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Q9Y312

- AAR2_HUMAN

UniProt

Q9Y312 - AAR2_HUMAN

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Protein
Protein AAR2 homolog
Gene
AAR2, C20orf4, CGI-23, PRO0225
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein AAR2 homolog
Alternative name(s):
AAR2 splicing factor homolog
Gene namesi
Name:AAR2
Synonyms:C20orf4
ORF Names:CGI-23, PRO0225
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:15886. AAR2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25753.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 384383Protein AAR2 homolog
PRO_0000209706Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine3 Publications

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y312.
PaxDbiQ9Y312.
PRIDEiQ9Y312.

PTM databases

PhosphoSiteiQ9Y312.

Expressioni

Gene expression databases

ArrayExpressiQ9Y312.
BgeeiQ9Y312.
CleanExiHS_C20orf4.
GenevestigatoriQ9Y312.

Organism-specific databases

HPAiCAB034220.
HPA048645.

Interactioni

Protein-protein interaction databases

BioGridi117464. 10 interactions.
IntActiQ9Y312. 5 interactions.
MINTiMINT-1454200.
STRINGi9606.ENSP00000313674.

Structurei

3D structure databases

ProteinModelPortaliQ9Y312.
SMRiQ9Y312. Positions 20-313.

Family & Domainsi

Sequence similaritiesi

Belongs to the AAR2 family.

Phylogenomic databases

eggNOGiNOG319701.
HOGENOMiHOG000225103.
HOVERGENiHBG051148.
KOiK13205.
OMAiPGVHFVY.
PhylomeDBiQ9Y312.
TreeFamiTF315089.

Family and domain databases

InterProiIPR007946. AAR2.
[Graphical view]
PANTHERiPTHR12689. PTHR12689. 1 hit.
PfamiPF05282. AAR2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y312-1 [UniParc]FASTAAdd to Basket

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MAAVQMDPEL AKRLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM    50
IPPGIHFLHY SSVDKANPKE VGPRMGFFLS LHQRGLTVLR WSTLREEVDL 100
SPAPESEVEA MRANLQELDQ FLGPYPYATL KKWISLTNFI SEATVEKLQP 150
ENRQICAFSD VLPVLSMKHT KDRVGQNLPR CGIECKSYQE GLARLPEMKP 200
RAGTEIRFSE LPTQMFPEGA TPAEITKHSM DLSYALETVL NKQFPSSPQD 250
VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSEAAMMK HHTLYINLIS 300
ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV DATLRKKAEK 350
FQAHLTKKFR WDFAAEPEDC APVVVELPEG IEMG 384
Length:384
Mass (Da):43,472
Last modified:October 19, 2002 - v2
Checksum:i01194E1DEC644F4D
GO

Sequence cautioni

The sequence AAF29578.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti124 – 1241P → T.
Corresponds to variant rs6121183 [ dbSNP | Ensembl ].
VAR_048127

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti45 – 451F → L in CAB55913. 1 Publication
Sequence conflicti70 – 701E → K in AAD27732. 1 Publication
Sequence conflicti92 – 921S → N in AAD27732. 1 Publication
Sequence conflicti146 – 1461E → K in CAB55913. 1 Publication
Sequence conflicti240 – 2401L → H in CAB55913. 1 Publication
Sequence conflicti241 – 2411N → I in AAD27732. 1 Publication
Sequence conflicti279 – 2791N → H in AAD27732. 1 Publication
Sequence conflicti299 – 2991I → M in AAD27732. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132957 mRNA. Translation: AAD27732.1.
AL117419 mRNA. Translation: CAB55913.1.
AL121895 Genomic DNA. Translation: CAC09921.1.
CH471077 Genomic DNA. Translation: EAW76141.1.
CH471077 Genomic DNA. Translation: EAW76142.1.
CH471077 Genomic DNA. Translation: EAW76143.1.
BC001751 mRNA. Translation: AAH01751.1.
BC019311 mRNA. Translation: AAH19311.1.
AF113672 mRNA. Translation: AAF29578.1. Different initiation.
CCDSiCCDS13273.1.
PIRiT17223.
RefSeqiNP_001258803.1. NM_001271874.1.
NP_056326.2. NM_015511.4.
XP_005260442.1. XM_005260385.2.
XP_006723833.1. XM_006723770.1.
UniGeneiHs.11314.
Hs.744306.

