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Protein

Zinc finger and BTB domain-containing protein 32

Gene

ZBTB32

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 395C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: UniProtKB
  • transcription corepressor activity Source: ProtInc
  • zinc ion binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011590-MONOMER.
ReactomeiR-HSA-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-HSA-6783310. Fanconi Anemia Pathway.
SIGNORiQ9Y2Y4.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 32
Alternative name(s):
FANCC-interacting protein
Fanconi anemia zinc finger protein
Testis zinc finger protein
Zinc finger protein 538
Gene namesi
Name:ZBTB32
Synonyms:FAZF, TZFP, ZNF538
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:16763. ZBTB32.

Subcellular locationi

  • Nucleus 1 Publication

  • Note: Located in nuclear speckles.

GO - Cellular componenti

  • nucleoplasm Source: Reactome
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi27033.
OpenTargetsiENSG00000011590.
PharmGKBiPA142670541.

Polymorphism and mutation databases

BioMutaiZBTB32.
DMDMi74762048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002734171 – 487Zinc finger and BTB domain-containing protein 32Add BLAST487

Proteomic databases

PaxDbiQ9Y2Y4.
PeptideAtlasiQ9Y2Y4.
PRIDEiQ9Y2Y4.

PTM databases

iPTMnetiQ9Y2Y4.
PhosphoSitePlusiQ9Y2Y4.

Expressioni

Tissue specificityi

Predominantly expressed in testis. Some isoforms are ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSG00000011590.
CleanExiHS_ZBTB32.
ExpressionAtlasiQ9Y2Y4. baseline and differential.
GenevisibleiQ9Y2Y4. HS.

Organism-specific databases

HPAiHPA052633.

Interactioni

Subunit structurei

Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-954098,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi117964. 21 interactors.
IntActiQ9Y2Y4. 4 interactors.
MINTiMINT-1452016.
STRINGi9606.ENSP00000262630.

Structurei

Secondary structure

1487
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 8Combined sources3
Turni11 – 14Combined sources4
Helixi16 – 24Combined sources9
Turni25 – 28Combined sources4
Beta strandi31 – 35Combined sources5
Beta strandi38 – 42Combined sources5
Helixi44 – 48Combined sources5
Helixi52 – 54Combined sources3
Beta strandi58 – 61Combined sources4
Helixi68 – 78Combined sources11
Beta strandi83 – 85Combined sources3
Helixi87 – 89Combined sources3
Helixi90 – 99Combined sources10
Helixi103 – 112Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M5BX-ray2.00A/B1-117[»]
ProteinModelPortaliQ9Y2Y4.
SMRiQ9Y2Y4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2Y4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 87BTBPROSITE-ProRule annotationAdd BLAST59

Domaini

The C-terminal zinc finger domain functions as a transcriptional transactivator.By similarity
The BTB (POZ) domain possesses repressor activity.By similarity

Sequence similaritiesi

Contains 1 BTB (POZ) domain.PROSITE-ProRule annotation
Contains 3 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri373 – 395C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri401 – 423C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri428 – 450C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063338.
HOGENOMiHOG000060112.
HOVERGENiHBG079944.
InParanoidiQ9Y2Y4.
KOiK10506.
OMAiSRPYSCS.
OrthoDBiEOG091G08Z7.
PhylomeDBiQ9Y2Y4.
TreeFamiTF350825.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2Y4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV
60 70 80 90 100
SQQLGRRGQW ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL
110 120 130 140 150
GVQSLEEACW RARGDRAKKP DPGLKKHQEE PEKPSRNPER ELGDPGEKQK
160 170 180 190 200
PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA TQEAQQEQTR SKEKRLQAPV
210 220 230 240 250
GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ TSVTPRPSWA
260 270 280 290 300
EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN
310 320 330 340 350
APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH
360 370 380 390 400
EDKAGCPPRP HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP
410 420 430 440 450
FSCSLCPQRS RDFSAMTKHL RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH
460 470 480
SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC CPSSSTT
Length:487
Mass (Da):52,963
Last modified:November 1, 1999 - v1
Checksum:iB528F3C2AFFC4838
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_030145174R → S.Corresponds to variant rs2227278dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130255 mRNA. Translation: AAD27708.1.
AF165097 mRNA. Translation: AAD48448.1.
BC017700 mRNA. Translation: AAH17700.1. Different termination.
CCDSiCCDS12471.1.
PIRiJC7126.
RefSeqiNP_001303831.1. NM_001316902.1.
NP_001303832.1. NM_001316903.1.
NP_055198.1. NM_014383.2.
XP_011525020.1. XM_011526718.2.
XP_016882078.1. XM_017026589.1.
UniGeneiHs.99430.

