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Protein

Neuronal vesicle trafficking-associated protein 2

Gene

NSG2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal vesicle trafficking-associated protein 2Imported
Alternative name(s):
Neuron-specific protein family member 2Imported
Protein p19
Short name:
Hmp191 Publication
Gene namesi
Name:NSG2Imported
Synonyms:CALY3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000170091.10
HGNCiHGNC:24955 NSG2
MIMi616752 gene
neXtProtiNX_Q9Y328

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 71CytoplasmicSequence analysisAdd BLAST71
Transmembranei72 – 92Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini93 – 171LumenalSequence analysisAdd BLAST79

Keywords - Cellular componenti

Cell projection, Cytoplasmic vesicle, Endosome, Golgi apparatus, Lysosome, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi51617
OpenTargetsiENSG00000170091

Polymorphism and mutation databases

BioMutaiNSG2
DMDMi21263843

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001643661 – 171Neuronal vesicle trafficking-associated protein 2Add BLAST171

Proteomic databases

PaxDbiQ9Y328
PeptideAtlasiQ9Y328
PRIDEiQ9Y328

PTM databases

iPTMnetiQ9Y328
PhosphoSitePlusiQ9Y328

Expressioni

Gene expression databases

BgeeiENSG00000170091
ExpressionAtlasiQ9Y328 baseline and differential
GenevisibleiQ9Y328 HS

Organism-specific databases

HPAiHPA056191

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi119640, 13 interactors
IntActiQ9Y328, 13 interactors
MINTiQ9Y328
STRINGi9606.ENSP00000307722

Structurei

3D structure databases

ProteinModelPortaliQ9Y328
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NSG family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJ7J Eukaryota
ENOG4111F06 LUCA
GeneTreeiENSGT00390000000483
HOGENOMiHOG000030909
HOVERGENiHBG012403
InParanoidiQ9Y328
OMAiVEDGFQN
OrthoDBiEOG091G0LR0
PhylomeDBiQ9Y328

Family and domain databases

InterProiView protein in InterPro
IPR009431 NSG
PANTHERiPTHR28546 PTHR28546, 1 hit
PfamiView protein in Pfam
PF06387 Calcyon, 1 hit
PIRSFiPIRSF002383 Calcyon, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y328-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKLNSNPSE KGTKPPSVED GFQTVPLITP LEVNHLQLPA PEKVIVKTRT
60 70 80 90 100
EYQPEQKNKG KFRVPKIAEF TVTILVSLAL AFLACIVFLV VYKAFTYDHS
110 120 130 140 150
CPEGFVYKHK RCIPASLDAY YSSQDPNSRS RFYTVISHYS VAKQSTARAI
160 170
GPWLSAAAVI HEPKPPKTQG H
Length:171
Mass (Da):19,085
Last modified:November 1, 1999 - v1
Checksum:iF5E69DEA61D0FFEC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti152P → R in AAF14874 (PubMed:10931946).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF133422 mRNA Translation: AAD30539.1
AF113537 mRNA Translation: AAF14874.1
AK312359 mRNA Translation: BAG35277.1
CH471062 Genomic DNA Translation: EAW61383.1
CH471062 Genomic DNA Translation: EAW61384.1
BC002619 mRNA Translation: AAH02619.1
CCDSiCCDS4391.1
RefSeqiNP_057064.1, NM_015980.4
UniGeneiHs.559412

Genome annotation databases

EnsembliENST00000303177; ENSP00000307722; ENSG00000170091
ENST00000519717; ENSP00000431119; ENSG00000170091
GeneIDi51617
KEGGihsa:51617
UCSCiuc003mcx.4 human

Similar proteinsi

Entry informationi

Entry nameiNSG2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y328
Secondary accession number(s): B2R5Y0, D3DQN0, Q9UHX8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 27, 2002
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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