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Protein

U6 snRNA-associated Sm-like protein LSm2

Gene

LSM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing.

GO - Molecular functioni

  • Ral GTPase binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • U6 snRNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-430039. mRNA decay by 5' to 3' exoribonuclease.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72165. mRNA Splicing - Minor Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm2
Alternative name(s):
Protein G7b
Small nuclear ribonuclear protein D homolog
snRNP core Sm-like protein Sm-x5
Gene namesi
Name:LSM2
Synonyms:C6orf28, G7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204392.10.
HGNCiHGNC:13940. LSM2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi57819.
OpenTargetsiENSG00000204392.
PharmGKBiPA25929.

Polymorphism and mutation databases

BioMutaiLSM2.
DMDMi10720079.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255561 – 95U6 snRNA-associated Sm-like protein LSm2Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y333.
MaxQBiQ9Y333.
PaxDbiQ9Y333.
PeptideAtlasiQ9Y333.
PRIDEiQ9Y333.
TopDownProteomicsiQ9Y333.

PTM databases

iPTMnetiQ9Y333.
PhosphoSitePlusiQ9Y333.
SwissPalmiQ9Y333.

Expressioni

Gene expression databases

BgeeiENSG00000204392.
CleanExiHS_LSM2.
GenevisibleiQ9Y333. HS.

Organism-specific databases

HPAiHPA066718.

Interactioni

Subunit structurei

Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • Ral GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121778. 66 interactors.
CORUMiQ9Y333.
DIPiDIP-31139N.
IntActiQ9Y333. 40 interactors.
MINTiMINT-1032572.
STRINGi9606.ENSP00000364813.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0021-95[»]
ProteinModelPortaliQ9Y333.
SMRiQ9Y333.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3448. Eukaryota.
COG1958. LUCA.
GeneTreeiENSGT00390000016597.
HOGENOMiHOG000166937.
HOVERGENiHBG000486.
InParanoidiQ9Y333.
KOiK12621.
OMAiMISVKNC.
OrthoDBiEOG091G0ZV5.
PhylomeDBiQ9Y333.
TreeFamiTF314960.

Family and domain databases

CDDicd01725. LSm2. 1 hit.
InterProiView protein in InterPro
IPR010920. LSM_dom.
IPR001163. LSM_dom_euk/arc.
IPR016654. U6_snRNA_Lsm2.
PANTHERiPTHR13829. PTHR13829. 1 hit.
PfamiView protein in Pfam
PF01423. LSM. 1 hit.
PIRSFiPIRSF016394. U6_snRNA_Lsm2. 1 hit.
SMARTiView protein in SMART
SM00651. Sm. 1 hit.
SUPFAMiSSF50182. SSF50182. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK
60 70 80 90
YPHMLSVKNC FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ
Length:95
Mass (Da):10,835
Last modified:November 1, 1999 - v1
Checksum:i623591A09A6ABACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182288 mRNA. Translation: AAD56226.1.
AJ245416 mRNA. Translation: CAB52190.1.
AF196468 mRNA. Translation: AAG33023.1.
AF134726 Genomic DNA. Translation: AAD21818.1.
BA000025 Genomic DNA. Translation: BAB63302.1.
AF136977 mRNA. Translation: AAG49438.1.
CR542146 mRNA. Translation: CAG46943.1.
CR542157 mRNA. Translation: CAG46954.1.
AL929592 Genomic DNA. No translation available.
CR759915 Genomic DNA. No translation available.
CR759787 Genomic DNA. No translation available.
CR925765 Genomic DNA. No translation available.
CH471081 Genomic DNA. Translation: EAX03525.1.
BC009192 mRNA. Translation: AAH09192.1.
CCDSiCCDS4722.1.
RefSeqiNP_067000.1. NM_021177.4.
UniGeneiHs.103106.

Genome annotation databases

EnsembliENST00000375661; ENSP00000364813; ENSG00000204392.
ENST00000383391; ENSP00000372883; ENSG00000172850.
ENST00000424975; ENSP00000403345; ENSG00000231502.
ENST00000432122; ENSP00000414006; ENSG00000224979.
ENST00000434125; ENSP00000406280; ENSG00000225998.
ENST00000455705; ENSP00000414634; ENSG00000236826.
GeneIDi57819.
KEGGihsa:57819.
UCSCiuc003nxg.4. human.

Similar proteinsi

Entry informationi

Entry nameiLSM2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y333
Secondary accession number(s): Q6FGG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families