Q9Y2Y9 (KLF13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Krueppel-like factor 13

Alternative name(s):
Basic transcription element-binding protein 3
Short name=BTE-binding protein 3
Novel Sp1-like zinc finger transcription factor 1
RANTES factor of late activated T-lymphocytes 1
Short name=RFLAT-1
Transcription factor BTEB3
Transcription factor NSLP1

Gene names

Name:	KLF13
Synonyms:	BTEB3, NSLP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	288 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells. Ref.4
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous.
Domain	The Ala/Pro-rich domain may contain discrete activation and repression subdomains and also can mediate protein-protein interactions.
Post-translational modification	Phosphorylated.
Sequence similarities	Belongs to the Sp1 C2H2-type zinc-finger protein family. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of cell proliferation Inferred from electronic annotation. Source: Compara negative regulation of erythrocyte differentiation Inferred from electronic annotation. Source: Compara positive regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription from RNA polymerase II promoter Traceable author statement Ref.1. Source: ProtInc
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
PRPF4B	Q13523	5	EBI-1255893,EBI-395940

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 288	288	Krueppel-like factor 13		PRO_0000047184
Regions
	Zinc finger	167 – 191	25	C2H2-type 1
	Zinc finger	197 – 221	25	C2H2-type 2
	Zinc finger	227 – 249	23	C2H2-type 3
	Compositional bias	2 – 145	144	Ala/Pro-rich
	Compositional bias	2 – 5	4	Poly-Ala
	Compositional bias	113 – 116	4	Poly-Ala
	Compositional bias	148 – 168	21	Arg/Lys-rich (basic)
	Compositional bias	264 – 287	24	Ser-rich
Experimental info
	Sequence conflict	39	1	A → S in AAD34020. Ref.2
	Sequence conflict	104 – 114	11	EPTSPGAEGAA → MSPPPPALKARR in AAD34020. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2Y9 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: DD2765EE00E9C049	FASTA	288	31,180
	10 20 30 40 50 60 MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE ERRDGKDSAS 70 80 90 100 110 120 LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP PAPEPTSPGA EGAAAAPPSP 130 140 150 160 170 180 AWSEPEPEAG LEPEREPGPA GSGEPGLRQR VRRGRSRADL ESPQRKHKCH YAGCEKVYGK 190 200 210 220 230 240 SSHLKAHLRT HTGERPFACS WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD 250 260 270 280 HLTKHARRHA NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes." Song A., Chen Y.F., Thamatrakoln K., Storm T.A., Krensky A.M. Immunity 10:93-103(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors." Cook T., Gebelein B., Urrutia R. Ann. N. Y. Acad. Sci. 880:94-102(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Pancreas.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[4]	"The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1." Kaczynski J., Zhang J.S., Ellenrieder V., Conley A., Duenes T., Kester H., van Der Burg B., Urrutia R. J. Biol. Chem. 276:36749-36756(2001) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF132599 mRNA. Translation: AAD26864.1. AF150628 mRNA. Translation: AAD34020.1. BC013946 mRNA. Translation: AAH13946.1. BC010438 mRNA. Translation: AAH10438.1. BC012741 mRNA. Translation: AAH12741.1.
IPI	IPI00219691.
RefSeq	NP_057079.2. NM_015995.2.
UniGene	Hs.525752.
3D structure databases
ProteinModelPortal	Q9Y2Y9.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2Y9. 1 interaction.
MINT	MINT-3379487.
STRING	9606.ENSP00000302456.
PTM databases
PhosphoSite	Q9Y2Y9.
Polymorphism databases
DMDM	17369913.
Proteomic databases
PaxDb	Q9Y2Y9.
PRIDE	Q9Y2Y9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000307145; ENSP00000302456; ENSG00000169926.
GeneID	51621.
KEGG	hsa:51621.
UCSC	uc001zfo.3. human.
Organism-specific databases
CTD	51621.
GeneCards	GC15P031619.
HGNC	HGNC:13672. KLF13.
MIM	605328. gene.
neXtProt	NX_Q9Y2Y9.
PharmGKB	PA30133.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000233575.
HOVERGEN	HBG050746.
InParanoid	Q9Y2Y9.
KO	K09208.
OMA	MDHFAAE.
OrthoDB	EOG4RNB9R.
PhylomeDB	Q9Y2Y9.
Gene expression databases
ArrayExpress	Q9Y2Y9.
Bgee	Q9Y2Y9.
CleanEx	HS_KLF13.
Genevestigator	Q9Y2Y9.
GermOnline	ENSG00000169926. Homo sapiens.
Family and domain databases
Gene3D	3.30.160.60. 3 hits.
InterPro	IPR007087. Znf_C2H2. IPR015880. Znf_C2H2-like. IPR013087. Znf_C2H2/integrase_DNA-bd. [Graphical view]
SMART	SM00355. ZnF_C2H2. 3 hits. [Graphical view]
PROSITE	PS00028. ZINC_FINGER_C2H2_1. 3 hits. PS50157. ZINC_FINGER_C2H2_2. 3 hits. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KLF13. human.
GenomeRNAi	51621.
NextBio	55535.
SOURCE	Search...

Entry information

Entry name

KLF13_HUMAN

Accession

Primary (citable) accession number: Q9Y2Y9
Secondary accession number(s): Q9Y356

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 2, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 111 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.