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Q9Y2Y4

- ZBT32_HUMAN

UniProt

Q9Y2Y4 - ZBT32_HUMAN

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Protein
Zinc finger and BTB domain-containing protein 32
Gene
ZBTB32, FAZF, TZFP, ZNF538
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

DNA-binding protein that binds to the to a 5'-TGTACAGTGT-3' core sequence. May function as a transcriptional transactivator and transcriptional repressor. Probably exerts its repressor effect by preventing GATA3 from binding to DNA. May play a role in regulating the differentiation and activation of helper T-cells By similarity.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri373 – 39523C2H2-type 1
Add
BLAST
Zinc fingeri401 – 42323C2H2-type 2
Add
BLAST
Zinc fingeri428 – 45023C2H2-type 3
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB
  2. protein binding Source: IntAct
  3. transcription corepressor activity Source: ProtInc
  4. zinc ion binding Source: UniProtKB

GO - Biological processi

  1. DNA repair Source: Reactome
  2. T cell proliferation Source: Ensembl
  3. hemopoiesis Source: Ensembl
  4. negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  5. regulation of cytokine production Source: Ensembl
  6. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_18265. Regulation of the Fanconi anemia pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 32
Alternative name(s):
FANCC-interacting protein
Fanconi anemia zinc finger protein
Testis zinc finger protein
Zinc finger protein 538
Gene namesi
Name:ZBTB32
Synonyms:FAZF, TZFP, ZNF538
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:16763. ZBTB32.

Subcellular locationi

Nucleus
Note: Located in nuclear speckles.1 Publication

GO - Cellular componenti

  1. nuclear chromosome Source: Ensembl
  2. nucleoplasm Source: Reactome
  3. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA142670541.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 487487Zinc finger and BTB domain-containing protein 32
PRO_0000273417Add
BLAST

Proteomic databases

PaxDbiQ9Y2Y4.
PRIDEiQ9Y2Y4.

PTM databases

PhosphoSiteiQ9Y2Y4.

Expressioni

Tissue specificityi

Predominantly expressed in testis. Some isoforms are ubiquitously expressed.1 Publication

Gene expression databases

ArrayExpressiQ9Y2Y4.
BgeeiQ9Y2Y4.
CleanExiHS_ZBTB32.
GenevestigatoriQ9Y2Y4.

Organism-specific databases

HPAiHPA052633.

Interactioni

Subunit structurei

Homodimer (via PTB domain). Interacts with the N-terminal of FANCC. Interacts with ZBTB16. Interacts with GATA3 By similarity.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Hoxa1P090223EBI-954098,EBI-3957603From a different organism.

Protein-protein interaction databases

BioGridi117964. 13 interactions.
IntActiQ9Y2Y4. 4 interactions.
MINTiMINT-1452016.
STRINGi9606.ENSP00000262630.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 83
Turni11 – 144
Helixi16 – 249
Turni25 – 284
Beta strandi31 – 355
Beta strandi38 – 425
Helixi44 – 485
Helixi52 – 543
Beta strandi58 – 614
Helixi68 – 7811
Beta strandi83 – 853
Helixi87 – 893
Helixi90 – 9910
Helixi103 – 11210

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3M5BX-ray2.00A/B1-117[»]
ProteinModelPortaliQ9Y2Y4.
SMRiQ9Y2Y4. Positions 5-113, 346-453.

Miscellaneous databases

EvolutionaryTraceiQ9Y2Y4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 8759BTB
Add
BLAST

Domaini

The C-terminal zinc finger domain functions as a transcriptional transactivator By similarity.
The BTB (POZ) domain possesses repressor activity By similarity.

Sequence similaritiesi

Contains 1 BTB (POZ) domain.

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiNOG296621.
HOGENOMiHOG000060112.
HOVERGENiHBG079944.
InParanoidiQ9Y2Y4.
KOiK10506.
OMAiGAWQEVW.
OrthoDBiEOG7F7W8T.
PhylomeDBiQ9Y2Y4.
TreeFamiTF350825.

Family and domain databases

Gene3Di3.30.160.60. 2 hits.
3.30.710.10. 1 hit.
InterProiIPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00651. BTB. 1 hit.
[Graphical view]
SMARTiSM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF54695. SSF54695. 1 hit.
PROSITEiPS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2Y4-1 [UniParc]FASTAAdd to Basket

« Hide

MSLPPIRLPS PYGSDRLVQL AARLRPALCD TLITVGSQEF PAHSLVLAGV    50
SQQLGRRGQW ALGEGISPST FAQLLNFVYG ESVELQPGEL RPLQEAARAL 100
GVQSLEEACW RARGDRAKKP DPGLKKHQEE PEKPSRNPER ELGDPGEKQK 150
PEQVSRTGGR EQEMLHKHSP PRGRPEMAGA TQEAQQEQTR SKEKRLQAPV 200
GQRGADGKHG VLTWLRENPG GSEESLRKLP GPLPPAGSLQ TSVTPRPSWA 250
EAPWLVGGQP ALWSILLMPP RYGIPFYHST PTTGAWQEVW REQRIPLSLN 300
APKGLWSQNQ LASSSPTPGS LPQGPAQLSP GEMEESDQGH TGALATCAGH 350
EDKAGCPPRP HPPPAPPARS RPYACSVCGK RFSLKHQMET HYRVHTGEKP 400
FSCSLCPQRS RDFSAMTKHL RTHGAAPYRC SLCGAGCPSL ASMQAHMRGH 450
SPSQLPPGWT IRSTFLYSSS RPSRPSTSPC CPSSSTT 487
Length:487
Mass (Da):52,963
Last modified:November 1, 1999 - v1
Checksum:iB528F3C2AFFC4838
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti174 – 1741R → S.
Corresponds to variant rs2227278 [ dbSNP | Ensembl ].
VAR_030145

