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Q9Y2Y9 (KLF13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Krueppel-like factor 13
Alternative name(s):
Basic transcription element-binding protein 3
Short name=BTE-binding protein 3
Novel Sp1-like zinc finger transcription factor 1
RANTES factor of late activated T-lymphocytes 1
Short name=RFLAT-1
Transcription factor BTEB3
Transcription factor NSLP1
Gene names
Name:KLF13
Synonyms:BTEB3, NSLP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length288 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. Ref.4

Subcellular location

Nucleus.

Tissue specificity

Ubiquitous.

Domain

The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.

Post-translational modification

Phosphorylated.

Sequence similarities

Belongs to the Sp1 C2H2-type zinc-finger protein family.

Contains 3 C2H2-type zinc fingers.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

GATA4P436943EBI-1255893,EBI-7049352
PRPF4BQ135235EBI-1255893,EBI-395940

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 288288Krueppel-like factor 13
PRO_0000047184

Regions

Zinc finger167 – 19125C2H2-type 1
Zinc finger197 – 22125C2H2-type 2
Zinc finger227 – 24923C2H2-type 3
Compositional bias2 – 145144Ala/Pro-rich
Compositional bias2 – 54Poly-Ala
Compositional bias113 – 1164Poly-Ala
Compositional bias148 – 16821Arg/Lys-rich (basic)
Compositional bias264 – 28724Ser-rich

Experimental info

Sequence conflict391A → S in AAD34020. Ref.2
Sequence conflict104 – 11411EPTSPGAEGAA → MSPPPPALKARR in AAD34020. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q9Y2Y9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: DD2765EE00E9C049

FASTA28831,180
        10         20         30         40         50         60 
MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE ERRDGKDSAS 

        70         80         90        100        110        120 
LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP PAPEPTSPGA EGAAAAPPSP 

       130        140        150        160        170        180 
AWSEPEPEAG LEPEREPGPA GSGEPGLRQR VRRGRSRADL ESPQRKHKCH YAGCEKVYGK 

       190        200        210        220        230        240 
SSHLKAHLRT HTGERPFACS WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD 

       250        260        270        280 
HLTKHARRHA NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP 

« Hide

References

« Hide 'large scale' references
[1]"RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes."
Song A., Chen Y.F., Thamatrakoln K., Storm T.A., Krensky A.M.
Immunity 10:93-103(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors."
Cook T., Gebelein B., Urrutia R.
Ann. N. Y. Acad. Sci. 880:94-102(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Pancreas.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[4]"The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1."
Kaczynski J., Zhang J.S., Ellenrieder V., Conley A., Duenes T., Kester H., van Der Burg B., Urrutia R.
J. Biol. Chem. 276:36749-36756(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132599 mRNA. Translation: AAD26864.1.
AF150628 mRNA. Translation: AAD34020.1.
BC013946 mRNA. Translation: AAH13946.1.
BC010438 mRNA. Translation: AAH10438.1.
BC012741 mRNA. Translation: AAH12741.1.
RefSeqNP_057079.2. NM_015995.2.
UniGeneHs.525752.

3D structure databases

ProteinModelPortalQ9Y2Y9.
SMRQ9Y2Y9. Positions 142-281.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid119642. 12 interactions.
IntActQ9Y2Y9. 3 interactions.
MINTMINT-3379487.
STRING9606.ENSP00000302456.

PTM databases

PhosphoSiteQ9Y2Y9.

Polymorphism databases

DMDM17369913.

Proteomic databases

PaxDbQ9Y2Y9.
PRIDEQ9Y2Y9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000307145; ENSP00000302456; ENSG00000169926.
GeneID51621.
KEGGhsa:51621.
UCSCuc001zfo.3. human.

Organism-specific databases

CTD51621.
GeneCardsGC15P031619.
HGNCHGNC:13672. KLF13.
MIM605328. gene.
neXtProtNX_Q9Y2Y9.
PharmGKBPA30133.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000233575.
HOVERGENHBG050746.
InParanoidQ9Y2Y9.
KOK09208.
OMACHYVGCE.
OrthoDBEOG7FJH0Q.
PhylomeDBQ9Y2Y9.
TreeFamTF351003.

Gene expression databases

ArrayExpressQ9Y2Y9.
BgeeQ9Y2Y9.
CleanExHS_KLF13.
GenevestigatorQ9Y2Y9.

Family and domain databases

Gene3D3.30.160.60. 3 hits.
InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 3 hits.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKLF13. human.
GeneWikiKLF13.
GenomeRNAi51621.
NextBio55535.
PROQ9Y2Y9.
SOURCESearch...

Entry information

Entry nameKLF13_HUMAN
AccessionPrimary (citable) accession number: Q9Y2Y9
Secondary accession number(s): Q9Y356
Entry history
Integrated into UniProtKB/Swiss-Prot: November 2, 2001
Last sequence update: November 1, 1999
Last modified: February 19, 2014
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 15

Human chromosome 15: entries, gene names and cross-references to MIM