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Q9Y2Y8

- PRG3_HUMAN

UniProt

Q9Y2Y8 - PRG3_HUMAN

Protein

Proteoglycan 3

Gene

PRG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 110 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Possesses similar cytotoxic and cytostimulatory activities to PRG2/MBP. In vitro, stimulates neutrophil superoxide production and IL8 release, and histamine and leukotriene C4 release from basophils.1 Publication

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro

    GO - Biological processi

    1. basophil activation Source: UniProtKB
    2. histamine biosynthetic process Source: UniProtKB
    3. immune response Source: InterPro
    4. leukotriene biosynthetic process Source: UniProtKB
    5. negative regulation of translation Source: UniProtKB
    6. neutrophil activation Source: UniProtKB
    7. positive regulation of interleukin-8 biosynthetic process Source: UniProtKB
    8. superoxide anion generation Source: UniProtKB

    Keywords - Ligandi

    Lectin

    Protein family/group databases

    MEROPSiI63.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proteoglycan 3
    Alternative name(s):
    Eosinophil major basic protein homolog
    Prepro-major basic protein homolog
    Short name:
    Prepro-MBPH
    Gene namesi
    Name:PRG3Imported
    Synonyms:MBPH2 Publications
    ORF Names:UNQ486/PRO1002
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:9363. PRG3.

    Subcellular locationi

    Cytoplasmic granule 1 Publication
    Note: Localized to the eosinophil secondary granule.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33735.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1717Sequence AnalysisAdd
    BLAST
    Chaini18 – 225208Proteoglycan 3Sequence AnalysisPRO_0000250421Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi128 ↔ 223PROSITE-ProRule annotation
    Disulfide bondi200 ↔ 215PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PaxDbiQ9Y2Y8.
    PRIDEiQ9Y2Y8.

    PTM databases

    PhosphoSiteiQ9Y2Y8.

    Expressioni

    Tissue specificityi

    Expressed in bone marrow. Not detected in placenta.1 Publication

    Gene expression databases

    BgeeiQ9Y2Y8.
    CleanExiHS_PRG3.
    GenevestigatoriQ9Y2Y8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2Y8.
    SMRiQ9Y2Y8. Positions 110-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini107 – 224118C-type lectinPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 C-type lectin domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG278428.
    HOGENOMiHOG000261603.
    HOVERGENiHBG005583.
    InParanoidiQ9Y2Y8.
    OMAiLPFVCSF.
    OrthoDBiEOG779P0F.
    PhylomeDBiQ9Y2Y8.
    TreeFamiTF336281.

    Family and domain databases

    Gene3Di3.10.100.10. 1 hit.
    InterProiIPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR002352. Eosinophil_major_basic.
    [Graphical view]
    PANTHERiPTHR10068. PTHR10068. 1 hit.
    PfamiPF00059. Lectin_C. 1 hit.
    [Graphical view]
    PRINTSiPR00770. EMAJORBASICP.
    SMARTiSM00034. CLECT. 1 hit.
    [Graphical view]
    SUPFAMiSSF56436. SSF56436. 1 hit.
    PROSITEiPS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y2Y8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQCLLLLPFL LLGTVSALHL ENDAPHLESL ETQADLGQDL DSSKEQERDL    50
    ALTEEVIQAE GEEVKASACQ DNFEDEEAME SDPAALDKDF QCPREEDIVE 100
    VQGSPRCKIC RYLLVRTPKT FAEAQNVCSR CYGGNLVSIH DFNFNYRIQC 150
    CTSTVNQAQV WIGGNLRGWF LWKRFCWTDG SHWNFAYWSP GQPGNGQGSC 200
    VALCTKGGYW RRAQCDKQLP FVCSF 225
    Length:225
    Mass (Da):25,406
    Last modified:May 18, 2010 - v2
    Checksum:iAA073254496F9624
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti3 – 31C → R.4 Publications
    Corresponds to variant rs669661 [ dbSNP | Ensembl ].
    VAR_050117
    Natural varianti109 – 1091I → T.4 Publications
    Corresponds to variant rs540687 [ dbSNP | Ensembl ].
    VAR_050118

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132209 mRNA. Translation: AAD24471.1.
    AF304354 Genomic DNA. Translation: AAG41952.1.
    AY358930 mRNA. Translation: AAQ89289.1.
    AP000781 Genomic DNA. No translation available.
    BC069126 mRNA. Translation: AAH69126.1.
    BC101613 mRNA. Translation: AAI01614.1.
    BC113411 mRNA. Translation: AAI13412.1.
    CCDSiCCDS7954.1.
    RefSeqiNP_006084.2. NM_006093.3.
    UniGeneiHs.251386.

