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Reviewed, UniProtKB/Swiss-Prot Q9Y315 (DEOC_HUMAN)

Last modified November 4, 2008. Version 56. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Putative deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA
Gene names
Name: DERA
ORF Names: CGI-26
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length318 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.

Pathway

Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose 1-phosphate: step 2/2.

Sequence similarities

Belongs to the deoC/fbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords

   LigandSchiff base
   Molecular functionLyase
   PTMPhosphoprotein

Gene Ontology (GO)

   Molecular functionprotein binding

Inferred from physical interaction. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PAAF1Q9BRP41EBI-1048152,EBI-1056358

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 318318Putative deoxyribose-phosphate aldolase
PRO_0000057310

Sites

Active site2181Schiff-base intermediate with acetaldehyde By similarity
Active site2541 By similarity

Amino acid modifications

Modified residue2611Phosphoserine

Sequences

Sequence LengthMass (Da)Tools
Q9Y315-1 [UniParc].

Last modified November 1, 2002. Version 2.
Checksum: E9576567D0E5CBDE

FASTA31835,231
        10         20         30         40         50         60 
MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS 

        70         80         90        100        110        120 
GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI 

       130        140        150        160        170        180 
PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK 

       190        200        210        220        230        240 
ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI 

       250        260        270        280        290        300 
RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 

       310 
IYHHVTGRYA AYHDLPMS 

« Hide

References

[1]"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column."
Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y.
Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, MASS SPECTROMETRY.

Cross-references

Sequence databases

AF132960 mRNA. Translation: AAD27735.1. Different initiation.
RefSeqNP_057038.2.
UniGeneHs.39429

3D structure databases

HSSPHSSP built from PDB template 1JCL based on UniProtKB P00882.
ModBaseSearch...

Protein-protein interaction databases

IntActQ9Y315.

PTM databases

PhosphoSiteQ9Y315.

Genome annotation databases

EnsemblENSG00000023697. Homo sapiens. [Contig view]
GeneID51071.
KEGGhsa:51071.
NMPDRfig|9606.3.peg.7251.

Organism-specific databases

HGNCHGNC:24269. DERA.
PharmGKBPA134943367.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOVERGENQ9Y315.

Gene expression databases

ArrayExpressQ9Y315.
CleanExHS_DERA.
GermOnlineENSG00000023697. Homo sapiens.

Family and domain databases

InterProIPR013785. Aldolase_TIM.
IPR011343. DeoC.
IPR002915. DeoC/AroFGH_arch.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHERPTHR10889. DeoC. 1 hit.
PfamPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFPIRSF001357. DeoC. 1 hit.
TIGRFAMsTIGR00126. deoC. 1 hit.
BLOCKSSearch...
ProtoNetSearch...

Other Resources

NextBio53683.

Entry information

Entry nameDEOC_HUMAN
AccessionPrimary (citable) accession number: Q9Y315
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 2002
Last sequence update: November 1, 2002
Last modified: November 4, 2008
This is version 56 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents