Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Kelch domain-containing protein 2

Gene

KLHDC2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding.1 Publication

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165516-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Kelch domain-containing protein 2
Alternative name(s):
Hepatocellular carcinoma-associated antigen 33
Host cell factor homolog LCP
Host cell factor-like protein 1
Short name:
HCLP-1
Gene namesi
Name:KLHDC2
Synonyms:HCA33
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:20231. KLHDC2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi23588.
OpenTargetsiENSG00000165516.
PharmGKBiPA134924955.

Polymorphism and mutation databases

BioMutaiKLHDC2.
DMDMi28380093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001191271 – 406Kelch domain-containing protein 2Add BLAST406

Proteomic databases

EPDiQ9Y2U9.
PaxDbiQ9Y2U9.
PeptideAtlasiQ9Y2U9.
PRIDEiQ9Y2U9.

PTM databases

iPTMnetiQ9Y2U9.
PhosphoSitePlusiQ9Y2U9.

Expressioni

Tissue specificityi

Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes.2 Publications

Gene expression databases

BgeeiENSG00000165516.
CleanExiHS_KLHDC2.
ExpressionAtlasiQ9Y2U9. baseline and differential.
GenevisibleiQ9Y2U9. HS.

Organism-specific databases

HPAiHPA000628.

Interactioni

Subunit structurei

Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA and herpes simplex virus transactivator VP16.1 Publication

Protein-protein interaction databases

BioGridi117123. 49 interactors.
IntActiQ9Y2U9. 19 interactors.
MINTiMINT-1371568.
STRINGi9606.ENSP00000298307.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2U9.
SMRiQ9Y2U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati43 – 89Kelch 1Add BLAST47
Repeati102 – 155Kelch 2Add BLAST54
Repeati157 – 202Kelch 3Add BLAST46
Repeati229 – 278Kelch 4Add BLAST50
Repeati280 – 329Kelch 5Add BLAST50
Repeati331 – 377Kelch 6Add BLAST47

Sequence similaritiesi

Contains 6 Kelch repeats.Curated

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000006587.
HOVERGENiHBG067471.
InParanoidiQ9Y2U9.
OMAiIWSQPIT.
OrthoDBiEOG091G06BF.
PhylomeDBiQ9Y2U9.
TreeFamiTF314081.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2U9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY
60 70 80 90 100
KSNQVRGLYD FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD
110 120 130 140 150
RVLYLFGGHH SRGNTNKFYM LDSRSTDRVL QWERIDCQGI PPSSKDKLGV
160 170 180 190 200
WVYKNKLIFF GGYGYLPEDK VLGTFEFDET SFWNSSHPRG WNDHVHILDT
210 220 230 240 250
ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA RMNDLHYLNL
260 270 280 290 300
DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTD KQPLSDAWTY
310 320 330 340 350
CISKNEWIQF NHPYTEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH
360 370 380 390 400
SNEILIFSVQ PKSLVRLSLE AVICFKEMLA NSWNCLPKHL LHSVNQRFGS

NNTSGS
Length:406
Mass (Da):46,099
Last modified:November 1, 1999 - v1
Checksum:i07486B06AC4E97FF
GO
Isoform 2 (identifier: Q9Y2U9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     239-249: DARMNDLHYLN → VSIQTTSMTCF
     250-406: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):28,198
Checksum:i19ED55962024271A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25E → D in CAG33486 (Ref. 5) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030165239 – 249DARMNDLHYLN → VSIQTTSMTCF in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_030166250 – 406Missing in isoform 2. 1 PublicationAdd BLAST157

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113131 mRNA. Translation: AAD21038.1.
AF244137 mRNA. Translation: AAF66246.1.
BX161429 mRNA. Translation: CAD61901.1.
AK001771 mRNA. Translation: BAA91898.1.
AK056298 mRNA. Translation: BAG51671.1.
CR457205 mRNA. Translation: CAG33486.1.
CH471078 Genomic DNA. Translation: EAW65749.1.
CH471078 Genomic DNA. Translation: EAW65750.1.
BC002335 mRNA. Translation: AAH02335.1.
BC024192 mRNA. Translation: AAH24192.1.
CCDSiCCDS9693.1. [Q9Y2U9-1]
RefSeqiNP_055130.1. NM_014315.2. [Q9Y2U9-1]
UniGeneiHs.509264.

