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Q9Y2X9

- ZN281_HUMAN

UniProt

Q9Y2X9 - ZN281_HUMAN

Protein

Zinc finger protein 281

Gene

ZNF281

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Transcription repressor that plays a role in regulation of embryonic stem cells (ESCs) differentiation. Required for ESCs differentiation and acts by mediating autorepression of NANOG in ESCs: binds to the NANOG promoter and promotes association of NANOG protein to its own promoter and recruits the NuRD complex, which deacetylates histones. Not required for establishement and maintenance of ESCs By similarity. Represses the transcription of a number of genes including GAST, ODC1 and VIM. Binds to the G-rich box in the enhancer region of these genes.By similarity2 Publications

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. core promoter binding Source: UniProtKB
    2. metal ion binding Source: UniProtKB-KW
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding Source: UniProtKB
    5. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    6. transcription corepressor activity Source: UniProtKB
    7. transcription regulatory region DNA binding Source: UniProtKB

    GO - Biological processi

    1. embryonic body morphogenesis Source: UniProtKB
    2. negative regulation of gene expression Source: UniProtKB
    3. negative regulation of transcription, DNA-templated Source: UniProtKB
    4. positive regulation of transcription, DNA-templated Source: UniProtKB
    5. stem cell differentiation Source: UniProtKB
    6. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Zinc finger protein 281
    Alternative name(s):
    GC-box-binding zinc finger protein 1
    Transcription factor ZBP-99
    Zinc finger DNA-binding protein 99
    Gene namesi
    Name:ZNF281
    Synonyms:GZP1, ZBP99
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13075. ZNF281.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA37651.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 895895Zinc finger protein 281PRO_0000047505Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei395 – 3951Phosphoserine1 Publication
    Modified residuei484 – 4841Phosphoserine1 Publication
    Modified residuei785 – 7851Phosphoserine1 Publication
    Modified residuei807 – 8071Phosphoserine1 Publication

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y2X9.
    PaxDbiQ9Y2X9.
    PRIDEiQ9Y2X9.

    PTM databases

    PhosphoSiteiQ9Y2X9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2X9.
    BgeeiQ9Y2X9.
    CleanExiHS_ZNF281.
    GenevestigatoriQ9Y2X9.

    Organism-specific databases

    HPAiHPA051228.

    Interactioni

    Protein-protein interaction databases

    BioGridi117074. 20 interactions.
    IntActiQ9Y2X9. 8 interactions.
    STRINGi9606.ENSP00000294740.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2X9.
    SMRiQ9Y2X9. Positions 223-366.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi4 – 3734Gly-richAdd
    BLAST
    Compositional biasi90 – 967Poly-Pro
    Compositional biasi141 – 1488Poly-His

    Sequence similaritiesi

    Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri261 – 28323C2H2-type 1PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri289 – 31123C2H2-type 2PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri317 – 33923C2H2-type 3PROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri345 – 36723C2H2-type 4; atypicalPROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5048.
    HOGENOMiHOG000293204.
    HOVERGENiHBG055321.
    InParanoidiQ9Y2X9.
    OMAiQKDIEPR.
    OrthoDBiEOG7VDXNJ.
    PhylomeDBiQ9Y2X9.
    TreeFamiTF331779.

