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Q9Y324

- FCF1_HUMAN

UniProt

Q9Y324 - FCF1_HUMAN

Protein

rRNA-processing protein FCF1 homolog

Gene

FCF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.By similarity

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    GO - Biological processi

    1. rRNA processing Source: UniProtKB-KW

    Keywords - Biological processi

    Ribosome biogenesis, rRNA processing

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    rRNA-processing protein FCF1 homolog
    Gene namesi
    Name:FCF1
    Synonyms:C14orf111
    ORF Names:CGI-35
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20220. FCF1.

    Subcellular locationi

    Nucleusnucleolus By similarity

    GO - Cellular componenti

    1. nucleolus Source: UniProtKB-SubCell
    2. small-subunit processome Source: InterPro

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162388159.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 198198rRNA-processing protein FCF1 homologPRO_0000089920Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y324.
    PaxDbiQ9Y324.
    PRIDEiQ9Y324.

    PTM databases

    PhosphoSiteiQ9Y324.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y324.
    BgeeiQ9Y324.
    CleanExiHS_FCF1.
    GenevestigatoriQ9Y324.

    Organism-specific databases

    HPAiHPA046681.

    Interactioni

    Protein-protein interaction databases

    MINTiMINT-2823343.
    STRINGi9606.ENSP00000344393.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y324.
    SMRiQ9Y324. Positions 55-180.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini67 – 166100PINcAdd
    BLAST

    Sequence similaritiesi

    Belongs to the UTP23/FCF1 family. FCF1 subfamily.Curated
    Contains 1 PINc domain.Curated

    Phylogenomic databases

    eggNOGiCOG1412.
    HOGENOMiHOG000183747.
    HOVERGENiHBG051022.
    InParanoidiQ9Y324.
    KOiK14566.
    OMAiNFSIQKK.
    PhylomeDBiQ9Y324.
    TreeFamiTF314992.

    Family and domain databases

    Gene3Di3.40.50.1010. 1 hit.
    InterProiIPR006984. Fcf1/Utp23.
    IPR002716. PIN_dom.
    IPR029060. PIN_domain-like.
    [Graphical view]
    PfamiPF04900. Fcf1. 1 hit.
    [Graphical view]
    SMARTiSM00670. PINc. 1 hit.
    [Graphical view]
    SUPFAMiSSF88723. SSF88723. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y324-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGKQKKTRKY ATMKRMLSLR DQRLKEKDRL KPKKKEKKDP SALKEREVPQ    50
    HPSCLFFQYN TQLGPPYHIL VDTNFINFSI KAKLDLVQSM MDCLYAKCIP 100
    CITDCVMAEI EKLGQKYRVA LRIAKDPRFE RLPCTHKGTY ADDCLVQRVT 150
    QHKCYIVATV DRDLKRRIRK IPGVPIMYIS NHRYNIERMP DDYGAPRF 198
    Length:198
    Mass (Da):23,370
    Last modified:November 1, 1999 - v1
    Checksum:iA0C98414C21F16AE
    GO

    Sequence cautioni

    The sequence CAD62599.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132969 mRNA. Translation: AAD27744.1.
    BX248271 mRNA. Translation: CAD62599.1. Different initiation.
    AC007956 Genomic DNA. No translation available.
    CCDSiCCDS9832.1.
    RefSeqiNP_057046.1. NM_015962.4.
    UniGeneiHs.579828.
    Hs.711584.

    Genome annotation databases

    EnsembliENST00000341162; ENSP00000344393; ENSG00000119616.
    GeneIDi51077.
    KEGGihsa:51077.
    UCSCiuc001xqh.3. human.

    Polymorphism databases

    DMDMi34582346.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132969 mRNA. Translation: AAD27744.1 .
    BX248271 mRNA. Translation: CAD62599.1 . Different initiation.
    AC007956 Genomic DNA. No translation available.
    CCDSi CCDS9832.1.
    RefSeqi NP_057046.1. NM_015962.4.
    UniGenei Hs.579828.
    Hs.711584.

    3D structure databases

    ProteinModelPortali Q9Y324.
    SMRi Q9Y324. Positions 55-180.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    MINTi MINT-2823343.
    STRINGi 9606.ENSP00000344393.

    PTM databases

    PhosphoSitei Q9Y324.

    Polymorphism databases

    DMDMi 34582346.

    Proteomic databases

    MaxQBi Q9Y324.
    PaxDbi Q9Y324.
    PRIDEi Q9Y324.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341162 ; ENSP00000344393 ; ENSG00000119616 .
    GeneIDi 51077.
    KEGGi hsa:51077.
    UCSCi uc001xqh.3. human.

    Organism-specific databases

    CTDi 51077.
    GeneCardsi GC14P075179.
    HGNCi HGNC:20220. FCF1.
    HPAi HPA046681.
    neXtProti NX_Q9Y324.
    PharmGKBi PA162388159.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1412.
    HOGENOMi HOG000183747.
    HOVERGENi HBG051022.
    InParanoidi Q9Y324.
    KOi K14566.
    OMAi NFSIQKK.
    PhylomeDBi Q9Y324.
    TreeFami TF314992.

    Miscellaneous databases

    ChiTaRSi FCF1. human.
    GeneWikii FCF1.
    GenomeRNAii 51077.
    NextBioi 53711.
    PROi Q9Y324.

    Gene expression databases

    ArrayExpressi Q9Y324.
    Bgeei Q9Y324.
    CleanExi HS_FCF1.
    Genevestigatori Q9Y324.

    Family and domain databases

    Gene3Di 3.40.50.1010. 1 hit.
    InterProi IPR006984. Fcf1/Utp23.
    IPR002716. PIN_dom.
    IPR029060. PIN_domain-like.
    [Graphical view ]
    Pfami PF04900. Fcf1. 1 hit.
    [Graphical view ]
    SMARTi SM00670. PINc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF88723. SSF88723. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Neuroblastoma.
    3. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiFCF1_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y324
    Secondary accession number(s): Q86TW8, Q8TBL8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 9, 2003
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 101 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3