Genome annotation databases

EnsembliENST00000320849; ENSP00000313674; ENSG00000131043.
ENST00000373932; ENSP00000363043; ENSG00000131043.
GeneIDi25980.
KEGGihsa:25980.
UCSCiuc002xfc.3. human.

Polymorphism databases

DMDMi24211603.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132957 mRNA. Translation: AAD27732.1 .
AL117419 mRNA. Translation: CAB55913.1 .
AL121895 Genomic DNA. Translation: CAC09921.1 .
CH471077 Genomic DNA. Translation: EAW76141.1 .
CH471077 Genomic DNA. Translation: EAW76142.1 .
CH471077 Genomic DNA. Translation: EAW76143.1 .
BC001751 mRNA. Translation: AAH01751.1 .
BC019311 mRNA. Translation: AAH19311.1 .
AF113672 mRNA. Translation: AAF29578.1 . Different initiation.
CCDSi CCDS13273.1.
PIRi T17223.
RefSeqi NP_001258803.1. NM_001271874.1.
NP_056326.2. NM_015511.4.
XP_005260442.1. XM_005260385.2.
XP_006723833.1. XM_006723770.1.
UniGenei Hs.11314.
Hs.744306.

3D structure databases

ProteinModelPortali Q9Y312.
SMRi Q9Y312. Positions 20-313.
ModBasei Search...

Protein-protein interaction databases

BioGridi 117464. 10 interactions.
IntActi Q9Y312. 5 interactions.
MINTi MINT-1454200.
STRINGi 9606.ENSP00000313674.

PTM databases

PhosphoSitei Q9Y312.

Polymorphism databases

DMDMi 24211603.

Proteomic databases

MaxQBi Q9Y312.
PaxDbi Q9Y312.
PRIDEi Q9Y312.

Protocols and materials databases

DNASUi 25980.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000320849 ; ENSP00000313674 ; ENSG00000131043 .
ENST00000373932 ; ENSP00000363043 ; ENSG00000131043 .
GeneIDi 25980.
KEGGi hsa:25980.
UCSCi uc002xfc.3. human.

Organism-specific databases

CTDi 25980.
GeneCardsi GC20P034825.
H-InvDB HIX0203050.
HGNCi HGNC:15886. AAR2.
HPAi CAB034220.
HPA048645.
neXtProti NX_Q9Y312.
PharmGKBi PA25753.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG319701.
HOGENOMi HOG000225103.
HOVERGENi HBG051148.
KOi K13205.
OMAi PGVHFVY.
PhylomeDBi Q9Y312.
TreeFami TF315089.

Miscellaneous databases

GenomeRNAii 25980.
NextBioi 47638.
PROi Q9Y312.

Gene expression databases

ArrayExpressi Q9Y312.
Bgeei Q9Y312.
CleanExi HS_C20orf4.
Genevestigatori Q9Y312.

Family and domain databases

InterProi IPR007946. AAR2.
[Graphical view ]
PANTHERi PTHR12689. PTHR12689. 1 hit.
Pfami PF05282. AAR2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
    Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
    Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung and Skin.
  6. "Functional prediction of the coding sequences of 32 new genes deduced by analysis of cDNA clones from human fetal liver."
    Zhang C., Yu Y., Zhang S., Ouyang S., Luo L., Wei H., Zhou G., Zhou W., Bi J., Zhang Y., Liu M., He F.
    Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-384.
    Tissue: Fetal liver.
  7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiAAR2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y312
Secondary accession number(s): E1P5S7
, Q9H4F9, Q9P1P3, Q9UFK9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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