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Protein

Acyl-coenzyme A thioesterase 9, mitochondrial

Gene

ACOT9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciZFISH:HS04631-MONOMER.
ReactomeiR-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-coenzyme A thioesterase 9, mitochondrial (EC:3.1.2.-)
Short name:
Acyl-CoA thioesterase 9
Alternative name(s):
Acyl-CoA thioester hydrolase 9
Gene namesi
Name:ACOT9
ORF Names:CGI-16
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

HGNCiHGNC:17152. ACOT9.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi23597.
OpenTargetsiENSG00000123130.
PharmGKBiPA142672656.

Polymorphism and mutation databases

BioMutaiACOT9.
DMDMi224471815.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 21MitochondrionBy similarityAdd BLAST21
ChainiPRO_000005381222 – 439Acyl-coenzyme A thioesterase 9, mitochondrialAdd BLAST418

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y305.
PaxDbiQ9Y305.
PeptideAtlasiQ9Y305.
PRIDEiQ9Y305.

PTM databases

iPTMnetiQ9Y305.
PhosphoSitePlusiQ9Y305.
SwissPalmiQ9Y305.

Expressioni

Gene expression databases

BgeeiENSG00000123130.
CleanExiHS_ACOT9.
ExpressionAtlasiQ9Y305. baseline and differential.
GenevisibleiQ9Y305. HS.

Organism-specific databases

HPAiHPA035533.

Interactioni

Subunit structurei

Interacts with NYAP1, NYAP2 and MYO16.By similarity

Protein-protein interaction databases

BioGridi117132. 35 interactors.
IntActiQ9Y305. 15 interactors.
MINTiMINT-3085225.
STRINGi9606.ENSP00000368605.

Structurei

3D structure databases

ProteinModelPortaliQ9Y305.
SMRiQ9Y305.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini84 – 209HotDog ACOT-type 1PROSITE-ProRule annotationAdd BLAST126
Domaini289 – 401HotDog ACOT-type 2PROSITE-ProRule annotationAdd BLAST113

Sequence similaritiesi

Belongs to the acyl coenzyme A hydrolase family.Curated
Contains 2 HotDog ACOT-type domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide

Phylogenomic databases

eggNOGiKOG2763. Eukaryota.
ENOG410XSYM. LUCA.
GeneTreeiENSGT00390000005330.
HOGENOMiHOG000188398.
HOVERGENiHBG004168.
InParanoidiQ9Y305.
KOiK17361.
OMAiMFQLHGN.
OrthoDBiEOG091G06UC.
PhylomeDBiQ9Y305.
TreeFamiTF313352.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 2 hits.
PROSITEiPS51770. HOTDOG_ACOT. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y305-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRAALRLCA LGKGQLTPGR GLTQGPQNPK KQGIFHIHEV RDKLREIVGA
60 70 80 90 100
STNWRDHVKA MEERKLLHSF LAKSQDGLPP RRMKDSYIEV LLPLGSEPEL
110 120 130 140 150
REKYLTVQNT VRFGRILEDL DSLGVLICYM HNKIHSAKMS PLSIVTALVD
160 170 180 190 200
KIDMCKKSLS PEQDIKFSGH VSWVGKTSME VKMQMFQLHG DEFCPVLDAT
210 220 230 240 250
FVMVARDSEN KGPAFVNPLI PESPEEEELF RQGELNKGRR IAFSSTSLLK
260 270 280 290 300
MAPSAEERTT IHEMFLSTLD PKTISFRSRV LPSNAVWMEN SKLKSLEICH
310 320 330 340 350
PQERNIFNRI FGGFLMRKAY ELAWATACSF GGSRPFVVAV DDIMFQKPVE
360 370 380 390 400
VGSLLFLSSQ VCFTQNNYIQ VRVHSEVASL QEKQHTTTNV FHFTFMSEKE
410 420 430
VPLVFPKTYG ESMLYLDGQR HFNSMSGPAT LRKDYLVEP
Note: No experimental confirmation available.
Length:439
Mass (Da):49,902
Last modified:March 3, 2009 - v2
Checksum:i1CE2158D4F83D4D6
GO
Isoform 2 (identifier: Q9Y305-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-39: ALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHE → PC

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):46,355
Checksum:i99ADE404D472CEEB
GO
Isoform 3 (identifier: Q9Y305-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: Missing.

