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Protein

U6 snRNA-associated Sm-like protein LSm2

Gene

LSM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds specifically to the 3'-terminal U-tract of U6 snRNA. May be involved in pre-mRNA splicing.

GO - Molecular functioni

  • Ral GTPase binding Source: UniProtKB
  • RNA binding Source: UniProtKB
  • U6 snRNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-430039 mRNA decay by 5' to 3' exoribonuclease
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72165 mRNA Splicing - Minor Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
U6 snRNA-associated Sm-like protein LSm2
Alternative name(s):
Protein G7b
Small nuclear ribonuclear protein D homolog
snRNP core Sm-like protein Sm-x5
Gene namesi
Name:LSM2
Synonyms:C6orf28, G7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000204392.10
HGNCiHGNC:13940 LSM2
MIMi607282 gene
neXtProtiNX_Q9Y333

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi57819
OpenTargetsiENSG00000204392
PharmGKBiPA25929

Polymorphism and mutation databases

BioMutaiLSM2
DMDMi10720079

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001255561 – 95U6 snRNA-associated Sm-like protein LSm2Add BLAST95

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei79PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y333
MaxQBiQ9Y333
PaxDbiQ9Y333
PeptideAtlasiQ9Y333
PRIDEiQ9Y333
ProteomicsDBi85967
TopDownProteomicsiQ9Y333

PTM databases

iPTMnetiQ9Y333
PhosphoSitePlusiQ9Y333
SwissPalmiQ9Y333

Expressioni

Gene expression databases

BgeeiENSG00000204392
CleanExiHS_LSM2
GenevisibleiQ9Y333 HS

Organism-specific databases

HPAiHPA066718

Interactioni

Subunit structurei

Identified in the spliceosome C complex. LSm subunits form a heteromer with a doughnut shape.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • Ral GTPase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121778, 66 interactors
CORUMiQ9Y333
DIPiDIP-31139N
IntActiQ9Y333, 41 interactors
MINTiQ9Y333
STRINGi9606.ENSP00000364813

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JCRelectron microscopy7.0021-95[»]
5O9Zelectron microscopy4.50o1-95[»]
ProteinModelPortaliQ9Y333
SMRiQ9Y333
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the snRNP Sm proteins family.Curated

Phylogenomic databases

eggNOGiKOG3448 Eukaryota
COG1958 LUCA
GeneTreeiENSGT00390000016597
HOGENOMiHOG000166937
HOVERGENiHBG000486
InParanoidiQ9Y333
KOiK12621
OMAiMISVKNC
OrthoDBiEOG091G0ZV5
PhylomeDBiQ9Y333
TreeFamiTF314960

Family and domain databases

CDDicd01725 LSm2, 1 hit
InterProiView protein in InterPro
IPR001163 LSM_dom_euk/arc
IPR010920 LSM_dom_sf
IPR016654 U6_snRNA_Lsm2
PANTHERiPTHR13829 PTHR13829, 1 hit
PfamiView protein in Pfam
PF01423 LSM, 1 hit
PIRSFiPIRSF016394 U6_snRNA_Lsm2, 1 hit
SMARTiView protein in SMART
SM00651 Sm, 1 hit
SUPFAMiSSF50182 SSF50182, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y333-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK
60 70 80 90
YPHMLSVKNC FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ
Length:95
Mass (Da):10,835
Last modified:November 1, 1999 - v1
Checksum:i623591A09A6ABACE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF182288 mRNA Translation: AAD56226.1
AJ245416 mRNA Translation: CAB52190.1
AF196468 mRNA Translation: AAG33023.1
AF134726 Genomic DNA Translation: AAD21818.1
BA000025 Genomic DNA Translation: BAB63302.1
AF136977 mRNA Translation: AAG49438.1
CR542146 mRNA Translation: CAG46943.1
CR542157 mRNA Translation: CAG46954.1
AL929592 Genomic DNA No translation available.
CR759915 Genomic DNA No translation available.
CR759787 Genomic DNA No translation available.
CR925765 Genomic DNA No translation available.
CH471081 Genomic DNA Translation: EAX03525.1
BC009192 mRNA Translation: AAH09192.1
CCDSiCCDS4722.1
RefSeqiNP_067000.1, NM_021177.4
UniGeneiHs.103106

Genome annotation databases

EnsembliENST00000375661; ENSP00000364813; ENSG00000204392
ENST00000383391; ENSP00000372883; ENSG00000172850
ENST00000424975; ENSP00000403345; ENSG00000231502
ENST00000432122; ENSP00000414006; ENSG00000224979
ENST00000434125; ENSP00000406280; ENSG00000225998
ENST00000455705; ENSP00000414634; ENSG00000236826
GeneIDi57819
KEGGihsa:57819
UCSCiuc003nxg.4 human

Similar proteinsi

Entry informationi

Entry nameiLSM2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y333
Secondary accession number(s): Q6FGG1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 175 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

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