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Protein

Proton-associated sugar transporter A

Gene

SLC45A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates glucose uptake along the pH gradient.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Protein family/group databases

TCDBi2.A.2.4.10. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-associated sugar transporter A
Short name:
PAST-A
Alternative name(s):
Deleted in neuroblastoma 5 protein
Short name:
DNb-5
Solute carrier family 45 member 1
Gene namesi
Name:SLC45A1
Synonyms:DNB5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:17939. SLC45A1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Transmembranei533 – 55321HelicalSequence analysisAdd
BLAST
Transmembranei573 – 59321HelicalSequence analysisAdd
BLAST
Transmembranei600 – 62021HelicalSequence analysisAdd
BLAST
Transmembranei627 – 64721HelicalSequence analysisAdd
BLAST
Transmembranei685 – 70521HelicalSequence analysisAdd
BLAST
Transmembranei708 – 72821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiSLC45A1.
DMDMi311033543.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 748748Proton-associated sugar transporter APRO_0000122514Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei497 – 4971PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9Y2W3.
PRIDEiQ9Y2W3.

PTM databases

iPTMnetiQ9Y2W3.
PhosphoSiteiQ9Y2W3.

Expressioni

Tissue specificityi

Expressed in adult heart, brain, muscle and kidney, with very strong expression in brain. Also expressed in fetal brain, kidney and lung.

Gene expression databases

BgeeiQ9Y2W3.
CleanExiHS_SLC45A1.
ExpressionAtlasiQ9Y2W3. baseline and differential.
GenevisibleiQ9Y2W3. HS.

Organism-specific databases

HPAiHPA053528.
HPA057766.

Interactioni

Protein-protein interaction databases

IntActiQ9Y2W3. 1 interaction.
STRINGi9606.ENSP00000289877.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2W3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410Y28T. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000231090.
HOVERGENiHBG053518.
InParanoidiQ9Y2W3.
OrthoDBiEOG7G4QDJ.
PhylomeDBiQ9Y2W3.
TreeFamiTF325412.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

Q9Y2W3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPAASSTPP GDALFPSVAP QDFWRSQVTG YSGSVTRHLS HRANNFKRHP
60 70 80 90 100
KRRKCIRPSP PPPPNTPCPL ELVDFGDLHP QRSFRELLFN GCILFGIEFS
110 120 130 140 150
YAMETAYVTP VLLQMGLPDQ LYSLVWFISP ILGFLLQPLL GAWSDRCTSR
160 170 180 190 200
FGRRRPFILV LAIGALLGLS LLLNGRDIGI ALADVTGNHK WGLLLTVCGV
210 220 230 240 250
VLMDFSADSA DNPSHAYMMD VCSPADQDRG LNIHALLAGL GGGFGYVVGG
260 270 280 290 300
IHWDKTGFGR ALGGQLRVIY LFTAVTLSVT TVLTLVSIPE RPLRPPSEKR
310 320 330 340 350
AAMKSPSLPL PPSPPVLPEE GPGDSLPSHT ATNFSSPISP PSPLTPKYGS
360 370 380 390 400
FISRDSSLTG ISEFASSFGT ANIDSVLIDC FTGGHDSYLA IPGSVPRPPI
410 420 430 440 450
SVSFPRAPDG FYRQDRGLLE GREGALTSGC DGDILRVGSL DTSKPRSSGI
460 470 480 490 500
LKRPQTLAIP DAAGGGGPET SRRRNVTFSQ QVANILLNGV KYESELTGSS
510 520 530 540 550
ERAEQPLSVG RLCSTICNMP KALRTLCVNH FLGWLSFEGM LLFYTDFMGE
560 570 580 590 600
VVFQGDPKAP HTSEAYQKYN SGVTMGCWGM CIYAFSAAFY SAILEKLEEF
610 620 630 640 650
LSVRTLYFIA YLAFGLGTGL ATLSRNLYVV LSLCITYGIL FSTLCTLPYS
660 670 680 690 700
LLCDYYQSKK FAGSSADGTR RGMGVDISLL SCQYFLAQIL VSLVLGPLTS
710 720 730 740
AVGSANGVMY FSSLVSFLGC LYSSLFVIYE IPPSDAADEE HRPLLLNV
Length:748
Mass (Da):80,843
Last modified:November 2, 2010 - v4
Checksum:i159F779C9EEF5A74
GO

Sequence cautioni

The sequence AAD27583.1 differs from that shown.Probable cloning artifact.Curated
The sequence CAH70515.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti248 – 2481V → L in AAD27583 (PubMed:10729226).Curated
Sequence conflicti266 – 2661L → F in AAD27583 (PubMed:10729226).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356072 Genomic DNA. Translation: CAH70515.2. Sequence problems.
AF118274 mRNA. Translation: AAD27583.1. Sequence problems.
UniGeneiHs.463036.

Genome annotation databases

EnsembliENST00000289877; ENSP00000289877; ENSG00000162426.
UCSCiuc001apb.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL356072 Genomic DNA. Translation: CAH70515.2. Sequence problems.
AF118274 mRNA. Translation: AAD27583.1. Sequence problems.
UniGeneiHs.463036.

3D structure databases

ProteinModelPortaliQ9Y2W3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y2W3. 1 interaction.
STRINGi9606.ENSP00000289877.

Protein family/group databases

TCDBi2.A.2.4.10. the glycoside-pentoside-hexuronide (gph):cation symporter family.

PTM databases

iPTMnetiQ9Y2W3.
PhosphoSiteiQ9Y2W3.

Polymorphism and mutation databases

BioMutaiSLC45A1.
DMDMi311033543.

Proteomic databases

PaxDbiQ9Y2W3.
PRIDEiQ9Y2W3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000289877; ENSP00000289877; ENSG00000162426.
UCSCiuc001apb.3. human.

Organism-specific databases

GeneCardsiSLC45A1.
H-InvDBHIX0028554.
HGNCiHGNC:17939. SLC45A1.
HPAiHPA053528.
HPA057766.
MIMi605763. gene.
neXtProtiNX_Q9Y2W3.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410Y28T. LUCA.
GeneTreeiENSGT00390000018882.
HOGENOMiHOG000231090.
HOVERGENiHBG053518.
InParanoidiQ9Y2W3.
OrthoDBiEOG7G4QDJ.
PhylomeDBiQ9Y2W3.
TreeFamiTF325412.

Miscellaneous databases

ChiTaRSiSLC45A1. human.
PROiQ9Y2W3.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2W3.
CleanExiHS_SLC45A1.
ExpressionAtlasiQ9Y2W3. baseline and differential.
GenevisibleiQ9Y2W3. HS.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP."
    Amler L.C., Bauer A., Corvi R., Dihlmann S., Praml C., Cavenee W.K., Schwab M., Hampton G.M.
    Genomics 64:195-202(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-748.

Entry informationi

Entry nameiS45A1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2W3
Secondary accession number(s): Q5VY46, Q5VY49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: November 2, 2010
Last modified: June 8, 2016
This is version 109 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.