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Protein

rRNA-processing protein FCF1 homolog

Gene

FCF1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA-processing protein FCF1 homolog
Gene namesi
Name:FCF1
Synonyms:C14orf111
ORF Names:CGI-35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20220. FCF1.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleolus Source: GO_Central
  2. small-subunit processome Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198rRNA-processing protein FCF1 homologPRO_0000089920Add
BLAST

Proteomic databases

MaxQBiQ9Y324.
PaxDbiQ9Y324.
PRIDEiQ9Y324.

PTM databases

PhosphoSiteiQ9Y324.

Expressioni

Gene expression databases

BgeeiQ9Y324.
CleanExiHS_FCF1.
ExpressionAtlasiQ9Y324. baseline and differential.
GenevestigatoriQ9Y324.

Organism-specific databases

HPAiHPA046681.

Interactioni

Protein-protein interaction databases

BioGridi119268. 2 interactions.
MINTiMINT-2823343.
STRINGi9606.ENSP00000344393.

Structurei

3D structure databases

ProteinModelPortaliQ9Y324.
SMRiQ9Y324. Positions 55-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 166100PINcAdd
BLAST

Sequence similaritiesi

Belongs to the UTP23/FCF1 family. FCF1 subfamily.Curated
Contains 1 PINc domain.Curated

Phylogenomic databases

eggNOGiCOG1412.
GeneTreeiENSGT00550000074979.
HOGENOMiHOG000183747.
HOVERGENiHBG051022.
InParanoidiQ9Y324.
KOiK14566.
OMAiFQHNTAL.
PhylomeDBiQ9Y324.
TreeFamiTF314992.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR006984. Fcf1/Utp23.
IPR002716. PIN_dom.
IPR029060. PIN_domain-like.
[Graphical view]
PfamiPF04900. Fcf1. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y324-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ
60 70 80 90 100
HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP
110 120 130 140 150
CITDCVMAEI EKLGQKYRVA LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT
160 170 180 190
QHKCYIVATV DRDLKRRIRK IPGVPIMYIS NHRYNIERMP DDYGAPRF
Length:198
Mass (Da):23,370
Last modified:October 31, 1999 - v1
Checksum:iA0C98414C21F16AE
GO

Sequence cautioni

The sequence CAD62599.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132969 mRNA. Translation: AAD27744.1.
BX248271 mRNA. Translation: CAD62599.1. Different initiation.
AC007956 Genomic DNA. No translation available.
CCDSiCCDS9832.1.
RefSeqiNP_057046.1. NM_015962.4.
UniGeneiHs.579828.
Hs.711584.

Genome annotation databases

EnsembliENST00000341162; ENSP00000344393; ENSG00000119616.
GeneIDi51077.
KEGGihsa:51077.
UCSCiuc001xqh.3. human.

Polymorphism databases

DMDMi34582346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132969 mRNA. Translation: AAD27744.1.
BX248271 mRNA. Translation: CAD62599.1. Different initiation.
AC007956 Genomic DNA. No translation available.
CCDSiCCDS9832.1.
RefSeqiNP_057046.1. NM_015962.4.
UniGeneiHs.579828.
Hs.711584.

3D structure databases

ProteinModelPortaliQ9Y324.
SMRiQ9Y324. Positions 55-180.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119268. 2 interactions.
MINTiMINT-2823343.
STRINGi9606.ENSP00000344393.

PTM databases

PhosphoSiteiQ9Y324.

Polymorphism databases

DMDMi34582346.

Proteomic databases

MaxQBiQ9Y324.
PaxDbiQ9Y324.
PRIDEiQ9Y324.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341162; ENSP00000344393; ENSG00000119616.
GeneIDi51077.
KEGGihsa:51077.
UCSCiuc001xqh.3. human.

Organism-specific databases

CTDi51077.
GeneCardsiGC14P075179.
HGNCiHGNC:20220. FCF1.
HPAiHPA046681.
neXtProtiNX_Q9Y324.
PharmGKBiPA162388159.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1412.
GeneTreeiENSGT00550000074979.
HOGENOMiHOG000183747.
HOVERGENiHBG051022.
InParanoidiQ9Y324.
KOiK14566.
OMAiFQHNTAL.
PhylomeDBiQ9Y324.
TreeFamiTF314992.

Miscellaneous databases

ChiTaRSiFCF1. human.
GeneWikiiFCF1.
GenomeRNAii51077.
NextBioi53711.
PROiQ9Y324.

Gene expression databases

BgeeiQ9Y324.
CleanExiHS_FCF1.
ExpressionAtlasiQ9Y324. baseline and differential.
GenevestigatoriQ9Y324.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR006984. Fcf1/Utp23.
IPR002716. PIN_dom.
IPR029060. PIN_domain-like.
[Graphical view]
PfamiPF04900. Fcf1. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFCF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y324
Secondary accession number(s): Q86TW8, Q8TBL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 8, 2003
Last sequence update: October 31, 1999
Last modified: February 3, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.