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Q9Y324 (FCF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
rRNA-processing protein FCF1 homolog
Gene names
Name:FCF1
Synonyms:C14orf111
ORF Names:CGI-35
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length198 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly By similarity.

Subcellular location

Nucleusnucleolus By similarity.

Sequence similarities

Belongs to the UTP23/FCF1 family. FCF1 subfamily.

Contains 1 PINc domain.

Sequence caution

The sequence CAD62599.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processRibosome biogenesis
rRNA processing
   Cellular componentNucleus
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processrRNA processing

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleolus

Inferred from electronic annotation. Source: UniProtKB-SubCell

small-subunit processome

Inferred from electronic annotation. Source: InterPro

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 198198rRNA-processing protein FCF1 homolog
PRO_0000089920

Regions

Domain67 – 166100PINc

Sequences

Sequence LengthMass (Da)Tools
Q9Y324 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: A0C98414C21F16AE

FASTA19823,370
        10         20         30         40         50         60 
MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ HPSCLFFQYN 

        70         80         90        100        110        120 
TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP CITDCVMAEI EKLGQKYRVA 

       130        140        150        160        170        180 
LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT QHKCYIVATV DRDLKRRIRK IPGVPIMYIS 

       190 
NHRYNIERMP DDYGAPRF 

« Hide

References

[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Neuroblastoma.
[3]"The DNA sequence and analysis of human chromosome 14."
Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. expand/collapse author list , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132969 mRNA. Translation: AAD27744.1.
BX248271 mRNA. Translation: CAD62599.1. Different initiation.
AC007956 Genomic DNA. No translation available.
RefSeqNP_057046.1. NM_015962.4.
UniGeneHs.579828.
Hs.711584.

3D structure databases

ProteinModelPortalQ9Y324.
SMRQ9Y324. Positions 55-180.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

MINTMINT-2823343.
STRING9606.ENSP00000344393.

PTM databases

PhosphoSiteQ9Y324.

Polymorphism databases

DMDM34582346.

Proteomic databases

PaxDbQ9Y324.
PRIDEQ9Y324.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000341162; ENSP00000344393; ENSG00000119616.
GeneID51077.
KEGGhsa:51077.
UCSCuc001xqh.3. human.

Organism-specific databases

CTD51077.
GeneCardsGC14P075179.
HGNCHGNC:20220. FCF1.
HPAHPA046681.
neXtProtNX_Q9Y324.
PharmGKBPA162388159.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG1412.
HOGENOMHOG000183747.
HOVERGENHBG051022.
InParanoidQ9Y324.
KOK14566.
OMAKLGHRYR.
PhylomeDBQ9Y324.
TreeFamTF314992.

Gene expression databases

ArrayExpressQ9Y324.
BgeeQ9Y324.
CleanExHS_FCF1.
GenevestigatorQ9Y324.

Family and domain databases

InterProIPR006984. Fcf1/Utp23.
IPR002716. PIN_dom.
[Graphical view]
PfamPF04900. Fcf1. 1 hit.
[Graphical view]
SMARTSM00670. PINc. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSFCF1. human.
GeneWikiFCF1.
GenomeRNAi51077.
NextBio53711.
PROQ9Y324.

Entry information

Entry nameFCF1_HUMAN
AccessionPrimary (citable) accession number: Q9Y324
Secondary accession number(s): Q86TW8, Q8TBL8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM