Q9Y2X0 (MED16_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Mediator of RNA polymerase II transcription subunit 16

Alternative name(s):
Mediator complex subunit 16
Thyroid hormone receptor-associated protein 5
Thyroid hormone receptor-associated protein complex 95 kDa component
Short name=Trap95
Vitamin D3 receptor-interacting protein complex 92 kDa component
Short name=DRIP92

Gene names

Name:	MED16
Synonyms:	DRIP92, THRAP5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	877 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Ref.1 Ref.2
Subunit structure	Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP. Ref.1 Ref.2 Ref.4 Ref.5
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the Mediator complex subunit 16 family. Contains 5 WD repeats.
Caution	It is uncertain whether Met-1 or Met-13 is the initiator.
Sequence caution	The sequence AAD31087.1 differs from that shown. Reason: Frameshift at position 609.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat WD repeat
Molecular function	Activator
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	androgen receptor signaling pathway Inferred from direct assay PubMed 12218053. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from direct assay Ref.1. Source: UniProtKB regulation of transcription from RNA polymerase II promoter Non-traceable author statement Ref.1. Source: UniProtKB transcription initiation from RNA polymerase II promoter Inferred from direct assay PubMed 12218053. Source: UniProtKB
Cellular_component	mediator complex Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	receptor activity Inferred from direct assay PubMed 12218053. Source: UniProtKB thyroid hormone receptor binding Inferred from direct assay Ref.1. Source: UniProtKB thyroid hormone receptor coactivator activity Inferred from direct assay Ref.1. Source: UniProtKB vitamin D receptor binding Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 Ref.1 (identifier: Q9Y2X0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2X0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     829-877: AVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP → CGGLWWRVPLSYP

Isoform 3 (identifier: Q9Y2X0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     700-700: C → FPSTGPCSVWVLLGWQPLPG
     829-877: AVEGRGPDACVTSRASEEAPAFVQLGPQSTHHSPRTPRSLDHLHPEDRP → CGGLWWRVPLSYP

Note: No experimental confirmation available.

Isoform 4 (identifier: Q9Y2X0-4)

The sequence of this isoform differs from the canonical sequence as follows:
     636-751: GSLLRPGHSF...LQPKQPLRLQ → VAMRAQRASR...CSSRPTEPRR
     752-877: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q9Y2X0-5)

The sequence of this isoform differs from the canonical sequence as follows:
     636-663: GSLLRPGHSFLRDGTSLGMLRELMVVIR → PCPTSEPCPTSEPSPTSEPSPTSEPSSP
     664-877: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 877	877	Mediator of RNA polymerase II transcription subunit 16		PRO_0000051292
Regions
	Repeat	79 – 118	40	WD 1
	Repeat	210 – 252	43	WD 2
	Repeat	275 – 319	45	WD 3
	Repeat	634 – 675	42	WD 4
	Repeat	790 – 829	40	WD 5
Natural variations
	Alternative sequence	636 – 751	116	GSLLR…PLRLQ → VAMRAQRASRTRRWWMNAAC CPASCLSPAWTGCQPATAWL AACSPSSPFVCSLAGRPRCL AVLPPCSSTASPGPQASPRS TTCGGCTLALAPRRNARPAP GAAVSPCSSRPTEPRR in isoform 4.		VSP_051721
	Alternative sequence	636 – 663	28	GSLLR…MVVIR → PCPTSEPCPTSEPSPTSEPS PTSEPSSP in isoform 5.		VSP_028749
	Alternative sequence	664 – 877	214	Missing in isoform 5.		VSP_028750
	Alternative sequence	700	1	C → FPSTGPCSVWVLLGWQPLPG in isoform 3.		VSP_051722
	Alternative sequence	752 – 877	126	Missing in isoform 4.		VSP_051723
	Alternative sequence	829 – 877	49	AVEGR…PEDRP → CGGLWWRVPLSYP in isoform 2 and isoform 3. Ref.2		VSP_051724
	Natural variant	770	1	L → F. Corresponds to variant rs34859566 [ dbSNP | Ensembl ].		VAR_053958
	Natural variant	874	1	E → K. Corresponds to variant rs13090 [ dbSNP | Ensembl ].		VAR_053959
Experimental info
	Sequence conflict	46	1	A → T in AAD30032. Ref.1
	Sequence conflict	211	1	G → A in AAD31087. Ref.2
	Sequence conflict	412	1	R → K in AAD30032. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 12, 2005. Version 2. Checksum: 15173F237A75D230	FASTA	877	96,793
	10 20 30 40 50 60 MCDLRRPAAG GMMDLAYVCE WEKWSKSTHC PSVPLACAWS CRNLIAFTMD LRSDDQDLTR 70 80 90 100 110 120 MIHILDTEHP WDLHSIPSEH HEAITCLEWD QSGSRLLSAD ADGQIKCWSM ADHLANSWES 130 140 150 160 170 180 SVGSLVEGDP IVALSWLHNG VKLALHVEKS GASSFGEKFS RVKFSPSLTL FGGKPMEGWI 190 200 210 220 230 240 AVTVSGLVTV SLLKPSGQVL TSTESLCRLR GRVALADIAF TGGGNIVVAT ADGSSASPVQ 250 260 270 280 290 300 FYKVCVSVVS EKCRIDTEIL PSLFMRCTTD LNRKDKFPAI THLKFLARDM SEQVLLCASS 310 320 330 340 350 360 QTSSIVECWS LRKEGLPVNN IFQQISPVVG DKQPTILKWR ILSATNDLDR VSAVALPKLP 370 380 390 400 410 420 ISLTNTDLKV ASDTQFYPGL GLALAFHDGS VHIVHRLSLQ TMAVFYSSAA PRPVDEPAMK 430 440 450 460 470 480 RPRTAGPAVH LKAMQLSWTS LALVGIDSHG KLSVLRLSPS MGHPLEVGLA LRHLLFLLEY 490 500 510 520 530 540 CMVTGYDWWD ILLHVQPSMV QSLVEKLHEE YTRQTAALQQ VLSTRILAMK ASLCKLSPCT 550 560 570 580 590 600 VTRVCDYHTK LFLIAISSTL KSLLRPHFLN TPDKSPGDRL TEICTKITDV DIDKVMINLK 610 620 630 640 650 660 TEEFVLDMNT LQALQQLLQW VGDFVLYLLA SLPNQGSLLR PGHSFLRDGT SLGMLRELMV 670 680 690 700 710 720 VIRIWGLLKP SCLPVYTATS DTQDSMSLLF RLLTKLWICC RDEGPASEPD EALVDECCLL 730 740 750 760 770 780 PSQLLIPSLD WLPASDGLVS RLQPKQPLRL QFGRAPTLPG SAATLQLDGL ARAPGQPKID 790 800 810 820 830 840 HLRRLHLGAC PTEECKACTR CGCVTMLKSP NRTTAVKQWE QRWIKNCLAV EGRGPDACVT 850 860 870 SRASEEAPAF VQLGPQSTHH SPRTPRSLDH LHPEDRP
	Isoform 2 [UniParc]. Checksum: 2D9CAF68001320C3	FASTA	841	93,029
