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Protein

Zinc finger and BTB domain-containing protein 32

Gene

ZBTB32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 395C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription by RNA polymerase II Source: ProtInc

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex
SIGNORiQ9Y2Y4

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 32
Alternative name(s):
FANCC-interacting protein
Fanconi anemia zinc finger protein
Testis zinc finger protein
Zinc finger protein 538
Gene namesi
Name:ZBTB32
Synonyms:FAZF, TZFP, ZNF538
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000011590.13
HGNCiHGNC:16763 ZBTB32
MIMi605859 gene
neXtProtiNX_Q9Y2Y4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27033
OpenTargetsiENSG00000011590
PharmGKBiPA142670541

Polymorphism and mutation databases

BioMutaiZBTB32
DMDMi74762048

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734171 – 487Zinc finger and BTB domain-containing protein 32Add BLAST487

Proteomic databases

PaxDbiQ9Y2Y4
PeptideAtlasiQ9Y2Y4
PRIDEiQ9Y2Y4
ProteomicsDBi85936

PTM databases

iPTMnetiQ9Y2Y4
PhosphoSitePlusiQ9Y2Y4

Expressioni

Tissue specificityi

Predominantly expressed in testis. Some isoforms are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000011590
CleanExiHS_ZBTB32
ExpressionAtlasiQ9Y2Y4 baseline and differential
GenevisibleiQ9Y2Y4 HS

Organism-specific databases

HPAiHPA076730

Interactioni

Subunit structurei

Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-954098,EBI-3957603From Mus musculus.

Protein-protein interaction databases

BioGridi117964, 26 interactors
IntActiQ9Y2Y4, 4 interactors
MINTiQ9Y2Y4
STRINGi9606.ENSP00000262630

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Turni11 – 14Combined sources4
Helixi16 – 24Combined sources9
Turni25 – 28Combined sources4
Beta strandi31 – 35Combined sources5
Beta strandi38 – 42Combined sources5
Helixi44 – 48Combined sources5
Helixi52 – 54Combined sources3
Beta strandi58 – 61Combined sources4
Helixi68 – 78Combined sources11
Beta strandi83 – 85Combined sources3
Helixi87 – 89Combined sources3
Helixi90 – 99Combined sources10
Helixi103 – 112Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M5BX-ray2.00A/B1-117[»]
ProteinModelPortaliQ9Y2Y4
SMRiQ9Y2Y4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2Y4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 87BTBPROSITE-ProRule annotationAdd BLAST59

Domaini

The C-terminal zinc finger domain functions as a transcriptional transactivator.By similarity
The BTB (POZ) domain possesses repressor activity.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 395C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00530000063338
HOGENOMiHOG000060112
HOVERGENiHBG079944
InParanoidiQ9Y2Y4
KOiK10506
OMAiSRPYSCS
OrthoDBiEOG091G08Z7
PhylomeDBiQ9Y2Y4
TreeFamiTF350825

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9Y2Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV
60 70 80 90 100
SQQLGRRGQW ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL
110 120 130 140 150
GVQSLEEACW RARGDRAKKP DPGLKKHQEE PEKPSRNPER ELGDPGEKQK
160 170 180 190 200
PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA TQEAQQEQTR SKEKRLQAPV
210 220 230 240 250
GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ TSVTPRPSWA
260 270 280 290 300
EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN
310 320 330 340 350
APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH
360 370 380 390 400
EDKAGCPPRP HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP
410 420 430 440 450
FSCSLCPQRS RDFSAMTKHL RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH
460 470 480
SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC CPSSSTT
Length:487
Mass (Da):52,963
Last modified:November 1, 1999 - v1
Checksum:iB528F3C2AFFC4838
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030145174R → S. Corresponds to variant dbSNP:rs2227278Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130255 mRNA Translation: AAD27708.1
AF165097 mRNA Translation: AAD48448.1
BC017700 mRNA Translation: AAH17700.1 Different termination.
CCDSiCCDS12471.1
PIRiJC7126
RefSeqiNP_001303831.1, NM_001316902.1
NP_001303832.1, NM_001316903.1
NP_055198.1, NM_014383.2
XP_011525020.1, XM_011526718.2
XP_016882078.1, XM_017026589.1
UniGeneiHs.99430

Genome annotation databases

EnsembliENST00000262630; ENSP00000262630; ENSG00000011590
ENST00000392197; ENSP00000376035; ENSG00000011590
GeneIDi27033
KEGGihsa:27033
UCSCiuc002oay.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiZBT32_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y4
Secondary accession number(s): Q8WVP2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 1, 1999
Last modified: June 20, 2018
This is version 150 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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