Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9Y2U2 (KCNK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 108. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Potassium channel subfamily K member 7
Gene names
Name:KCNK7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length307 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

Subunit structure

Homodimer Potential.

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Keywords
   Biological processIon transport
Potassium transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   LigandPotassium
   Molecular functionIon channel
Potassium channel
Voltage-gated channel
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsynaptic transmission

Traceable author statement. Source: Reactome

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Traceable author statement. Source: Reactome

   Molecular_functionpotassium channel activity

Traceable author statement Ref.1. Source: ProtInc

voltage-gated ion channel activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q9Y2U2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q9Y2U2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     241-252: YLLLGLLAMLLA → GGTSLQGTAWEG
     253-307: Missing.
Isoform C (identifier: Q9Y2U2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     241-257: YLLLGLLAMLLAVETFS → KSSHLTACGGRGKRSLD
     258-307: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 307307Potassium channel subfamily K member 7
PRO_0000101751

Regions

Topological domain1 – 1010Cytoplasmic Potential
Transmembrane11 – 3121Helical; Potential
Intramembrane92 – 11928Pore-forming; Name=Pore-forming 1; Potential
Transmembrane120 – 14021Helical; Potential
Topological domain141 – 17030Cytoplasmic Potential
Transmembrane171 – 19121Helical; Potential
Intramembrane199 – 22729Pore-forming; Name=Pore-forming 2; Potential
Transmembrane233 – 25321Helical; Potential
Topological domain254 – 30754Cytoplasmic Potential

Amino acid modifications

Glycosylation831N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence241 – 25717YLLLG…VETFS → KSSHLTACGGRGKRSLD in isoform C.
VSP_006695
Alternative sequence241 – 25212YLLLG…AMLLA → GGTSLQGTAWEG in isoform B.
VSP_006693
Alternative sequence253 – 30755Missing in isoform B.
VSP_006694
Alternative sequence258 – 30750Missing in isoform C.
VSP_006696

Sequences

Sequence LengthMass (Da)Tools
Isoform A [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: BD4A36DD9591ADAC

FASTA30731,947
        10         20         30         40         50         60 
MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF QAEHRACLPP 

        70         80         90        100        110        120 
GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA SILTTTGYGH MAPLSPGGKA 

       130        140        150        160        170        180 
FCMVYAALGL PASLALVATL RHCLLPVLSR PRAWVAVHWQ LSPARAALLQ AVALGLLVAS 

       190        200        210        220        230        240 
SFVLLPALVL WGLQGDCSLL GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG 

       250        260        270        280        290        300 
YLLLGLLAML LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA 


SGQAPAC 

« Hide

Isoform B [UniParc].

Checksum: A0C93A5D690C3295
Show »

FASTA25226,212
Isoform C [UniParc].

Checksum: 73FBC250F69D67FB
Show »

FASTA25726,822

References

« Hide 'large scale' references
[1]"Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure."
Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G., Lazdunski M.
J. Biol. Chem. 274:11751-11760(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
Tissue: Brain.
[2]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF110522 mRNA. Translation: AAD29578.1.
AF110524 mRNA. Translation: AAD29580.1.
AF110523 mRNA. Translation: AAD29579.1.
CH471076 Genomic DNA. Translation: EAW74413.1.
BC103809 mRNA. Translation: AAI03810.1.
RefSeqNP_005705.1. NM_005714.1.
NP_203133.1. NM_033347.1.
NP_203134.1. NM_033348.1.
NP_258416.1. NM_033455.1.
UniGeneHs.175218.

3D structure databases

ProteinModelPortalQ9Y2U2.
SMRQ9Y2U2. Positions 10-269.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM13124109.

Proteomic databases

PaxDbQ9Y2U2.
PRIDEQ9Y2U2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000340313; ENSP00000344820; ENSG00000173338. [Q9Y2U2-1]
ENST00000342202; ENSP00000343923; ENSG00000173338. [Q9Y2U2-2]
ENST00000394216; ENSP00000377764; ENSG00000173338. [Q9Y2U2-3]
ENST00000394217; ENSP00000377765; ENSG00000173338. [Q9Y2U2-2]
GeneID10089.
KEGGhsa:10089.
UCSCuc001oeq.3. human. [Q9Y2U2-2]
uc001oes.3. human. [Q9Y2U2-1]
uc001oeu.3. human. [Q9Y2U2-3]

Organism-specific databases

CTD10089.
GeneCardsGC11M065360.
HGNCHGNC:6282. KCNK7.
MIM603940. gene.
neXtProtNX_Q9Y2U2.
PharmGKBPA30064.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG265536.
HOGENOMHOG000286014.
HOVERGENHBG052237.
InParanoidQ9Y2U2.
KOK04918.
OMAYGACLPP.
TreeFamTF313947.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

BgeeQ9Y2U2.
CleanExHS_KCNK7.
GenevestigatorQ9Y2U2.

Family and domain databases

InterProIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
[Graphical view]
PfamPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSPR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.
ProtoNetSearch...

Other

GeneWikiKCNK7.
GenomeRNAi10089.
NextBio38151.
PROQ9Y2U2.
SOURCESearch...

Entry information

Entry nameKCNK7_HUMAN
AccessionPrimary (citable) accession number: Q9Y2U2
Secondary accession number(s): Q3SYI2, Q9Y2U3, Q9Y2U4
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: March 19, 2014
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM