Reviewed,
UniProtKB/Swiss-Prot Q9Y2X8 (UB2D4_HUMAN)
Last modified
January 19, 2010.
Version 73.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ubiquitin-conjugating enzyme E2 D4 EC=6.3.2.19 Alternative name(s): Ubiquitin-protein ligase D4 Ubiquitin carrier protein D4 HBUCE1 | ||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||
| Taxonomic identifier | 9606 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 147 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins By similarity. |
| Catalytic activity | ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. |
| Pathway | |
| Sequence similarities | Belongs to the ubiquitin-conjugating enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Ubl conjugation pathway |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| PTM | Acetylation |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | modification-dependent protein catabolic process Inferred from electronic annotation. Source: UniProtKB-KW post-translational protein modificationInferred from electronic annotation. Source: InterPro regulation of protein metabolic processInferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from physical interaction. Source: IntAct ubiquitin-protein ligase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular cloning and screening of two ubiquitin conjugation enzymes." Li G., Jin J., Hu S., Li W., Yuan J., Qiang B. Submitted (JAN-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. Tsui L.-C.Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
| [6] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-144, MASS SPECTROMETRY. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF125044 mRNA. Translation: AAD31180.1. AK001446 mRNA. Translation: BAA91697.1. CH236951 Genomic DNA. Translation: EAL24010.1. CH471073 Genomic DNA. Translation: EAW94182.1. BC004104 mRNA. Translation: AAH04104.1. |
| IPI | IPI00006475. |
| RefSeq | NP_057067.1. |
| UniGene | Hs.19196 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1Z2U based on UniProtKB P35129. |
| SMR | Q9Y2X8. Positions 1-147. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q9Y2X8. 56 interactions. |
| STRING | Q9Y2X8. |
Proteomic databases | |
| PRIDE | Q9Y2X8. |
Genome annotation databases | |
| Ensembl | ENST00000222402; ENSP00000222402; ENSG00000078967; Homo sapiens. [Genome view] |
| GeneID | 51619. |
| KEGG | hsa:51619. |
| UCSC | uc003tja.1. human. |
Organism-specific databases | |
| CTD | 51619. |
| GeneCards | GC07P043932. |
| HGNC | HGNC:21647. UBE2D4. |
| HPA | HPA003920. |
| PharmGKB | PA134954568. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG756483. |
| HOVERGEN | Q9Y2X8. |
| InParanoid | Q9Y2X8. |
| OMA | PEIAHMC. |
| OrthoDB | EOG9GXJ67. |
| PhylomeDB | Q9Y2X8. |
Enzyme and pathway databases | |
| BRENDA | 6.3.2.19. 247. |
Gene expression databases | |
| ArrayExpress | Q9Y2X8. |
| Bgee | Q9Y2X8. |
| CleanEx | HS_UBE2D4. |
| Genevestigator | Q9Y2X8. |
Family and domain databases | |
| InterPro | IPR016135. UBQ-conjugat/RWD-like. IPR000608. UBQ-conjugat_E2. [Graphical view] |
| Gene3D | G3DSA:3.10.110.10. UBQ-conjugat_E2. 1 hit. |
| Pfam | PF00179. UQ_con. 1 hit. [Graphical view] |
| SMART | SM00212. UBCc. 1 hit. [Graphical view] |
| PROSITE | PS00183. UBIQUITIN_CONJUGAT_1. 1 hit. PS50127. UBIQUITIN_CONJUGAT_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 55531. |
Entry information
| Entry name | UB2D4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y2X8 Secondary accession number(s): A4D1V0 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 7 Human chromosome 7: entries, gene names and cross-references to MIM |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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