Q9Y315 (DEOC_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative deoxyribose-phosphate aldolase
Short name=DERA
EC=4.1.2.4

Alternative name(s):
2-deoxy-D-ribose 5-phosphate aldolase
Phosphodeoxyriboaldolase
Short name=Deoxyriboaldolase

Gene names

Name:	DERA
ORF Names:	CGI-26

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate By similarity.
Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-alpha-D-ribose 1-phosphate: step 2/2.
Sequence similarities	Belongs to the DeoC/FbaB aldolase family. DeoC type 2 subfamily.
Sequence caution	The sequence AAD27735.1 differs from that shown. Reason: Erroneous initiation. The sequence AAH56234.1 differs from that shown. Reason: Erroneous initiation. The sequence BAD96261.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	Schiff base
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	deoxyribonucleoside catabolic process Inferred from direct assay PubMed 9226884. Source: UniProtKB deoxyribonucleotide catabolic process Inferred from electronic annotation. Source: InterPro deoxyribose phosphate catabolic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	deoxyribose-phosphate aldolase activity Inferred from direct assay PubMed 9226884. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PAAF1	Q9BRP4	1	EBI-1048152,EBI-1056358

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Putative deoxyribose-phosphate aldolase		PRO_0000057310
Sites
	Active site	218	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	254	1	By similarity
Experimental info
	Sequence conflict	159	1	N → S in BAD96261. Ref.2
	Sequence conflict	234	1	I → T in BAD96261. Ref.2
	Sequence conflict	240	1	I → T in BAD96261. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y315 [UniParc]. Last modified November 1, 2002. Version 2. Checksum: E9576567D0E5CBDE	FASTA	318	35,231
	10 20 30 40 50 60 MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS 70 80 90 100 110 120 GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI 130 140 150 160 170 180 PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK 190 200 210 220 230 240 ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI 250 260 270 280 290 300 RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 310 IYHHVTGRYA AYHDLPMS

References

[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Adipose tissue.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Skin.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF132960 mRNA. Translation: AAD27735.1. Different initiation. AK222541 mRNA. Translation: BAD96261.1. Different initiation. BC056234 mRNA. Translation: AAH56234.1. Different initiation.
IPI	IPI00219677.
RefSeq	NP_057038.2. NM_015954.2.
UniGene	Hs.39429.
3D structure databases
ProteinModelPortal	Q9Y315.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000416583.
PTM databases
PhosphoSite	Q9Y315.
Polymorphism databases
DMDM	24636817.
Proteomic databases
PaxDb	Q9Y315.
PRIDE	Q9Y315.
Protocols and materials databases
DNASU	51071.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428559; ENSP00000416583; ENSG00000023697.
GeneID	51071.
KEGG	hsa:51071.
UCSC	uc001rde.3. human.
Organism-specific databases
CTD	51071.
GeneCards	GC12P016064.
HGNC	HGNC:24269. DERA.
neXtProt	NX_Q9Y315.
PharmGKB	PA134943367.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0274.
HOGENOM	HOG000241644.
HOVERGEN	HBG030164.
InParanoid	Q9Y315.
KO	K01619.
OMA	MVIDRGA.
OrthoDB	EOG46T323.
PhylomeDB	Q9Y315.
Enzyme and pathway databases
UniPathway	UPA00002; UER00468.
Gene expression databases
ArrayExpress	Q9Y315.
Bgee	Q9Y315.
CleanEx	HS_DERA.
Genevestigator	Q9Y315.
GermOnline	ENSG00000023697. Homo sapiens.
Family and domain databases
Gene3D	3.20.20.70. 1 hit.
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/FbaB/lacD_aldolase. [Graphical view]
PANTHER	PTHR10889. PTHR10889. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	51071.
NextBio	53683.

Entry information

Entry name

DEOC_HUMAN

Accession

Primary (citable) accession number: Q9Y315
Secondary accession number(s): Q53HN9, Q6PHW2

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	November 1, 2002
Last modified:	May 1, 2013
This is version 101 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.