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Protein

Protein MEMO1

Gene

MEMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration.2 Publications

GO - Biological processi

  • regulation of cell motility Source: Reactome
  • regulation of microtubule-based process Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162959-MONOMER.
ReactomeiR-HSA-6785631. ERBB2 Regulates Cell Motility.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein MEMO1
Alternative name(s):
C21orf19-like protein
Hepatitis C virus NS5A-transactivated protein 7
Short name:
HCV NS5A-transactivated protein 7
Mediator of ErbB2-driven cell motility 1
Short name:
Mediator of cell motility 1
Short name:
Memo-1
Gene namesi
Name:MEMO1
Synonyms:C2orf4, MEMO, NS5ATP7
ORF Names:CGI-27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:14014. MEMO1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: UniProtKB
  • nucleus Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi16W → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi49H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi54Y → A: Diminishes interaction with ERBB2. 1 Publication1
Mutagenesisi81H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi192H → A: Abolishes interaction with ERBB2. 1 Publication1
Mutagenesisi244C → A: Abolishes interaction with ERBB2. 1 Publication1

Organism-specific databases

DisGeNETi51072.
OpenTargetsiENSG00000162959.
PharmGKBiPA162395745.

Polymorphism and mutation databases

BioMutaiMEMO1.
DMDMi7388490.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001343941 – 297Protein MEMO1Add BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei210PhosphotyrosineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ9Y316.
PaxDbiQ9Y316.
PeptideAtlasiQ9Y316.
PRIDEiQ9Y316.

PTM databases

iPTMnetiQ9Y316.
PhosphoSitePlusiQ9Y316.

Expressioni

Gene expression databases

BgeeiENSG00000162959.
CleanExiHS_MEMO1.
ExpressionAtlasiQ9Y316. baseline and differential.
GenevisibleiQ9Y316. HS.

Organism-specific databases

HPAiHPA042603.

Interactioni

Subunit structurei

Interacts with ERBB2 phosphorylated on 'Tyr-1248'.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ERBB2P046266EBI-1104564,EBI-641062
LNX1Q8TBB15EBI-1104564,EBI-739832
LZTS2Q9BRK43EBI-1104564,EBI-741037
RBM45Q8IUH33EBI-1104564,EBI-2512147
RELQ048643EBI-1104564,EBI-307352
TACC1O754104EBI-1104564,EBI-624237
TCF4P158843EBI-1104564,EBI-533224
TRIM27P143733EBI-1104564,EBI-719493
TRIP6Q156543EBI-1104564,EBI-742327

Protein-protein interaction databases

BioGridi119263. 33 interactors.
IntActiQ9Y316. 16 interactors.
MINTiMINT-3085289.
STRINGi9606.ENSP00000295065.

Structurei

Secondary structure

1297
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni11 – 15Combined sources5
Helixi21 – 32Combined sources12
Beta strandi43 – 47Combined sources5
Helixi52 – 63Combined sources12
Turni68 – 70Combined sources3
Beta strandi73 – 79Combined sources7
Beta strandi81 – 83Combined sources3
Beta strandi86 – 90Combined sources5
Beta strandi94 – 96Combined sources3
Beta strandi103 – 105Combined sources3
Helixi107 – 115Combined sources9
Beta strandi119 – 121Combined sources3
Helixi124 – 129Combined sources6
Helixi134 – 136Combined sources3
Helixi137 – 143Combined sources7
Helixi145 – 147Combined sources3
Beta strandi152 – 158Combined sources7
Helixi163 – 177Combined sources15
Beta strandi182 – 187Combined sources6
Beta strandi192 – 194Combined sources3
Helixi195 – 197Combined sources3
Helixi204 – 206Combined sources3
Helixi209 – 225Combined sources17
Helixi229 – 239Combined sources11
Helixi246 – 261Combined sources16
Beta strandi266 – 277Combined sources12
Beta strandi286 – 296Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BCZX-ray2.10A/B/C/D5-297[»]
3BD0X-ray3.01A/B/C/D5-297[»]
ProteinModelPortaliQ9Y316.
SMRiQ9Y316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y316.

Family & Domainsi

Sequence similaritiesi

Belongs to the MEMO1 family.Curated

Phylogenomic databases

eggNOGiKOG3086. Eukaryota.
COG1355. LUCA.
GeneTreeiENSGT00390000006408.
HOGENOMiHOG000225260.
HOVERGENiHBG050811.
InParanoidiQ9Y316.
KOiK06990.
OMAiYTYCGAC.
OrthoDBiEOG091G0GVZ.
PhylomeDBiQ9Y316.
TreeFamiTF300014.

Family and domain databases

CDDicd07361. MEMO_like. 1 hit.
HAMAPiMF_00055. MEMO1. 1 hit.
InterProiIPR002737. MEMO1_fam.
[Graphical view]
PANTHERiPTHR11060. PTHR11060. 1 hit.
PfamiPF01875. Memo. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04336. AmmeMemoSam_B. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y316-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSNRVVCREA SHAGSWYTAS GPQLNAQLEG WLSQVQSTKR PARAIIAPHA
60 70 80 90 100
GYTYCGSCAA HAYKQVDPSI TRRIFILGPS HHVPLSRCAL SSVDIYRTPL
110 120 130 140 150
YDLRIDQKIY GELWKTGMFE RMSLQTDEDE HSIEMHLPYT AKAMESHKDE
160 170 180 190 200
FTIIPVLVGA LSESKEQEFG KLFSKYLADP SNLFVVSSDF CHWGQRFRYS
210 220 230 240 250
YYDESQGEIY RSIEHLDKMG MSIIEQLDPV SFSNYLKKYH NTICGRHPIG
260 270 280 290
VLLNAITELQ KNGMNMSFSF LNYAQSSQCR NWQDSSVSYA AGALTVH
Length:297
Mass (Da):33,733
Last modified:November 1, 1999 - v1
Checksum:iE315FD5587776211
GO
Isoform 2 (identifier: Q9Y316-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     49-71: Missing.

Show »
Length:274
Mass (Da):31,307
Checksum:i1BE5B4A07A5D44D8
GO
Isoform 3 (identifier: Q9Y316-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MSNRVVCREASHAGSWYTAS → MPLWRADKCQDVQSASWRPRRAD

Show »
Length:300
Mass (Da):34,294
Checksum:i0778186B7CCA0ADA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23Q → H in AAH70046 (PubMed:15489334).Curated1
Sequence conflicti172L → P in BAG59632 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0476931 – 20MSNRV…WYTAS → MPLWRADKCQDVQSASWRPR RAD in isoform 3. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_04109249 – 71Missing in isoform 2. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363446 mRNA. Translation: AAL34462.1.
AB041018 mRNA. Translation: BAD74066.1.
AB041019 mRNA. Translation: BAD74067.1.
AF529368 mRNA. Translation: AAQ09602.1.
AF132961 mRNA. Translation: AAD27736.1.
AK297128 mRNA. Translation: BAG59632.1.
AL121652 Genomic DNA. No translation available.
AL121655 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00467.1.
CH471053 Genomic DNA. Translation: EAX00469.1.
CH471053 Genomic DNA. Translation: EAX00470.1.
CH471053 Genomic DNA. Translation: EAX00472.1.
BC018733 mRNA. Translation: AAH18733.1.
BC070046 mRNA. Translation: AAH70046.1.
BC094681 mRNA. Translation: AAH94681.1.
CCDSiCCDS1776.1. [Q9Y316-1]
CCDS46255.1. [Q9Y316-2]
RefSeqiNP_001131074.1. NM_001137602.2. [Q9Y316-2]
NP_001288762.1. NM_001301833.1. [Q9Y316-1]
NP_001288781.1. NM_001301852.1.
NP_057039.1. NM_015955.3. [Q9Y316-1]
XP_011531194.1. XM_011532892.2. [Q9Y316-1]
XP_016859744.1. XM_017004255.1. [Q9Y316-1]
UniGeneiHs.444969.

Genome annotation databases

EnsembliENST00000295065; ENSP00000295065; ENSG00000162959. [Q9Y316-1]
ENST00000379383; ENSP00000368691; ENSG00000162959. [Q9Y316-3]
ENST00000404530; ENSP00000385557; ENSG00000162959. [Q9Y316-1]
ENST00000426310; ENSP00000400795; ENSG00000162959. [Q9Y316-2]
GeneIDi51072.
KEGGihsa:51072.
UCSCiuc002rnx.4. human. [Q9Y316-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF363446 mRNA. Translation: AAL34462.1.
AB041018 mRNA. Translation: BAD74066.1.
AB041019 mRNA. Translation: BAD74067.1.
AF529368 mRNA. Translation: AAQ09602.1.
AF132961 mRNA. Translation: AAD27736.1.
AK297128 mRNA. Translation: BAG59632.1.
AL121652 Genomic DNA. No translation available.
AL121655 Genomic DNA. No translation available.
CH471053 Genomic DNA. Translation: EAX00467.1.
CH471053 Genomic DNA. Translation: EAX00469.1.
CH471053 Genomic DNA. Translation: EAX00470.1.
CH471053 Genomic DNA. Translation: EAX00472.1.
BC018733 mRNA. Translation: AAH18733.1.
BC070046 mRNA. Translation: AAH70046.1.
BC094681 mRNA. Translation: AAH94681.1.
CCDSiCCDS1776.1. [Q9Y316-1]
CCDS46255.1. [Q9Y316-2]
RefSeqiNP_001131074.1. NM_001137602.2. [Q9Y316-2]
NP_001288762.1. NM_001301833.1. [Q9Y316-1]
NP_001288781.1. NM_001301852.1.
NP_057039.1. NM_015955.3. [Q9Y316-1]
XP_011531194.1. XM_011532892.2. [Q9Y316-1]
XP_016859744.1. XM_017004255.1. [Q9Y316-1]
UniGeneiHs.444969.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3BCZX-ray2.10A/B/C/D5-297[»]
3BD0X-ray3.01A/B/C/D5-297[»]
ProteinModelPortaliQ9Y316.
SMRiQ9Y316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119263. 33 interactors.
IntActiQ9Y316. 16 interactors.
MINTiMINT-3085289.
STRINGi9606.ENSP00000295065.

PTM databases

iPTMnetiQ9Y316.
PhosphoSitePlusiQ9Y316.

Polymorphism and mutation databases

BioMutaiMEMO1.
DMDMi7388490.

Proteomic databases

EPDiQ9Y316.
PaxDbiQ9Y316.
PeptideAtlasiQ9Y316.
PRIDEiQ9Y316.

Protocols and materials databases

DNASUi51072.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000295065; ENSP00000295065; ENSG00000162959. [Q9Y316-1]
ENST00000379383; ENSP00000368691; ENSG00000162959. [Q9Y316-3]
ENST00000404530; ENSP00000385557; ENSG00000162959. [Q9Y316-1]
ENST00000426310; ENSP00000400795; ENSG00000162959. [Q9Y316-2]
GeneIDi51072.
KEGGihsa:51072.
UCSCiuc002rnx.4. human. [Q9Y316-1]

Organism-specific databases

DisGeNETi51072.
GeneCardsiMEMO1.
HGNCiHGNC:14014. MEMO1.
HPAiHPA042603.
MIMi611786. gene.
neXtProtiNX_Q9Y316.
OpenTargetsiENSG00000162959.
PharmGKBiPA162395745.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3086. Eukaryota.
COG1355. LUCA.
GeneTreeiENSGT00390000006408.
HOGENOMiHOG000225260.
HOVERGENiHBG050811.
InParanoidiQ9Y316.
KOiK06990.
OMAiYTYCGAC.
OrthoDBiEOG091G0GVZ.
PhylomeDBiQ9Y316.
TreeFamiTF300014.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000162959-MONOMER.
ReactomeiR-HSA-6785631. ERBB2 Regulates Cell Motility.

Miscellaneous databases

ChiTaRSiMEMO1. human.
EvolutionaryTraceiQ9Y316.
GenomeRNAii51072.
PROiQ9Y316.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000162959.
CleanExiHS_MEMO1.
ExpressionAtlasiQ9Y316. baseline and differential.
GenevisibleiQ9Y316. HS.

Family and domain databases

CDDicd07361. MEMO_like. 1 hit.
HAMAPiMF_00055. MEMO1. 1 hit.
InterProiIPR002737. MEMO1_fam.
[Graphical view]
PANTHERiPTHR11060. PTHR11060. 1 hit.
PfamiPF01875. Memo. 1 hit.
[Graphical view]
TIGRFAMsiTIGR04336. AmmeMemoSam_B. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMEMO1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y316
Secondary accession number(s): B4DLS0
, D6W575, Q5R2V8, Q5R2V9, Q6NSL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 141 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Uncharacterized protein families (UPF)
    List of uncharacterized protein family (UPF) entries

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.