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Protein

WW domain-binding protein 11

Gene

WBP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Activates pre-mRNA splicing. May inhibit PP1 phosphatase activity.3 Publications

GO - Molecular functioni

  • poly(A) RNA binding Source: UniProtKB
  • protein phosphatase type 1 regulator activity Source: Ensembl
  • single-stranded DNA binding Source: ProtInc
  • WW domain binding Source: UniProtKB

GO - Biological processi

  • mRNA cis splicing, via spliceosome Source: GO_Central
  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • regulation of mitophagy Source: ParkinsonsUK-UCL
  • rRNA processing Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

mRNA processing, mRNA splicing, rRNA processing

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084463-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
WW domain-binding protein 11
Short name:
WBP-11
Alternative name(s):
Npw38-binding protein
Short name:
NpwBP
SH3 domain-binding protein SNP70
Splicing factor that interacts with PQBP-1 and PP1
Gene namesi
Name:WBP11
Synonyms:NPWBP, SIPP1, SNP70
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:16461. WBP11.

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Predominantly located in the nucleus with granular heterogeneous distribution. Excluded from nucleoli in interphase cells, distributed throughout cytoplasm in dividing cells. Colocalized with SC35 and U2B in the nucleus. In the cytoplasm, associates with the intermediate filament protein vimentin.

GO - Cellular componenti

  • cytoplasm Source: HPA
  • intracellular membrane-bounded organelle Source: HPA
  • nuclear speck Source: Ensembl
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
  • spliceosomal complex Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi192R → A: Loss of PQBP1-binding; when associated with A-197 and A-198. 1 Publication1
Mutagenesisi197R → A: Loss of PQBP1-binding; when associated with A-192 and A-198. 1 Publication1
Mutagenesisi198K → A: Loss of PQBP1-binding; when associated with A-192 and A-197. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000084463.
PharmGKBiPA38144.

Polymorphism and mutation databases

BioMutaiWBP11.
DMDMi74735242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000659451 – 641WW domain-binding protein 11Add BLAST641

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei13N6-acetyllysineCombined sources1
Modified residuei181PhosphoserineCombined sources1
Modified residuei192Omega-N-methylarginineCombined sources1
Modified residuei236PhosphotyrosineBy similarity1
Modified residuei237PhosphoserineCombined sources1
Modified residuei279PhosphoserineCombined sources1
Modified residuei283PhosphoserineCombined sources1
Modified residuei353PhosphoserineCombined sources1
Modified residuei361PhosphoserineCombined sources1
Modified residuei364PhosphoserineCombined sources1
Modified residuei565N6-acetyllysineBy similarity1
Modified residuei600PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2W2.
MaxQBiQ9Y2W2.
PaxDbiQ9Y2W2.
PeptideAtlasiQ9Y2W2.
PRIDEiQ9Y2W2.

PTM databases

iPTMnetiQ9Y2W2.
PhosphoSitePlusiQ9Y2W2.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in the heart, pancreas, kidney skeletal muscle, placenta and brain (at protein level). Weakly expressed in liver and lung.1 Publication

Gene expression databases

BgeeiENSG00000084463.
CleanExiHS_WBP11.
ExpressionAtlasiQ9Y2W2. baseline and differential.
GenevisibleiQ9Y2W2. HS.

Organism-specific databases

HPAiHPA039710.
HPA040037.
HPA046403.
HPA049126.

Interactioni

Subunit structurei

Interacts with PPP1CA, PPP1CB and PPP1CC (By similarity). Interacts via the PGR motif with PQBP1 in the nucleus. Interacts with the WW domains of WBP4.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Q99IB83EBI-714455,EBI-6927928From a different organism.
FYNP062413EBI-714455,EBI-515315
GRB2P629934EBI-714455,EBI-401755
PCBP1Q153652EBI-714455,EBI-946095
PPP1CAP621363EBI-714455,EBI-357253
PQBP1O608283EBI-714455,EBI-713867
TESCQ96BS23EBI-714455,EBI-740653
TRAF4Q9BUZ43EBI-714455,EBI-3650647

GO - Molecular functioni

  • WW domain binding Source: UniProtKB

Protein-protein interaction databases

BioGridi119702. 45 interactors.
IntActiQ9Y2W2. 36 interactors.
MINTiMINT-112641.
STRINGi9606.ENSP00000261167.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2W2.
SMRiQ9Y2W2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 45Required for nuclear importBy similarityAdd BLAST45
Regioni217 – 221Interaction with PP1By similarity5
Regioni306 – 310Interaction with PP1By similarity5

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili75 – 133Sequence analysisAdd BLAST59

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi455 – 466PGRAdd BLAST12

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi140 – 209Pro-richAdd BLAST70
Compositional biasi246 – 297Asp-richAdd BLAST52
Compositional biasi319 – 322Poly-Lys4
Compositional biasi393 – 538Pro-richAdd BLAST146

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG4672. Eukaryota.
ENOG41115S5. LUCA.
GeneTreeiENSGT00730000111015.
HOGENOMiHOG000154840.
HOVERGENiHBG056793.
InParanoidiQ9Y2W2.
KOiK12866.
OMAiGQRGHDD.
OrthoDBiEOG091G0BKC.
PhylomeDBiQ9Y2W2.
TreeFamiTF323226.

