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Q9Y2U9 (KLDC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kelch domain-containing protein 2
Alternative name(s):
Hepatocellular carcinoma-associated antigen 33
Host cell factor homolog LCP
Host cell factor-like protein 1
Short name=HCLP-1
Gene names
Name:KLHDC2
Synonyms:HCA33
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Represses CREB3-mediated transcription by interfering with CREB3-DNA binding. Ref.1

Subunit structure

Directly interacts with CREB3, but not with CREB1, ATF4, ATF6, JUN, FOS, CEBPA and herpes simplex virus transactivator VP16. Ref.1

Subcellular location

Nucleus Ref.1.

Tissue specificity

Widely expressed, with high levels in skeletal muscle, heart, pancreas and liver. Undetectable in peripheral blood leukocytes. Ref.1 Ref.8

Sequence similarities

Contains 6 Kelch repeats.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainKelch repeat
Repeat
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y2U9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y2U9-2)

The sequence of this isoform differs from the canonical sequence as follows:
     239-249: DARMNDLHYLN → VSIQTTSMTCF
     250-406: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Kelch domain-containing protein 2
PRO_0000119127

Regions

Repeat43 – 8947Kelch 1
Repeat102 – 15554Kelch 2
Repeat157 – 20246Kelch 3
Repeat229 – 27850Kelch 4
Repeat280 – 32950Kelch 5
Repeat331 – 37747Kelch 6

Natural variations

Alternative sequence239 – 24911DARMNDLHYLN → VSIQTTSMTCF in isoform 2.
VSP_030165
Alternative sequence250 – 406157Missing in isoform 2.
VSP_030166

Experimental info

Sequence conflict251E → D in CAG33486. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 07486B06AC4E97FF

FASTA40646,099
        10         20         30         40         50         60 
MADGNEDLRA DDLPGPAFES YESMELACPA ERSGHVAVSD GRHMFVWGGY KSNQVRGLYD 

        70         80         90        100        110        120 
FYLPREELWI YNMETGRWKK INTEGDVPPS MSGSCAVCVD RVLYLFGGHH SRGNTNKFYM 

       130        140        150        160        170        180 
LDSRSTDRVL QWERIDCQGI PPSSKDKLGV WVYKNKLIFF GGYGYLPEDK VLGTFEFDET 

       190        200        210        220        230        240 
SFWNSSHPRG WNDHVHILDT ETFTWSQPIT TGKAPSPRAA HACATVGNRG FVFGGRYRDA 

       250        260        270        280        290        300 
RMNDLHYLNL DTWEWNELIP QGICPVGRSW HSLTPVSSDH LFLFGGFTTD KQPLSDAWTY 

       310        320        330        340        350        360 
CISKNEWIQF NHPYTEKPRL WHTACASDEG EVIVFGGCAN NLLVHHRAAH SNEILIFSVQ 

       370        380        390        400 
PKSLVRLSLE AVICFKEMLA NSWNCLPKHL LHSVNQRFGS NNTSGS 

« Hide

Isoform 2 [UniParc].

Checksum: 19ED55962024271A
Show »

FASTA24928,198

References

« Hide 'large scale' references
[1]"Inhibition of LZIP-mediated transcription through direct interaction with a novel host cell factor-like protein."
Zhou H.-J., Wong C.-M., Chen J.-H., Qiang B.-Q., Yuan J.-G., Jin D.-Y.
J. Biol. Chem. 276:28933-28938(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, INTERACTION WITH CREB3, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies."
Wang Y., Han K.-J., Pang X.-W., Vaughan H.A., Qu W., Dong X.-Y., Peng J.-R., Zhao H.-T., Rui J.-A., Leng X.-S., Cebon J., Burgess A.W., Chen W.-F.
J. Immunol. 169:1102-1109(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Tissue: Hepatoma.
[3]"Full-length cDNA libraries and normalization."
Li W.B., Gruber C., Jessee J., Polayes D.
Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Placenta.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Ovarian carcinoma.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Brain and Kidney.
[8]"Differential subcellular localization and activity of kelch repeat proteins KLHDC1 and KLHDC2."
Chin K.-T., Xu H.-T., Ching Y.-P., Jin D.-Y.
Mol. Cell. Biochem. 296:109-119(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF113131 mRNA. Translation: AAD21038.1.
AF244137 mRNA. Translation: AAF66246.1.
BX161429 mRNA. Translation: CAD61901.1.
AK001771 mRNA. Translation: BAA91898.1.
AK056298 mRNA. Translation: BAG51671.1.
CR457205 mRNA. Translation: CAG33486.1.
CH471078 Genomic DNA. Translation: EAW65749.1.
CH471078 Genomic DNA. Translation: EAW65750.1.
BC002335 mRNA. Translation: AAH02335.1.
BC024192 mRNA. Translation: AAH24192.1.
RefSeqNP_055130.1. NM_014315.2.
UniGeneHs.509264.

3D structure databases

ProteinModelPortalQ9Y2U9.
SMRQ9Y2U9. Positions 227-337.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117123. 10 interactions.
IntActQ9Y2U9. 9 interactions.
MINTMINT-1371568.
STRING9606.ENSP00000298307.

PTM databases

PhosphoSiteQ9Y2U9.

Polymorphism databases

DMDM28380093.

Proteomic databases

PaxDbQ9Y2U9.
PRIDEQ9Y2U9.

Protocols and materials databases

DNASU23588.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000298307; ENSP00000298307; ENSG00000165516. [Q9Y2U9-1]
ENST00000555443; ENSP00000450944; ENSG00000165516. [Q9Y2U9-2]
ENST00000555739; ENSP00000450539; ENSG00000165516. [Q9Y2U9-2]
GeneID23588.
KEGGhsa:23588.
UCSCuc001wwx.3. human. [Q9Y2U9-1]

Organism-specific databases

CTD23588.
GeneCardsGC14P050234.
HGNCHGNC:20231. KLHDC2.
HPAHPA000628.
MIM611280. gene.
neXtProtNX_Q9Y2U9.
PharmGKBPA134924955.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG321152.
HOGENOMHOG000006587.
HOVERGENHBG067471.
InParanoidQ9Y2U9.
OMALDTETFI.
OrthoDBEOG75TMBP.
PhylomeDBQ9Y2U9.
TreeFamTF314081.

Gene expression databases

ArrayExpressQ9Y2U9.
BgeeQ9Y2U9.
CleanExHS_KLHDC2.
GenevestigatorQ9Y2U9.

Family and domain databases

Gene3D2.120.10.80. 2 hits.
InterProIPR015915. Kelch-typ_b-propeller.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi23588.
NextBio46222.
PROQ9Y2U9.
SOURCESearch...

Entry information

Entry nameKLDC2_HUMAN
AccessionPrimary (citable) accession number: Q9Y2U9
Secondary accession number(s): B3KPF9, Q6IAF0, Q86TY9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 14

Human chromosome 14: entries, gene names and cross-references to MIM