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF130255 mRNA. Translation: AAD27708.1.
AF165097 mRNA. Translation: AAD48448.1.
BC017700 mRNA. Translation: AAH17700.1. Different termination.
CCDSiCCDS12471.1.
PIRiJC7126.
RefSeqiNP_055198.1. NM_014383.1.
XP_005258796.1. XM_005258739.1.
UniGeneiHs.99430.

Genome annotation databases

EnsembliENST00000262630; ENSP00000262630; ENSG00000011590.
ENST00000392197; ENSP00000376035; ENSG00000011590.
ENST00000481182; ENSP00000433657; ENSG00000011590.
GeneIDi27033.
KEGGihsa:27033.
UCSCiuc002oay.3. human.

Polymorphism databases

DMDMi74762048.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF130255 mRNA. Translation: AAD27708.1 .
AF165097 mRNA. Translation: AAD48448.1 .
BC017700 mRNA. Translation: AAH17700.1 . Different termination.
CCDSi CCDS12471.1.
PIRi JC7126.
RefSeqi NP_055198.1. NM_014383.1.
XP_005258796.1. XM_005258739.1.
UniGenei Hs.99430.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3M5B X-ray 2.00 A/B 1-117 [» ]
ProteinModelPortali Q9Y2Y4.
SMRi Q9Y2Y4. Positions 5-113, 346-453.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117964. 13 interactions.
IntActi Q9Y2Y4. 4 interactions.
MINTi MINT-1452016.
STRINGi 9606.ENSP00000262630.

PTM databases

PhosphoSitei Q9Y2Y4.

Polymorphism databases

DMDMi 74762048.

Proteomic databases

PaxDbi Q9Y2Y4.
PRIDEi Q9Y2Y4.

Protocols and materials databases

DNASUi 27033.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262630 ; ENSP00000262630 ; ENSG00000011590 .
ENST00000392197 ; ENSP00000376035 ; ENSG00000011590 .
ENST00000481182 ; ENSP00000433657 ; ENSG00000011590 .
GeneIDi 27033.
KEGGi hsa:27033.
UCSCi uc002oay.3. human.

Organism-specific databases

CTDi 27033.
GeneCardsi GC19P036203.
HGNCi HGNC:16763. ZBTB32.
HPAi HPA052633.
MIMi 605859. gene.
neXtProti NX_Q9Y2Y4.
PharmGKBi PA142670541.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG296621.
HOGENOMi HOG000060112.
HOVERGENi HBG079944.
InParanoidi Q9Y2Y4.
KOi K10506.
OMAi GAWQEVW.
OrthoDBi EOG7F7W8T.
PhylomeDBi Q9Y2Y4.
TreeFami TF350825.

Enzyme and pathway databases

Reactomei REACT_18265. Regulation of the Fanconi anemia pathway.

Miscellaneous databases

EvolutionaryTracei Q9Y2Y4.
GeneWikii ZBTB32.
GenomeRNAii 27033.
NextBioi 49578.
PROi Q9Y2Y4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2Y4.
Bgeei Q9Y2Y4.
CleanExi HS_ZBTB32.
Genevestigatori Q9Y2Y4.

Family and domain databases

Gene3Di 3.30.160.60. 2 hits.
3.30.710.10. 1 hit.
InterProi IPR000210. BTB/POZ-like.
IPR011333. BTB/POZ_fold.
IPR013069. BTB_POZ.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view ]
Pfami PF00651. BTB. 1 hit.
[Graphical view ]
SMARTi SM00225. BTB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view ]
SUPFAMi SSF54695. SSF54695. 1 hit.
PROSITEi PS50097. BTB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 2 hits.
PS50157. ZINC_FINGER_C2H2_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and gene structure of a novel human PLZF-related transcription factor gene, TZFP."
    Lin W.-C., Lai C.-H., Tang C.J., Huang C.-J., Tang T.K.
    Biochem. Biophys. Res. Commun. 264:789-795(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], ALTERNATIVE SPLICING, TISSUE SPECIFICITY.
    Tissue: Testis.
  2. "A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF."
    Hoatlin M.E., Zhi Y., Ball H., Silvey K., Melnick A., Stone S., Arai S., Hawe N., Owen G., Zelent A., Licht J.D.
    Blood 94:3737-3747(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, ALTERNATIVE SPLICING, INTERACTION WITH ZBTB16 AND FANCC.
    Tissue: B-cell.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-294.
    Tissue: Lymph.
  4. "Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1."
    Stogios P.J., Cuesta-Seijo J.A., Chen L., Pomroy N.C., Prive G.G.
    J. Mol. Biol. 400:983-997(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-117, SUBUNIT.

Entry informationi

Entry nameiZBT32_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y4
Secondary accession number(s): Q8WVP2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi