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Protein

Calcium-regulated heat-stable protein 1

Gene

CARHSP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds mRNA and regulates the stability of target mRNA. Binds single-stranded DNA (in vitro).2 Publications

GO - Molecular functioni

  • DNA binding Source: InterPro
  • mRNA 3'-UTR binding Source: UniProtKB
  • phosphatase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

SIGNORiQ9Y2V2.

Names & Taxonomyi

Protein namesi
Recommended name:
Calcium-regulated heat-stable protein 1
Alternative name(s):
Calcium-regulated heat-stable protein of 24 kDa
Short name:
CRHSP-24
Gene namesi
Name:CARHSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:17150. CARHSP1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi41S → D: Reduced affinity for single-stranded DNA. Abolishes location at cytoplasmic stress granules. 1 Publication1
Mutagenesisi76H → Q: Reduced affinity for single-stranded DNA. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000153048.
PharmGKBiPA38440.

Polymorphism and mutation databases

DMDMi41016932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001002302 – 147Calcium-regulated heat-stable protein 1Add BLAST146

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei30PhosphoserineCombined sources1 Publication1
Modified residuei32PhosphoserineCombined sources1 Publication1
Modified residuei41PhosphoserineCombined sources1 Publication1
Modified residuei45PhosphothreonineCombined sources1
Modified residuei52PhosphoserineCombined sources1 Publication1
Modified residuei58PhosphoserineCombined sources1
Modified residuei146PhosphoserineCombined sources1
Modified residuei147PhosphoserineCombined sources1

Post-translational modificationi

Dephosphorylated by calcineurin in a Ca2+ dependent manner (By similarity). Can be phosphorylated by DYRK2 (in vitro).By similarity1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2V2.
MaxQBiQ9Y2V2.
PaxDbiQ9Y2V2.
PeptideAtlasiQ9Y2V2.
PRIDEiQ9Y2V2.
TopDownProteomicsiQ9Y2V2.

PTM databases

iPTMnetiQ9Y2V2.
PhosphoSitePlusiQ9Y2V2.

Expressioni

Gene expression databases

BgeeiENSG00000153048.
CleanExiHS_CARHSP1.
ExpressionAtlasiQ9Y2V2. baseline and differential.
GenevisibleiQ9Y2V2. HS.

Organism-specific databases

HPAiHPA051911.

Interactioni

Subunit structurei

Homodimer. Interacts with STYX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
DOCK8Q8NF503EBI-718719,EBI-2548605
DOCK8Q8NF50-23EBI-718719,EBI-10174653
KRTAP10-7P604093EBI-718719,EBI-10172290
KRTAP10-8P604105EBI-718719,EBI-10171774
NOTCH2NLQ7Z3S93EBI-718719,EBI-945833
PNMA1Q8ND903EBI-718719,EBI-302345
TRAF1Q130773EBI-718719,EBI-359224

GO - Molecular functioni

  • phosphatase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi117124. 27 interactors.
IntActiQ9Y2V2. 15 interactors.
MINTiMINT-1432836.
STRINGi9606.ENSP00000311847.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi51 – 59Combined sources9
Beta strandi63 – 70Combined sources8
Turni72 – 74Combined sources3
Beta strandi75 – 84Combined sources10
Beta strandi88 – 91Combined sources4
Helixi92 – 94Combined sources3
Beta strandi95 – 99Combined sources5
Beta strandi106 – 113Combined sources8
Beta strandi121 – 130Combined sources10
Beta strandi133 – 135Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQQX-ray2.80A/B/C/D1-147[»]
ProteinModelPortaliQ9Y2V2.
SMRiQ9Y2V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini62 – 129CSDAdd BLAST68

Sequence similaritiesi

Contains 1 CSD (cold-shock) domain.Curated

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ9Y2V2.
OMAiCTIPPKN.
OrthoDBiEOG091G0TYX.
PhylomeDBiQ9Y2V2.
TreeFamiTF324381.

Family and domain databases

CDDicd04458. CSP_CDS. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSEPPPPPQ PPTHQASVGL LDTPRSRERS PSPLRGNVVP SPLPTRRTRT
60 70 80 90 100
FSATVRASQG PVYKGVCKCF CRSKGHGFIT PADGGPDIFL HISDVEGEYV
110 120 130 140
PVEGDEVTYK MCSIPPKNEK LQAVEVVITH LAPGTKHETW SGHVISS
Length:147
Mass (Da):15,892
Last modified:January 16, 2004 - v2
Checksum:i83D70DAE7B1FC573
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60G → V in AAD25021 (PubMed:9712905).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115345 mRNA. Translation: AAD25021.1.
AK311777 mRNA. Translation: BAG34720.1.
CH471112 Genomic DNA. Translation: EAW85196.1.
CH471112 Genomic DNA. Translation: EAW85197.1.
CH471112 Genomic DNA. Translation: EAW85198.1.
CH471112 Genomic DNA. Translation: EAW85199.1.
BC003366 mRNA. Translation: AAH03366.1.
BC108283 mRNA. Translation: AAI08284.1.
CCDSiCCDS10537.1.
RefSeqiNP_001035941.1. NM_001042476.2.
NP_001265189.1. NM_001278260.1.
NP_001265190.1. NM_001278261.1.
NP_001265191.1. NM_001278262.1.
NP_001265192.1. NM_001278263.1.
NP_001265193.1. NM_001278264.1.
NP_001265194.1. NM_001278265.1.
NP_001265195.1. NM_001278266.1.
NP_055131.2. NM_014316.3.
XP_005255286.1. XM_005255229.4.
XP_011520746.1. XM_011522444.2.
UniGeneiHs.632184.

