant rs273690 [ dbSNP | Ensembl ].
VAR_033622

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei402 – 46362GPLTE…IKIHR → ILNHFIGFPTFLGLGFEFLL NLRDLCCHPDSEFYVYHFSH FRLIKNIAGEIVWSLEGKIL WLLDVSDFFHWFFLICVG in isoform 2. 1 PublicationVSP_054106Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135027 Genomic DNA. Translation: AAD26428.2.
AF247180 mRNA. Translation: AAF87223.1.
AF227924 mRNA. Translation: AAF71455.1.
AB026265 mRNA. Translation: BAB41100.1.
AY358913 mRNA. Translation: AAQ89272.1.
AK297043 mRNA. Translation: BAG59570.1.
AC011473 Genomic DNA. Translation: AAG23261.1.
BC035365 mRNA. Translation: AAH35365.2.
CCDSiCCDS12825.1. [Q9Y336-1]
CCDS56100.1. [Q9Y336-2]
RefSeqiNP_001185487.1. NM_001198558.1. [Q9Y336-2]
NP_055256.1. NM_014441.2. [Q9Y336-1]
UniGeneiHs.245828.

Genome annotation databases

EnsembliENST00000250360; ENSP00000250360; ENSG00000129450. [Q9Y336-1]
ENST00000440804; ENSP00000413861; ENSG00000129450. [Q9Y336-2]
GeneIDi27180.
KEGGihsa:27180.
UCSCiuc002pvu.3. human. [Q9Y336-1]

Polymorphism databases

DMDMi25009270.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Siglec-9

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF135027 Genomic DNA. Translation: AAD26428.2 .
AF247180 mRNA. Translation: AAF87223.1 .
AF227924 mRNA. Translation: AAF71455.1 .
AB026265 mRNA. Translation: BAB41100.1 .
AY358913 mRNA. Translation: AAQ89272.1 .
AK297043 mRNA. Translation: BAG59570.1 .
AC011473 Genomic DNA. Translation: AAG23261.1 .
BC035365 mRNA. Translation: AAH35365.2 .
CCDSi CCDS12825.1. [Q9Y336-1 ]
CCDS56100.1. [Q9Y336-2 ]
RefSeqi NP_001185487.1. NM_001198558.1. [Q9Y336-2 ]
NP_055256.1. NM_014441.2. [Q9Y336-1 ]
UniGenei Hs.245828.

3D structure databases

ProteinModelPortali Q9Y336.
SMRi Q9Y336. Positions 23-233.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118056. 1 interaction.
STRINGi 9606.ENSP00000250360.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei Q9Y336.

Polymorphism databases

DMDMi 25009270.

Proteomic databases

PaxDbi Q9Y336.
PRIDEi Q9Y336.

Protocols and materials databases

DNASUi 27180.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000250360 ; ENSP00000250360 ; ENSG00000129450 . [Q9Y336-1 ]
ENST00000440804 ; ENSP00000413861 ; ENSG00000129450 . [Q9Y336-2 ]
GeneIDi 27180.
KEGGi hsa:27180.
UCSCi uc002pvu.3. human. [Q9Y336-1 ]

Organism-specific databases

CTDi 27180.
GeneCardsi GC19P051628.
HGNCi HGNC:10878. SIGLEC9.
HPAi HPA010682.
MIMi 605640. gene.
neXtProti NX_Q9Y336.
PharmGKBi PA35779.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147919.
GeneTreei ENSGT00760000119139.
HOGENOMi HOG000236324.
HOVERGENi HBG036161.
InParanoidi Q9Y336.
KOi K06740.
OMAi FREKANI.
PhylomeDBi Q9Y336.

Miscellaneous databases

GeneWikii SIGLEC9.
GenomeRNAii 27180.
NextBioi 50008.
PROi Q9Y336.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y336.
CleanExi HS_SIGLEC9.
Genevestigatori Q9Y336.

Family and domain databases

Gene3Di 2.60.40.10. 3 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 1 hit.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and molecular characterization of a novel member of the siglec family (SIGLEC9)."
    Foussias G., Yousef G.M., Diamandis E.P.
    Genomics 67:171-178(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Tissue: Bone marrow.
  2. "Siglec-9, a novel sialic acid binding member of the immunoglobulin superfamily expressed broadly on human blood leukocytes."
    Zhang J.Q., Nicoll G., Jones C., Crocker P.R.
    J. Biol. Chem. 275:22121-22126(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning, characterization, and phylogenetic analysis of siglec-9, a new member of the CD33-related group of siglecs. Evidence for co-evolution with sialic acid synthesis pathways."
    Angata T., Varki A.
    J. Biol. Chem. 275:22127-22135(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), MUTAGENESIS OF ARG-120.
    Tissue: Peripheral blood.
  4. "Molecular cloning of a novel gene, FOAP-9, which are induced by oxydized LDL in human macrophages."
    Takayama K., Fujii Y., Turitani K., Naitou K., Kawaguchi A., Ukai Y., Amemiya C., Yajima Y., Yazaki M.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-315.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
  7. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS GLU-100 AND GLU-315.
    Tissue: Brain.

Entry informationi

Entry nameiSIGL9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y336
Secondary accession number(s): Q6GTU4, Q9BYI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3