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Q9Y312

- AAR2_HUMAN

UniProt

Q9Y312 - AAR2_HUMAN

Protein

Protein AAR2 homolog

Gene

AAR2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 103 (01 Oct 2014)
      Sequence version 2 (19 Oct 2002)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein AAR2 homolog
    Alternative name(s):
    AAR2 splicing factor homolog
    Gene namesi
    Name:AAR2
    Synonyms:C20orf4
    ORF Names:CGI-23, PRO0225
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 20

    Organism-specific databases

    HGNCiHGNC:15886. AAR2.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25753.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed3 Publications
    Chaini2 – 384383Protein AAR2 homologPRO_0000209706Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine3 Publications

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y312.
    PaxDbiQ9Y312.
    PRIDEiQ9Y312.

    PTM databases

    PhosphoSiteiQ9Y312.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y312.
    BgeeiQ9Y312.
    CleanExiHS_C20orf4.
    GenevestigatoriQ9Y312.

    Organism-specific databases

    HPAiCAB034220.
    HPA048645.

    Interactioni

    Protein-protein interaction databases

    BioGridi117464. 10 interactions.
    IntActiQ9Y312. 8 interactions.
    MINTiMINT-1454200.
    STRINGi9606.ENSP00000313674.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y312.
    SMRiQ9Y312. Positions 20-313.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the AAR2 family.Curated

    Phylogenomic databases

    eggNOGiNOG319701.
    HOGENOMiHOG000225103.
    HOVERGENiHBG051148.
    KOiK13205.
    OMAiPGVHFVY.
    PhylomeDBiQ9Y312.
    TreeFamiTF315089.

    Family and domain databases

    InterProiIPR007946. AAR2.
    [Graphical view]
    PANTHERiPTHR12689. PTHR12689. 1 hit.
    PfamiPF05282. AAR2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y312-1 [UniParc]FASTAAdd to Basket

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    MAAVQMDPEL AKRLFFEGAT VVILNMPKGT EFGIDYNSWE VGPKFRGVKM    50
    IPPGIHFLHY SSVDKANPKE VGPRMGFFLS LHQRGLTVLR WSTLREEVDL 100
    SPAPESEVEA MRANLQELDQ FLGPYPYATL KKWISLTNFI SEATVEKLQP 150
    ENRQICAFSD VLPVLSMKHT KDRVGQNLPR CGIECKSYQE GLARLPEMKP 200
    RAGTEIRFSE LPTQMFPEGA TPAEITKHSM DLSYALETVL NKQFPSSPQD 250
    VLGELQFAFV CFLLGNVYEA FEHWKRLLNL LCRSEAAMMK HHTLYINLIS 300
    ILYHQLGEIP ADFFVDIVSQ DNFLTSTLQV FFSSACSIAV DATLRKKAEK 350
    FQAHLTKKFR WDFAAEPEDC APVVVELPEG IEMG 384
    Length:384
    Mass (Da):43,472
    Last modified:October 19, 2002 - v2
    Checksum:i01194E1DEC644F4D
    GO

    Sequence cautioni

    The sequence AAF29578.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti45 – 451F → L in CAB55913. (PubMed:11230166)Curated
    Sequence conflicti70 – 701E → K in AAD27732. (PubMed:10810093)Curated
    Sequence conflicti92 – 921S → N in AAD27732. (PubMed:10810093)Curated
    Sequence conflicti146 – 1461E → K in CAB55913. (PubMed:11230166)Curated
    Sequence conflicti240 – 2401L → H in CAB55913. (PubMed:11230166)Curated
    Sequence conflicti241 – 2411N → I in AAD27732. (PubMed:10810093)Curated
    Sequence conflicti279 – 2791N → H in AAD27732. (PubMed:10810093)Curated
    Sequence conflicti299 – 2991I → M in AAD27732. (PubMed:10810093)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti124 – 1241P → T.
    Corresponds to variant rs6121183 [ dbSNP | Ensembl ].
    VAR_048127

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132957 mRNA. Translation: AAD27732.1.
    AL117419 mRNA. Translation: CAB55913.1.
    AL121895 Genomic DNA. Translation: CAC09921.1.
    CH471077 Genomic DNA. Translation: EAW76141.1.
    CH471077 Genomic DNA. Translation: EAW76142.1.
    CH471077 Genomic DNA. Translation: EAW76143.1.
    BC001751 mRNA. Translation: AAH01751.1.
    BC019311 mRNA. Translation: AAH19311.1.
    AF113672 mRNA. Translation: AAF29578.1. Different initiation.
    CCDSiCCDS13273.1.
    PIRiT17223.
    RefSeqiNP_001258803.1. NM_001271874.1.
    NP_056326.2. NM_015511.4.
    XP_005260442.1. XM_005260385.2.
    XP_006723833.1. XM_006723770.1.
    UniGeneiHs.11314.
    Hs.744306.

