Reviewed,
UniProtKB/Swiss-Prot Q9Y2V7 (COG6_HUMAN)
Last modified
November 24, 2009.
Version 69.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Conserved oligomeric Golgi complex subunit 6 Short name=COG complex subunit 6 Alternative name(s): Component of oligomeric Golgi complex 6 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 657 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Required for normal Golgi function By similarity. |
| Subunit structure | Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization By similarity. |
| Subcellular location | Golgi apparatus membrane; Peripheral membrane protein By similarity. |
| Sequence similarities | Belongs to the COG6 family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein transport Transport |
| Cellular component | Golgi apparatus Membrane |
| Coding sequence diversity | Alternative splicing Polymorphism |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | protein transport Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | Golgi transport complex Inferred from direct assay. Source: UniProtKB extrinsic to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Complete GO annotation... | |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q9Y2V7-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q9Y2V7-2) The sequence of this isoform differs from the canonical sequence as follows: 610-615: EQIVKQ → RPPNGP 616-657: Missing. | ||||||
| Note: No experimental confirmation available. | ||||||
| Isoform 3 (identifier: Q9Y2V7-3) The sequence of this isoform differs from the canonical sequence as follows: 1-52: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 657 | 657 | Conserved oligomeric Golgi complex subunit 6 | PRO_0000213513 | |||||
Natural variations | |||||||||
| Alternative sequence | 1 – 52 | 52 | Missing in isoform 3. | VSP_032748 | |||||
| Alternative sequence | 610 – 615 | 6 | EQIVKQ → RPPNGP in isoform 2. | VSP_001131 | |||||
| Alternative sequence | 616 – 657 | 42 | Missing in isoform 2. | VSP_001132 | |||||
| Natural variant | 10 | 1 | A → T: dbSNP rs3812882. Ref.2 | VAR_048759 | |||||
| Natural variant | 32 | 1 | C → S: dbSNP rs3812883. Ref.2 | VAR_048760 | |||||
| Natural variant | 300 | 1 | H → Y: dbSNP rs34555836. | VAR_048761 | |||||
Experimental info | |||||||||
| Sequence conflict | 158 | 1 | S → F in CAH10495. Ref.2 | ||||||
| Sequence conflict | 379 | 1 | N → S in CAH10495. Ref.2 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | Wei Y.J., Ding J.F., Xiong H., Zhou Y., Hui R.T., Liew C.C. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3). Tissue: Aorta. |
| [2] | "The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANTS THR-10 AND SER-32. Tissue: Fetal skin. |
| [3] | "The DNA sequence and analysis of human chromosome 13." Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T. Ross M.T.Nature 428:522-528(2004) [PubMed: 15057823] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain. |
| [6] | "Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain." Hirosawa M., Nagase T., Ishikawa K., Kikuno R., Nomura N., Ohara O. DNA Res. 6:329-336(1999) [PubMed: 10574461] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 5-657 (ISOFORM 2). Tissue: Brain. |
| [7] | "Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function." Ungar D., Oka T., Brittle E.E., Vasile E., Lupashin V.V., Chatterton J.E., Heuser J.E., Krieger M., Waters M.G. J. Cell Biol. 157:405-415(2002) [PubMed: 11980916] [Abstract] Cited for: IDENTIFICATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF116827 mRNA. Translation: AAD29633.1. CR627406 mRNA. Translation: CAH10495.1. AL512505 Genomic DNA. Translation: CAI16937.1. AL512505 Genomic DNA. Translation: CAM23735.1. CH471075 Genomic DNA. Translation: EAX08619.1. BC051723 mRNA. Translation: AAH51723.1. AB032960 mRNA. Translation: BAA86448.1. | |
| IPI | IPI00398963. IPI00889669. IPI00940437. |
| RefSeq | NP_001138551.1. NP_065802.1. |
| UniGene | Hs.507805 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9Y2V7. |
PTM databases | |
| PhosphoSite | Q9Y2V7. |
Proteomic databases | |
| PRIDE | Q9Y2V7. |
Genome annotation databases | |
| Ensembl | ENST00000255468; ENSP00000255468; ENSG00000133103; Homo sapiens. [Genome view] ENST00000455146; ENSP00000397441; ENSG00000133103; Homo sapiens. [Genome view] |
| GeneID | 57511. |
| KEGG | hsa:57511. |
| UCSC | uc001uxh.1. human. uc001uxi.1. human. uc010acb.1. human. |
Organism-specific databases | |
| CTD | 57511. |
| GeneCards | GC13P039127. |
| H-InvDB | HIX0011256. |
| HGNC | HGNC:18621. COG6. |
| MIM | 606977. gene. |
| PharmGKB | PA38604. |
| HUGE | Search... |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOVERGEN | Q9Y2V7. |
| OrthoDB | EOG966Z5J |
Gene expression databases | |
| ArrayExpress | Q9Y2V7. |
| Bgee | Q9Y2V7. |
| CleanEx | HS_COG6. |
| Genevestigator | Q9Y2V7. |
| GermOnline | ENSG00000133103. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR010490. COG6. [Graphical view] |
| PANTHER | PTHR21506. COG6. 1 hit. |
| Pfam | PF06419. COG6. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 63870. |
| SOURCE | Search... |
Entry information
| Entry name | COG6_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q9Y2V7 Secondary accession number(s): Q5T0U1 Q9ULT5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 13 Human chromosome 13: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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