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Protein

Zinc finger and BTB domain-containing protein 12

Gene

ZBTB12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri359 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri387 – 409C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 438C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161853-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 12
Alternative name(s):
Protein G10
Gene namesi
Name:ZBTB12
Synonyms:C6orf46, G10, NG35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:19066. ZBTB12.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi221527.
OpenTargetsiENSG00000204366.
ENSG00000206366.
ENSG00000234196.
ENSG00000234852.
ENSG00000237900.
PharmGKBiPA38784.

Polymorphism and mutation databases

BioMutaiZBTB12.
DMDMi38257796.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000477281 – 459Zinc finger and BTB domain-containing protein 12Add BLAST459

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei19PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y330.
PaxDbiQ9Y330.
PeptideAtlasiQ9Y330.
PRIDEiQ9Y330.

PTM databases

iPTMnetiQ9Y330.
PhosphoSitePlusiQ9Y330.

Expressioni

Gene expression databases

BgeeiENSG00000204366.
CleanExiHS_ZBTB12.
GenevisibleiQ9Y330. HS.

Organism-specific databases

HPAiHPA047161.

Interactioni

Protein-protein interaction databases

BioGridi128737. 1 interactor.
IntActiQ9Y330. 1 interactor.
STRINGi9606.ENSP00000364677.

Structurei

3D structure databases

ProteinModelPortaliQ9Y330.
SMRiQ9Y330.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 97BTBPROSITE-ProRule annotationAdd BLAST65

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi155 – 179Pro-richAdd BLAST25
Compositional biasi227 – 327Gly-richAdd BLAST101

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri333 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri359 – 381C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri387 – 409C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri415 – 438C2H2-type 4PROSITE-ProRule annotationAdd BLAST24

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ9Y330.
KOiK10499.
OMAiRSEERFC.
OrthoDBiEOG091G11CA.
PhylomeDBiQ9Y330.
TreeFamiTF333162.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y330-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASGVEVLRF QLPGHEAATL RNMNQLRAEE RFCDVTIVAD SLKFRGHKVI
60 70 80 90 100
LAACSPFLRD QFLLNPSSEL QVSLMHSARI VADLLLSCYT GALEFAVRDI
110 120 130 140 150
VNYLTAASYL QMEHVVEKCR NALSQFIEPK IGLKEDGVSE ASLVSSISAT
160 170 180 190 200
KSLLPPARTP KPAPKPPPPP PLPPPLLRPV KLEFPLDEDL ELKAEEEDED
210 220 230 240 250
EDEDVSDICI VKVESALEVA HRLKPPGGLG GGLGIGGSVG GHLGELAQSS
260 270 280 290 300
VPPSTVAPPQ GVVKACYSLS EDAEGEGLLL IPGGRASVGA TSGLVEAAAV
310 320 330 340 350
AMAARGAGGS LGAGGSRGPL PGGFSGGNPL KNIKCTKCPE VFQGVEKLVF
360 370 380 390 400
HMRAQHFIFM CPRCGKQFNH SSNLNRHMNV HRGVKSHSCG ICGKCFTQKS
410 420 430 440 450
TLHDHLNLHS GARPYRCSYC DVRFAHKPAI RRHLKEQHGK TTAENVLEAS

VAEINVLIR
Length:459
Mass (Da):49,148
Last modified:November 1, 1999 - v1
Checksum:iEF6DD3FCC888E86F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134726 Genomic DNA. Translation: AAD21810.1.
BA000025 Genomic DNA. Translation: BAB63293.1.
AL671762 Genomic DNA. Translation: CAI18229.1.
AL844853 Genomic DNA. Translation: CAI41855.1.
AL662834 Genomic DNA. Translation: CAI17750.1.
CR388219 Genomic DNA. Translation: CAQ07475.1.
CR759784 Genomic DNA. Translation: CAQ09313.1.
CH471081 Genomic DNA. Translation: EAX03546.1.
BC043609 mRNA. Translation: AAH43609.1.
CCDSiCCDS4727.1.
RefSeqiNP_862825.1. NM_181842.2.
XP_011512685.2. XM_011514383.2.
UniGeneiHs.234027.

Genome annotation databases

EnsembliENST00000375525; ENSP00000364675; ENSG00000206366.
ENST00000375527; ENSP00000364677; ENSG00000204366.
ENST00000432044; ENSP00000392328; ENSG00000234196.
ENST00000441555; ENSP00000414777; ENSG00000237900.
ENST00000458242; ENSP00000391563; ENSG00000234852.
GeneIDi221527.
KEGGihsa:221527.
UCSCiuc003nyd.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF134726 Genomic DNA. Translation: AAD21810.1.
BA000025 Genomic DNA. Translation: BAB63293.1.
AL671762 Genomic DNA. Translation: CAI18229.1.
AL844853 Genomic DNA. Translation: CAI41855.1.
AL662834 Genomic DNA. Translation: CAI17750.1.
CR388219 Genomic DNA. Translation: CAQ07475.1.
CR759784 Genomic DNA. Translation: CAQ09313.1.
CH471081 Genomic DNA. Translation: EAX03546.1.
BC043609 mRNA. Translation: AAH43609.1.
CCDSiCCDS4727.1.
RefSeqiNP_862825.1. NM_181842.2.
XP_011512685.2. XM_011514383.2.
UniGeneiHs.234027.

3D structure databases

ProteinModelPortaliQ9Y330.
SMRiQ9Y330.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi128737. 1 interactor.
IntActiQ9Y330. 1 interactor.
STRINGi9606.ENSP00000364677.

PTM databases

iPTMnetiQ9Y330.
PhosphoSitePlusiQ9Y330.

Polymorphism and mutation databases

BioMutaiZBTB12.
DMDMi38257796.

Proteomic databases

EPDiQ9Y330.
PaxDbiQ9Y330.
PeptideAtlasiQ9Y330.
PRIDEiQ9Y330.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000375525; ENSP00000364675; ENSG00000206366.
ENST00000375527; ENSP00000364677; ENSG00000204366.
ENST00000432044; ENSP00000392328; ENSG00000234196.
ENST00000441555; ENSP00000414777; ENSG00000237900.
ENST00000458242; ENSP00000391563; ENSG00000234852.
GeneIDi221527.
KEGGihsa:221527.
UCSCiuc003nyd.2. human.

Organism-specific databases

CTDi221527.
DisGeNETi221527.
GeneCardsiZBTB12.
HGNCiHGNC:19066. ZBTB12.
HPAiHPA047161.
neXtProtiNX_Q9Y330.
OpenTargetsiENSG00000204366.
ENSG00000206366.
ENSG00000234196.
ENSG00000234852.
ENSG00000237900.
PharmGKBiPA38784.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00760000119063.
HOGENOMiHOG000232051.
HOVERGENiHBG056199.
InParanoidiQ9Y330.
KOiK10499.
OMAiRSEERFC.
OrthoDBiEOG091G11CA.
PhylomeDBiQ9Y330.
TreeFamiTF333162.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000161853-MONOMER.

Miscellaneous databases

GenomeRNAii221527.
PROiQ9Y330.

Gene expression databases

BgeeiENSG00000204366.
CleanExiHS_ZBTB12.
GenevisibleiQ9Y330. HS.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 4 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 4 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT12_HUMAN
AccessioniPrimary (citable) accession number: Q9Y330
Secondary accession number(s): B0UY00, Q5JQ98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 7, 2003
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.