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Protein

Proteoglycan 3

Gene

PRG3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.1 Publication

GO - Molecular functioni

GO - Biological processi

  • basophil activation Source: UniProtKB
  • histamine biosynthetic process Source: UniProtKB
  • immune response Source: InterPro
  • leukotriene biosynthetic process Source: UniProtKB
  • negative regulation of translation Source: UniProtKB
  • neutrophil activation Source: UniProtKB
  • positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  • superoxide anion generation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteoglycan 3
Alternative name(s):
Eosinophil major basic protein homolog
Prepro-major basic protein homolog
Short name:
Prepro-MBPH
Gene namesi
Name:PRG3Imported
Synonyms:MBPH2 Publications
ORF Names:UNQ486/PRO1002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9363. PRG3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33735.

Polymorphism and mutation databases

BioMutaiPRG3.
DMDMi296452870.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 225208Proteoglycan 3Sequence AnalysisPRO_0000250421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi128 ↔ 223PROSITE-ProRule annotation
Disulfide bondi200 ↔ 215PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y2Y8.
PRIDEiQ9Y2Y8.

PTM databases

PhosphoSiteiQ9Y2Y8.

Expressioni

Tissue specificityi

Expressed in bone marrow. Not detected in placenta.1 Publication

Gene expression databases

BgeeiQ9Y2Y8.
CleanExiHS_PRG3.
GenevisibleiQ9Y2Y8. HS.

Organism-specific databases

HPAiHPA064183.

Interactioni

Protein-protein interaction databases

BioGridi115666. 34 interactions.
STRINGi9606.ENSP00000287143.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Y8.
SMRiQ9Y2Y8. Positions 110-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 224118C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278428.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiQ9Y2Y8.
OMAiLPFVCSF.
OrthoDBiEOG779P0F.
PhylomeDBiQ9Y2Y8.
TreeFamiTF336281.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00770. EMAJORBASICP.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQCLLLLPFL LLGTVSALHL ENDAPHLESL ETQADLGQDL DSSKEQERDL
60 70 80 90 100
ALTEEVIQAE GEEVKASACQ DNFEDEEAME SDPAALDKDF QCPREEDIVE
110 120 130 140 150
VQGSPRCKIC RYLLVRTPKT FAEAQNVCSR CYGGNLVSIH DFNFNYRIQC
160 170 180 190 200
CTSTVNQAQV WIGGNLRGWF LWKRFCWTDG SHWNFAYWSP GQPGNGQGSC
210 220
VALCTKGGYW RRAQCDKQLP FVCSF
Length:225
Mass (Da):25,406
Last modified:May 18, 2010 - v2
Checksum:iAA073254496F9624
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31C → R.4 Publications
Corresponds to variant rs669661 [ dbSNP | Ensembl ].
VAR_050117
Natural varianti109 – 1091I → T.4 Publications
Corresponds to variant rs540687 [ dbSNP | Ensembl ].
VAR_050118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132209 mRNA. Translation: AAD24471.1.
AF304354 Genomic DNA. Translation: AAG41952.1.
AY358930 mRNA. Translation: AAQ89289.1.
AP000781 Genomic DNA. No translation available.
BC069126 mRNA. Translation: AAH69126.1.
BC101613 mRNA. Translation: AAI01614.1.
BC113411 mRNA. Translation: AAI13412.1.
CCDSiCCDS7954.1.
RefSeqiNP_006084.2. NM_006093.3.
UniGeneiHs.251386.

Genome annotation databases

EnsembliENST00000287143; ENSP00000287143; ENSG00000156575.
GeneIDi10394.
KEGGihsa:10394.
UCSCiuc001njv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein homolog

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132209 mRNA. Translation: AAD24471.1.
AF304354 Genomic DNA. Translation: AAG41952.1.
AY358930 mRNA. Translation: AAQ89289.1.
AP000781 Genomic DNA. No translation available.
BC069126 mRNA. Translation: AAH69126.1.
BC101613 mRNA. Translation: AAI01614.1.
BC113411 mRNA. Translation: AAI13412.1.
CCDSiCCDS7954.1.
RefSeqiNP_006084.2. NM_006093.3.
UniGeneiHs.251386.

3D structure databases

ProteinModelPortaliQ9Y2Y8.
SMRiQ9Y2Y8. Positions 110-225.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115666. 34 interactions.
STRINGi9606.ENSP00000287143.

Protein family/group databases

MEROPSiI63.001.

PTM databases

PhosphoSiteiQ9Y2Y8.

Polymorphism and mutation databases

BioMutaiPRG3.
DMDMi296452870.

Proteomic databases

PaxDbiQ9Y2Y8.
PRIDEiQ9Y2Y8.

Protocols and materials databases

DNASUi10394.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287143; ENSP00000287143; ENSG00000156575.
GeneIDi10394.
KEGGihsa:10394.
UCSCiuc001njv.2. human.

Organism-specific databases

CTDi10394.
GeneCardsiGC11M057144.
H-InvDBHIX0035870.
HGNCiHGNC:9363. PRG3.
HPAiHPA064183.
MIMi606814. gene.
neXtProtiNX_Q9Y2Y8.
PharmGKBiPA33735.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG278428.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiQ9Y2Y8.
OMAiLPFVCSF.
OrthoDBiEOG779P0F.
PhylomeDBiQ9Y2Y8.
TreeFamiTF336281.

Miscellaneous databases

ChiTaRSiPRG3. human.
GenomeRNAii10394.
NextBioi39378.
PROiQ9Y2Y8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2Y8.
CleanExiHS_PRG3.
GenevisibleiQ9Y2Y8. HS.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00770. EMAJORBASICP.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, VARIANTS ARG-3 AND THR-109.
  2. "Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes."
    Plager D.A., Weiler D.A., Loegering D.A., Johnson W.B., Haley L., Eddy R.L., Shows T.B., Gleich G.J.
    Genomics 71:271-281(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-3 AND THR-109.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
    Tissue: LiverImported.

Entry informationi

Entry nameiPRG3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: June 24, 2015
This is version 117 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.