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Q9Y2U9

- KLDC2_HUMAN

UniProt

Q9Y2U9 - KLDC2_HUMAN

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Protein

Kelch domain-containing protein 2

Gene
KLHDC2, HCA33
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 2
Alternative name(s):
Hepatocellular carcinoma-associated antigen 33
Host cell factor homolog LCP
Host cell factor-like protein 1
Short name:
HCLP-1
Gene namesi
Name:KLHDC2
Synonyms:HCA33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 14

Organism-specific databases

HGNCiHGNC:20231. KLHDC2.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134924955.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 406406Kelch domain-containing protein 2PRO_0000119127Add
BLAST

Proteomic databases

MaxQBiQ9Y2U9.
PaxDbiQ9Y2U9.
PRIDEiQ9Y2U9.

PTM databases

PhosphoSiteiQ9Y2U9.

Expressioni

Tissue specificityi

Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.2 Publications

Gene expression databases

ArrayExpressiQ9Y2U9.
BgeeiQ9Y2U9.
CleanExiHS_KLHDC2.
GenevestigatoriQ9Y2U9.

Organism-specific databases

HPAiHPA000628.

Interactioni

Subunit structurei

Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA and herpes simplex virus transactivator VP16.1 Publication

Protein-protein interaction databases

BioGridi117123. 10 interactions.
IntActiQ9Y2U9. 9 interactions.
MINTiMINT-1371568.
STRINGi9606.ENSP00000298307.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2U9.
SMRiQ9Y2U9. Positions 227-337.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati43 – 8947Kelch 1Add
BLAST
Repeati102 – 15554Kelch 2Add
BLAST
Repeati157 – 20246Kelch 3Add
BLAST
Repeati229 – 27850Kelch 4Add
BLAST
Repeati280 – 32950Kelch 5Add
BLAST
Repeati331 – 37747Kelch 6Add
BLAST

Sequence similaritiesi

Contains 6 Kelch repeats.

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiNOG321152.
HOGENOMiHOG000006587.
HOVERGENiHBG067471.
InParanoidiQ9Y2U9.
OMAiTFIWSQP.
OrthoDBiEOG75TMBP.
PhylomeDBiQ9Y2U9.
TreeFamiTF314081.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2U9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY    50
KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD 100
RVLYLFGGHH SRGNTNKFYM LDSRSTDRVL QWERIDCQGI PPSSKDKLGV 150
WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT 200
ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA RMNDLHYLNL 250
DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTD KQPLSDAWTY 300
CISKNEWIQF NHPYTEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH 350
SNEILIFSVQ PKSLVRLSLE AVICFKEMLA NSWNCLPKHL LHSVNQRFGS 400
NNTSGS 406
Length:406
Mass (Da):46,099
Last modified:November 1, 1999 - v1
Checksum:i07486B06AC4E97FF
GO
Isoform 2 (identifier: Q9Y2U9-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-249: DARMNDLHYLN → VSIQTTSMTCF
     250-406: Missing.

Note: No experimental confirmation available.

Show »
Length:249
Mass (Da):28,198
Checksum:i19ED55962024271A
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei239 – 24911DARMNDLHYLN → VSIQTTSMTCF in isoform 2. VSP_030165Add
BLAST
Alternative sequencei250 – 406157Missing in isoform 2. VSP_030166Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251E → D in CAG33486. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF113131 mRNA. Translation: AAD21038.1.
AF244137 mRNA. Translation: AAF66246.1.
BX161429 mRNA. Translation: CAD61901.1.
AK001771 mRNA. Translation: BAA91898.1.
AK056298 mRNA. Translation: BAG51671.1.
CR457205 mRNA. Translation: CAG33486.1.
CH471078 Genomic DNA. Translation: EAW65749.1.
CH471078 Genomic DNA. Translation: EAW65750.1.
BC002335 mRNA. Translation: AAH02335.1.
BC024192 mRNA. Translation: AAH24192.1.
CCDSiCCDS9693.1. [Q9Y2U9-1]
RefSeqiNP_055130.1. NM_014315.2. [Q9Y2U9-1]
UniGeneiHs.509264.