	10 20 30 40 50 60 MCDLRRPAAG GMMDLAYVCE WEKWSKSTHC PSVPLACAWS CRNLIAFTMD LRSDDQDLTR 70 80 90 100 110 120 MIHILDTEHP WDLHSIPSEH HEAITCLEWD QSGSRLLSAD ADGQIKCWSM ADHLANSWES 130 140 150 160 170 180 SVGSLVEGDP IVALSWLHNG VKLALHVEKS GASSFGEKFS RVKFSPSLTL FGGKPMEGWI 190 200 210 220 230 240 AVTVSGLVTV SLLKPSGQVL TSTESLCRLR GRVALADIAF TGGGNIVVAT ADGSSASPVQ 250 260 270 280 290 300 FYKVCVSVVS EKCRIDTEIL PSLFMRCTTD LNRKDKFPAI THLKFLARDM SEQVLLCASS 310 320 330 340 350 360 QTSSIVECWS LRKEGLPVNN IFQQISPVVG DKQPTILKWR ILSATNDLDR VSAVALPKLP 370 380 390 400 410 420 ISLTNTDLKV ASDTQFYPGL GLALAFHDGS VHIVHRLSLQ TMAVFYSSAA PRPVDEPAMK 430 440 450 460 470 480 RPRTAGPAVH LKAMQLSWTS LALVGIDSHG KLSVLRLSPS MGHPLEVGLA LRHLLFLLEY 490 500 510 520 530 540 CMVTGYDWWD ILLHVQPSMV QSLVEKLHEE YTRQTAALQQ VLSTRILAMK ASLCKLSPCT 550 560 570 580 590 600 VTRVCDYHTK LFLIAISSTL KSLLRPHFLN TPDKSPGDRL TEICTKITDV DIDKVMINLK 610 620 630 640 650 660 TEEFVLDMNT LQALQQLLQW VGDFVLYLLA SLPNQGSLLR PGHSFLRDGT SLGMLRELMV 670 680 690 700 710 720 VIRIWGLLKP SCLPVYTATS DTQDSMSLLF RLLTKLWICC RDEGPASEPD EALVDECCLL 730 740 750 760 770 780 PSQLLIPSLD WLPASDGLVS RLQPKQPLRL QFGRAPTLPG SAATLQLDGL ARAPGQPKID 790 800 810 820 830 840 HLRRLHLGAC PTEECKACTR CGCVTMLKSP NRTTAVKQWE QRWIKNCLCG GLWWRVPLSY P
	Isoform 3 [UniParc]. Checksum: 546EA25BE3AB56CF	FASTA	860	95,050
	10 20 30 40 50 60 MCDLRRPAAG GMMDLAYVCE WEKWSKSTHC PSVPLACAWS CRNLIAFTMD LRSDDQDLTR 70 80 90 100 110 120 MIHILDTEHP WDLHSIPSEH HEAITCLEWD QSGSRLLSAD ADGQIKCWSM ADHLANSWES 130 140 150 160 170 180 SVGSLVEGDP IVALSWLHNG VKLALHVEKS GASSFGEKFS RVKFSPSLTL FGGKPMEGWI 190 200 210 220 230 240 AVTVSGLVTV SLLKPSGQVL TSTESLCRLR GRVALADIAF TGGGNIVVAT ADGSSASPVQ 250 260 270 280 290 300 FYKVCVSVVS EKCRIDTEIL PSLFMRCTTD LNRKDKFPAI THLKFLARDM SEQVLLCASS 310 320 330 340 350 360 QTSSIVECWS LRKEGLPVNN IFQQISPVVG DKQPTILKWR ILSATNDLDR VSAVALPKLP 370 380 390 400 410 420 ISLTNTDLKV ASDTQFYPGL GLALAFHDGS VHIVHRLSLQ TMAVFYSSAA PRPVDEPAMK 430 440 450 460 470 480 RPRTAGPAVH LKAMQLSWTS LALVGIDSHG KLSVLRLSPS MGHPLEVGLA LRHLLFLLEY 490 500 510 520 530 540 CMVTGYDWWD ILLHVQPSMV QSLVEKLHEE YTRQTAALQQ VLSTRILAMK ASLCKLSPCT 550 560 570 580 590 600 VTRVCDYHTK LFLIAISSTL KSLLRPHFLN TPDKSPGDRL TEICTKITDV DIDKVMINLK 610 620 630 640 650 660 TEEFVLDMNT LQALQQLLQW VGDFVLYLLA SLPNQGSLLR PGHSFLRDGT SLGMLRELMV 670 680 690 700 710 720 VIRIWGLLKP SCLPVYTATS DTQDSMSLLF RLLTKLWICF PSTGPCSVWV LLGWQPLPGR 730 740 750 760 770 780 DEGPASEPDE ALVDECCLLP SQLLIPSLDW LPASDGLVSR LQPKQPLRLQ FGRAPTLPGS 790 800 810 820 830 840 AATLQLDGLA RAPGQPKIDH LRRLHLGACP TEECKACTRC GCVTMLKSPN RTTAVKQWEQ 850 860 RWIKNCLCGG LWWRVPLSYP
	Isoform 4 [UniParc]. Checksum: 6B77C11B864902BD	FASTA	751	82,179