Genome annotation databases

EnsembliENST00000298307; ENSP00000298307; ENSG00000165516. [Q9Y2U9-1]
ENST00000555443; ENSP00000450944; ENSG00000165516. [Q9Y2U9-2]
ENST00000555739; ENSP00000450539; ENSG00000165516. [Q9Y2U9-2]
GeneIDi23588.
KEGGihsa:23588.
UCSCiuc001wwx.4. human. [Q9Y2U9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF113131 mRNA. Translation: AAD21038.1.
AF244137 mRNA. Translation: AAF66246.1.
BX161429 mRNA. Translation: CAD61901.1.
AK001771 mRNA. Translation: BAA91898.1.
AK056298 mRNA. Translation: BAG51671.1.
CR457205 mRNA. Translation: CAG33486.1.
CH471078 Genomic DNA. Translation: EAW65749.1.
CH471078 Genomic DNA. Translation: EAW65750.1.
BC002335 mRNA. Translation: AAH02335.1.
BC024192 mRNA. Translation: AAH24192.1.
CCDSiCCDS9693.1. [Q9Y2U9-1]
RefSeqiNP_055130.1. NM_014315.2. [Q9Y2U9-1]
UniGeneiHs.509264.

3D structure databases

ProteinModelPortaliQ9Y2U9.
SMRiQ9Y2U9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117123. 49 interactors.
IntActiQ9Y2U9. 19 interactors.
MINTiMINT-1371568.
STRINGi9606.ENSP00000298307.

PTM databases

iPTMnetiQ9Y2U9.
PhosphoSitePlusiQ9Y2U9.

Polymorphism and mutation databases

BioMutaiKLHDC2.
DMDMi28380093.

Proteomic databases

EPDiQ9Y2U9.
PaxDbiQ9Y2U9.
PeptideAtlasiQ9Y2U9.
PRIDEiQ9Y2U9.

Protocols and materials databases

DNASUi23588.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000298307; ENSP00000298307; ENSG00000165516. [Q9Y2U9-1]
ENST00000555443; ENSP00000450944; ENSG00000165516. [Q9Y2U9-2]
ENST00000555739; ENSP00000450539; ENSG00000165516. [Q9Y2U9-2]
GeneIDi23588.
KEGGihsa:23588.
UCSCiuc001wwx.4. human. [Q9Y2U9-1]

Organism-specific databases

CTDi23588.
DisGeNETi23588.
GeneCardsiKLHDC2.
HGNCiHGNC:20231. KLHDC2.
HPAiHPA000628.
MIMi611280. gene.
neXtProtiNX_Q9Y2U9.
OpenTargetsiENSG00000165516.
PharmGKBiPA134924955.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0379. Eukaryota.
ENOG410Y5WM. LUCA.
GeneTreeiENSGT00760000119086.
HOGENOMiHOG000006587.
HOVERGENiHBG067471.
InParanoidiQ9Y2U9.
OMAiIWSQPIT.
OrthoDBiEOG091G06BF.
PhylomeDBiQ9Y2U9.
TreeFamiTF314081.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000165516-MONOMER.

Miscellaneous databases

GenomeRNAii23588.
PROiQ9Y2U9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000165516.
CleanExiHS_KLHDC2.
ExpressionAtlasiQ9Y2U9. baseline and differential.
GenevisibleiQ9Y2U9. HS.

Family and domain databases

Gene3Di2.120.10.80. 2 hits.
InterProiIPR015915. Kelch-typ_b-propeller.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKLDC2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2U9
Secondary accession number(s): B3KPF9, Q6IAF0, Q86TY9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.