    Genome annotation databases

    EnsembliENST00000320849; ENSP00000313674; ENSG00000131043.
    ENST00000373932; ENSP00000363043; ENSG00000131043.
    GeneIDi25980.
    KEGGihsa:25980.
    UCSCiuc002xfc.3. human.

    Polymorphism databases

    DMDMi24211603.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132957 mRNA. Translation: AAD27732.1 .
    AL117419 mRNA. Translation: CAB55913.1 .
    AL121895 Genomic DNA. Translation: CAC09921.1 .
    CH471077 Genomic DNA. Translation: EAW76141.1 .
    CH471077 Genomic DNA. Translation: EAW76142.1 .
    CH471077 Genomic DNA. Translation: EAW76143.1 .
    BC001751 mRNA. Translation: AAH01751.1 .
    BC019311 mRNA. Translation: AAH19311.1 .
    AF113672 mRNA. Translation: AAF29578.1 . Different initiation.
    CCDSi CCDS13273.1.
    PIRi T17223.
    RefSeqi NP_001258803.1. NM_001271874.1.
    NP_056326.2. NM_015511.4.
    XP_005260442.1. XM_005260385.2.
    XP_006723833.1. XM_006723770.1.
    UniGenei Hs.11314.
    Hs.744306.

    3D structure databases

    ProteinModelPortali Q9Y312.
    SMRi Q9Y312. Positions 20-313.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117464. 10 interactions.
    IntActi Q9Y312. 8 interactions.
    MINTi MINT-1454200.
    STRINGi 9606.ENSP00000313674.

    PTM databases

    PhosphoSitei Q9Y312.

    Polymorphism databases

    DMDMi 24211603.

    Proteomic databases

    MaxQBi Q9Y312.
    PaxDbi Q9Y312.
    PRIDEi Q9Y312.

    Protocols and materials databases

    DNASUi 25980.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000320849 ; ENSP00000313674 ; ENSG00000131043 .
    ENST00000373932 ; ENSP00000363043 ; ENSG00000131043 .
    GeneIDi 25980.
    KEGGi hsa:25980.
    UCSCi uc002xfc.3. human.

    Organism-specific databases

    CTDi 25980.
    GeneCardsi GC20P034825.
    H-InvDB HIX0203050.
    HGNCi HGNC:15886. AAR2.
    HPAi CAB034220.
    HPA048645.
    neXtProti NX_Q9Y312.
    PharmGKBi PA25753.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG319701.
    HOGENOMi HOG000225103.
    HOVERGENi HBG051148.
    KOi K13205.
    OMAi PGVHFVY.
    PhylomeDBi Q9Y312.
    TreeFami TF315089.

    Miscellaneous databases

    GenomeRNAii 25980.
    NextBioi 47638.
    PROi Q9Y312.

    Gene expression databases

    ArrayExpressi Q9Y312.
    Bgeei Q9Y312.
    CleanExi HS_C20orf4.
    Genevestigatori Q9Y312.

    Family and domain databases

    InterProi IPR007946. AAR2.
    [Graphical view ]
    PANTHERi PTHR12689. PTHR12689. 1 hit.
    Pfami PF05282. AAR2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."
      Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C.
      Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
      , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
      Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung and Skin.
    6. "Functional prediction of the coding sequences of 32 new genes deduced by analysis of cDNA clones from human fetal liver."
      Zhang C., Yu Y., Zhang S., Ouyang S., Luo L., Wei H., Zhou G., Zhou W., Bi J., Zhang Y., Liu M., He F.
      Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 228-384.
      Tissue: Fetal liver.
    7. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiAAR2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y312
    Secondary accession number(s): E1P5S7
    , Q9H4F9, Q9P1P3, Q9UFK9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 19, 2002
    Last sequence update: October 19, 2002
    Last modified: October 1, 2014
    This is version 103 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 20
      Human chromosome 20: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3