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Protein

DNA-directed RNA polymerase III subunit RPC10

Gene

POLR3K

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).By similarity2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 28C4-typeSequence analysisAdd BLAST24
Zinc fingeri65 – 107TFIIS-typePROSITE-ProRule annotationAdd BLAST43

GO - Molecular functioni

  • DNA-directed 5'-3' RNA polymerase activity Source: ProtInc
  • nucleic acid binding Source: InterPro
  • zinc ion binding Source: InterPro

GO - Biological processi

Keywordsi

Biological processAntiviral defense, Immunity, Innate immunity, Transcription
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-1834949 Cytosolic sensors of pathogen-associated DNA
R-HSA-73780 RNA Polymerase III Chain Elongation
R-HSA-73980 RNA Polymerase III Transcription Termination
R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation
R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter
R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter
R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase III subunit RPC10
Short name:
RNA polymerase III subunit C10
Alternative name(s):
DNA-directed RNA polymerase III subunit K
RNA polymerase III 12.5 kDa subunit
Short name:
RPC12.5
RNA polymerase III subunit C11
Short name:
HsC11p
Short name:
RPC11
Short name:
hRPC11
Gene namesi
Name:POLR3K
Synonyms:RPC11
ORF Names:My010
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000161980.5
HGNCiHGNC:14121 POLR3K
MIMi606007 gene
neXtProtiNX_Q9Y2Y1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

DNA-directed RNA polymerase, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi51728
PharmGKBiPA33521

Polymorphism and mutation databases

BioMutaiPOLR3K
DMDMi116242768

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001214751 – 108DNA-directed RNA polymerase III subunit RPC10Add BLAST108

Proteomic databases

EPDiQ9Y2Y1
MaxQBiQ9Y2Y1
PaxDbiQ9Y2Y1
PeptideAtlasiQ9Y2Y1
PRIDEiQ9Y2Y1

PTM databases

iPTMnetiQ9Y2Y1
PhosphoSitePlusiQ9Y2Y1

Expressioni

Gene expression databases

BgeeiENSG00000161980
CleanExiHS_POLR3K
GenevisibleiQ9Y2Y1 HS

Organism-specific databases

HPAiHPA005891

Interactioni

Subunit structurei

Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.By similarity

Protein-protein interaction databases

BioGridi119701, 19 interactors
IntActiQ9Y2Y1, 4 interactors
STRINGi9606.ENSP00000293860

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Y1
SMRiQ9Y2Y1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri5 – 28C4-typeSequence analysisAdd BLAST24
Zinc fingeri65 – 107TFIIS-typePROSITE-ProRule annotationAdd BLAST43

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2906 Eukaryota
COG1594 LUCA
HOGENOMiHOG000228131
HOVERGENiHBG055716
InParanoidiQ9Y2Y1
KOiK03019
OrthoDBiEOG091G13NA
PhylomeDBiQ9Y2Y1
TreeFamiTF103031

Family and domain databases

CDDicd10509 Zn-ribbon_RPC11, 1 hit
InterProiView protein in InterPro
IPR019761 DNA-dir_RNA_pol-M_15_CS
IPR001529 DNA-dir_RNA_pol_M/15kDasu
IPR012164 Rpa12/Rpb9/Rpc10/TFS
IPR034014 Zn_ribbon_RPC11_C
IPR001222 Znf_TFIIS
PfamiView protein in Pfam
PF02150 RNA_POL_M_15KD, 1 hit
PF01096 TFIIS_C, 1 hit
PIRSFiPIRSF005586 RNApol_RpoM, 1 hit
SMARTiView protein in SMART
SM00661 RPOL9, 1 hit
SM00440 ZnF_C2C2, 1 hit
PROSITEiView protein in PROSITE
PS01030 RNA_POL_M_15KD, 1 hit
PS00466 ZF_TFIIS_1, 1 hit
PS51133 ZF_TFIIS_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y2Y1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLFCPGCGN GLIVEEGQRC HRFSCNTCPY VHNITRKVTN RKYPKLKEVD
60 70 80 90 100
DVLGGAAAWE NVDSTAESCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA

QCGHRWRD
Length:108
Mass (Da):12,336
Last modified:October 17, 2006 - v2
Checksum:i2C85F2F2AA907CE5
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02791824S → A5 PublicationsCorresponds to variant dbSNP:rs183360Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126531 Genomic DNA Translation: AAD31424.1
AF051316 mRNA Translation: AAF18268.1
AF060223 mRNA Translation: AAG43123.1
DQ431198 Genomic DNA Translation: ABD95903.1
AE006462 Genomic DNA Translation: AAK61210.1
Z69719 Genomic DNA Translation: CAI95605.1
BC011932 mRNA Translation: AAH11932.1
CCDSiCCDS10395.1
RefSeqiNP_057394.3, NM_016310.4
UniGeneiHs.632223

Genome annotation databases

EnsembliENST00000293860; ENSP00000293860; ENSG00000161980
GeneIDi51728
KEGGihsa:51728
UCSCiuc002cfi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRPC10_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Y1
Secondary accession number(s): Q1W6H4, Q96S35
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: October 17, 2006
Last modified: May 23, 2018
This is version 167 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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