Family and domain databases

InterProiIPR019007. WW_dom-bd_prot_11.
[Graphical view]
PfamiPF09429. Wbp11. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRRSTSSTK SGKFMNPTDQ ARKEARKREL KKNKKQRMMV RAAVLKMKDP
60 70 80 90 100
KQIIRDMEKL DEMEFNPVQQ PQLNEKVLKD KRKKLRETFE RILRLYEKEN
110 120 130 140 150
PDIYKELRKL EVEYEQKRAQ LSQYFDAVKN AQHVEVESIP LPDMPHAPSN
160 170 180 190 200
ILIQDIPLPG AQPPSILKKT SAYGPPTRAV SILPLLGHGV PRLPPGRKPP
210 220 230 240 250
GPPPGPPPPQ VVQMYGRKVG FALDLPPRRR DEDMLYSPEL AQRGHDDDVS
260 270 280 290 300
STSEDDGYPE DMDQDKHDDS TDDSDTDKSD GESDGDEFVH RDNGERDNNE
310 320 330 340 350
EKKSGLSVRF ADMPGKSRKK KKNMKELTPL QAMMLRMAGQ EIPEEGREVE
360 370 380 390 400
EFSEDDDEDD SDDSEAEKQS QKQHKEESHS DGTSTASSQQ QAPPQSVPPS
410 420 430 440 450
QIQAPPMPGP PPLGPPPAPP LRPPGPPTGL PPGPPPGAPP FLRPPGMPGL
460 470 480 490 500
RGPLPRLLPP GPPPGRPPGP PPGPPPGLPP GPPPRGPPPR LPPPAPPGIP
510 520 530 540 550
PPRPGMMRPP LVPPLGPAPP GLFPPAPLPN PGVLSAPPNL IQRPKADDTS
560 570 580 590 600
AATIEKKATA TISAKPQITN PKAEITRFVP TALRVRRENK GATAAPQRKS
610 620 630 640
EDDSAVPLAK AAPKSGPSVP VSVQTKDDVY EAFMKEMEGL L
Length:641
Mass (Da):69,998
Last modified:November 1, 1999 - v1
Checksum:iC94F9687D132CE77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029309 mRNA. Translation: BAA88410.1.
AF118023 mRNA. Translation: AAD30425.1.
BC001621 mRNA. Translation: AAH01621.1.
BC016441 mRNA. Translation: AAH16441.2.
BC023532 mRNA. Translation: AAH23532.1.
CCDSiCCDS8666.1.
RefSeqiNP_057396.1. NM_016312.2.
UniGeneiHs.655138.

Genome annotation databases

EnsembliENST00000261167; ENSP00000261167; ENSG00000084463.
GeneIDi51729.
KEGGihsa:51729.
UCSCiuc001rci.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB029309 mRNA. Translation: BAA88410.1.
AF118023 mRNA. Translation: AAD30425.1.
BC001621 mRNA. Translation: AAH01621.1.
BC016441 mRNA. Translation: AAH16441.2.
BC023532 mRNA. Translation: AAH23532.1.
CCDSiCCDS8666.1.
RefSeqiNP_057396.1. NM_016312.2.
UniGeneiHs.655138.

3D structure databases

ProteinModelPortaliQ9Y2W2.
SMRiQ9Y2W2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119702. 45 interactors.
IntActiQ9Y2W2. 36 interactors.
MINTiMINT-112641.
STRINGi9606.ENSP00000261167.

PTM databases

iPTMnetiQ9Y2W2.
PhosphoSitePlusiQ9Y2W2.

Polymorphism and mutation databases

BioMutaiWBP11.
DMDMi74735242.

Proteomic databases

EPDiQ9Y2W2.
MaxQBiQ9Y2W2.
PaxDbiQ9Y2W2.
PeptideAtlasiQ9Y2W2.
PRIDEiQ9Y2W2.

Protocols and materials databases

DNASUi51729.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000261167; ENSP00000261167; ENSG00000084463.
GeneIDi51729.
KEGGihsa:51729.
UCSCiuc001rci.4. human.

Organism-specific databases

CTDi51729.
GeneCardsiWBP11.
HGNCiHGNC:16461. WBP11.
HPAiHPA039710.
HPA040037.
HPA046403.
HPA049126.
neXtProtiNX_Q9Y2W2.
OpenTargetsiENSG00000084463.
PharmGKBiPA38144.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4672. Eukaryota.
ENOG41115S5. LUCA.
GeneTreeiENSGT00730000111015.
HOGENOMiHOG000154840.
HOVERGENiHBG056793.
InParanoidiQ9Y2W2.
KOiK12866.
OMAiGQRGHDD.
OrthoDBiEOG091G0BKC.
PhylomeDBiQ9Y2W2.
TreeFamiTF323226.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000084463-MONOMER.
ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.

Miscellaneous databases

ChiTaRSiWBP11. human.
GeneWikiiWBP11.
GenomeRNAii51729.
PROiQ9Y2W2.

Gene expression databases

BgeeiENSG00000084463.
CleanExiHS_WBP11.
ExpressionAtlasiQ9Y2W2. baseline and differential.
GenevisibleiQ9Y2W2. HS.

Family and domain databases

InterProiIPR019007. WW_dom-bd_prot_11.
[Graphical view]
PfamiPF09429. Wbp11. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWBP11_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2W2
Secondary accession number(s): Q96AY8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.