Q9Y2W3 (S45A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proton-associated sugar transporter A
Short name=PAST-A

Alternative name(s):
Deleted in neuroblastoma 5 protein
Short name=DNb-5
Solute carrier family 45 member 1

Gene names

Name:	SLC45A1
Synonyms:	DNB5

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	748 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Mediates glucose uptake along the pH gradient By similarity.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Tissue specificity	Expressed in adult heart, brain, muscle and kidney, with very strong expression in brain. Also expressed in fetal brain, kidney and lung.
Sequence similarities	Belongs to the glycoside-pentoside-hexuronide (GPH) cation symporter transporter (TC 2.A.2) family. [View classification]
Sequence caution	The sequence AAD27583.1 differs from that shown. Reason: Probable cloning artifact. The sequence CAH70515.2 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Sugar transport Symport Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	carbohydrate transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	symporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 748	748	Proton-associated sugar transporter A		PRO_0000122514
Regions
	Transmembrane	93 – 113	21	Helical; Potential
	Transmembrane	123 – 143	21	Helical; Potential
	Transmembrane	155 – 175	21	Helical; Potential
	Transmembrane	191 – 211	21	Helical; Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Transmembrane	268 – 288	21	Helical; Potential
	Transmembrane	533 – 553	21	Helical; Potential
	Transmembrane	573 – 593	21	Helical; Potential
	Transmembrane	600 – 620	21	Helical; Potential
	Transmembrane	627 – 647	21	Helical; Potential
	Transmembrane	685 – 705	21	Helical; Potential
	Transmembrane	708 – 728	21	Helical; Potential
Experimental info
	Sequence conflict	248	1	V → L in AAD27583. Ref.2
	Sequence conflict	266	1	L → F in AAD27583. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2W3 [UniParc]. Last modified November 2, 2010. Version 4. Checksum: 159F779C9EEF5A74	FASTA	748	80,843
	10 20 30 40 50 60 MIPAASSTPP GDALFPSVAP QDFWRSQVTG YSGSVTRHLS HRANNFKRHP KRRKCIRPSP 70 80 90 100 110 120 PPPPNTPCPL ELVDFGDLHP QRSFRELLFN GCILFGIEFS YAMETAYVTP VLLQMGLPDQ 130 140 150 160 170 180 LYSLVWFISP ILGFLLQPLL GAWSDRCTSR FGRRRPFILV LAIGALLGLS LLLNGRDIGI 190 200 210 220 230 240 ALADVTGNHK WGLLLTVCGV VLMDFSADSA DNPSHAYMMD VCSPADQDRG LNIHALLAGL 250 260 270 280 290 300 GGGFGYVVGG IHWDKTGFGR ALGGQLRVIY LFTAVTLSVT TVLTLVSIPE RPLRPPSEKR 310 320 330 340 350 360 AAMKSPSLPL PPSPPVLPEE GPGDSLPSHT ATNFSSPISP PSPLTPKYGS FISRDSSLTG 370 380 390 400 410 420 ISEFASSFGT ANIDSVLIDC FTGGHDSYLA IPGSVPRPPI SVSFPRAPDG FYRQDRGLLE 430 440 450 460 470 480 GREGALTSGC DGDILRVGSL DTSKPRSSGI LKRPQTLAIP DAAGGGGPET SRRRNVTFSQ 490 500 510 520 530 540 QVANILLNGV KYESELTGSS ERAEQPLSVG RLCSTICNMP KALRTLCVNH FLGWLSFEGM 550 560 570 580 590 600 LLFYTDFMGE VVFQGDPKAP HTSEAYQKYN SGVTMGCWGM CIYAFSAAFY SAILEKLEEF 610 620 630 640 650 660 LSVRTLYFIA YLAFGLGTGL ATLSRNLYVV LSLCITYGIL FSTLCTLPYS LLCDYYQSKK 670 680 690 700 710 720 FAGSSADGTR RGMGVDISLL SCQYFLAQIL VSLVLGPLTS AVGSANGVMY FSSLVSFLGC 730 740 LYSSLFVIYE IPPSDAADEE HRPLLLNV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP." Amler L.C., Bauer A., Corvi R., Dihlmann S., Praml C., Cavenee W.K., Schwab M., Hampton G.M. Genomics 64:195-202(2000) [PubMed: 10729226] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 242-748.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL356072 Genomic DNA. Translation: CAH70515.2. Sequence problems. AF118274 mRNA. Translation: AAD27583.1. Sequence problems.
IPI	IPI00740308.
RefSeq	NP_001073866.1. NM_001080397.1.
UniGene	Hs.463036.
3D structure databases
ProteinModelPortal	Q9Y2W3.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y2W3.
PTM databases
PhosphoSite	Q9Y2W3.
Polymorphism databases
DMDM	311033543.
Proteomic databases
PRIDE	Q9Y2W3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000377479; ENSP00000366699; ENSG00000162426.
GeneID	50651.
KEGG	hsa:50651.
UCSC	uc001apb.1. human.
Organism-specific databases
CTD	50651.
GeneCards	GC01P008300.
HGNC	HGNC:17939. SLC45A1.
MIM	605763. gene.
neXtProt	NX_Q9Y2W3.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG05067.
GeneTree	ENSGT00390000018882.
HOGENOM	HBG445264.
HOVERGEN	HBG053518.
InParanoid	Q9Y2W3.
Gene expression databases
ArrayExpress	Q9Y2W3.
Bgee	Q9Y2W3.
CleanEx	HS_SLC45A1.
Genevestigator	Q9Y2W3.
Family and domain databases
InterPro	IPR011701. MFS. IPR016196. MFS_dom_general_subst_transpt. [Graphical view]
KO	K15378.
Pfam	PF07690. MFS_1. 1 hit. [Graphical view]
SUPFAM	SSF103473. MFS_gen_substrate_transporter. 2 hits.
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

S45A1_HUMAN

Accession

Primary (citable) accession number: Q9Y2W3
Secondary accession number(s): Q5VY46, Q5VY49

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 24, 2003
Last sequence update:	November 2, 2010
Last modified:	January 25, 2012
This is version 72 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.