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Q9Y2Y8

- PRG3_HUMAN

UniProt

Q9Y2Y8 - PRG3_HUMAN

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Protein

Proteoglycan 3

Gene

PRG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.1 Publication

GO - Molecular functioni

  1. carbohydrate binding Source: UniProtKB-KW

GO - Biological processi

  1. basophil activation Source: UniProtKB
  2. histamine biosynthetic process Source: UniProtKB
  3. immune response Source: InterPro
  4. leukotriene biosynthetic process Source: UniProtKB
  5. negative regulation of translation Source: UniProtKB
  6. neutrophil activation Source: UniProtKB
  7. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
  8. superoxide anion generation Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Lectin

Protein family/group databases

MEROPSiI63.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Proteoglycan 3
Alternative name(s):
Eosinophil major basic protein homolog
Prepro-major basic protein homolog
Short name:
Prepro-MBPH
Gene namesi
Name:PRG3Imported
Synonyms:MBPH2 Publications
ORF Names:UNQ486/PRO1002
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:9363. PRG3.

Subcellular locationi

Cytoplasmic granule 1 Publication
Note: Localized to the eosinophil secondary granule.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33735.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1717Sequence AnalysisAdd
BLAST
Chaini18 – 225208Proteoglycan 3Sequence AnalysisPRO_0000250421Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi128 ↔ 223PROSITE-ProRule annotation
Disulfide bondi200 ↔ 215PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ9Y2Y8.
PRIDEiQ9Y2Y8.

PTM databases

PhosphoSiteiQ9Y2Y8.

Expressioni

Tissue specificityi

Expressed in bone marrow. Not detected in placenta.1 Publication

Gene expression databases

BgeeiQ9Y2Y8.
CleanExiHS_PRG3.
GenevestigatoriQ9Y2Y8.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Y8.
SMRiQ9Y2Y8. Positions 110-225.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini107 – 224118C-type lectinPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG278428.
GeneTreeiENSGT00440000039859.
HOGENOMiHOG000261603.
HOVERGENiHBG005583.
InParanoidiQ9Y2Y8.
OMAiLPFVCSF.
OrthoDBiEOG779P0F.
PhylomeDBiQ9Y2Y8.
TreeFamiTF336281.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERiPTHR10068. PTHR10068. 1 hit.
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSiPR00770. EMAJORBASICP.
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2Y8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQCLLLLPFL LLGTVSALHL ENDAPHLESL ETQADLGQDL DSSKEQERDL
60 70 80 90 100
ALTEEVIQAE GEEVKASACQ DNFEDEEAME SDPAALDKDF QCPREEDIVE
110 120 130 140 150
VQGSPRCKIC RYLLVRTPKT FAEAQNVCSR CYGGNLVSIH DFNFNYRIQC
160 170 180 190 200
CTSTVNQAQV WIGGNLRGWF LWKRFCWTDG SHWNFAYWSP GQPGNGQGSC
210 220
VALCTKGGYW RRAQCDKQLP FVCSF
Length:225
Mass (Da):25,406
Last modified:May 18, 2010 - v2
Checksum:iAA073254496F9624
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti3 – 31C → R.4 Publications
Corresponds to variant rs669661 [ dbSNP | Ensembl ].
VAR_050117
Natural varianti109 – 1091I → T.4 Publications
Corresponds to variant rs540687 [ dbSNP | Ensembl ].
VAR_050118

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132209 mRNA. Translation: AAD24471.1.
AF304354 Genomic DNA. Translation: AAG41952.1.
AY358930 mRNA. Translation: AAQ89289.1.
AP000781 Genomic DNA. No translation available.
BC069126 mRNA. Translation: AAH69126.1.
BC101613 mRNA. Translation: AAI01614.1.
BC113411 mRNA. Translation: AAI13412.1.
CCDSiCCDS7954.1.
RefSeqiNP_006084.2. NM_006093.3.
UniGeneiHs.251386.

Genome annotation databases

EnsembliENST00000287143; ENSP00000287143; ENSG00000156575.
GeneIDi10394.
KEGGihsa:10394.
UCSCiuc001njv.2. human.

Polymorphism databases

DMDMi296452870.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein homolog

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF132209 mRNA. Translation: AAD24471.1 .
AF304354 Genomic DNA. Translation: AAG41952.1 .
AY358930 mRNA. Translation: AAQ89289.1 .
AP000781 Genomic DNA. No translation available.
BC069126 mRNA. Translation: AAH69126.1 .
BC101613 mRNA. Translation: AAI01614.1 .
BC113411 mRNA. Translation: AAI13412.1 .
CCDSi CCDS7954.1.
RefSeqi NP_006084.2. NM_006093.3.
UniGenei Hs.251386.

3D structure databases

ProteinModelPortali Q9Y2Y8.
SMRi Q9Y2Y8. Positions 110-225.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi I63.001.

PTM databases

PhosphoSitei Q9Y2Y8.

Polymorphism databases

DMDMi 296452870.

Proteomic databases

PaxDbi Q9Y2Y8.
PRIDEi Q9Y2Y8.

Protocols and materials databases

DNASUi 10394.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000287143 ; ENSP00000287143 ; ENSG00000156575 .
GeneIDi 10394.
KEGGi hsa:10394.
UCSCi uc001njv.2. human.

Organism-specific databases

CTDi 10394.
GeneCardsi GC11M057144.
H-InvDB HIX0035870.
HGNCi HGNC:9363. PRG3.
MIMi 606814. gene.
neXtProti NX_Q9Y2Y8.
PharmGKBi PA33735.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG278428.
GeneTreei ENSGT00440000039859.
HOGENOMi HOG000261603.
HOVERGENi HBG005583.
InParanoidi Q9Y2Y8.
OMAi LPFVCSF.
OrthoDBi EOG779P0F.
PhylomeDBi Q9Y2Y8.
TreeFami TF336281.

Miscellaneous databases

ChiTaRSi PRG3. human.
GenomeRNAii 10394.
NextBioi 39378.
PROi Q9Y2Y8.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2Y8.
CleanExi HS_PRG3.
Genevestigatori Q9Y2Y8.

Family and domain databases

Gene3Di 3.10.100.10. 1 hit.
InterProi IPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR002352. Eosinophil_major_basic.
[Graphical view ]
PANTHERi PTHR10068. PTHR10068. 1 hit.
Pfami PF00059. Lectin_C. 1 hit.
[Graphical view ]
PRINTSi PR00770. EMAJORBASICP.
SMARTi SM00034. CLECT. 1 hit.
[Graphical view ]
SUPFAMi SSF56436. SSF56436. 1 hit.
PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, VARIANTS ARG-3 AND THR-109.
  2. "Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes."
    Plager D.A., Weiler D.A., Loegering D.A., Johnson W.B., Haley L., Eddy R.L., Shows T.B., Gleich G.J.
    Genomics 71:271-281(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-3 AND THR-109.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
    Tissue: LiverImported.

Entry informationi

Entry nameiPRG3_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: November 26, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3