    Family and domain databases

    Gene3Di3.30.160.60. 4 hits.
    InterProiIPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view]
    SMARTiSM00355. ZnF_C2H2. 4 hits.
    [Graphical view]
    PROSITEiPS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2X9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKIGSGFLSG GGGTGSSGGS GSGGGGSGGG GGGGSSGRRA EMEPTFPQGM    50
    VMFNHRLPPV TSFTRPAGSA APPPQCVLSS STSAAPAAEP PPPPAPDMTF 100
    KKEPAASAAA FPSQRTSWGF LQSLVSIKQE KPADPEEQQS HHHHHHHHYG 150
    GLFAGAEERS PGLGGGEGGS HGVIQDLSIL HQHVQQQPAQ HHRDVLLSSS 200
    SRTDDHHGTE EPKQDTNVKK AKRPKPESQG IKAKRKPSAS SKPSLVGDGE 250
    GAILSPSQKP HICDHCSAAF RSSYHLRRHV LIHTGERPFQ CSQCSMGFIQ 300
    KYLLQRHEKI HSREKPFGCD QCSMKFIQKY HMERHKRTHS GEKPYKCDTC 350
    QQYFSRTDRL LKHRRTCGEV IVKGATSAEP GSSNHTNMGN LAVLSQGNTS 400
    SSRRKTKSKS IAIENKEQKT GKTNESQISN NINMQSYSVE MPTVSSSGGI 450
    IGTGIDELQK RVPKLIFKKG SRKNTDKNYL NFVSPLPDIV GQKSLSGKPS 500
    GSLGIVSNNS VETIGLLQST SGKQGQISSN YDDAMQFSKK RRYLPTASSN 550
    SAFSINVGHM VSQQSVIQSA GVSVLDNEAP LSLIDSSALN AEIKSCHDKS 600
    GIPDEVLQSI LDQYSNKSES QKEDPFNIAE PRVDLHTSGE HSELVQEENL 650
    SPGTQTPSND KASMLQEYSK YLQQAFEKST NASFTLGHGF QFVSLSSPLH 700
    NHTLFPEKQI YTTSPLECGF GQSVTSVLPS SLPKPPFGML FGSQPGLYLS 750
    ALDATHQQLT PSQELDDLID SQKNLETSSA FQSSSQKLTS QKEQKNLESS 800
    TGFQIPSQEL ASQIDPQKDI EPRTTYQIEN FAQAFGSQFK SGSRVPMTFI 850
    TNSNGEVDHR VRTSVSDFSG YTNMMSDVSE PCSTRVKTPT SQSYR 895
    Length:895
    Mass (Da):96,915
    Last modified:November 1, 1999 - v1
    Checksum:i556FAAEA8D095FB7
    GO
    Isoform 2 (identifier: Q9Y2X9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         49-84: Missing.

    Note: Gene prediction based on EST data.

    Show »
    Length:859
    Mass (Da):93,232
    Checksum:i180A44DE154DD4FD
    GO

    Sequence cautioni

    The sequence CAB70967.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti63 – 631F → L in BAG51134. (PubMed:14702039)Curated
    Sequence conflicti206 – 2061H → Y in AAH51905. (PubMed:15489334)Curated
    Sequence conflicti482 – 4821F → L in BAG51134. (PubMed:14702039)Curated
    Sequence conflicti635 – 6351L → I in BAG51134. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti527 – 5271I → T in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035576

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei49 – 8436Missing in isoform 2. CuratedVSP_054815Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125158 mRNA. Translation: AAD21084.1.
    AJ132591 mRNA. Translation: CAB70967.1. Different initiation.
    AJ132592 mRNA. Translation: CAB70968.1.
    AK022916 mRNA. Translation: BAG51134.1.
    AC104461 Genomic DNA. No translation available.
    BC051905 mRNA. Translation: AAH51905.1.
    BC060820 mRNA. Translation: AAH60820.1.
    CCDSiCCDS1402.1. [Q9Y2X9-1]
    CCDS60384.1. [Q9Y2X9-2]
    PIRiJC7089.
    RefSeqiNP_001268222.1. NM_001281293.1. [Q9Y2X9-1]
    NP_001268223.1. NM_001281294.1. [Q9Y2X9-2]
    NP_036614.1. NM_012482.4. [Q9Y2X9-1]
    UniGeneiHs.59757.
    Hs.703449.
    Hs.735801.

    Genome annotation databases

    EnsembliENST00000294740; ENSP00000294740; ENSG00000162702. [Q9Y2X9-1]
    ENST00000367352; ENSP00000356321; ENSG00000162702. [Q9Y2X9-2]
    ENST00000367353; ENSP00000356322; ENSG00000162702. [Q9Y2X9-1]
    GeneIDi23528.
    KEGGihsa:23528.
    UCSCiuc001gve.3. human. [Q9Y2X9-1]

    Polymorphism databases

    DMDMi13124664.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF125158 mRNA. Translation: AAD21084.1 .
    AJ132591 mRNA. Translation: CAB70967.1 . Different initiation.
    AJ132592 mRNA. Translation: CAB70968.1 .
    AK022916 mRNA. Translation: BAG51134.1 .
    AC104461 Genomic DNA. No translation available.
    BC051905 mRNA. Translation: AAH51905.1 .
    BC060820 mRNA. Translation: AAH60820.1 .
    CCDSi CCDS1402.1. [Q9Y2X9-1 ]
    CCDS60384.1. [Q9Y2X9-2 ]
    PIRi JC7089.
    RefSeqi NP_001268222.1. NM_001281293.1. [Q9Y2X9-1 ]
    NP_001268223.1. NM_001281294.1. [Q9Y2X9-2 ]
    NP_036614.1. NM_012482.4. [Q9Y2X9-1 ]
    UniGenei Hs.59757.
    Hs.703449.
    Hs.735801.

    3D structure databases

    ProteinModelPortali Q9Y2X9.
    SMRi Q9Y2X9. Positions 223-366.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117074. 20 interactions.
    IntActi Q9Y2X9. 8 interactions.
    STRINGi 9606.ENSP00000294740.

    PTM databases

    PhosphoSitei Q9Y2X9.

    Polymorphism databases

    DMDMi 13124664.

    Proteomic databases

    MaxQBi Q9Y2X9.
    PaxDbi Q9Y2X9.
    PRIDEi Q9Y2X9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000294740 ; ENSP00000294740 ; ENSG00000162702 . [Q9Y2X9-1 ]
    ENST00000367352 ; ENSP00000356321 ; ENSG00000162702 . [Q9Y2X9-2 ]
    ENST00000367353 ; ENSP00000356322 ; ENSG00000162702 . [Q9Y2X9-1 ]
    GeneIDi 23528.
    KEGGi hsa:23528.
    UCSCi uc001gve.3. human. [Q9Y2X9-1 ]

    Organism-specific databases

    CTDi 23528.
    GeneCardsi GC01M200375.
    HGNCi HGNC:13075. ZNF281.
    HPAi HPA051228.
    neXtProti NX_Q9Y2X9.
    PharmGKBi PA37651.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5048.
    HOGENOMi HOG000293204.
    HOVERGENi HBG055321.
    InParanoidi Q9Y2X9.
    OMAi QKDIEPR.
    OrthoDBi EOG7VDXNJ.
    PhylomeDBi Q9Y2X9.
    TreeFami TF331779.

    Miscellaneous databases

    GeneWikii ZNF281.
    GenomeRNAii 23528.
    NextBioi 35462517.
    PROi Q9Y2X9.

    Gene expression databases

    ArrayExpressi Q9Y2X9.
    Bgeei Q9Y2X9.
    CleanExi HS_ZNF281.
    Genevestigatori Q9Y2X9.

    Family and domain databases

    Gene3Di 3.30.160.60. 4 hits.
    InterProi IPR007087. Znf_C2H2.
    IPR015880. Znf_C2H2-like.
    IPR013087. Znf_C2H2/integrase_DNA-bd.
    [Graphical view ]
    SMARTi SM00355. ZnF_C2H2. 4 hits.
    [Graphical view ]
    PROSITEi PS00028. ZINC_FINGER_C2H2_1. 3 hits.
    PS50157. ZINC_FINGER_C2H2_2. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "ZBP-99 defines a conserved family of transcription factors and regulates ornithine decarboxylase gene expression."
      Law D.J., Du M., Law G.L., Merchant J.L.
      Biochem. Biophys. Res. Commun. 262:113-120(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION.
    2. "Identification of human GC-box-binding zinc finger protein, a new Krueppel-like zinc finger protein, by the yeast one-hybrid screening with a GC-rich target sequence."
      Lisowsky T., Loguercio Polosa P., Sagliano A., Roberti M., Gadaleta M.N., Cantatore P.
      FEBS Lett. 453:369-374(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Liver.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta and Skin.
    6. "ZBP-89 represses vimentin gene transcription by interacting with the transcriptional activator, Sp1."
      Zhang X., Diab I.H., Zehner Z.E.
      Nucleic Acids Res. 31:2900-2914(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    7. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-395; SER-785 AND SER-807, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-484, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: VARIANT [LARGE SCALE ANALYSIS] THR-527.

    Entry informationi

    Entry nameiZN281_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2X9
    Secondary accession number(s): A6NF48
    , B3KMX2, Q5RKW5, Q9NY92
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3