Genome annotation databases

EnsembliENST00000311052; ENSP00000311847; ENSG00000153048.
ENST00000396593; ENSP00000379838; ENSG00000153048.
ENST00000561530; ENSP00000455284; ENSG00000153048.
ENST00000567554; ENSP00000455855; ENSG00000153048.
ENST00000610831; ENSP00000478055; ENSG00000153048.
ENST00000611932; ENSP00000481550; ENSG00000153048.
ENST00000614449; ENSP00000480542; ENSG00000153048.
ENST00000618335; ENSP00000483591; ENSG00000153048.
ENST00000619881; ENSP00000480144; ENSG00000153048.
GeneIDi23589.
KEGGihsa:23589.
UCSCiuc002czh.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF115345 mRNA. Translation: AAD25021.1.
AK311777 mRNA. Translation: BAG34720.1.
CH471112 Genomic DNA. Translation: EAW85196.1.
CH471112 Genomic DNA. Translation: EAW85197.1.
CH471112 Genomic DNA. Translation: EAW85198.1.
CH471112 Genomic DNA. Translation: EAW85199.1.
BC003366 mRNA. Translation: AAH03366.1.
BC108283 mRNA. Translation: AAI08284.1.
CCDSiCCDS10537.1.
RefSeqiNP_001035941.1. NM_001042476.2.
NP_001265189.1. NM_001278260.1.
NP_001265190.1. NM_001278261.1.
NP_001265191.1. NM_001278262.1.
NP_001265192.1. NM_001278263.1.
NP_001265193.1. NM_001278264.1.
NP_001265194.1. NM_001278265.1.
NP_001265195.1. NM_001278266.1.
NP_055131.2. NM_014316.3.
XP_005255286.1. XM_005255229.4.
XP_011520746.1. XM_011522444.2.
UniGeneiHs.632184.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3AQQX-ray2.80A/B/C/D1-147[»]
ProteinModelPortaliQ9Y2V2.
SMRiQ9Y2V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117124. 27 interactors.
IntActiQ9Y2V2. 15 interactors.
MINTiMINT-1432836.
STRINGi9606.ENSP00000311847.

PTM databases

iPTMnetiQ9Y2V2.
PhosphoSitePlusiQ9Y2V2.

Polymorphism and mutation databases

DMDMi41016932.

Proteomic databases

EPDiQ9Y2V2.
MaxQBiQ9Y2V2.
PaxDbiQ9Y2V2.
PeptideAtlasiQ9Y2V2.
PRIDEiQ9Y2V2.
TopDownProteomicsiQ9Y2V2.

Protocols and materials databases

DNASUi23589.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311052; ENSP00000311847; ENSG00000153048.
ENST00000396593; ENSP00000379838; ENSG00000153048.
ENST00000561530; ENSP00000455284; ENSG00000153048.
ENST00000567554; ENSP00000455855; ENSG00000153048.
ENST00000610831; ENSP00000478055; ENSG00000153048.
ENST00000611932; ENSP00000481550; ENSG00000153048.
ENST00000614449; ENSP00000480542; ENSG00000153048.
ENST00000618335; ENSP00000483591; ENSG00000153048.
ENST00000619881; ENSP00000480144; ENSG00000153048.
GeneIDi23589.
KEGGihsa:23589.
UCSCiuc002czh.2. human.

Organism-specific databases

CTDi23589.
GeneCardsiCARHSP1.
HGNCiHGNC:17150. CARHSP1.
HPAiHPA051911.
MIMi616885. gene.
neXtProtiNX_Q9Y2V2.
OpenTargetsiENSG00000153048.
PharmGKBiPA38440.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3070. Eukaryota.
COG1278. LUCA.
GeneTreeiENSGT00390000000022.
HOGENOMiHOG000059524.
HOVERGENiHBG050947.
InParanoidiQ9Y2V2.
OMAiCTIPPKN.
OrthoDBiEOG091G0TYX.
PhylomeDBiQ9Y2V2.
TreeFamiTF324381.

Enzyme and pathway databases

SIGNORiQ9Y2V2.

Miscellaneous databases

ChiTaRSiCARHSP1. human.
GeneWikiiCARHSP1.
GenomeRNAii23589.
PROiQ9Y2V2.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153048.
CleanExiHS_CARHSP1.
ExpressionAtlasiQ9Y2V2. baseline and differential.
GenevisibleiQ9Y2V2. HS.

Family and domain databases

CDDicd04458. CSP_CDS. 1 hit.
InterProiIPR019844. Cold-shock_CS.
IPR011129. Cold_shock_prot.
IPR002059. CSP_DNA-bd.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF00313. CSD. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS00352. COLD_SHOCK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHSP1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2V2
Secondary accession number(s): B2R4C3
, D3DUF5, Q2YDX5, Q9BQ53
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: January 16, 2004
Last modified: November 30, 2016
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.