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Q9Y2Y8 (PRG3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Proteoglycan 3
Alternative name(s):
Eosinophil major basic protein homolog
Prepro-major basic protein homolog
Short name=Prepro-MBPH
Gene names
Name:PRG3
Synonyms:MBPH
ORF Names:UNQ486/PRO1002
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils. Ref.1

Subcellular location

Cytoplasmic granule. Note: Localized to the eosinophil secondary granule. Ref.1

Tissue specificity

Expressed in bone marrow. Not detected in placenta. Ref.1

Sequence similarities

Contains 1 C-type lectin domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1717 Potential
Chain18 – 225208Proteoglycan 3
PRO_0000250421

Regions

Domain107 – 224118C-type lectin

Amino acid modifications

Disulfide bond128 ↔ 223 By similarity
Disulfide bond200 ↔ 215 By similarity

Natural variations

Natural variant31C → R. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs669661 [ dbSNP | Ensembl ].
VAR_050117
Natural variant1091I → T. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs540687 [ dbSNP | Ensembl ].
VAR_050118

Sequences

Sequence LengthMass (Da)Tools
Q9Y2Y8 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: AA073254496F9624

FASTA22525,406
        10         20         30         40         50         60 
MQCLLLLPFL LLGTVSALHL ENDAPHLESL ETQADLGQDL DSSKEQERDL ALTEEVIQAE 

        70         80         90        100        110        120 
GEEVKASACQ DNFEDEEAME SDPAALDKDF QCPREEDIVE VQGSPRCKIC RYLLVRTPKT 

       130        140        150        160        170        180 
FAEAQNVCSR CYGGNLVSIH DFNFNYRIQC CTSTVNQAQV WIGGNLRGWF LWKRFCWTDG 

       190        200        210        220 
SHWNFAYWSP GQPGNGQGSC VALCTKGGYW RRAQCDKQLP FVCSF 

« Hide

References

« Hide 'large scale' references
[1]"A novel and highly divergent homolog of human eosinophil granule major basic protein."
Plager D.A., Loegering D.A., Weiler D.A., Checkel J.L., Wagner J.M., Clarke N.J., Naylor S., Page S.M., Thomas L.L., Akerblom I., Cocks B., Stuart S., Gleich G.J.
J. Biol. Chem. 274:14464-14473(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, VARIANTS ARG-3 AND THR-109.
[2]"Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes."
Plager D.A., Weiler D.A., Loegering D.A., Johnson W.B., Haley L., Eddy R.L., Shows T.B., Gleich G.J.
Genomics 71:271-281(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-3 AND THR-109.
[3]"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J., Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P., Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E. expand/collapse author list , Heldens S., Huang A., Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D., Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L., Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C., Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J., Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
[4]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
Tissue: Liver.
+Additional computationally mapped references.

Web resources

Functional Glycomics Gateway - Glycan Binding

Eosinophil major basic protein homolog

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF132209 mRNA. Translation: AAD24471.1.
AF304354 Genomic DNA. Translation: AAG41952.1.
AY358930 mRNA. Translation: AAQ89289.1.
AP000781 Genomic DNA. No translation available.
BC069126 mRNA. Translation: AAH69126.1.
BC101613 mRNA. Translation: AAI01614.1.
BC113411 mRNA. Translation: AAI13412.1.
CCDSCCDS7954.1.
RefSeqNP_006084.2. NM_006093.3.
UniGeneHs.251386.

3D structure databases

ProteinModelPortalQ9Y2Y8.
SMRQ9Y2Y8. Positions 110-225.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSI63.001.

PTM databases

PhosphoSiteQ9Y2Y8.

Polymorphism databases

DMDM296452870.

Proteomic databases

PaxDbQ9Y2Y8.
PRIDEQ9Y2Y8.

Protocols and materials databases

DNASU10394.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000287143; ENSP00000287143; ENSG00000156575.
GeneID10394.
KEGGhsa:10394.
UCSCuc001njv.2. human.

Organism-specific databases

CTD10394.
GeneCardsGC11M057144.
H-InvDBHIX0035870.
HGNCHGNC:9363. PRG3.
MIM606814. gene.
neXtProtNX_Q9Y2Y8.
PharmGKBPA33735.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG278428.
HOGENOMHOG000261603.
HOVERGENHBG005583.
InParanoidQ9Y2Y8.
OMALPFVCSF.
OrthoDBEOG779P0F.
PhylomeDBQ9Y2Y8.
TreeFamTF336281.

Gene expression databases

BgeeQ9Y2Y8.
CleanExHS_PRG3.
GenevestigatorQ9Y2Y8.

Family and domain databases

Gene3D3.10.100.10. 1 hit.
InterProIPR001304. C-type_lectin.
IPR016186. C-type_lectin-like.
IPR018378. C-type_lectin_CS.
IPR016187. C-type_lectin_fold.
IPR002352. Eosinophil_major_basic.
[Graphical view]
PANTHERPTHR10068. PTHR10068. 1 hit.
PfamPF00059. Lectin_C. 1 hit.
[Graphical view]
PRINTSPR00770. EMAJORBASICP.
SMARTSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMSSF56436. SSF56436. 1 hit.
PROSITEPS00615. C_TYPE_LECTIN_1. 1 hit.
PS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10394.
NextBio39378.
PROQ9Y2Y8.
SOURCESearch...

Entry information

Entry namePRG3_HUMAN
AccessionPrimary (citable) accession number: Q9Y2Y8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM