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Q9Y2Y9

- KLF13_HUMAN

UniProt

Q9Y2Y9 - KLF13_HUMAN

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Protein

Krueppel-like factor 13

Gene
KLF13, BTEB3, NSLP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 19125C2H2-type 1Add
BLAST
Zinc fingeri197 – 22125C2H2-type 2Add
BLAST
Zinc fingeri227 – 24923C2H2-type 3Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. protein binding Source: IntAct

GO - Biological processi

  1. negative regulation of cell proliferation Source: Ensembl
  2. negative regulation of erythrocyte differentiation Source: Ensembl
  3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  4. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Krueppel-like factor 13
Alternative name(s):
Basic transcription element-binding protein 3
Short name:
BTE-binding protein 3
Novel Sp1-like zinc finger transcription factor 1
RANTES factor of late activated T-lymphocytes 1
Short name:
RFLAT-1
Transcription factor BTEB3
Transcription factor NSLP1
Gene namesi
Name:KLF13
Synonyms:BTEB3, NSLP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 15

Organism-specific databases

HGNCiHGNC:13672. KLF13.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30133.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Krueppel-like factor 13PRO_0000047184Add
BLAST

Post-translational modificationi

Phosphorylated.

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ9Y2Y9.
PaxDbiQ9Y2Y9.
PRIDEiQ9Y2Y9.

PTM databases

PhosphoSiteiQ9Y2Y9.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ9Y2Y9.
BgeeiQ9Y2Y9.
CleanExiHS_KLF13.
GenevestigatoriQ9Y2Y9.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
GATA4P436943EBI-1255893,EBI-7049352
PRPF4BQ135235EBI-1255893,EBI-395940

Protein-protein interaction databases

BioGridi119642. 12 interactions.
IntActiQ9Y2Y9. 3 interactions.
MINTiMINT-3379487.
STRINGi9606.ENSP00000302456.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Y9.
SMRiQ9Y2Y9. Positions 142-281.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi2 – 145144Ala/Pro-richAdd
BLAST
Compositional biasi2 – 54Poly-Ala
Compositional biasi113 – 1164Poly-Ala
Compositional biasi148 – 16821Arg/Lys-rich (basic)Add
BLAST
Compositional biasi264 – 28724Ser-richAdd
BLAST

Domaini

The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri167 – 19125C2H2-type 1Add
BLAST
Zinc fingeri197 – 22125C2H2-type 2Add
BLAST
Zinc fingeri227 – 24923C2H2-type 3Add
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiCOG5048.
HOGENOMiHOG000233575.
HOVERGENiHBG050746.
InParanoidiQ9Y2Y9.
KOiK09208.
OMAiECSWQEC.
OrthoDBiEOG7FJH0Q.
PhylomeDBiQ9Y2Y9.
TreeFamiTF351003.

Family and domain databases

Gene3Di3.30.160.60. 3 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2Y9-1 [UniParc]FASTAAdd to Basket

« Hide

MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE    50
ERRDGKDSAS LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP 100
PAPEPTSPGA EGAAAAPPSP AWSEPEPEAG LEPEREPGPA GSGEPGLRQR 150
VRRGRSRADL ESPQRKHKCH YAGCEKVYGK SSHLKAHLRT HTGERPFACS 200
WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD HLTKHARRHA 250
NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP 288
Length:288
Mass (Da):31,180
Last modified:November 1, 1999 - v1
Checksum:iDD2765EE00E9C049
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti39 – 391A → S in AAD34020. 1 Publication
Sequence conflicti104 – 11411EPTSPGAEGAA → MSPPPPALKARR in AAD34020. 1 PublicationAdd
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132599 mRNA. Translation: AAD26864.1.
AF150628 mRNA. Translation: AAD34020.1.
BC013946 mRNA. Translation: AAH13946.1.
BC010438 mRNA. Translation: AAH10438.1.
BC012741 mRNA. Translation: AAH12741.1.
CCDSiCCDS10025.1.
RefSeqiNP_057079.2. NM_015995.2.
UniGeneiHs.525752.

Genome annotation databases

EnsembliENST00000307145; ENSP00000302456; ENSG00000169926.
GeneIDi51621.
KEGGihsa:51621.
UCSCiuc001zfo.3. human.

Polymorphism databases

DMDMi17369913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF132599 mRNA. Translation: AAD26864.1 .
AF150628 mRNA. Translation: AAD34020.1 .
BC013946 mRNA. Translation: AAH13946.1 .
BC010438 mRNA. Translation: AAH10438.1 .
BC012741 mRNA. Translation: AAH12741.1 .
CCDSi CCDS10025.1.
RefSeqi NP_057079.2. NM_015995.2.
UniGenei Hs.525752.

3D structure databases

ProteinModelPortali Q9Y2Y9.
SMRi Q9Y2Y9. Positions 142-281.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119642. 12 interactions.
IntActi Q9Y2Y9. 3 interactions.
MINTi MINT-3379487.
STRINGi 9606.ENSP00000302456.

PTM databases

PhosphoSitei Q9Y2Y9.

Polymorphism databases

DMDMi 17369913.

Proteomic databases

MaxQBi Q9Y2Y9.
PaxDbi Q9Y2Y9.
PRIDEi Q9Y2Y9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000307145 ; ENSP00000302456 ; ENSG00000169926 .
GeneIDi 51621.
KEGGi hsa:51621.
UCSCi uc001zfo.3. human.

Organism-specific databases

CTDi 51621.
GeneCardsi GC15P031619.
HGNCi HGNC:13672. KLF13.
MIMi 605328. gene.
neXtProti NX_Q9Y2Y9.
PharmGKBi PA30133.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5048.
HOGENOMi HOG000233575.
HOVERGENi HBG050746.
InParanoidi Q9Y2Y9.
KOi K09208.
OMAi ECSWQEC.
OrthoDBi EOG7FJH0Q.
PhylomeDBi Q9Y2Y9.
TreeFami TF351003.

Miscellaneous databases

ChiTaRSi KLF13. human.
GeneWikii KLF13.
GenomeRNAii 51621.
NextBioi 55535.
PROi Q9Y2Y9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2Y9.
Bgeei Q9Y2Y9.
CleanExi HS_KLF13.
Genevestigatori Q9Y2Y9.

Family and domain databases

Gene3Di 3.30.160.60. 3 hits.
InterProi IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
SMARTi SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes."
    Song A., Chen Y.F., Thamatrakoln K., Storm T.A., Krensky A.M.
    Immunity 10:93-103(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors."
    Cook T., Gebelein B., Urrutia R.
    Ann. N. Y. Acad. Sci. 880:94-102(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Pancreas.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  4. "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1."
    Kaczynski J., Zhang J.S., Ellenrieder V., Conley A., Duenes T., Kester H., van Der Burg B., Urrutia R.
    J. Biol. Chem. 276:36749-36756(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiKLF13_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y9
Secondary accession number(s): Q9Y356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 119 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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