Reviewed, UniProtKB/Swiss-Prot Q9Y315 (DEOC_HUMAN)

Names and origin

Protein names

Recommended name:
    Putative deoxyribose-phosphate aldolase
    EC=4.1.2.4
Alternative name(s):
    Phosphodeoxyriboaldolase
      Short name=Deoxyriboaldolase
      Short name=DERA

Gene names

Name:	DERA
ORF Names:	CGI-26

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Catalytic activity	2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde.
Pathway	Carbohydrate degradation; 2-deoxy-D-ribose 1-phosphate degradation; D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose 1-phosphate: step 2/2.
Sequence similarities	Belongs to the deoC/fbaB aldolase family. DeoC type 2 subfamily.

Ontologies

Keywords
Ligand	Schiff base
Molecular function	Lyase
PTM	Phosphoprotein
Gene Ontology (GO)
Molecular function	protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PAAF1	Q9BRP4	1	EBI-1048152,EBI-1056358

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	Putative deoxyribose-phosphate aldolase		PRO_0000057310
Sites
	Active site	218	1	Schiff-base intermediate with acetaldehyde By similarity
	Active site	254	1	By similarity
Amino acid modifications
	Modified residue	261	1	Phosphoserine

Sequences

	Sequence		Length	Mass (Da)
	Q9Y315-1 [UniParc]. Last modified November 1, 2002. Version 2. Checksum: E9576567D0E5CBDE	FASTA	318	35,231
	10 20 30 40 50 60 MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS 70 80 90 100 110 120 GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI 130 140 150 160 170 180 PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK 190 200 210 220 230 240 ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI 250 260 270 280 290 300 RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ 310 IYHHVTGRYA AYHDLPMS

References

[1]	"Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[2]	"Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column." Imami K., Sugiyama N., Kyono Y., Tomita M., Ishihama Y. Anal. Sci. 24:161-166(2008) [PubMed: 18187866] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261, MASS SPECTROMETRY.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF132960 mRNA. Translation: AAD27735.1. Different initiation.
RefSeq	NP_057038.2.
UniGene	Hs.39429
3D structure databases
HSSP	HSSP built from PDB template 1JCL based on UniProtKB P00882.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y315.
PTM databases
PhosphoSite	Q9Y315.
Genome annotation databases
Ensembl	ENSG00000023697. Homo sapiens. [Contig view]
GeneID	51071.
KEGG	hsa:51071.
NMPDR	fig|9606.3.peg.7251.
Organism-specific databases
HGNC	HGNC:24269. DERA.
PharmGKB	PA134943367.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOVERGEN	Q9Y315.
Gene expression databases
ArrayExpress	Q9Y315.
CleanEx	HS_DERA.
GermOnline	ENSG00000023697. Homo sapiens.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR011343. DeoC. IPR002915. DeoC/AroFGH_arch. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PANTHER	PTHR10889. DeoC. 1 hit.
Pfam	PF01791. DeoC. 1 hit. [Graphical view]
PIRSF	PIRSF001357. DeoC. 1 hit.
TIGRFAMs	TIGR00126. deoC. 1 hit.
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	53683.

Entry information

Entry name

DEOC_HUMAN

Accession

Primary (citable) accession number: Q9Y315

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 2002
Last sequence update:	November 1, 2002
Last modified:	November 4, 2008
This is version 56 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)