	10 20 30 40 50 60 MCDLRRPAAG GMMDLAYVCE WEKWSKSTHC PSVPLACAWS CRNLIAFTMD LRSDDQDLTR 70 80 90 100 110 120 MIHILDTEHP WDLHSIPSEH HEAITCLEWD QSGSRLLSAD ADGQIKCWSM ADHLANSWES 130 140 150 160 170 180 SVGSLVEGDP IVALSWLHNG VKLALHVEKS GASSFGEKFS RVKFSPSLTL FGGKPMEGWI 190 200 210 220 230 240 AVTVSGLVTV SLLKPSGQVL TSTESLCRLR GRVALADIAF TGGGNIVVAT ADGSSASPVQ 250 260 270 280 290 300 FYKVCVSVVS EKCRIDTEIL PSLFMRCTTD LNRKDKFPAI THLKFLARDM SEQVLLCASS 310 320 330 340 350 360 QTSSIVECWS LRKEGLPVNN IFQQISPVVG DKQPTILKWR ILSATNDLDR VSAVALPKLP 370 380 390 400 410 420 ISLTNTDLKV ASDTQFYPGL GLALAFHDGS VHIVHRLSLQ TMAVFYSSAA PRPVDEPAMK 430 440 450 460 470 480 RPRTAGPAVH LKAMQLSWTS LALVGIDSHG KLSVLRLSPS MGHPLEVGLA LRHLLFLLEY 490 500 510 520 530 540 CMVTGYDWWD ILLHVQPSMV QSLVEKLHEE YTRQTAALQQ VLSTRILAMK ASLCKLSPCT 550 560 570 580 590 600 VTRVCDYHTK LFLIAISSTL KSLLRPHFLN TPDKSPGDRL TEICTKITDV DIDKVMINLK 610 620 630 640 650 660 TEEFVLDMNT LQALQQLLQW VGDFVLYLLA SLPNQVAMRA QRASRTRRWW MNAACCPASC 670 680 690 700 710 720 LSPAWTGCQP ATAWLAACSP SSPFVCSLAG RPRCLAVLPP CSSTASPGPQ ASPRSTTCGG 730 740 750 CTLALAPRRN ARPAPGAAVS PCSSRPTEPR R
	Isoform 5 [UniParc]. Checksum: 311F7B98C3912283	FASTA	663	72,967
	10 20 30 40 50 60 MCDLRRPAAG GMMDLAYVCE WEKWSKSTHC PSVPLACAWS CRNLIAFTMD LRSDDQDLTR 70 80 90 100 110 120 MIHILDTEHP WDLHSIPSEH HEAITCLEWD QSGSRLLSAD ADGQIKCWSM ADHLANSWES 130 140 150 160 170 180 SVGSLVEGDP IVALSWLHNG VKLALHVEKS GASSFGEKFS RVKFSPSLTL FGGKPMEGWI 190 200 210 220 230 240 AVTVSGLVTV SLLKPSGQVL TSTESLCRLR GRVALADIAF TGGGNIVVAT ADGSSASPVQ 250 260 270 280 290 300 FYKVCVSVVS EKCRIDTEIL PSLFMRCTTD LNRKDKFPAI THLKFLARDM SEQVLLCASS 310 320 330 340 350 360 QTSSIVECWS LRKEGLPVNN IFQQISPVVG DKQPTILKWR ILSATNDLDR VSAVALPKLP 370 380 390 400 410 420 ISLTNTDLKV ASDTQFYPGL GLALAFHDGS VHIVHRLSLQ TMAVFYSSAA PRPVDEPAMK 430 440 450 460 470 480 RPRTAGPAVH LKAMQLSWTS LALVGIDSHG KLSVLRLSPS MGHPLEVGLA LRHLLFLLEY 490 500 510 520 530 540 CMVTGYDWWD ILLHVQPSMV QSLVEKLHEE YTRQTAALQQ VLSTRILAMK ASLCKLSPCT 550 560 570 580 590 600 VTRVCDYHTK LFLIAISSTL KSLLRPHFLN TPDKSPGDRL TEICTKITDV DIDKVMINLK 610 620 630 640 650 660 TEEFVLDMNT LQALQQLLQW VGDFVLYLLA SLPNQPCPTS EPCPTSEPSP TSEPSPTSEP SSP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators." Ito M., Yuan C.-X., Malik S., Gu W., Fondell J.D., Yamamura S., Fu Z.-Y., Zhang X., Qin J., Roeder R.G. Mol. Cell 3:361-370(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 277-283, IDENTIFICATION IN TRAP COMPLEX, FUNCTION OF TRAP COMPLEX. Tissue: Cervix carcinoma.
[2]	"Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex." Rachez C., Lemon B.D., Suldan Z., Bromleigh V., Gamble M., Naeaer A.M., Erdjument-Bromage H., Tempst P., Freedman L.P. Nature 398:824-828(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5), PROTEIN SEQUENCE OF 27-42 AND 755-772, IDENTIFICATION IN ARC COMPLEX, FUNCTION OF ARC COMPLEX. Tissue: B-cell.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 248-877 (ISOFORM 4). Tissue: Skin and Uterus.
[4]	"A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology." Sato S., Tomomori-Sato C., Parmely T.J., Florens L., Zybailov B., Swanson S.K., Banks C.A.S., Jin J., Cai Y., Washburn M.P., Conaway J.W., Conaway R.C. Mol. Cell 14:685-691(2004) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX.