    Genome annotation databases

    EnsembliENST00000287143; ENSP00000287143; ENSG00000156575.
    GeneIDi10394.
    KEGGihsa:10394.
    UCSCiuc001njv.2. human.

    Polymorphism databases

    DMDMi296452870.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Functional Glycomics Gateway - Glycan Binding

    Eosinophil major basic protein homolog

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF132209 mRNA. Translation: AAD24471.1 .
    AF304354 Genomic DNA. Translation: AAG41952.1 .
    AY358930 mRNA. Translation: AAQ89289.1 .
    AP000781 Genomic DNA. No translation available.
    BC069126 mRNA. Translation: AAH69126.1 .
    BC101613 mRNA. Translation: AAI01614.1 .
    BC113411 mRNA. Translation: AAI13412.1 .
    CCDSi CCDS7954.1.
    RefSeqi NP_006084.2. NM_006093.3.
    UniGenei Hs.251386.

    3D structure databases

    ProteinModelPortali Q9Y2Y8.
    SMRi Q9Y2Y8. Positions 110-225.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi I63.001.

    PTM databases

    PhosphoSitei Q9Y2Y8.

    Polymorphism databases

    DMDMi 296452870.

    Proteomic databases

    PaxDbi Q9Y2Y8.
    PRIDEi Q9Y2Y8.

    Protocols and materials databases

    DNASUi 10394.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000287143 ; ENSP00000287143 ; ENSG00000156575 .
    GeneIDi 10394.
    KEGGi hsa:10394.
    UCSCi uc001njv.2. human.

    Organism-specific databases

    CTDi 10394.
    GeneCardsi GC11M057144.
    H-InvDB HIX0035870.
    HGNCi HGNC:9363. PRG3.
    MIMi 606814. gene.
    neXtProti NX_Q9Y2Y8.
    PharmGKBi PA33735.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG278428.
    HOGENOMi HOG000261603.
    HOVERGENi HBG005583.
    InParanoidi Q9Y2Y8.
    OMAi LPFVCSF.
    OrthoDBi EOG779P0F.
    PhylomeDBi Q9Y2Y8.
    TreeFami TF336281.

    Miscellaneous databases

    GenomeRNAii 10394.
    NextBioi 39378.
    PROi Q9Y2Y8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y2Y8.
    CleanExi HS_PRG3.
    Genevestigatori Q9Y2Y8.

    Family and domain databases

    Gene3Di 3.10.100.10. 1 hit.
    InterProi IPR001304. C-type_lectin.
    IPR016186. C-type_lectin-like.
    IPR018378. C-type_lectin_CS.
    IPR016187. C-type_lectin_fold.
    IPR002352. Eosinophil_major_basic.
    [Graphical view ]
    PANTHERi PTHR10068. PTHR10068. 1 hit.
    Pfami PF00059. Lectin_C. 1 hit.
    [Graphical view ]
    PRINTSi PR00770. EMAJORBASICP.
    SMARTi SM00034. CLECT. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56436. SSF56436. 1 hit.
    PROSITEi PS00615. C_TYPE_LECTIN_1. 1 hit.
    PS50041. C_TYPE_LECTIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, VARIANTS ARG-3 AND THR-109.
    2. "Comparative structure, proximal promoter elements, and chromosome location of the human eosinophil major basic protein genes."
      Plager D.A., Weiler D.A., Loegering D.A., Johnson W.B., Haley L., Eddy R.L., Shows T.B., Gleich G.J.
      Genomics 71:271-281(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS ARG-3 AND THR-109.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS ARG-3 AND THR-109.
      Tissue: LiverImported.

    Entry informationi

    Entry nameiPRG3_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2Y8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2006
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 110 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3