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Q9Y2Y4

- ZBT32_HUMAN

UniProt

Q9Y2Y4 - ZBT32_HUMAN

Protein

Zinc finger and BTB domain-containing protein 32

Gene

ZBTB32

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri373 – 39523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB
    2. protein binding Source: IntAct
    3. transcription corepressor activity Source: ProtInc
    4. zinc ion binding Source: UniProtKB

    GO - Biological processi

    1. DNA repair Source: Reactome
    2. hemopoiesis Source: Ensembl
    3. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
    4. regulation of cytokine production Source: Ensembl
    5. T cell proliferation Source: Ensembl
    6. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_18265. Regulation of the Fanconi anemia pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger and BTB domain-containing protein 32
    Alternative name(s):
    FANCC-interacting protein
    Fanconi anemia zinc finger protein
    Testis zinc finger protein
    Zinc finger protein 538
    Gene namesi
    Name:ZBTB32
    Synonyms:FAZF, TZFP, ZNF538
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:16763. ZBTB32.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Located in nuclear speckles.

    GO - Cellular componenti

    1. nuclear chromosome Source: Ensembl
    2. nucleoplasm Source: Reactome
    3. nucleus Source: ProtInc

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA142670541.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 487487Zinc finger and BTB domain-containing protein 32PRO_0000273417Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y2Y4.
    PRIDEiQ9Y2Y4.

    PTM databases

    PhosphoSiteiQ9Y2Y4.

    Expressioni

    Tissue specificityi

    Predominantly expressed in testis. Some isoforms are ubiquitously expressed.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y2Y4.
    BgeeiQ9Y2Y4.
    CleanExiHS_ZBTB32.
    GenevestigatoriQ9Y2Y4.

    Organism-specific databases

    HPAiHPA052633.

    Interactioni

    Subunit structurei

    Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    Hoxa1P090223EBI-954098,EBI-3957603From a different organism.

    Protein-protein interaction databases

    BioGridi117964. 13 interactions.
    IntActiQ9Y2Y4. 4 interactions.
    MINTiMINT-1452016.
    STRINGi9606.ENSP00000262630.

    Structurei

    Secondary structure

    1
    487
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 83
    Turni11 – 144
    Helixi16 – 249
    Turni25 – 284
    Beta strandi31 – 355
    Beta strandi38 – 425
    Helixi44 – 485
    Helixi52 – 543
    Beta strandi58 – 614
    Helixi68 – 7811
    Beta strandi83 – 853
    Helixi87 – 893
    Helixi90 – 9910
    Helixi103 – 11210

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3M5BX-ray2.00A/B1-117[»]
    ProteinModelPortaliQ9Y2Y4.
    SMRiQ9Y2Y4. Positions 5-113, 346-453.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9Y2Y4.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 8759BTBPROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The C-terminal zinc finger domain functions as a transcriptional transactivator.By similarity
    The BTB (POZ) domain possesses repressor activity.By similarity

    Sequence similaritiesi

    Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
    Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri373 – 39523C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri401 – 42323C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri428 – 45023C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG296621.
    HOGENOMiHOG000060112.
    HOVERGENiHBG079944.
    InParanoidiQ9Y2Y4.
    KOiK10506.
    OMAiGAWQEVW.
    OrthoDBiEOG7F7W8T.
    PhylomeDBiQ9Y2Y4.
    TreeFamiTF350825.

    Family and domain databases

    Gene3Di3.30.160.60. 2 hits.
    3.30.710.10. 1 hit.
    InterProiIPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    PfamiPF00651. BTB. 1 hit.
    [Graphical view]
    SMARTiSM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view]
    SUPFAMiSSF54695. SSF54695. 1 hit.
    PROSITEiPS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2Y4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV    50
    SQQLGRRGQW ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL 100
    GVQSLEEACW RARGDRAKKP DPGLKKHQEE PEKPSRNPER ELGDPGEKQK 150
    PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA TQEAQQEQTR SKEKRLQAPV 200
    GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ TSVTPRPSWA 250
    EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN 300
    APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH 350
    EDKAGCPPRP HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP 400
    FSCSLCPQRS RDFSAMTKHL RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH 450
    SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC CPSSSTT 487
    Length:487
    Mass (Da):52,963
    Last modified:November 1, 1999 - v1
    Checksum:iB528F3C2AFFC4838
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti174 – 1741R → S.
    Corresponds to variant rs2227278 [ dbSNP | Ensembl ].
    VAR_030145

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130255 mRNA. Translation: AAD27708.1.
    AF165097 mRNA. Translation: AAD48448.1.
    BC017700 mRNA. Translation: AAH17700.1. Different termination.
    CCDSiCCDS12471.1.
    PIRiJC7126.
    RefSeqiNP_055198.1. NM_014383.1.
    XP_005258796.1. XM_005258739.1.
    UniGeneiHs.99430.

