Zinc finger and BTB domain-containing protein 32

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Q9Y2Y4 (ZBT32_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 105. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Zinc finger and BTB domain-containing protein 32

Alternative name(s):
FANCC-interacting protein
Fanconi anemia zinc finger protein
Testis zinc finger protein
Zinc finger protein 538

Gene names

Name:	ZBTB32
Synonyms:	FAZF, TZFP, ZNF538

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells By similarity. Ref.2
Subunit structure	Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 By similarity. Ref.2 Ref.4
Subcellular location	Nucleus. Note: Located in nuclear speckles. Ref.2
Tissue specificity	Predominantly expressed in testis. Some isoforms are ubiquitously expressed. Ref.1
Domain	The C-terminal zinc finger domain functions as a transcriptional transactivator By similarity. The BTB (POZ) domain possesses repressor activity By similarity.
Sequence similarities	Belongs to the krueppel C2H2-type zinc-finger protein family. Contains 1 BTB (POZ) domain. Contains 3 C2H2-type zinc fingers.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Repeat Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	DNA repair Traceable author statement. Source: Reactome T cell proliferation Inferred from electronic annotation. Source: Compara hemopoiesis Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Traceable author statement Ref.2. Source: ProtInc regulation of cytokine production Inferred from electronic annotation. Source: Compara transcription from RNA polymerase II promoter Traceable author statement Ref.2. Source: ProtInc
Cellular_component	nuclear chromosome Inferred from electronic annotation. Source: Compara nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB transcription corepressor activity Traceable author statement Ref.2. Source: ProtInc zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Hoxa1	P09022	3	EBI-954098,EBI-3957603	From a different organism.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 487

487

Zinc finger and BTB domain-containing protein 32

PRO_0000273417

Regions

Domain

29 – 87

BTB

Zinc finger

373 – 395

C2H2-type 1

Zinc finger

401 – 423

C2H2-type 2

Zinc finger

428 – 450

C2H2-type 3

Natural variations

Natural variant

174

R → S.
Corresponds to variant rs2227278 [ dbSNP | Ensembl ].

VAR_030145

Secondary structure

487

Helix Strand Turn

Details...

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y2Y4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: B528F3C2AFFC4838
Show »

FASTA

487

52,963

        10         20         30         40         50         60 
MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV SQQLGRRGQW 

        70         80         90        100        110        120 
ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL GVQSLEEACW RARGDRAKKP 

       130        140        150        160        170        180 
DPGLKKHQEE PEKPSRNPER ELGDPGEKQK PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA 

       190        200        210        220        230        240 
TQEAQQEQTR SKEKRLQAPV GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ 

       250        260        270        280        290        300 
TSVTPRPSWA EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN 

       310        320        330        340        350        360 
APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH EDKAGCPPRP 

       370        380        390        400        410        420 
HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP FSCSLCPQRS RDFSAMTKHL 

       430        440        450        460        470        480 
RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC 


CPSSSTT

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP." Lin W.-C., Lai C.-H., Tang C.J., Huang C.-J., Tang T.K. Biochem. Biophys. Res. Commun. 264:789-795(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF." Hoatlin M.E., Zhi Y., Ball H., Silvey K., Melnick A., Stone S., Arai S., Hawe N., Owen G., Zelent A., Licht J.D. Blood 94:3737-3747(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH ZBTB16 AND FANCC. Tissue: B-cell.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-294. Tissue: Lymph.
[4]	"Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1." Stogios P.J., Cuesta-Seijo J.A., Chen L., Pomroy N.C., Prive G.G. J. Mol. Biol. 400:983-997(2010) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-117, SUBUNIT.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF130255 mRNA. Translation: AAD27708.1.
AF165097 mRNA. Translation: AAD48448.1.
BC017700 mRNA. Translation: AAH17700.1. Different termination.

IPI

IPI00003915.

PIR

JC7126.

RefSeq

NP_055198.1. NM_014383.1.

UniGene

Hs.99430.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
3M5B	X-ray	2.00	A/B	1-117	[»]

ProteinModelPortal

Q9Y2Y4.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q9Y2Y4. 3 interactions.

MINT

MINT-1452016.

STRING

9606.ENSP00000262630.

PTM databases

PhosphoSite

Q9Y2Y4.

Polymorphism databases

DMDM

74762048.

Proteomic databases

PaxDb

Q9Y2Y4.

PRIDE

Q9Y2Y4.

Protocols and materials databases

DNASU

27033.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000262630; ENSP00000262630; ENSG00000011590.
ENST00000392197; ENSP00000376035; ENSG00000011590.
ENST00000481182; ENSP00000433657; ENSG00000011590.

GeneID

27033.

KEGG

hsa:27033.

UCSC

uc002oay.3. human.

Organism-specific databases

CTD

27033.

GeneCards

GC19P036203.

HGNC

HGNC:16763. ZBTB32.

MIM

605859. gene.

neXtProt

NX_Q9Y2Y4.

PharmGKB

PA142670541.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG296621.

HOGENOM

HOG000060112.

HOVERGEN

HBG079944.

InParanoid

Q9Y2Y4.

K10506.

OMA

PWWAEAP.

OrthoDB

EOG402WS2.

PhylomeDB

Q9Y2Y4.

Enzyme and pathway databases

Reactome

REACT_216. DNA Repair.

Gene expression databases

Bgee

Q9Y2Y4.

CleanEx

HS_ZBTB32.

Genevestigator

Q9Y2Y4.

Family and domain databases

Gene3D

3.30.160.60. 2 hits.
3.30.710.10. 1 hit.

InterPro

IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]

Pfam

PF00651. BTB. 1 hit.
[Graphical view]

SMART

SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]

SUPFAM

SSF54695. BTB/POZ_fold. 1 hit.

PROSITE

PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

Q9Y2Y4.

GenomeRNAi

27033.

NextBio

49578.

SOURCE

Search...

Entry information

Entry name

ZBT32_HUMAN

Accession

Primary (citable) accession number: Q9Y2Y4
Secondary accession number(s): Q8WVP2

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 105 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Secondary structure

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents