Reviewed, UniProtKB/Swiss-Prot Q9Y2W3 (S45A1_HUMAN)

Names and origin

Protein names

Recommended name:
    Proton-associated sugar transporter A
      Short name=PAST-A
Alternative name(s):
    Solute carrier family 45 member 1
    Deleted in neuroblastoma 5 protein
      Short name=DNb-5

Gene names

Name:	SLC45A1
Synonyms:	DNB5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	782 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Mediates glucose uptake along the pH gradient By similarity.
Subcellular location	Membrane; Multi-pass membrane proteinPotential.
Tissue specificity	Expressed in adult heart, brain, muscle and kidney, with very strong expression in brain. Also expressed in fetal brain, kidney and lung.
Sequence similarities	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. [View classification]
Sequence caution	The sequence AAD27583.1 differs from that shown. Reason: Miscellaneous discrepancy. The N-terminus differs for unknown reasons.

Ontologies

Keywords
Biological process	Sugar transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane
Gene Ontology (GO)
Biological process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	sugar:hydrogen symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 782	782	Proton-associated sugar transporter A		PRO_0000122514
Regions
	Transmembrane	127 – 147	21	Potential
	Transmembrane	157 – 177	21	Potential
	Transmembrane	189 – 209	21	Potential
	Transmembrane	225 – 245	21	Potential
	Transmembrane	267 – 287	21	Potential
	Transmembrane	302 – 322	21	Potential
	Transmembrane	567 – 587	21	Potential
	Transmembrane	607 – 627	21	Potential
	Transmembrane	634 – 654	21	Potential
	Transmembrane	661 – 681	21	Potential
	Transmembrane	719 – 739	21	Potential
	Transmembrane	742 – 762	21	Potential
Experimental info
	Sequence conflict	282	1	V → L in AAD27583. Ref.2
	Sequence conflict	300	1	L → F in AAD27583. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2W3-1 [UniParc]. Last modified February 15, 2005. Version 3. Checksum: CC841FDE4159A2DB	FASTA	782	84,541
	10 20 30 40 50 60 MLQQPGPRPG RQQPSGDRDA CRLHPQGRPP ALPTMIPAAS STPPGDALFP SVAPQDFWRS 70 80 90 100 110 120 QVTGYSGSVT RHLSHRANNF KRHPKRRKCI RPSPPPPPNT PCPLELVDFG DLHPQRSFRE 130 140 150 160 170 180 LLFNGCILFG IEFSYAMETA YVTPVLLQMG LPDQLYSLVW FISPILGFLL QPLLGAWSDR 190 200 210 220 230 240 CTSRFGRRRP FILVLAIGAL LGLSLLLNGR DIGIALADVT GNHKWGLLLT VCGVVLMDFS 250 260 270 280 290 300 ADSADNPSHA YMMDVCSPAD QDRGLNIHAL LAGLGGGFGY VVGGIHWDKT GFGRALGGQL 310 320 330 340 350 360 RVIYLFTAVT LSVTTVLTLV SIPERPLRPP SEKRAAMKSP SLPLPPSPPV LPEEGPGDSL 370 380 390 400 410 420 PSHTATNFSS PISPPSPLTP KYGSFISRDS SLTGISEFAS SFGTANIDSV LIDCFTGGHD 430 440 450 460 470 480 SYLAIPGSVP RPPISVSFPR APDGFYRQDR GLLEGREGAL TSGCDGDILR VGSLDTSKPR 490 500 510 520 530 540 SSGILKRPQT LAIPDAAGGG GPETSRRRNV TFSQQVANIL LNGVKYESEL TGSSERAEQP 550 560 570 580 590 600 LSVGRLCSTI CNMPKALRTL CVNHFLGWLS FEGMLLFYTD FMGEVVFQGD PKAPHTSEAY 610 620 630 640 650 660 QKYNSGVTMG CWGMCIYAFS AAFYSAILEK LEEFLSVRTL YFIAYLAFGL GTGLATLSRN 670 680 690 700 710 720 LYVVLSLCIT YGILFSTLCT LPYSLLCDYY QSKKFAGSSA DGTRRGMGVD ISLLSCQYFL 730 740 750 760 770 780 AQILVSLVLG PLTSAVGSAN GVMYFSSLVS FLGCLYSSLF VIYEIPPSDA ADEEHRPLLL NV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP." Amler L.C., Bauer A., Corvi R., Dihlmann S., Praml C., Cavenee W.K., Schwab M., Hampton G.M. Genomics 64:195-202(2000) [PubMed: 10729226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 275-782.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL356072 Genomic DNA. Translation: CAH70515.2. AF118274 mRNA. Translation: AAD27583.1. Sequence problems.
UniGene	Hs.463036
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q9Y2W3.
Genome annotation databases
Ensembl	ENSG00000162426. Homo sapiens. [Contig view]
Organism-specific databases
HGNC	HGNC:17939. SLC45A1.
MIM	605763. gene.
PharmGKB	PA134982862.
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y2W3.
HOVERGEN	Q9Y2W3.
Gene expression databases
ArrayExpress	Q9Y2W3.
CleanEx	HS_SLC45A1.
Family and domain databases
InterPro	IPR011701. MFS_1. [Graphical view]
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

S45A1_HUMAN

Accession

Primary (citable) accession number: Q9Y2W3
Secondary accession number(s): Q5VY46, Q5VY49

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	February 15, 2005
Last modified:	November 4, 2008
This is version 44 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)