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Protein

Protein AAR2 homolog

Gene

AAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AAR2 homolog
Alternative name(s):
AAR2 splicing factor homolog
Gene namesi
Name:AAR2
Synonyms:C20orf4
ORF Names:CGI-23, PRO0225
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15886. AAR2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed3 Publications
Chaini2 – 384383Protein AAR2 homologPRO_0000209706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y312.
PaxDbiQ9Y312.
PRIDEiQ9Y312.

PTM databases

PhosphoSiteiQ9Y312.

Expressioni

Gene expression databases

BgeeiQ9Y312.
CleanExiHS_C20orf4.
ExpressionAtlasiQ9Y312. baseline and differential.
GenevestigatoriQ9Y312.

Organism-specific databases

HPAiCAB034220.
HPA048645.

Interactioni

Protein-protein interaction databases

BioGridi117464. 21 interactions.
IntActiQ9Y312. 8 interactions.
MINTiMINT-1454200.
STRINGi9606.ENSP00000313674.

Structurei

3D structure databases

ProteinModelPortaliQ9Y312.
SMRiQ9Y312. Positions 20-313.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAR2 family.Curated

Phylogenomic databases

eggNOGiNOG319701.
GeneTreeiENSGT00390000007796.
HOGENOMiHOG000225103.
HOVERGENiHBG051148.
InParanoidiQ9Y312.
KOiK13205.
OMAiPGVHFVY.
PhylomeDBiQ9Y312.
TreeFamiTF315089.

Family and domain databases

InterProiIPR007946. AAR2.
[Graphical view]
PANTHERiPTHR12689. PTHR12689. 1 hit.
PfamiPF05282. AAR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVQMDPEL AKRLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM
60 70 80 90 100
IPPGIHFLHY SSVDKANPKE VGPRMGFFLS LHQRGLTVLR WSTLREEVDL
110 120 130 140 150
SPAPESEVEA MRANLQELDQ FLGPYPYATL KKWISLTNFI SEATVEKLQP
160 170 180 190 200
ENRQICAFSD VLPVLSMKHT KDRVGQNLPR CGIECKSYQE GLARLPEMKP
210 220 230 240 250
RAGTEIRFSE LPTQMFPEGA TPAEITKHSM DLSYALETVL NKQFPSSPQD
260 270 280 290 300
VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSEAAMMK HHTLYINLIS
310 320 330 340 350
ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV DATLRKKAEK
360 370 380
FQAHLTKKFR WDFAAEPEDC APVVVELPEG IEMG
Length:384
Mass (Da):43,472
Last modified:October 18, 2002 - v2
Checksum:i01194E1DEC644F4D
GO

Sequence cautioni

The sequence AAF29578.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451F → L in CAB55913 (PubMed:11230166).Curated
Sequence conflicti70 – 701E → K in AAD27732 (PubMed:10810093).Curated
Sequence conflicti92 – 921S → N in AAD27732 (PubMed:10810093).Curated
Sequence conflicti146 – 1461E → K in CAB55913 (PubMed:11230166).Curated
Sequence conflicti240 – 2401L → H in CAB55913 (PubMed:11230166).Curated
Sequence conflicti241 – 2411N → I in AAD27732 (PubMed:10810093).Curated
Sequence conflicti279 – 2791N → H in AAD27732 (PubMed:10810093).Curated
Sequence conflicti299 – 2991I → M in AAD27732 (PubMed:10810093).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241P → T.
Corresponds to variant rs6121183 [ dbSNP | Ensembl ].
VAR_048127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132957 mRNA. Translation: AAD27732.1.
AL117419 mRNA. Translation: CAB55913.1.
AL121895 Genomic DNA. Translation: CAC09921.1.
CH471077 Genomic DNA. Translation: EAW76141.1.
CH471077 Genomic DNA. Translation: EAW76142.1.
CH471077 Genomic DNA. Translation: EAW76143.1.
BC001751 mRNA. Translation: AAH01751.1.
BC019311 mRNA. Translation: AAH19311.1.
AF113672 mRNA. Translation: AAF29578.1. Different initiation.
CCDSiCCDS13273.1.
PIRiT17223.
RefSeqiNP_001258803.1. NM_001271874.1.
NP_056326.2. NM_015511.4.
XP_005260442.1. XM_005260385.2.
XP_006723833.1. XM_006723770.1.
UniGeneiHs.11314.
Hs.744306.