Genome annotation databases

EnsembliENST00000262630; ENSP00000262630; ENSG00000011590.
ENST00000392197; ENSP00000376035; ENSG00000011590.
GeneIDi27033.
KEGGihsa:27033.
UCSCiuc002oay.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF130255 mRNA. Translation: AAD27708.1.
AF165097 mRNA. Translation: AAD48448.1.
BC017700 mRNA. Translation: AAH17700.1. Different termination.
CCDSiCCDS12471.1.
PIRiJC7126.
RefSeqiNP_001303831.1. NM_001316902.1.
NP_001303832.1. NM_001316903.1.
NP_055198.1. NM_014383.2.
XP_011525020.1. XM_011526718.2.
XP_016882078.1. XM_017026589.1.
UniGeneiHs.99430.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3M5BX-ray2.00A/B1-117[»]
ProteinModelPortaliQ9Y2Y4.
SMRiQ9Y2Y4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117964. 21 interactors.
IntActiQ9Y2Y4. 4 interactors.
MINTiMINT-1452016.
STRINGi9606.ENSP00000262630.

PTM databases

iPTMnetiQ9Y2Y4.
PhosphoSitePlusiQ9Y2Y4.

Polymorphism and mutation databases

BioMutaiZBTB32.
DMDMi74762048.

Proteomic databases

PaxDbiQ9Y2Y4.
PeptideAtlasiQ9Y2Y4.
PRIDEiQ9Y2Y4.

Protocols and materials databases

DNASUi27033.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262630; ENSP00000262630; ENSG00000011590.
ENST00000392197; ENSP00000376035; ENSG00000011590.
GeneIDi27033.
KEGGihsa:27033.
UCSCiuc002oay.3. human.

Organism-specific databases

CTDi27033.
DisGeNETi27033.
GeneCardsiZBTB32.
HGNCiHGNC:16763. ZBTB32.
HPAiHPA052633.
MIMi605859. gene.
neXtProtiNX_Q9Y2Y4.
OpenTargetsiENSG00000011590.
PharmGKBiPA142670541.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00530000063338.
HOGENOMiHOG000060112.
HOVERGENiHBG079944.
InParanoidiQ9Y2Y4.
KOiK10506.
OMAiSRPYSCS.
OrthoDBiEOG091G08Z7.
PhylomeDBiQ9Y2Y4.
TreeFamiTF350825.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000011590-MONOMER.
ReactomeiR-HSA-110314. Recognition of DNA damage by PCNA-containing replication complex.
R-HSA-6783310. Fanconi Anemia Pathway.
SIGNORiQ9Y2Y4.

Miscellaneous databases

EvolutionaryTraceiQ9Y2Y4.
GeneWikiiZBTB32.
GenomeRNAii27033.
PROiQ9Y2Y4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000011590.
CleanExiHS_ZBTB32.
ExpressionAtlasiQ9Y2Y4. baseline and differential.
GenevisibleiQ9Y2Y4. HS.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
InterProiIPR000210. BTB/POZ_dom.
IPR011333. SKP1/BTB/POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZBT32_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y4
Secondary accession number(s): Q8WVP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 1, 1999
Last modified: November 2, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.