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Q9Y315

- DEOC_HUMAN

UniProt

Q9Y315 - DEOC_HUMAN

Protein

Putative deoxyribose-phosphate aldolase

Gene

DERA

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 112 (01 Oct 2014)
      Sequence version 2 (01 Nov 2002)
      Previous versions | rss
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    Functioni

    Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.By similarity

    Catalytic activityi

    2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei218 – 2181Schiff-base intermediate with acetaldehydeBy similarity
    Active sitei254 – 2541By similarity

    GO - Molecular functioni

    1. deoxyribose-phosphate aldolase activity Source: UniProtKB

    GO - Biological processi

    1. deoxyribonucleoside catabolic process Source: UniProtKB
    2. deoxyribonucleotide catabolic process Source: InterPro
    3. deoxyribose phosphate catabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Schiff base

    Enzyme and pathway databases

    SABIO-RKQ9Y315.
    UniPathwayiUPA00002; UER00468.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative deoxyribose-phosphate aldolase (EC:4.1.2.4)
    Short name:
    DERA
    Alternative name(s):
    2-deoxy-D-ribose 5-phosphate aldolase
    Phosphodeoxyriboaldolase
    Short name:
    Deoxyriboaldolase
    Gene namesi
    Name:DERA
    ORF Names:CGI-26
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:24269. DERA.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: InterPro
    2. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134943367.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 318318Putative deoxyribose-phosphate aldolasePRO_0000057310Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y315.
    PaxDbiQ9Y315.
    PRIDEiQ9Y315.

    PTM databases

    PhosphoSiteiQ9Y315.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y315.
    BgeeiQ9Y315.
    CleanExiHS_DERA.
    GenevestigatoriQ9Y315.

    Organism-specific databases

    HPAiHPA059619.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PAAF1Q9BRP41EBI-1048152,EBI-1056358

    Protein-protein interaction databases

    BioGridi119262. 5 interactions.
    STRINGi9606.ENSP00000416583.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y315.
    SMRiQ9Y315. Positions 48-289.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0274.
    HOGENOMiHOG000241644.
    HOVERGENiHBG030164.
    InParanoidiQ9Y315.
    KOiK01619.
    OMAiGQWQALY.
    OrthoDBiEOG7B5WWC.
    PhylomeDBiQ9Y315.
    TreeFamiTF314251.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    InterProiIPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view]
    PANTHERiPTHR10889. PTHR10889. 1 hit.
    PfamiPF01791. DeoC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001357. DeoC. 1 hit.
    TIGRFAMsiTIGR00126. deoC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9Y315-1 [UniParc]FASTAAdd to Basket

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    MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA    50
    VTFIDLTTLS GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC 100
    VYPARVCDAV KALKAAGCNI PVASVAAGFP AGQTHLKTRL EEIRLAVEDG 150
    ATEIDVVINR SLVLTGQWEA LYDEIRQFRK ACGEAHLKTI LATGELGTLT 200
    NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI RDFFWKTGNK 250
    IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 300
    IYHHVTGRYA AYHDLPMS 318
    Length:318
    Mass (Da):35,231
    Last modified:November 1, 2002 - v2
    Checksum:iE9576567D0E5CBDE
    GO

    Sequence cautioni

    The sequence AAD27735.1 differs from that shown. Reason: Erroneous initiation.
    The sequence AAH56234.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAD96261.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti159 – 1591N → S in BAD96261. 1 PublicationCurated
    Sequence conflicti234 – 2341I → T in BAD96261. 1 PublicationCurated
    Sequence conflicti240 – 2401I → T in BAD96261. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132960 mRNA. Translation: AAD27735.1. Different initiation.
    AK222541 mRNA. Translation: BAD96261.1. Different initiation.
    BC056234 mRNA. Translation: AAH56234.1. Different initiation.
    CCDSiCCDS44838.1.
    RefSeqiNP_057038.2. NM_015954.2.
    UniGeneiHs.39429.

    Genome annotation databases

    EnsembliENST00000428559; ENSP00000416583; ENSG00000023697.
    GeneIDi51071.
    KEGGihsa:51071.
    UCSCiuc001rde.3. human.

    Polymorphism databases

    DMDMi24636817.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132960 mRNA. Translation: AAD27735.1 . Different initiation.
    AK222541 mRNA. Translation: BAD96261.1 . Different initiation.
    BC056234 mRNA. Translation: AAH56234.1 . Different initiation.
    CCDSi CCDS44838.1.
    RefSeqi NP_057038.2. NM_015954.2.
    UniGenei Hs.39429.

    3D structure databases

    ProteinModelPortali Q9Y315.
    SMRi Q9Y315. Positions 48-289.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119262. 5 interactions.
    STRINGi 9606.ENSP00000416583.

    PTM databases

    PhosphoSitei Q9Y315.

    Polymorphism databases

    DMDMi 24636817.

    Proteomic databases

    MaxQBi Q9Y315.
    PaxDbi Q9Y315.
    PRIDEi Q9Y315.

    Protocols and materials databases

    DNASUi 51071.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428559 ; ENSP00000416583 ; ENSG00000023697 .
    GeneIDi 51071.
    KEGGi hsa:51071.
    UCSCi uc001rde.3. human.

    Organism-specific databases

    CTDi 51071.
    GeneCardsi GC12P016064.
    HGNCi HGNC:24269. DERA.
    HPAi HPA059619.
    neXtProti NX_Q9Y315.
    PharmGKBi PA134943367.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0274.
    HOGENOMi HOG000241644.
    HOVERGENi HBG030164.
    InParanoidi Q9Y315.
    KOi K01619.
    OMAi GQWQALY.
    OrthoDBi EOG7B5WWC.
    PhylomeDBi Q9Y315.
    TreeFami TF314251.

    Enzyme and pathway databases

    UniPathwayi UPA00002 ; UER00468 .
    SABIO-RK Q9Y315.

    Miscellaneous databases

    GenomeRNAii 51071.
    NextBioi 53683.
    PROi Q9Y315.

    Gene expression databases

    ArrayExpressi Q9Y315.
    Bgeei Q9Y315.
    CleanExi HS_DERA.
    Genevestigatori Q9Y315.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    InterProi IPR013785. Aldolase_TIM.
    IPR011343. DeoC.
    IPR002915. DeoC/FbaB/lacD_aldolase.
    [Graphical view ]
    PANTHERi PTHR10889. PTHR10889. 1 hit.
    Pfami PF01791. DeoC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001357. DeoC. 1 hit.
    TIGRFAMsi TIGR00126. deoC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Adipose tissue.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDEOC_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y315
    Secondary accession number(s): Q53HN9, Q6PHW2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 2002
    Last sequence update: November 1, 2002
    Last modified: October 1, 2014
    This is version 112 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3