Reviewed, UniProtKB/Swiss-Prot Q9Y2V7 (COG6_HUMAN)

Names and origin

Protein names

Recommended name:
    Conserved oligomeric Golgi complex subunit 6
      Short name=COG complex subunit 6
Alternative name(s):
    Component of oligomeric Golgi complex 6

Gene names

Name:	COG6
Synonyms:	KIAA1134

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	657 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Required for normal Golgi function By similarity.
Subunit structure	Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization By similarity.
Subcellular location	Golgi apparatus membrane; Peripheral membrane protein By similarity.
Sequence similarities	Belongs to the COG6 family.

Ontologies

Keywords
Biological process	Protein transport Transport
Cellular component	Golgi apparatus Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	protein transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	Golgi transport complex Inferred from direct assay. Source: UniProtKB extrinsic to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2V7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2V7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     610-615: EQIVKQ → RPPNGP
     616-657: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q9Y2V7-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-52: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 657	657	Conserved oligomeric Golgi complex subunit 6		PRO_0000213513
Natural variations
	Alternative sequence	1 – 52	52	Missing in isoform 3.		VSP_032748
	Alternative sequence	610 – 615	6	EQIVKQ → RPPNGP in isoform 2.		VSP_001131
	Alternative sequence	616 – 657	42	Missing in isoform 2.		VSP_001132
	Natural variant	10	1	A → T: dbSNP rs3812882. Ref.2		VAR_048759
	Natural variant	32	1	C → S: dbSNP rs3812883. Ref.2		VAR_048760
	Natural variant	300	1	H → Y: dbSNP rs34555836.		VAR_048761
Experimental info
	Sequence conflict	158	1	S → F in CAH10495. Ref.2
	Sequence conflict	379	1	N → S in CAH10495. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 8, 2008. Version 2. Checksum: 0F29785E722B5185	FASTA	657	73,279
	10 20 30 40 50 60 MAEGSGEVVA VSATGAANGL NNGAGGTSAT TCNPLSRKLH KILETRLDND KEMLEALKAL 70 80 90 100 110 120 STFFVENSLR TRRNLRGDIE RKSLAINEEF VSIFKEVKEE LESISEDVQA MSNCCQDMTS 130 140 150 160 170 180 RLQAAKEQTQ DLIVKTTKLQ SESQKLEIRA QVADAFLSKF QLTSDEMSLL RGTREGPITE 190 200 210 220 230 240 DFFKALGRVK QIHNDVKVLL RTNQQTAGLE IMEQMALLQE TAYERLYRWA QSECRTLTQE 250 260 270 280 290 300 SCDVSPVLTQ AMEALQDRPV LYKYTLDEFG TARRSTVVRG FIDALTRGGP GGTPRPIEMH 310 320 330 340 350 360 SHDPLRYVGD MLAWLHQATA SEKEHLEALL KHVTTQGVEE NIQEVVGHIT EGVCRPLKVR 370 380 390 400 410 420 IEQVIVAEPG AVLLYKISNL LKFYHHTISG IVGNSATALL TTIEEMHLLS KKIFFNSLSL 430 440 450 460 470 480 HASKLMDKVE LPPPDLGPSS ALNQTLMLLR EVLASHDSSV VPLDARQADF VQVLSCVLDP 490 500 510 520 530 540 LLQMCTVSAS NLGTADMATF MVNSLYMMKT TLALFEFTDR RLEMLQFQIE AHLDTLINEQ 550 560 570 580 590 600 ASYVLTRVGL SYIYNTVQQH KPEQGSLANM PNLDSVTLKA AMVQFDRYLS APDNLLIPQL 610 620 630 640 650 NFLLSATVKE QIVKQSTELV CRAYGEVYAA VMNPINEYKD PENILHRSPQ QVQTLLS
	Isoform 2. Checksum: 5329CF6140B57331	FASTA	615	68,411
	10 20 30 40 50 60 MAEGSGEVVA VSATGAANGL NNGAGGTSAT TCNPLSRKLH KILETRLDND KEMLEALKAL 70 80 90 100 110 120 STFFVENSLR TRRNLRGDIE RKSLAINEEF VSIFKEVKEE LESISEDVQA MSNCCQDMTS 130 140 150 160 170 180 RLQAAKEQTQ DLIVKTTKLQ SESQKLEIRA QVADAFLSKF QLTSDEMSLL RGTREGPITE 190 200 210 220 230 240 DFFKALGRVK QIHNDVKVLL RTNQQTAGLE IMEQMALLQE TAYERLYRWA QSECRTLTQE 250 260 270 280 290 300 SCDVSPVLTQ AMEALQDRPV LYKYTLDEFG TARRSTVVRG FIDALTRGGP GGTPRPIEMH 310 320 330 340 350 360 SHDPLRYVGD MLAWLHQATA SEKEHLEALL KHVTTQGVEE NIQEVVGHIT EGVCRPLKVR 370 380 390 400 410 420 IEQVIVAEPG AVLLYKISNL LKFYHHTISG IVGNSATALL TTIEEMHLLS KKIFFNSLSL 430 440 450 460 470 480 HASKLMDKVE LPPPDLGPSS ALNQTLMLLR EVLASHDSSV VPLDARQADF VQVLSCVLDP 490 500 510 520 530 540 LLQMCTVSAS NLGTADMATF MVNSLYMMKT TLALFEFTDR RLEMLQFQIE AHLDTLINEQ 550 560 570 580 590 600 ASYVLTRVGL SYIYNTVQQH KPEQGSLANM PNLDSVTLKA AMVQFDRYLS APDNLLIPQL 610 NFLLSATVKR PPNGP