[5]	"MED1/TRAP220 exists predominantly in a TRAP/Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription." Zhang X., Krutchinsky A., Fukuda A., Chen W., Yamamura S., Chait B.T., Roeder R.G. Mol. Cell 19:89-100(2005) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH MED1; MED10; MED21 AND MED30, IDENTIFICATION BY MASS SPECTROMETRY, IDENTIFICATION IN THE MEDIATOR COMPLEX, ASSOCIATION OF THE MEDIATOR COMPLEX WITH RNA POLYMERASE II.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF121228 mRNA. Translation: AAD30032.1. AF106934 mRNA. Translation: AAD31087.1. Frameshift. BC004554 mRNA. Translation: AAH04554.1. BC007853 mRNA. Translation: AAH07853.2. BC011841 mRNA. Translation: AAH11841.1. BC017282 mRNA. Translation: AAH17282.1.
IPI	IPI00037401. IPI00063274. IPI00157783. IPI00556603. IPI00869327.
RefSeq	NP_005472.2. NM_005481.2.
UniGene	Hs.365207.
3D structure databases
ProteinModelPortal	Q9Y2X0.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-31463N.
IntAct	Q9Y2X0. 9 interactions.
MINT	MINT-6744281.
STRING	9606.ENSP00000325612.
PTM databases
PhosphoSite	Q9Y2X0.
Polymorphism databases
DMDM	62511180.
Proteomic databases
PaxDb	Q9Y2X0.
PRIDE	Q9Y2X0.
Protocols and materials databases
DNASU	10025.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000269814; ENSP00000269814; ENSG00000175221. ENST00000312090; ENSP00000308528; ENSG00000175221. ENST00000325464; ENSP00000325612; ENSG00000175221. ENST00000395808; ENSP00000379153; ENSG00000175221. ENST00000589119; ENSP00000464810; ENSG00000175221.
GeneID	10025.
KEGG	hsa:10025.
UCSC	uc002lqd.1. human. uc002lqe.3. human. uc002lqf.3. human. uc010drw.2. human.
Organism-specific databases
CTD	10025.
GeneCards	GC19M000819.
H-InvDB	HIX0015548.
HGNC	HGNC:17556. MED16.
HPA	HPA030685.
MIM	604062. gene.
neXtProt	NX_Q9Y2X0.
PharmGKB	PA162395406.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG85731.
HOGENOM	HOG000113526.
HOVERGEN	HBG054317.
InParanoid	Q9Y2X0.
KO	K15159.
OMA	HVLNTPD.
OrthoDB	EOG4HDSSV.
PhylomeDB	Q9Y2X0.
Enzyme and pathway databases
Reactome	REACT_111045. Developmental Biology. REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q9Y2X0.
Bgee	Q9Y2X0.
CleanEx	HS_MED16.
Genevestigator	Q9Y2X0.
GermOnline	ENSG00000175221. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 2 hits.
InterPro	IPR021665. Mediator_Med16. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
Pfam	PF11635. Med16. 1 hit. PF00400. WD40. 1 hit. [Graphical view]
SMART	SM00320. WD40. 1 hit. [Graphical view]
SUPFAM	SSF50978. WD40_like. 2 hits.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	10025.
NextBio	37883.
SOURCE	Search...

Entry information

Entry name

MED16_HUMAN

Accession

Primary (citable) accession number: Q9Y2X0
Secondary accession number(s): Q6PJT2 , Q96AD4, Q96I35, Q9Y652

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 12, 2005
Last sequence update:	April 12, 2005
Last modified:	May 1, 2013
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.