Note: No experimental confirmation available.
Show »
Length:379
Mass (Da):43,207
Checksum:iAC76325AB9264911
GO
Isoform 4 (identifier: Q9Y305-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-39: E → EACSSIHVNH

Show »
Length:448
Mass (Da):50,851
Checksum:iAA20C18EF239983D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188L → S in BAG51291 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062668305N → H in a pancreatic ductal adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364201 – 60Missing in isoform 3. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_0364195 – 39ALRLC…FHIHE → PC in isoform 2. 1 PublicationAdd BLAST35
Alternative sequenceiVSP_04109339E → EACSSIHVNH in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132950 mRNA. Translation: AAD27725.1.
AK024337 mRNA. Translation: BAG51291.1.
BX648512 mRNA. No translation available.
AC093011 Genomic DNA. No translation available.
AC131011 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98998.1.
BC136671 mRNA. Translation: AAI36672.1.
BC144360 mRNA. Translation: AAI44361.1.
CCDSiCCDS35216.1. [Q9Y305-1]
CCDS43924.1. [Q9Y305-4]
CCDS83460.1. [Q9Y305-3]
RefSeqiNP_001028755.2. NM_001033583.2. [Q9Y305-1]
NP_001032248.1. NM_001037171.1. [Q9Y305-4]
NP_001317188.1. NM_001330259.1.
UniGeneiHs.298885.

Genome annotation databases

EnsembliENST00000336430; ENSP00000336580; ENSG00000123130. [Q9Y305-1]
ENST00000379295; ENSP00000368597; ENSG00000123130. [Q9Y305-3]
ENST00000379303; ENSP00000368605; ENSG00000123130. [Q9Y305-4]
GeneIDi23597.
KEGGihsa:23597.
UCSCiuc004dao.4. human. [Q9Y305-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132950 mRNA. Translation: AAD27725.1.
AK024337 mRNA. Translation: BAG51291.1.
BX648512 mRNA. No translation available.
AC093011 Genomic DNA. No translation available.
AC131011 Genomic DNA. No translation available.
CH471074 Genomic DNA. Translation: EAW98998.1.
BC136671 mRNA. Translation: AAI36672.1.
BC144360 mRNA. Translation: AAI44361.1.
CCDSiCCDS35216.1. [Q9Y305-1]
CCDS43924.1. [Q9Y305-4]
CCDS83460.1. [Q9Y305-3]
RefSeqiNP_001028755.2. NM_001033583.2. [Q9Y305-1]
NP_001032248.1. NM_001037171.1. [Q9Y305-4]
NP_001317188.1. NM_001330259.1.
UniGeneiHs.298885.

3D structure databases

ProteinModelPortaliQ9Y305.
SMRiQ9Y305.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117132. 35 interactors.
IntActiQ9Y305. 15 interactors.
MINTiMINT-3085225.
STRINGi9606.ENSP00000368605.

PTM databases

iPTMnetiQ9Y305.
PhosphoSitePlusiQ9Y305.
SwissPalmiQ9Y305.

Polymorphism and mutation databases

BioMutaiACOT9.
DMDMi224471815.

Proteomic databases

EPDiQ9Y305.
PaxDbiQ9Y305.
PeptideAtlasiQ9Y305.
PRIDEiQ9Y305.

Protocols and materials databases

DNASUi23597.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000336430; ENSP00000336580; ENSG00000123130. [Q9Y305-1]
ENST00000379295; ENSP00000368597; ENSG00000123130. [Q9Y305-3]
ENST00000379303; ENSP00000368605; ENSG00000123130. [Q9Y305-4]
GeneIDi23597.
KEGGihsa:23597.
UCSCiuc004dao.4. human. [Q9Y305-1]

Organism-specific databases

CTDi23597.
DisGeNETi23597.
GeneCardsiACOT9.
HGNCiHGNC:17152. ACOT9.
HPAiHPA035533.
MIMi300862. gene.
neXtProtiNX_Q9Y305.
OpenTargetsiENSG00000123130.
PharmGKBiPA142672656.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2763. Eukaryota.
ENOG410XSYM. LUCA.
GeneTreeiENSGT00390000005330.
HOGENOMiHOG000188398.
HOVERGENiHBG004168.
InParanoidiQ9Y305.
KOiK17361.
OMAiMFQLHGN.
OrthoDBiEOG091G06UC.
PhylomeDBiQ9Y305.
TreeFamiTF313352.

Enzyme and pathway databases

BioCyciZFISH:HS04631-MONOMER.
ReactomeiR-HSA-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

GenomeRNAii23597.
PROiQ9Y305.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000123130.
CleanExiHS_ACOT9.
ExpressionAtlasiQ9Y305. baseline and differential.
GenevisibleiQ9Y305. HS.

Family and domain databases

Gene3Di3.10.129.10. 2 hits.
InterProiIPR033120. HOTDOG_ACOT.
IPR029069. HotDog_dom.
[Graphical view]
SUPFAMiSSF54637. SSF54637. 2 hits.
PROSITEiPS51770. HOTDOG_ACOT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACOT9_HUMAN
AccessioniPrimary (citable) accession number: Q9Y305
Secondary accession number(s): B3KNC9, B7ZM94
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: March 3, 2009
Last modified: November 30, 2016
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.