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Protein

Protein AAR2 homolog

Gene

AAR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131043-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AAR2 homolog
Alternative name(s):
AAR2 splicing factor homolog
Gene namesi
Name:AAR2
Synonyms:C20orf4
ORF Names:CGI-23, PRO0225
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:15886. AAR2.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000131043.
PharmGKBiPA25753.

Polymorphism and mutation databases

DMDMi24211603.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00002097062 – 384Protein AAR2 homologAdd BLAST383

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y312.
MaxQBiQ9Y312.
PaxDbiQ9Y312.
PeptideAtlasiQ9Y312.
PRIDEiQ9Y312.

PTM databases

iPTMnetiQ9Y312.
PhosphoSitePlusiQ9Y312.

Expressioni

Gene expression databases

BgeeiENSG00000131043.
CleanExiHS_C20orf4.
ExpressionAtlasiQ9Y312. baseline and differential.
GenevisibleiQ9Y312. HS.

Organism-specific databases

HPAiCAB034220.
HPA048645.

Interactioni

Protein-protein interaction databases

BioGridi117464. 28 interactors.
IntActiQ9Y312. 10 interactors.
MINTiMINT-1454200.
STRINGi9606.ENSP00000313674.

Structurei

3D structure databases

ProteinModelPortaliQ9Y312.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAR2 family.Curated

Phylogenomic databases

eggNOGiKOG3937. Eukaryota.
ENOG410XSI4. LUCA.
GeneTreeiENSGT00390000007796.
HOGENOMiHOG000225103.
HOVERGENiHBG051148.
InParanoidiQ9Y312.
KOiK13205.
OMAiTYMKYSE.
PhylomeDBiQ9Y312.
TreeFamiTF315089.

Family and domain databases

CDDicd13778. Aar2_C. 1 hit.
cd13777. Aar2_N. 1 hit.
InterProiIPR007946. AAR2.
IPR033648. AAR2_C.
IPR033647. Aar2_N.
[Graphical view]
PANTHERiPTHR12689. PTHR12689. 1 hit.
PfamiPF05282. AAR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y312-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAVQMDPEL AKRLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM
60 70 80 90 100
IPPGIHFLHY SSVDKANPKE VGPRMGFFLS LHQRGLTVLR WSTLREEVDL
110 120 130 140 150
SPAPESEVEA MRANLQELDQ FLGPYPYATL KKWISLTNFI SEATVEKLQP
160 170 180 190 200
ENRQICAFSD VLPVLSMKHT KDRVGQNLPR CGIECKSYQE GLARLPEMKP
210 220 230 240 250
RAGTEIRFSE LPTQMFPEGA TPAEITKHSM DLSYALETVL NKQFPSSPQD
260 270 280 290 300
VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSEAAMMK HHTLYINLIS
310 320 330 340 350
ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV DATLRKKAEK
360 370 380
FQAHLTKKFR WDFAAEPEDC APVVVELPEG IEMG
Length:384
Mass (Da):43,472
Last modified:October 19, 2002 - v2
Checksum:i01194E1DEC644F4D
GO

Sequence cautioni

The sequence AAF29578 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45F → L in CAB55913 (PubMed:11230166).Curated1
Sequence conflicti70E → K in AAD27732 (PubMed:10810093).Curated1
Sequence conflicti92S → N in AAD27732 (PubMed:10810093).Curated1
Sequence conflicti146E → K in CAB55913 (PubMed:11230166).Curated1
Sequence conflicti240L → H in CAB55913 (PubMed:11230166).Curated1
Sequence conflicti241N → I in AAD27732 (PubMed:10810093).Curated1
Sequence conflicti279N → H in AAD27732 (PubMed:10810093).Curated1
Sequence conflicti299I → M in AAD27732 (PubMed:10810093).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048127124P → T.Corresponds to variant rs6121183dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132957 mRNA. Translation: AAD27732.1.
AL117419 mRNA. Translation: CAB55913.1.
AL121895 Genomic DNA. Translation: CAC09921.1.
CH471077 Genomic DNA. Translation: EAW76141.1.
CH471077 Genomic DNA. Translation: EAW76142.1.
CH471077 Genomic DNA. Translation: EAW76143.1.
BC001751 mRNA. Translation: AAH01751.1.
BC019311 mRNA. Translation: AAH19311.1.
AF113672 mRNA. Translation: AAF29578.1. Different initiation.
CCDSiCCDS13273.1.
PIRiT17223.
RefSeqiNP_001258803.1. NM_001271874.1.
NP_056326.2. NM_015511.4.
XP_006723833.1. XM_006723770.3.
XP_011527064.1. XM_011528762.2.
XP_011527065.1. XM_011528763.2.
UniGeneiHs.11314.
Hs.744306.