    Genome annotation databases

    EnsembliENST00000262630; ENSP00000262630; ENSG00000011590.
    ENST00000392197; ENSP00000376035; ENSG00000011590.
    ENST00000481182; ENSP00000433657; ENSG00000011590.
    GeneIDi27033.
    KEGGihsa:27033.
    UCSCiuc002oay.3. human.

    Polymorphism databases

    DMDMi74762048.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF130255 mRNA. Translation: AAD27708.1 .
    AF165097 mRNA. Translation: AAD48448.1 .
    BC017700 mRNA. Translation: AAH17700.1 . Different termination.
    CCDSi CCDS12471.1.
    PIRi JC7126.
    RefSeqi NP_055198.1. NM_014383.1.
    XP_005258796.1. XM_005258739.1.
    UniGenei Hs.99430.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3M5B X-ray 2.00 A/B 1-117 [» ]
    ProteinModelPortali Q9Y2Y4.
    SMRi Q9Y2Y4. Positions 5-113, 346-453.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117964. 13 interactions.
    IntActi Q9Y2Y4. 4 interactions.
    MINTi MINT-1452016.
    STRINGi 9606.ENSP00000262630.

    PTM databases

    PhosphoSitei Q9Y2Y4.

    Polymorphism databases

    DMDMi 74762048.

    Proteomic databases

    PaxDbi Q9Y2Y4.
    PRIDEi Q9Y2Y4.

    Protocols and materials databases

    DNASUi 27033.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262630 ; ENSP00000262630 ; ENSG00000011590 .
    ENST00000392197 ; ENSP00000376035 ; ENSG00000011590 .
    ENST00000481182 ; ENSP00000433657 ; ENSG00000011590 .
    GeneIDi 27033.
    KEGGi hsa:27033.
    UCSCi uc002oay.3. human.

    Organism-specific databases

    CTDi 27033.
    GeneCardsi GC19P036203.
    HGNCi HGNC:16763. ZBTB32.
    HPAi HPA052633.
    MIMi 605859. gene.
    neXtProti NX_Q9Y2Y4.
    PharmGKBi PA142670541.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG296621.
    HOGENOMi HOG000060112.
    HOVERGENi HBG079944.
    InParanoidi Q9Y2Y4.
    KOi K10506.
    OMAi GAWQEVW.
    OrthoDBi EOG7F7W8T.
    PhylomeDBi Q9Y2Y4.
    TreeFami TF350825.

    Enzyme and pathway databases

    Reactomei REACT_18265. Regulation of the Fanconi anemia pathway.

    Miscellaneous databases

    EvolutionaryTracei Q9Y2Y4.
    GeneWikii ZBTB32.
    GenomeRNAii 27033.
    NextBioi 49578.
    PROi Q9Y2Y4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2Y4.
    Bgeei Q9Y2Y4.
    CleanExi HS_ZBTB32.
    Genevestigatori Q9Y2Y4.

    Family and domain databases

    Gene3Di 3.30.160.60. 2 hits.
    3.30.710.10. 1 hit.
    InterProi IPR000210. BTB/POZ-like.
    IPR011333. BTB/POZ_fold.
    IPR013069. BTB_POZ.
    IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    Pfami PF00651. BTB. 1 hit.
    [Graphical view ]
    SMARTi SM00225. BTB. 1 hit.
    SM00355. ZnF_C2H2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF54695. SSF54695. 1 hit.
    PROSITEi PS50097. BTB. 1 hit.
    PS00028. ZINC_FINGER_C2H2_1. 2 hits.
    PS50157. ZINC_FINGER_C2H2_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP."
      Lin W.-C., Lai C.-H., Tang C.J., Huang C.-J., Tang T.K.
      Biochem. Biophys. Res. Commun. 264:789-795(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
      Tissue: Testis.
    2. "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF."
      Hoatlin M.E., Zhi Y., Ball H., Silvey K., Melnick A., Stone S., Arai S., Hawe N., Owen G., Zelent A., Licht J.D.
      Blood 94:3737-3747(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH ZBTB16 AND FANCC.
      Tissue: B-cell.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-294.
      Tissue: Lymph.
    4. "Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1."
      Stogios P.J., Cuesta-Seijo J.A., Chen L., Pomroy N.C., Prive G.G.
      J. Mol. Biol. 400:983-997(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-117, SUBUNIT.

    Entry informationi

    Entry nameiZBT32_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2Y4
    Secondary accession number(s): Q8WVP2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 116 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3