Q9Y2Y8 (PRG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proteoglycan 3

Alternative name(s):
Eosinophil major basic protein homolog
Prepro-major basic protein homolog
Short name=Prepro-MBPH

Gene names

Name:	PRG3
Synonyms:	MBPH
ORF Names:	UNQ486/PRO1002

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. Ref.1
Subcellular location	Cytoplasmic granule. Note: Localized to the eosinophil secondary granule. Ref.1
Tissue specificity	Expressed in bone marrow. Not detected in placenta. Ref.1
Sequence similarities	Contains 1 C-type lectin domain.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
Domain	Signal
Ligand	Lectin
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	basophil activation Inferred from direct assay Ref.1. Source: UniProtKB histamine biosynthetic process Inferred from direct assay Ref.1. Source: UniProtKB immune response Inferred from electronic annotation. Source: InterPro leukotriene biosynthetic process Inferred from direct assay Ref.1. Source: UniProtKB negative regulation of translation Inferred from direct assay Ref.1. Source: UniProtKB neutrophil activation Inferred from direct assay Ref.1. Source: UniProtKB positive regulation of interleukin-8 biosynthetic process Inferred from direct assay Ref.1. Source: UniProtKB superoxide anion generation Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	carbohydrate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 17	17	Potential
	Chain	18 – 225	208	Proteoglycan 3		PRO_0000250421
Regions
	Domain	107 – 224	118	C-type lectin
Amino acid modifications
	Disulfide bond	128 ↔ 223		By similarity
	Disulfide bond	200 ↔ 215		By similarity
Natural variations
	Natural variant	3	1	C → R. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs669661 [ dbSNP | Ensembl ].		VAR_050117
	Natural variant	109	1	I → T. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs540687 [ dbSNP | Ensembl ].		VAR_050118

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2Y8 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: AA073254496F9624	FASTA	225	25,406
	10 20 30 40 50 60 MQCLLLLPFL LLGTVSALHL ENDAPHLESL ETQADLGQDL DSSKEQERDL ALTEEVIQAE 70 80 90 100 110 120 GEEVKASACQ DNFEDEEAME SDPAALDKDF QCPREEDIVE VQGSPRCKIC RYLLVRTPKT 130 140 150 160 170 180 FAEAQNVCSR CYGGNLVSIH DFNFNYRIQC CTSTVNQAQV WIGGNLRGWF LWKRFCWTDG 190 200 210 220 SHWNFAYWSP GQPGNGQGSC VALCTKGGYW RRAQCDKQLP FVCSF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A novel and highly divergent homolog of human eosinophil granule major basic protein." Plager D.A., Loegering D.A., Weiler D.A., Checkel J.L., Wagner J.M., Clarke N.J., Naylor S., Page S.M., Thomas L.L., Akerblom I., Cocks B., Stuart S., Gleich G.J. J. Biol. Chem. 274:14464-14473(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, VARIANTS ARG-3 AND THR-109.
[2]	"Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes." Plager D.A., Weiler D.A., Loegering D.A., Johnson W.B., Haley L., Eddy R.L., Shows T.B., Gleich G.J. Genomics 71:271-281(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-3 AND THR-109.
[3]	"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M. Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
[4]	"Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y. Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein homolog

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF132209 mRNA. Translation: AAD24471.1. AF304354 Genomic DNA. Translation: AAG41952.1. AY358930 mRNA. Translation: AAQ89289.1. AP000781 Genomic DNA. No translation available. BC069126 mRNA. Translation: AAH69126.1. BC101613 mRNA. Translation: AAI01614.1. BC113411 mRNA. Translation: AAI13412.1.
IPI	IPI00005778.
RefSeq	NP_006084.2. NM_006093.3.
UniGene	Hs.251386.
3D structure databases
HSSP	HSSP built from PDB template 1H8U based on UniProtKB P13727.
ProteinModelPortal	Q9Y2Y8.
SMR	Q9Y2Y8. Positions 110-225.
ModBase	Search...
PTM databases
PhosphoSite	Q9Y2Y8.
Polymorphism databases
DMDM	296452870.
Proteomic databases
PaxDb	Q9Y2Y8.
PRIDE	Q9Y2Y8.
Protocols and materials databases
DNASU	10394.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000287143; ENSP00000287143; ENSG00000156575.
GeneID	10394.
KEGG	hsa:10394.
UCSC	uc001njv.2. human.
Organism-specific databases
CTD	10394.
GeneCards	GC11M057144.
H-InvDB	HIX0035870.
HGNC	HGNC:9363. PRG3.
MIM	606814. gene.
neXtProt	NX_Q9Y2Y8.
PharmGKB	PA33735.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG278428.
HOGENOM	HOG000261603.
HOVERGEN	HBG005583.
InParanoid	Q9Y2Y8.
OMA	LPFVCSF.
OrthoDB	EOG49KFRG.
PhylomeDB	Q9Y2Y8.
Gene expression databases
Bgee	Q9Y2Y8.
CleanEx	HS_PRG3.
Genevestigator	Q9Y2Y8.
GermOnline	ENSG00000156575. Homo sapiens.
Family and domain databases
Gene3D	3.10.100.10. 1 hit.
InterPro	IPR001304. C-type_lectin. IPR016186. C-type_lectin-like. IPR018378. C-type_lectin_CS. IPR016187. C-type_lectin_fold. IPR002352. Eosinophil_major_basic. [Graphical view]
PANTHER	PTHR10068. PTHR10068. 1 hit.
Pfam	PF00059. Lectin_C. 1 hit. [Graphical view]
PRINTS	PR00770. EMAJORBASICP.
SMART	SM00034. CLECT. 1 hit. [Graphical view]
SUPFAM	SSF56436. C-type_lectin_fold. 1 hit.
PROSITE	PS00615. C_TYPE_LECTIN_1. 1 hit. PS50041. C_TYPE_LECTIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10394.
NextBio	39378.
SOURCE	Search...

Entry information

Entry name

PRG3_HUMAN

Accession

Primary (citable) accession number: Q9Y2Y8

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.