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Q9Y2U9

- KLDC2_HUMAN

UniProt

Q9Y2U9 - KLDC2_HUMAN

Protein

Kelch domain-containing protein 2

Gene

KLHDC2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 109 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.1 Publication

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kelch domain-containing protein 2
    Alternative name(s):
    Hepatocellular carcinoma-associated antigen 33
    Host cell factor homolog LCP
    Host cell factor-like protein 1
    Short name:
    HCLP-1
    Gene namesi
    Name:KLHDC2
    Synonyms:HCA33
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:20231. KLHDC2.

    Subcellular locationi

    Nucleus 1 Publication

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134924955.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 406406Kelch domain-containing protein 2PRO_0000119127Add
    BLAST

    Proteomic databases

    MaxQBiQ9Y2U9.
    PaxDbiQ9Y2U9.
    PRIDEiQ9Y2U9.

    PTM databases

    PhosphoSiteiQ9Y2U9.

    Expressioni

    Tissue specificityi

    Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.2 Publications

    Gene expression databases

    ArrayExpressiQ9Y2U9.
    BgeeiQ9Y2U9.
    CleanExiHS_KLHDC2.
    GenevestigatoriQ9Y2U9.

    Organism-specific databases

    HPAiHPA000628.

    Interactioni

    Subunit structurei

    Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA and herpes simplex virus transactivator VP16.1 Publication

    Protein-protein interaction databases

    BioGridi117123. 10 interactions.
    IntActiQ9Y2U9. 10 interactions.
    MINTiMINT-1371568.
    STRINGi9606.ENSP00000298307.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2U9.
    SMRiQ9Y2U9. Positions 227-337.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati43 – 8947Kelch 1Add
    BLAST
    Repeati102 – 15554Kelch 2Add
    BLAST
    Repeati157 – 20246Kelch 3Add
    BLAST
    Repeati229 – 27850Kelch 4Add
    BLAST
    Repeati280 – 32950Kelch 5Add
    BLAST
    Repeati331 – 37747Kelch 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 Kelch repeats.Curated

    Keywords - Domaini

    Kelch repeat, Repeat

    Phylogenomic databases

    eggNOGiNOG321152.
    HOGENOMiHOG000006587.
    HOVERGENiHBG067471.
    InParanoidiQ9Y2U9.
    OMAiTFIWSQP.
    OrthoDBiEOG75TMBP.
    PhylomeDBiQ9Y2U9.
    TreeFamiTF314081.

    Family and domain databases

    Gene3Di2.120.10.80. 2 hits.
    InterProiIPR015915. Kelch-typ_b-propeller.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2U9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY    50
    KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD 100
    RVLYLFGGHH SRGNTNKFYM LDSRSTDRVL QWERIDCQGI PPSSKDKLGV 150
    WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT 200
    ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA RMNDLHYLNL 250
    DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTD KQPLSDAWTY 300
    CISKNEWIQF NHPYTEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH 350
    SNEILIFSVQ PKSLVRLSLE AVICFKEMLA NSWNCLPKHL LHSVNQRFGS 400
    NNTSGS 406
    Length:406
    Mass (Da):46,099
    Last modified:November 1, 1999 - v1
    Checksum:i07486B06AC4E97FF
    GO
    Isoform 2 (identifier: Q9Y2U9-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         239-249: DARMNDLHYLN → VSIQTTSMTCF
         250-406: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:249
    Mass (Da):28,198
    Checksum:i19ED55962024271A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251E → D in CAG33486. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei239 – 24911DARMNDLHYLN → VSIQTTSMTCF in isoform 2. 1 PublicationVSP_030165Add
    BLAST
    Alternative sequencei250 – 406157Missing in isoform 2. 1 PublicationVSP_030166Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113131 mRNA. Translation: AAD21038.1.
    AF244137 mRNA. Translation: AAF66246.1.
    BX161429 mRNA. Translation: CAD61901.1.
    AK001771 mRNA. Translation: BAA91898.1.
    AK056298 mRNA. Translation: BAG51671.1.
    CR457205 mRNA. Translation: CAG33486.1.
    CH471078 Genomic DNA. Translation: EAW65749.1.
    CH471078 Genomic DNA. Translation: EAW65750.1.
    BC002335 mRNA. Translation: AAH02335.1.
    BC024192 mRNA. Translation: AAH24192.1.
    CCDSiCCDS9693.1. [Q9Y2U9-1]
    RefSeqiNP_055130.1. NM_014315.2. [Q9Y2U9-1]
    UniGeneiHs.509264.

    Genome annotation databases

    EnsembliENST00000298307; ENSP00000298307; ENSG00000165516. [Q9Y2U9-1]
    ENST00000555443; ENSP00000450944; ENSG00000165516. [Q9Y2U9-2]
    ENST00000555739; ENSP00000450539; ENSG00000165516. [Q9Y2U9-2]
    GeneIDi23588.
    KEGGihsa:23588.
    UCSCiuc001wwx.3. human. [Q9Y2U9-1]

    Polymorphism databases

    DMDMi28380093.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF113131 mRNA. Translation: AAD21038.1 .
    AF244137 mRNA. Translation: AAF66246.1 .
    BX161429 mRNA. Translation: CAD61901.1 .
    AK001771 mRNA. Translation: BAA91898.1 .
    AK056298 mRNA. Translation: BAG51671.1 .
    CR457205 mRNA. Translation: CAG33486.1 .
    CH471078 Genomic DNA. Translation: EAW65749.1 .
    CH471078 Genomic DNA. Translation: EAW65750.1 .
    BC002335 mRNA. Translation: AAH02335.1 .
    BC024192 mRNA. Translation: AAH24192.1 .
    CCDSi CCDS9693.1. [Q9Y2U9-1 ]
    RefSeqi NP_055130.1. NM_014315.2. [Q9Y2U9-1 ]
    UniGenei Hs.509264.

    3D structure databases

    ProteinModelPortali Q9Y2U9.
    SMRi Q9Y2U9. Positions 227-337.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 117123. 10 interactions.
    IntActi Q9Y2U9. 10 interactions.
    MINTi MINT-1371568.
    STRINGi 9606.ENSP00000298307.

    PTM databases

    PhosphoSitei Q9Y2U9.

    Polymorphism databases

    DMDMi 28380093.

    Proteomic databases

    MaxQBi Q9Y2U9.
    PaxDbi Q9Y2U9.
    PRIDEi Q9Y2U9.

    Protocols and materials databases

    DNASUi 23588.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000298307 ; ENSP00000298307 ; ENSG00000165516 . [Q9Y2U9-1 ]
    ENST00000555443 ; ENSP00000450944 ; ENSG00000165516 . [Q9Y2U9-2 ]
    ENST00000555739 ; ENSP00000450539 ; ENSG00000165516 . [Q9Y2U9-2 ]
    GeneIDi 23588.
    KEGGi hsa:23588.
    UCSCi uc001wwx.3. human. [Q9Y2U9-1 ]

    Organism-specific databases

    CTDi 23588.
    GeneCardsi GC14P050234.
    HGNCi HGNC:20231. KLHDC2.
    HPAi HPA000628.
    MIMi 611280. gene.
    neXtProti NX_Q9Y2U9.
    PharmGKBi PA134924955.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG321152.
    HOGENOMi HOG000006587.
    HOVERGENi HBG067471.
    InParanoidi Q9Y2U9.
    OMAi TFIWSQP.
    OrthoDBi EOG75TMBP.
    PhylomeDBi Q9Y2U9.
    TreeFami TF314081.

    Miscellaneous databases

    GenomeRNAii 23588.
    NextBioi 46222.
    PROi Q9Y2U9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2U9.
    Bgeei Q9Y2U9.
    CleanExi HS_KLHDC2.
    Genevestigatori Q9Y2U9.

    Family and domain databases

    Gene3Di 2.120.10.80. 2 hits.
    InterProi IPR015915. Kelch-typ_b-propeller.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein."
      Zhou H.-J., Wong C.-M., Chen J.-H., Qiang B.-Q., Yuan J.-G., Jin D.-Y.
      J. Biol. Chem. 276:28933-28938(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CREB3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
      Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
      J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Hepatoma.
    3. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Placenta.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Ovarian carcinoma.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Kidney.
    8. "Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2."
      Chin K.-T., Xu H.-T., Ching Y.-P., Jin D.-Y.
      Mol. Cell. Biochem. 296:109-119(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiKLDC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2U9
    Secondary accession number(s): B3KPF9, Q6IAF0, Q86TY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 12, 2003
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 109 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3