Genome annotation databases

EnsembliENST00000298307; ENSP00000298307; ENSG00000165516. [Q9Y2U9-1]
ENST00000555443; ENSP00000450944; ENSG00000165516. [Q9Y2U9-2]
ENST00000555739; ENSP00000450539; ENSG00000165516. [Q9Y2U9-2]
GeneIDi23588.
KEGGihsa:23588.
UCSCiuc001wwx.3. human. [Q9Y2U9-1]

Polymorphism databases

DMDMi28380093.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF113131 mRNA. Translation: AAD21038.1 .
AF244137 mRNA. Translation: AAF66246.1 .
BX161429 mRNA. Translation: CAD61901.1 .
AK001771 mRNA. Translation: BAA91898.1 .
AK056298 mRNA. Translation: BAG51671.1 .
CR457205 mRNA. Translation: CAG33486.1 .
CH471078 Genomic DNA. Translation: EAW65749.1 .
CH471078 Genomic DNA. Translation: EAW65750.1 .
BC002335 mRNA. Translation: AAH02335.1 .
BC024192 mRNA. Translation: AAH24192.1 .
CCDSi CCDS9693.1. [Q9Y2U9-1 ]
RefSeqi NP_055130.1. NM_014315.2. [Q9Y2U9-1 ]
UniGenei Hs.509264.

3D structure databases

ProteinModelPortali Q9Y2U9.
SMRi Q9Y2U9. Positions 227-337.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117123. 10 interactions.
IntActi Q9Y2U9. 9 interactions.
MINTi MINT-1371568.
STRINGi 9606.ENSP00000298307.

PTM databases

PhosphoSitei Q9Y2U9.

Polymorphism databases

DMDMi 28380093.

Proteomic databases

MaxQBi Q9Y2U9.
PaxDbi Q9Y2U9.
PRIDEi Q9Y2U9.

Protocols and materials databases

DNASUi 23588.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000298307 ; ENSP00000298307 ; ENSG00000165516 . [Q9Y2U9-1 ]
ENST00000555443 ; ENSP00000450944 ; ENSG00000165516 . [Q9Y2U9-2 ]
ENST00000555739 ; ENSP00000450539 ; ENSG00000165516 . [Q9Y2U9-2 ]
GeneIDi 23588.
KEGGi hsa:23588.
UCSCi uc001wwx.3. human. [Q9Y2U9-1 ]

Organism-specific databases

CTDi 23588.
GeneCardsi GC14P050234.
HGNCi HGNC:20231. KLHDC2.
HPAi HPA000628.
MIMi 611280. gene.
neXtProti NX_Q9Y2U9.
PharmGKBi PA134924955.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321152.
HOGENOMi HOG000006587.
HOVERGENi HBG067471.
InParanoidi Q9Y2U9.
OMAi TFIWSQP.
OrthoDBi EOG75TMBP.
PhylomeDBi Q9Y2U9.
TreeFami TF314081.

Miscellaneous databases

GenomeRNAii 23588.
NextBioi 46222.
PROi Q9Y2U9.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2U9.
Bgeei Q9Y2U9.
CleanExi HS_KLHDC2.
Genevestigatori Q9Y2U9.

Family and domain databases

Gene3Di 2.120.10.80. 2 hits.
InterProi IPR015915. Kelch-typ_b-propeller.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein."
    Zhou H.-J., Wong C.-M., Chen J.-H., Qiang B.-Q., Yuan J.-G., Jin D.-Y.
    J. Biol. Chem. 276:28933-28938(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CREB3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
    Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
    J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Hepatoma.
  3. "Full-length cDNA libraries and normalization."
    Li W.B., Gruber C., Jessee J., Polayes D.
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Placenta.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Ovarian carcinoma.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain and Kidney.
  8. "Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2."
    Chin K.-T., Xu H.-T., Ching Y.-P., Jin D.-Y.
    Mol. Cell. Biochem. 296:109-119(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiKLDC2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2U9
Secondary accession number(s): B3KPF9, Q6IAF0, Q86TY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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