	Isoform 3. Checksum: 98176D73F5C52B0C	FASTA	605	68,069
	10 20 30 40 50 60 MLEALKALST FFVENSLRTR RNLRGDIERK SLAINEEFVS IFKEVKEELE SISEDVQAMS 70 80 90 100 110 120 NCCQDMTSRL QAAKEQTQDL IVKTTKLQSE SQKLEIRAQV ADAFLSKFQL TSDEMSLLRG 130 140 150 160 170 180 TREGPITEDF FKALGRVKQI HNDVKVLLRT NQQTAGLEIM EQMALLQETA YERLYRWAQS 190 200 210 220 230 240 ECRTLTQESC DVSPVLTQAM EALQDRPVLY KYTLDEFGTA RRSTVVRGFI DALTRGGPGG 250 260 270 280 290 300 TPRPIEMHSH DPLRYVGDML AWLHQATASE KEHLEALLKH VTTQGVEENI QEVVGHITEG 310 320 330 340 350 360 VCRPLKVRIE QVIVAEPGAV LLYKISNLLK FYHHTISGIV GNSATALLTT IEEMHLLSKK 370 380 390 400 410 420 IFFNSLSLHA SKLMDKVELP PPDLGPSSAL NQTLMLLREV LASHDSSVVP LDARQADFVQ 430 440 450 460 470 480 VLSCVLDPLL QMCTVSASNL GTADMATFMV NSLYMMKTTL ALFEFTDRRL EMLQFQIEAH 490 500 510 520 530 540 LDTLINEQAS YVLTRVGLSY IYNTVQQHKP EQGSLANMPN LDSVTLKAAM VQFDRYLSAP 550 560 570 580 590 600 DNLLIPQLNF LLSATVKEQI VKQSTELVCR AYGEVYAAVM NPINEYKDPE NILHRSPQQV QTLLS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Wei Y.J., Ding J.F., Xiong H., Zhou Y., Hui R.T., Liew C.C. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Aorta.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-10 AND SER-32. Tissue: Fetal skin.
[3]	"The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T. Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[6]	"Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-657 (ISOFORM 2). Tissue: Brain.
[7]	"Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function." Ungar D., Oka T., Brittle E.E., Vasile E., Lupashin V.V., Chatterton J.E., Heuser J.E., Krieger M., Waters M.G. J. Cell Biol. 157:405-415(2002) [PubMed: 11980916] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF116827 mRNA. Translation: AAD29633.1. CR627406 mRNA. Translation: CAH10495.1. AL512505 Genomic DNA. Translation: CAI16937.1. AL512505 Genomic DNA. Translation: CAM23735.1. CH471075 Genomic DNA. Translation: EAX08619.1. BC051723 mRNA. Translation: AAH51723.1. AB032960 mRNA. Translation: BAA86448.1.
IPI	IPI00398963. IPI00889669. IPI00940437.
RefSeq	NP_001138551.1. NP_065802.1.
UniGene	Hs.507805
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y2V7.
PTM databases
PhosphoSite	Q9Y2V7.
Proteomic databases
PRIDE	Q9Y2V7.
Genome annotation databases
Ensembl	ENST00000255468; ENSP00000255468; ENSG00000133103; Homo sapiens. [Genome view] ENST00000455146; ENSP00000397441; ENSG00000133103; Homo sapiens. [Genome view]
GeneID	57511.
KEGG	hsa:57511.
UCSC	uc001uxh.1. human. uc001uxi.1. human. uc010acb.1. human.
Organism-specific databases
CTD	57511.
GeneCards	GC13P039127.
H-InvDB	HIX0011256.
HGNC	HGNC:18621. COG6.
MIM	606977. gene.
PharmGKB	PA38604.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q9Y2V7.
OrthoDB	EOG966Z5J
Gene expression databases
ArrayExpress	Q9Y2V7.
Bgee	Q9Y2V7.
CleanEx	HS_COG6.
Genevestigator	Q9Y2V7.
GermOnline	ENSG00000133103. Homo sapiens.
Family and domain databases
InterPro	IPR010490. COG6. [Graphical view]
PANTHER	PTHR21506. COG6. 1 hit.
Pfam	PF06419. COG6. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	63870.
SOURCE	Search...

Entry information

Entry name

COG6_HUMAN

Accession

Primary (citable) accession number: Q9Y2V7
Secondary accession number(s): Q5T0U1 , Q6AI19, Q86V49, Q9ULT5

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	April 8, 2008
Last modified:	November 24, 2009
This is version 69 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.