Reviewed,
UniProtKB/Swiss-Prot Q9Y305 (ACOT9_HUMAN)
Last modified
December 15, 2009.
Version 61.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
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Names and origin
| Protein names | Recommended name: Acyl-coenzyme A thioesterase 9, mitochondrial Short name=Acyl-CoA thioesterase 9 EC=3.1.2.- Alternative name(s): Acyl-CoA thioester hydrolase 9 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 439 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Active on long chain acyl-CoAs. |
| Subcellular location | Mitochondrion By similarity. |
| Sequence similarities | Belongs to the acyl coenzyme A hydrolase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Coding sequence diversity | Alternative splicing |
| Domain | Transit peptide |
| Molecular function | Hydrolase Serine esterase |
| PTM | Acetylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | acyl-CoA metabolic process Inferred from sequence or structural similarity. Source: HGNC |
| Cellular component | mitochondrion Inferred from sequence or structural similarity. Source: HGNC |
| Molecular function | acetyl-CoA hydrolase activity Inferred from sequence or structural similarity. Source: HGNC carboxylesterase activityInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9Y305-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 2 (identifier: Q9Y305-2) The sequence of this isoform differs from the canonical sequence as follows: 5-39: ALRLCALGKGQLTPGRGLTQGPQNPKKQGIFHIHE → PC | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q9Y305-3) The sequence of this isoform differs from the canonical sequence as follows: 1-60: Missing. | ||||||
| Note: No experimental confirmation available. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 21 | 21 | Mitochondrion By similarity | ||||||
| Chain | 22 – 439 | 418 | Acyl-coenzyme A thioesterase 9, mitochondrial | PRO_0000053812 | |||||
Amino acid modifications | |||||||||
| Modified residue | 103 | 1 | N6-acetyllysine Ref.6 | ||||||
| Modified residue | 157 | 1 | N6-acetyllysine Ref.6 | ||||||
| Modified residue | 250 | 1 | N6-acetyllysine Ref.6 | ||||||
| Modified residue | 407 | 1 | N6-acetyllysine Ref.6 | ||||||
Natural variations | |||||||||
| Alternative sequence | 1 – 60 | 60 | Missing in isoform 3. | VSP_036420 | |||||
| Alternative sequence | 5 – 39 | 35 | ALRLC…FHIHE → PC in isoform 2. | VSP_036419 | |||||
Experimental info | |||||||||
| Sequence conflict | 188 | 1 | L → S in BAG51291. Ref.2 | ||||||
Sequences
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References
| [1] | "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics." Lai C.-H., Chou C.-Y., Ch'ang L.-Y., Liu C.-S., Lin W.-C. Genome Res. 10:703-713(2000) [PubMed: 10810093] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Placenta. |
| [3] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain and Testis. |
| [5] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [6] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-103; LYS-157; LYS-250 AND LYS-407, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| AF132950 mRNA. Translation: AAD27725.1. AK024337 mRNA. Translation: BAG51291.1. CH471074 Genomic DNA. Translation: EAW98998.1. BC136671 mRNA. Translation: AAI36672.1. BC144360 mRNA. Translation: AAI44361.1. | |
| IPI | IPI00220710. IPI00748985. IPI00921986. |
| RefSeq | NP_001028755.2. |
| UniGene | Hs.298885 |
3D structure databases | |
| ModBase | Search... |
Proteomic databases | |
| PRIDE | Q9Y305. |
Genome annotation databases | |
| Ensembl | ENST00000336430; ENSP00000336580; ENSG00000123130; Homo sapiens. [Genome view] |
| GeneID | 23597. |
| KEGG | hsa:23597. |
| UCSC | uc004dao.1. human. |
Organism-specific databases | |
| CTD | 23597. |
| GeneCards | GC0XM023629. |
| HGNC | HGNC:17152. ACOT9. |
| PharmGKB | PA142672656. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9Y305. |
| InParanoid | Q9Y305. |
Gene expression databases | |
| ArrayExpress | Q9Y305. |
| Bgee | Q9Y305. |
| CleanEx | HS_ACOT9. |
| Genevestigator | Q9Y305. |
| GermOnline | ENSG00000123130. Homo sapiens. |
Family and domain databases | |
| ProtoNet | Search... |
Entry information
| Entry name | ACOT9_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y305 Secondary accession number(s): B3KNC9, B7ZM94 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome X Human chromosome X: entries, gene names and cross-references to MIM |
| SIMILARITY comments Index of protein domains and families |

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