Genome annotation databases

EnsembliENST00000320849; ENSP00000313674; ENSG00000131043.
ENST00000373932; ENSP00000363043; ENSG00000131043.
GeneIDi25980.
KEGGihsa:25980.
UCSCiuc002xfc.3. human.

Polymorphism databases

DMDMi24211603.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132957 mRNA. Translation: AAD27732.1.
AL117419 mRNA. Translation: CAB55913.1.
AL121895 Genomic DNA. Translation: CAC09921.1.
CH471077 Genomic DNA. Translation: EAW76141.1.
CH471077 Genomic DNA. Translation: EAW76142.1.
CH471077 Genomic DNA. Translation: EAW76143.1.
BC001751 mRNA. Translation: AAH01751.1.
BC019311 mRNA. Translation: AAH19311.1.
AF113672 mRNA. Translation: AAF29578.1. Different initiation.
CCDSiCCDS13273.1.
PIRiT17223.
RefSeqiNP_001258803.1. NM_001271874.1.
NP_056326.2. NM_015511.4.
XP_005260442.1. XM_005260385.2.
XP_006723833.1. XM_006723770.1.
UniGeneiHs.11314.
Hs.744306.

3D structure databases

ProteinModelPortaliQ9Y312.
SMRiQ9Y312. Positions 20-313.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117464. 21 interactions.
IntActiQ9Y312. 8 interactions.
MINTiMINT-1454200.
STRINGi9606.ENSP00000313674.

PTM databases

PhosphoSiteiQ9Y312.

Polymorphism databases

DMDMi24211603.

Proteomic databases

MaxQBiQ9Y312.
PaxDbiQ9Y312.
PRIDEiQ9Y312.

Protocols and materials databases

DNASUi25980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320849; ENSP00000313674; ENSG00000131043.
ENST00000373932; ENSP00000363043; ENSG00000131043.
GeneIDi25980.
KEGGihsa:25980.
UCSCiuc002xfc.3. human.

Organism-specific databases

CTDi25980.
GeneCardsiGC20P034825.
H-InvDBHIX0203050.
HGNCiHGNC:15886. AAR2.
HPAiCAB034220.
HPA048645.
neXtProtiNX_Q9Y312.
PharmGKBiPA25753.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG319701.
GeneTreeiENSGT00390000007796.
HOGENOMiHOG000225103.
HOVERGENiHBG051148.
InParanoidiQ9Y312.
KOiK13205.
OMAiPGVHFVY.
PhylomeDBiQ9Y312.
TreeFamiTF315089.

Miscellaneous databases

GenomeRNAii25980.
NextBioi47638.
PROiQ9Y312.

Gene expression databases

BgeeiQ9Y312.
CleanExiHS_C20orf4.
ExpressionAtlasiQ9Y312. baseline and differential.
GenevestigatoriQ9Y312.

Family and domain databases

InterProiIPR007946. AAR2.
[Graphical view]
PANTHERiPTHR12689. PTHR12689. 1 hit.
PfamiPF05282. AAR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  6. "Functional prediction of the coding sequences of 32 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Ouyang S., Luo L., Wei H., Zhou G., Zhou W., Bi J., Zhang Y., Liu M., He F.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-384.
    Tissue: Fetal liver.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAAR2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y312
Secondary accession number(s): E1P5S7
, Q9H4F9, Q9P1P3, Q9UFK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 18, 2002
Last sequence update: October 18, 2002
Last modified: March 3, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.