Reviewed, UniProtKB/Swiss-Prot Q9Y2Y9 (KLF13_HUMAN)

Names and origin

Protein names

Recommended name:
    Krueppel-like factor 13
Alternative name(s):
    Transcription factor BTEB3
    Basic transcription element-binding protein 3
      Short name=BTE-binding protein 3
    RANTES factor of late activated T-lymphocytes 1
      Short name=RFLAT-1
    Transcription factor NSLP1
    Novel Sp1-like zinc finger transcription factor 1

Gene names

Name:	KLF13
Synonyms:	BTEB3, NSLP1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. Ref.4
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous.
Domain	The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
Post-translational modification	Phosphorylated.
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW RNA polymerase II transcription factor activity Ref.1 Traceable author statement. Source: ProtInc protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRPF4B	Q13523	3	EBI-1255893,EBI-395940

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Krueppel-like factor 13		PRO_0000047184
Regions
	Zinc finger	167 – 191	25	C2H2-type 1
	Zinc finger	197 – 221	25	C2H2-type 2
	Zinc finger	227 – 249	23	C2H2-type 3
	Compositional bias	2 – 145	144	Ala/Pro-rich
	Compositional bias	2 – 5	4	Poly-Ala
	Compositional bias	113 – 116	4	Poly-Ala
	Compositional bias	148 – 168	21	Arg/Lys-rich (basic)
	Compositional bias	264 – 287	24	Ser-rich
Experimental info
	Sequence conflict	39	1	A → S in AAD34020. Ref.2
	Sequence conflict	104 – 114	11	EPTSPGAEGAA → MSPPPPALKARR in AAD34020. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2Y9-1 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: DD2765EE00E9C049	FASTA	288	31,180
	10 20 30 40 50 60 MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE ERRDGKDSAS 70 80 90 100 110 120 LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP PAPEPTSPGA EGAAAAPPSP 130 140 150 160 170 180 AWSEPEPEAG LEPEREPGPA GSGEPGLRQR VRRGRSRADL ESPQRKHKCH YAGCEKVYGK 190 200 210 220 230 240 SSHLKAHLRT HTGERPFACS WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD 250 260 270 280 HLTKHARRHA NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes." Song A., Chen Y.F., Thamatrakoln K., Storm T.A., Krensky A.M. Immunity 10:93-103(1999) [PubMed: 10023774] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors." Cook T., Gebelein B., Urrutia R. Ann. N. Y. Acad. Sci. 880:94-102(1999) [PubMed: 10415854] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1." Kaczynski J., Zhang J.S., Ellenrieder V., Conley A., Duenes T., Kester H., van Der Burg B., Urrutia R. J. Biol. Chem. 276:36749-36756(2001) [PubMed: 11477107] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF132599 mRNA. Translation: AAD26864.1. AF150628 mRNA. Translation: AAD34020.1. BC013946 mRNA. Translation: AAH13946.1. BC010438 mRNA. Translation: AAH10438.1. BC012741 mRNA. Translation: AAH12741.1.
IPI	IPI00219691.
RefSeq	NP_057079.2.
UniGene	Hs.525752
3D structure databases
HSSP	HSSP built from PDB template 1SP2 based on UniProtKB P08047.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2Y9. 2 interactions.
PTM databases
PhosphoSite	Q9Y2Y9.
Proteomic databases
PRIDE	Q9Y2Y9.
Genome annotation databases
Ensembl	ENSG00000169926. Homo sapiens. [Contig view]
GeneID	51621.
KEGG	hsa:51621.
UCSC	uc001zfo.1. human.
Organism-specific databases
GeneCards	GC15P029335.
H-InvDB	HIX0012066.
HGNC	HGNC:13672. KLF13.
MIM	605328. gene.
PharmGKB	PA30133.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q9Y2Y9.
HOVERGEN	Q9Y2Y9.
OMA	Q9Y2Y9. MAAAAYV.
Gene expression databases
ArrayExpress	Q9Y2Y9.
Bgee	Q9Y2Y9.
CleanEx	HS_KLF13.
GermOnline	ENSG00000169926. Homo sapiens.
Family and domain databases
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
Gene3D	G3DSA:3.30.160.60. Znf_C2H2/integrase_DNA-bd. 1 hit.
Pfam	PF00096. zf-C2H2. 3 hits. [Graphical view]
ProDom	PD000003. Znf_C2H2. 2 hits. [Graphical view] [Entries sharing at least one domain]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	55535.
SOURCE	Search...

Entry information

Entry name

KLF13_HUMAN

Accession

Primary (citable) accession number: Q9Y2Y9
Secondary accession number(s): Q9Y356

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 1, 1999
Last modified:	July 7, 2009
This is version 75 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)