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Q9Y2Y9

- KLF13_HUMAN

UniProt

Q9Y2Y9 - KLF13_HUMAN

Protein

Krueppel-like factor 13

Gene

KLF13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri167 – 19125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 22125C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: IntAct

    GO - Biological processi

    1. negative regulation of cell proliferation Source: Ensembl
    2. negative regulation of erythrocyte differentiation Source: Ensembl
    3. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    4. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator, Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Krueppel-like factor 13
    Alternative name(s):
    Basic transcription element-binding protein 3
    Short name:
    BTE-binding protein 3
    Novel Sp1-like zinc finger transcription factor 1
    RANTES factor of late activated T-lymphocytes 1
    Short name:
    RFLAT-1
    Transcription factor BTEB3
    Transcription factor NSLP1
    Gene namesi
    Name:KLF13
    Synonyms:BTEB3, NSLP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 15

    Organism-specific databases

    HGNCiHGNC:13672. KLF13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30133.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 288288Krueppel-like factor 13PRO_0000047184Add
    BLAST

    Post-translational modificationi

    Phosphorylated.

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y2Y9.
    PaxDbiQ9Y2Y9.
    PRIDEiQ9Y2Y9.

    PTM databases

    PhosphoSiteiQ9Y2Y9.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ9Y2Y9.
    BgeeiQ9Y2Y9.
    CleanExiHS_KLF13.
    GenevestigatoriQ9Y2Y9.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    GATA4P436943EBI-1255893,EBI-7049352
    PRPF4BQ135235EBI-1255893,EBI-395940

    Protein-protein interaction databases

    BioGridi119642. 12 interactions.
    IntActiQ9Y2Y9. 3 interactions.
    MINTiMINT-3379487.
    STRINGi9606.ENSP00000302456.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2Y9.
    SMRiQ9Y2Y9. Positions 142-281.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi2 – 145144Ala/Pro-richAdd
    BLAST
    Compositional biasi2 – 54Poly-Ala
    Compositional biasi113 – 1164Poly-Ala
    Compositional biasi148 – 16821Arg/Lys-rich (basic)Add
    BLAST
    Compositional biasi264 – 28724Ser-richAdd
    BLAST

    Domaini

    The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.

    Sequence similaritiesi

    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri167 – 19125C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri197 – 22125C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri227 – 24923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000233575.
    HOVERGENiHBG050746.
    InParanoidiQ9Y2Y9.
    KOiK09208.
    OMAiECSWQEC.
    OrthoDBiEOG7FJH0Q.
    PhylomeDBiQ9Y2Y9.
    TreeFamiTF351003.

    Family and domain databases

    Gene3Di3.30.160.60. 3 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2Y9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE    50
    ERRDGKDSAS LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP 100
    PAPEPTSPGA EGAAAAPPSP AWSEPEPEAG LEPEREPGPA GSGEPGLRQR 150
    VRRGRSRADL ESPQRKHKCH YAGCEKVYGK SSHLKAHLRT HTGERPFACS 200
    WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD HLTKHARRHA 250
    NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP 288
    Length:288
    Mass (Da):31,180
    Last modified:November 1, 1999 - v1
    Checksum:iDD2765EE00E9C049
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti39 – 391A → S in AAD34020. (PubMed:10415854)Curated
    Sequence conflicti104 – 11411EPTSPGAEGAA → MSPPPPALKARR in AAD34020. (PubMed:10415854)CuratedAdd
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132599 mRNA. Translation: AAD26864.1.
    AF150628 mRNA. Translation: AAD34020.1.
    BC013946 mRNA. Translation: AAH13946.1.
    BC010438 mRNA. Translation: AAH10438.1.
    BC012741 mRNA. Translation: AAH12741.1.
    CCDSiCCDS10025.1.
    RefSeqiNP_057079.2. NM_015995.2.
    UniGeneiHs.525752.

    Genome annotation databases

    EnsembliENST00000307145; ENSP00000302456; ENSG00000169926.
    GeneIDi51621.
    KEGGihsa:51621.
    UCSCiuc001zfo.3. human.

    Polymorphism databases

    DMDMi17369913.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132599 mRNA. Translation: AAD26864.1 .
    AF150628 mRNA. Translation: AAD34020.1 .
    BC013946 mRNA. Translation: AAH13946.1 .
    BC010438 mRNA. Translation: AAH10438.1 .
    BC012741 mRNA. Translation: AAH12741.1 .
    CCDSi CCDS10025.1.
    RefSeqi NP_057079.2. NM_015995.2.
    UniGenei Hs.525752.

    3D structure databases

    ProteinModelPortali Q9Y2Y9.
    SMRi Q9Y2Y9. Positions 142-281.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119642. 12 interactions.
    IntActi Q9Y2Y9. 3 interactions.
    MINTi MINT-3379487.
    STRINGi 9606.ENSP00000302456.

    PTM databases

    PhosphoSitei Q9Y2Y9.

    Polymorphism databases

    DMDMi 17369913.

    Proteomic databases

    MaxQBi Q9Y2Y9.
    PaxDbi Q9Y2Y9.
    PRIDEi Q9Y2Y9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307145 ; ENSP00000302456 ; ENSG00000169926 .
    GeneIDi 51621.
    KEGGi hsa:51621.
    UCSCi uc001zfo.3. human.

    Organism-specific databases

    CTDi 51621.
    GeneCardsi GC15P031619.
    HGNCi HGNC:13672. KLF13.
    MIMi 605328. gene.
    neXtProti NX_Q9Y2Y9.
    PharmGKBi PA30133.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000233575.
    HOVERGENi HBG050746.
    InParanoidi Q9Y2Y9.
    KOi K09208.
    OMAi ECSWQEC.
    OrthoDBi EOG7FJH0Q.
    PhylomeDBi Q9Y2Y9.
    TreeFami TF351003.

    Miscellaneous databases

    ChiTaRSi KLF13. human.
    GeneWikii KLF13.
    GenomeRNAii 51621.
    NextBioi 55535.
    PROi Q9Y2Y9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2Y9.
    Bgeei Q9Y2Y9.
    CleanExi HS_KLF13.
    Genevestigatori Q9Y2Y9.

    Family and domain databases

    Gene3Di 3.30.160.60. 3 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes."
      Song A., Chen Y.F., Thamatrakoln K., Storm T.A., Krensky A.M.
      Immunity 10:93-103(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors."
      Cook T., Gebelein B., Urrutia R.
      Ann. N. Y. Acad. Sci. 880:94-102(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pancreas.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    4. "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1."
      Kaczynski J., Zhang J.S., Ellenrieder V., Conley A., Duenes T., Kester H., van Der Burg B., Urrutia R.
      J. Biol. Chem. 276:36749-36756(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiKLF13_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2Y9
    Secondary accession number(s): Q9Y356
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 2, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 120 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 15
      Human chromosome 15: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3