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Q9Y324

- FCF1_HUMAN

UniProt

Q9Y324 - FCF1_HUMAN

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Protein

rRNA-processing protein FCF1 homolog

Gene

FCF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.By similarity

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Ribosome biogenesis, rRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
rRNA-processing protein FCF1 homolog
Gene namesi
Name:FCF1
Synonyms:C14orf111
ORF Names:CGI-35
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20220. FCF1.

Subcellular locationi

Nucleusnucleolus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
  2. small-subunit processome Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162388159.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 198198rRNA-processing protein FCF1 homologPRO_0000089920Add
BLAST

Proteomic databases

MaxQBiQ9Y324.
PaxDbiQ9Y324.
PRIDEiQ9Y324.

PTM databases

PhosphoSiteiQ9Y324.

Expressioni

Gene expression databases

BgeeiQ9Y324.
CleanExiHS_FCF1.
ExpressionAtlasiQ9Y324. baseline and differential.
GenevestigatoriQ9Y324.

Organism-specific databases

HPAiHPA046681.

Interactioni

Protein-protein interaction databases

BioGridi119268. 2 interactions.
MINTiMINT-2823343.
STRINGi9606.ENSP00000344393.

Structurei

3D structure databases

ProteinModelPortaliQ9Y324.
SMRiQ9Y324. Positions 55-180.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 166100PINcAdd
BLAST

Sequence similaritiesi

Belongs to the UTP23/FCF1 family. FCF1 subfamily.Curated
Contains 1 PINc domain.Curated

Phylogenomic databases

eggNOGiCOG1412.
GeneTreeiENSGT00550000074979.
HOGENOMiHOG000183747.
HOVERGENiHBG051022.
InParanoidiQ9Y324.
KOiK14566.
OMAiNFSIQKK.
PhylomeDBiQ9Y324.
TreeFamiTF314992.

Family and domain databases

Gene3Di3.40.50.1010. 1 hit.
InterProiIPR006984. Fcf1/Utp23.
IPR002716. PIN_dom.
IPR029060. PIN_domain-like.
[Graphical view]
PfamiPF04900. Fcf1. 1 hit.
[Graphical view]
SMARTiSM00670. PINc. 1 hit.
[Graphical view]
SUPFAMiSSF88723. SSF88723. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y324-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ
60 70 80 90 100
HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP
110 120 130 140 150
CITDCVMAEI EKLGQKYRVA LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT
160 170 180 190
QHKCYIVATV DRDLKRRIRK IPGVPIMYIS NHRYNIERMP DDYGAPRF
Length:198
Mass (Da):23,370
Last modified:November 1, 1999 - v1
Checksum:iA0C98414C21F16AE
GO

Sequence cautioni

The sequence CAD62599.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132969 mRNA. Translation: AAD27744.1.
BX248271 mRNA. Translation: CAD62599.1. Different initiation.
AC007956 Genomic DNA. No translation available.
CCDSiCCDS9832.1.
RefSeqiNP_057046.1. NM_015962.4.
UniGeneiHs.579828.
Hs.711584.

Genome annotation databases

EnsembliENST00000341162; ENSP00000344393; ENSG00000119616.
GeneIDi51077.
KEGGihsa:51077.
UCSCiuc001xqh.3. human.

Polymorphism databases

DMDMi34582346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132969 mRNA. Translation: AAD27744.1 .
BX248271 mRNA. Translation: CAD62599.1 . Different initiation.
AC007956 Genomic DNA. No translation available.
CCDSi CCDS9832.1.
RefSeqi NP_057046.1. NM_015962.4.
UniGenei Hs.579828.
Hs.711584.

3D structure databases

ProteinModelPortali Q9Y324.
SMRi Q9Y324. Positions 55-180.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119268. 2 interactions.
MINTi MINT-2823343.
STRINGi 9606.ENSP00000344393.

PTM databases

PhosphoSitei Q9Y324.

Polymorphism databases

DMDMi 34582346.

Proteomic databases

MaxQBi Q9Y324.
PaxDbi Q9Y324.
PRIDEi Q9Y324.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000341162 ; ENSP00000344393 ; ENSG00000119616 .
GeneIDi 51077.
KEGGi hsa:51077.
UCSCi uc001xqh.3. human.

Organism-specific databases

CTDi 51077.
GeneCardsi GC14P075179.
HGNCi HGNC:20220. FCF1.
HPAi HPA046681.
neXtProti NX_Q9Y324.
PharmGKBi PA162388159.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1412.
GeneTreei ENSGT00550000074979.
HOGENOMi HOG000183747.
HOVERGENi HBG051022.
InParanoidi Q9Y324.
KOi K14566.
OMAi NFSIQKK.
PhylomeDBi Q9Y324.
TreeFami TF314992.

Miscellaneous databases

ChiTaRSi FCF1. human.
GeneWikii FCF1.
GenomeRNAii 51077.
NextBioi 53711.
PROi Q9Y324.

Gene expression databases

Bgeei Q9Y324.
CleanExi HS_FCF1.
ExpressionAtlasi Q9Y324. baseline and differential.
Genevestigatori Q9Y324.

Family and domain databases

Gene3Di 3.40.50.1010. 1 hit.
InterProi IPR006984. Fcf1/Utp23.
IPR002716. PIN_dom.
IPR029060. PIN_domain-like.
[Graphical view ]
Pfami PF04900. Fcf1. 1 hit.
[Graphical view ]
SMARTi SM00670. PINc. 1 hit.
[Graphical view ]
SUPFAMi SSF88723. SSF88723. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Neuroblastoma.
  3. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiFCF1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y324
Secondary accession number(s): Q86TW8, Q8TBL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3