Genome annotation databases

EnsembliENST00000320849; ENSP00000313674; ENSG00000131043.
ENST00000373932; ENSP00000363043; ENSG00000131043.
GeneIDi25980.
KEGGihsa:25980.
UCSCiuc002xfc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132957 mRNA. Translation: AAD27732.1.
AL117419 mRNA. Translation: CAB55913.1.
AL121895 Genomic DNA. Translation: CAC09921.1.
CH471077 Genomic DNA. Translation: EAW76141.1.
CH471077 Genomic DNA. Translation: EAW76142.1.
CH471077 Genomic DNA. Translation: EAW76143.1.
BC001751 mRNA. Translation: AAH01751.1.
BC019311 mRNA. Translation: AAH19311.1.
AF113672 mRNA. Translation: AAF29578.1. Different initiation.
CCDSiCCDS13273.1.
PIRiT17223.
RefSeqiNP_001258803.1. NM_001271874.1.
NP_056326.2. NM_015511.4.
XP_006723833.1. XM_006723770.3.
XP_011527064.1. XM_011528762.2.
XP_011527065.1. XM_011528763.2.
UniGeneiHs.11314.
Hs.744306.

3D structure databases

ProteinModelPortaliQ9Y312.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117464. 28 interactors.
IntActiQ9Y312. 10 interactors.
MINTiMINT-1454200.
STRINGi9606.ENSP00000313674.

PTM databases

iPTMnetiQ9Y312.
PhosphoSitePlusiQ9Y312.

Polymorphism and mutation databases

DMDMi24211603.

Proteomic databases

EPDiQ9Y312.
MaxQBiQ9Y312.
PaxDbiQ9Y312.
PeptideAtlasiQ9Y312.
PRIDEiQ9Y312.

Protocols and materials databases

DNASUi25980.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000320849; ENSP00000313674; ENSG00000131043.
ENST00000373932; ENSP00000363043; ENSG00000131043.
GeneIDi25980.
KEGGihsa:25980.
UCSCiuc002xfc.4. human.

Organism-specific databases

CTDi25980.
GeneCardsiAAR2.
H-InvDBHIX0203050.
HGNCiHGNC:15886. AAR2.
HPAiCAB034220.
HPA048645.
neXtProtiNX_Q9Y312.
OpenTargetsiENSG00000131043.
PharmGKBiPA25753.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3937. Eukaryota.
ENOG410XSI4. LUCA.
GeneTreeiENSGT00390000007796.
HOGENOMiHOG000225103.
HOVERGENiHBG051148.
InParanoidiQ9Y312.
KOiK13205.
OMAiTYMKYSE.
PhylomeDBiQ9Y312.
TreeFamiTF315089.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131043-MONOMER.

Miscellaneous databases

GenomeRNAii25980.
PROiQ9Y312.

Gene expression databases

BgeeiENSG00000131043.
CleanExiHS_C20orf4.
ExpressionAtlasiQ9Y312. baseline and differential.
GenevisibleiQ9Y312. HS.

Family and domain databases

CDDicd13778. Aar2_C. 1 hit.
cd13777. Aar2_N. 1 hit.
InterProiIPR007946. AAR2.
IPR033648. AAR2_C.
IPR033647. Aar2_N.
[Graphical view]
PANTHERiPTHR12689. PTHR12689. 1 hit.
PfamiPF05282. AAR2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAAR2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y312
Secondary accession number(s): E1P5S7
, Q9H4F9, Q9P1P3, Q9UFK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.