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Reviewed, UniProtKB/Swiss-Prot Q9Y333 (LSM2_HUMAN)

Last modified July 7, 2009. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    U6 snRNA-associated Sm-like protein LSm2
Alternative name(s):
    snRNP core Sm-like protein Sm-x5
    Small nuclear ribonuclear protein D homolog
    Protein G7b
Gene names
Name: LSM2
Synonyms: C6orf28, G7B
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length95 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing.

Subunit structure

Identified in the spliceosome C complex, at least composed of AQR, ASCC3L1, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, WDR57, XAB2 and ZCCHC8. LSm subunits form a heteromer with a donut shape.

Subcellular location

Nucleus Potential.

Post-translational modification

Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.9 Ref.10

Sequence similarities

Belongs to the snRNP Sm proteins family.

Ontologies

Keywords
   Biological processmRNA processing
mRNA splicing
   Cellular componentNucleus
Spliceosome
   LigandRNA-binding
   Molecular functionRibonucleoprotein
   PTMPhosphoprotein
   Technical termComplete proteome
Direct protein sequencing
Gene Ontology (GO)
   Biological processnuclear mRNA splicing, via spliceosome

Non-traceable author statement. Source: UniProtKB

   Cellular componentspliceosome

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionU6 snRNA binding Ref.1

Non-traceable author statement. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9595U6 snRNA-associated Sm-like protein LSm2
PRO_0000125556

Amino acid modifications

Modified residue351Phosphotyrosine Ref.9
Modified residue791Phosphothreonine Ref.10

Sequences

Sequence LengthMass (Da)Tools
Q9Y333-1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 623591A09A6ABACE

FASTA9510,835
        10         20         30         40         50         60 
MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK YPHMLSVKNC 

        70         80         90 
FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ 

« Hide

References

« Hide 'large scale' references
[1]"A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro."
Achsel T., Brahms H., Kastner B., Bachi A., Wilm M., Luehrmann R.
EMBO J. 18:5789-5802(1999) [PubMed: 10523320] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PARTIAL PROTEIN SEQUENCE.
[2]"Characterisation of the novel gene G7b located in the class III region of the human major histocompatibility complex."
Olavesen M.G., Campbell R.D.
Submitted (AUG-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Human SMX5 homolog."
Schmarda A., Fresser F., Paulmichl M.
Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[4]"Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse."
Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D., Hood L.
Genome Res. 13:2621-2636(2003) [PubMed: 14656967] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
Shiina S., Tamiya G., Oka A., Inoko H.
Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning."
Hu R.-M., Han Z.-G., Song H.-D., Peng Y.-D., Huang Q.-H., Ren S.-X., Gu Y.-J., Huang C.-H., Li Y.-B., Jiang C.-L., Fu G., Zhang Q.-H., Gu B.-W., Dai M., Mao Y.-F., Gao G.-F., Rong R., Ye M. expand/collapse author list , Zhou J., Xu S.-H., Gu J., Shi J.-X., Jin W.-R., Zhang C.-K., Wu T.-M., Huang G.-Y., Chen Z., Chen M.-D., Chen J.-L.
Proc. Natl. Acad. Sci. U.S.A. 97:9543-9548(2000) [PubMed: 10931946] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Hypothalamus.
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Placenta.
[8]"Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis."
Jurica M.S., Licklider L.J., Gygi S.P., Grigorieff N., Moore M.J.
RNA 8:426-439(2002) [PubMed: 11991638] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE SPICEOSOMAL C COMPLEX.
[9]"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J., Moritz A., Lee K.A., Guo A., Goss V.L., Spek E.J., Zhang H., Zha X.-M., Polakiewicz R.D., Comb M.J.
Nat. Biotechnol. 23:94-101(2005) [PubMed: 15592455] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-35, MASS SPECTROMETRY.
[10]"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.
Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-79, MASS SPECTROMETRY.
[11]Colinge J., Superti-Furga G., Bennett K.L.
Submitted (OCT-2008) to UniProtKB
Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.

Cross-references

Sequence databases

AF182288 mRNA. Translation: AAD56226.1.
AJ245416 mRNA. Translation: CAB52190.1.
AF196468 mRNA. Translation: AAG33023.1.
AF134726 Genomic DNA. Translation: AAD21818.1.
BA000025 Genomic DNA. Translation: BAB63302.1.
AF136977 mRNA. Translation: AAG49438.1.
BC009192 mRNA. Translation: AAH09192.1.
IPIIPI00032460.
RefSeqNP_067000.1.
UniGeneHs.103106

3D structure databases

HSSPHSSP built from PDB template 1B34 based on UniProtKB P13641.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y333. 15 interactions.

PTM databases

PhosphoSiteQ9Y333.

Proteomic databases

PeptideAtlasQ9Y333.
PRIDEQ9Y333.

Genome annotation databases

EnsemblENSG00000111987. Homo sapiens. [Contig view]
ENSG00000172850. Homo sapiens. [Contig view]
ENSG00000204392. Homo sapiens. [Contig view]
GeneID57819.
KEGGhsa:57819.
UCSCuc003nxg.1. human.

Organism-specific databases

GeneCardsGC06M031873.
H-InvDBHIX0005732.
HIX0057905.
HIX0058082.
HGNCHGNC:13940. LSM2.
MIM607282. gene.
PharmGKBPA25929.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ9Y333.
HOVERGENQ9Y333.
OMAQ9Y333. FIRGSTV.

Enzyme and pathway databases

ReactomeREACT_125. Processing of Capped Intron-Containing Pre-mRNA.
REACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9Y333.
CleanExHS_LSM2.
GermOnlineENSG00000204392. Homo sapiens.

Family and domain databases

InterProIPR006649. Euk_arc_LSM_core.
IPR001163. LSM_snRNP_core.
IPR016654. U6_snRNA_Lsm2.
[Graphical view]
PfamPF01423. LSM. 1 hit.
[Graphical view]
PIRSFPIRSF016394. U6_snRNA_Lsm2. 1 hit.
SMARTSM00651. Sm. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio64772.
SOURCESearch...

Entry information

Entry nameLSM2_HUMAN
AccessionPrimary (citable) accession number: Q9Y333
Entry history
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 7, 2009
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 6

Human chromosome 6: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents