SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9Y315

- DEOC_HUMAN

UniProt

Q9Y315 - DEOC_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Putative deoxyribose-phosphate aldolase
Gene
DERA, CGI-26
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity.

Catalytic activityi

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei218 – 2181Schiff-base intermediate with acetaldehyde By similarity
Active sitei254 – 2541 By similarity

GO - Molecular functioni

  1. deoxyribose-phosphate aldolase activity Source: UniProtKB

GO - Biological processi

  1. deoxyribonucleoside catabolic process Source: UniProtKB
  2. deoxyribonucleotide catabolic process Source: InterPro
  3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Ligandi

Schiff base

Enzyme and pathway databases

SABIO-RKQ9Y315.
UniPathwayiUPA00002; UER00468.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative deoxyribose-phosphate aldolase (EC:4.1.2.4)
Short name:
DERA
Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name:
Deoxyriboaldolase
Gene namesi
Name:DERA
ORF Names:CGI-26
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:24269. DERA.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134943367.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 318318Putative deoxyribose-phosphate aldolase
PRO_0000057310Add
BLAST

Proteomic databases

MaxQBiQ9Y315.
PaxDbiQ9Y315.
PRIDEiQ9Y315.

PTM databases

PhosphoSiteiQ9Y315.

Expressioni

Gene expression databases

ArrayExpressiQ9Y315.
BgeeiQ9Y315.
CleanExiHS_DERA.
GenevestigatoriQ9Y315.

Organism-specific databases

HPAiHPA059619.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
PAAF1Q9BRP41EBI-1048152,EBI-1056358

Protein-protein interaction databases

BioGridi119262. 5 interactions.
STRINGi9606.ENSP00000416583.

Structurei

3D structure databases

ProteinModelPortaliQ9Y315.
SMRiQ9Y315. Positions 48-289.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0274.
HOGENOMiHOG000241644.
HOVERGENiHBG030164.
InParanoidiQ9Y315.
KOiK01619.
OMAiGQWQALY.
OrthoDBiEOG7B5WWC.
PhylomeDBiQ9Y315.
TreeFamiTF314251.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view]
PANTHERiPTHR10889. PTHR10889. 1 hit.
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF001357. DeoC. 1 hit.
TIGRFAMsiTIGR00126. deoC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y315-1 [UniParc]FASTAAdd to Basket

« Hide

MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA    50
VTFIDLTTLS GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC 100
VYPARVCDAV KALKAAGCNI PVASVAAGFP AGQTHLKTRL EEIRLAVEDG 150
ATEIDVVINR SLVLTGQWEA LYDEIRQFRK ACGEAHLKTI LATGELGTLT 200
NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI RDFFWKTGNK 250
IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 300
IYHHVTGRYA AYHDLPMS 318
Length:318
Mass (Da):35,231
Last modified:November 1, 2002 - v2
Checksum:iE9576567D0E5CBDE
GO

Sequence cautioni

The sequence AAD27735.1 differs from that shown. Reason: Erroneous initiation.
The sequence AAH56234.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD96261.1 differs from that shown. Reason: Erroneous initiation.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591N → S in BAD96261. 1 Publication
Sequence conflicti234 – 2341I → T in BAD96261. 1 Publication
Sequence conflicti240 – 2401I → T in BAD96261. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132960 mRNA. Translation: AAD27735.1. Different initiation.
AK222541 mRNA. Translation: BAD96261.1. Different initiation.
BC056234 mRNA. Translation: AAH56234.1. Different initiation.
CCDSiCCDS44838.1.
RefSeqiNP_057038.2. NM_015954.2.
UniGeneiHs.39429.

Genome annotation databases

EnsembliENST00000428559; ENSP00000416583; ENSG00000023697.
GeneIDi51071.
KEGGihsa:51071.
UCSCiuc001rde.3. human.

Polymorphism databases

DMDMi24636817.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132960 mRNA. Translation: AAD27735.1 . Different initiation.
AK222541 mRNA. Translation: BAD96261.1 . Different initiation.
BC056234 mRNA. Translation: AAH56234.1 . Different initiation.
CCDSi CCDS44838.1.
RefSeqi NP_057038.2. NM_015954.2.
UniGenei Hs.39429.

3D structure databases

ProteinModelPortali Q9Y315.
SMRi Q9Y315. Positions 48-289.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119262. 5 interactions.
STRINGi 9606.ENSP00000416583.

PTM databases

PhosphoSitei Q9Y315.

Polymorphism databases

DMDMi 24636817.

Proteomic databases

MaxQBi Q9Y315.
PaxDbi Q9Y315.
PRIDEi Q9Y315.

Protocols and materials databases

DNASUi 51071.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000428559 ; ENSP00000416583 ; ENSG00000023697 .
GeneIDi 51071.
KEGGi hsa:51071.
UCSCi uc001rde.3. human.

Organism-specific databases

CTDi 51071.
GeneCardsi GC12P016064.
HGNCi HGNC:24269. DERA.
HPAi HPA059619.
neXtProti NX_Q9Y315.
PharmGKBi PA134943367.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0274.
HOGENOMi HOG000241644.
HOVERGENi HBG030164.
InParanoidi Q9Y315.
KOi K01619.
OMAi GQWQALY.
OrthoDBi EOG7B5WWC.
PhylomeDBi Q9Y315.
TreeFami TF314251.

Enzyme and pathway databases

UniPathwayi UPA00002 ; UER00468 .
SABIO-RK Q9Y315.

Miscellaneous databases

GenomeRNAii 51071.
NextBioi 53683.
PROi Q9Y315.

Gene expression databases

ArrayExpressi Q9Y315.
Bgeei Q9Y315.
CleanExi HS_DERA.
Genevestigatori Q9Y315.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/FbaB/lacD_aldolase.
[Graphical view ]
PANTHERi PTHR10889. PTHR10889. 1 hit.
Pfami PF01791. DeoC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001357. DeoC. 1 hit.
TIGRFAMsi TIGR00126. deoC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Adipose tissue.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiDEOC_HUMAN
AccessioniPrimary (citable) accession number: Q9Y315
Secondary accession number(s): Q53HN9, Q6PHW2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: September 3, 2014
This is version 111 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi