Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Y315 (DEOC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 110. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative deoxyribose-phosphate aldolase

Short name=DERA
EC=4.1.2.4
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase
Gene names
Name:DERA
ORF Names:CGI-26
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity.

Catalytic activity

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathway

Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.

Sequence similarities

Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.

Sequence caution

The sequence AAD27735.1 differs from that shown. Reason: Erroneous initiation.

The sequence AAH56234.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAD96261.1 differs from that shown. Reason: Erroneous initiation.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PAAF1Q9BRP41EBI-1048152,EBI-1056358

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Putative deoxyribose-phosphate aldolase
PRO_0000057310

Sites

Active site2181Schiff-base intermediate with acetaldehyde By similarity
Active site2541 By similarity

Experimental info

Sequence conflict1591N → S in BAD96261. Ref.2
Sequence conflict2341I → T in BAD96261. Ref.2
Sequence conflict2401I → T in BAD96261. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y315 [UniParc].

Last modified November 1, 2002. Version 2.
Checksum: E9576567D0E5CBDE

FASTA31835,231
        10         20         30         40         50         60 
MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS 

        70         80         90        100        110        120 
GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI 

       130        140        150        160        170        180 
PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK 

       190        200        210        220        230        240 
ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI 

       250        260        270        280        290        300 
RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 

       310 
IYHHVTGRYA AYHDLPMS 

« Hide

References

[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Adipose tissue.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Skin.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132960 mRNA. Translation: AAD27735.1. Different initiation.
AK222541 mRNA. Translation: BAD96261.1. Different initiation.
BC056234 mRNA. Translation: AAH56234.1. Different initiation.
CCDSCCDS44838.1.
RefSeqNP_057038.2. NM_015954.2.
UniGeneHs.39429.

3D structure databases

ProteinModelPortalQ9Y315.
SMRQ9Y315. Positions 48-289.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119262. 5 interactions.
STRING9606.ENSP00000416583.

PTM databases

PhosphoSiteQ9Y315.

Polymorphism databases

DMDM24636817.

Proteomic databases

MaxQBQ9Y315.
PaxDbQ9Y315.
PRIDEQ9Y315.

Protocols and materials databases

DNASU51071.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000428559; ENSP00000416583; ENSG00000023697.
GeneID51071.
KEGGhsa:51071.
UCSCuc001rde.3. human.

Organism-specific databases

CTD51071.
GeneCardsGC12P016064.
HGNCHGNC:24269. DERA.
HPAHPA059619.
neXtProtNX_Q9Y315.
PharmGKBPA134943367.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0274.
HOGENOMHOG000241644.
HOVERGENHBG030164.
InParanoidQ9Y315.
KOK01619.
OMAGQWQALY.
OrthoDBEOG7B5WWC.
PhylomeDBQ9Y315.
TreeFamTF314251.

Enzyme and pathway databases

SABIO-RKQ9Y315.
UniPathwayUPA00002; UER00468.

Gene expression databases

ArrayExpressQ9Y315.
BgeeQ9Y315.
CleanExHS_DERA.
GenevestigatorQ9Y315.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
InterProIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PANTHERPTHR10889. PTHR10889. 1 hit.
PfamPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFPIRSF001357. DeoC. 1 hit.
TIGRFAMsTIGR00126. deoC. 1 hit.
ProtoNetSearch...

Other

GenomeRNAi51071.
NextBio53683.
PROQ9Y315.

Entry information

Entry nameDEOC_HUMAN
AccessionPrimary (citable) accession number: Q9Y315
Secondary accession number(s): Q53HN9, Q6PHW2
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: July 9, 2014
This is version 110 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM