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Q9Y2U2

- KCNK7_HUMAN

UniProt

Q9Y2U2 - KCNK7_HUMAN

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Protein
Potassium channel subfamily K member 7
Gene
KCNK7
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

GO - Molecular functioni

  1. potassium channel activity Source: ProtInc
  2. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. potassium ion transport Source: ProtInc
  2. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 7
Gene namesi
Name:KCNK7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6282. KCNK7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010Cytoplasmic Reviewed prediction
Transmembranei11 – 3121Helical; Reviewed prediction
Add
BLAST
Intramembranei92 – 11928Pore-forming; Name=Pore-forming 1; Reviewed prediction
Add
BLAST
Transmembranei120 – 14021Helical; Reviewed prediction
Add
BLAST
Topological domaini141 – 17030Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei171 – 19121Helical; Reviewed prediction
Add
BLAST
Intramembranei199 – 22729Pore-forming; Name=Pore-forming 2; Reviewed prediction
Add
BLAST
Transmembranei233 – 25321Helical; Reviewed prediction
Add
BLAST
Topological domaini254 – 30754Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Potassium channel subfamily K member 7
PRO_0000101751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y2U2.
PRIDEiQ9Y2U2.

Expressioni

Gene expression databases

BgeeiQ9Y2U2.
CleanExiHS_KCNK7.
GenevestigatoriQ9Y2U2.

Interactioni

Subunit structurei

Homodimer Reviewed prediction.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2U2.
SMRiQ9Y2U2. Positions 10-269.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265536.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiQ9Y2U2.
KOiK04918.
OMAiYGACLPP.
PhylomeDBiQ9Y2U2.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9Y2U2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF    50
QAEHRACLPP GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA 100
SILTTTGYGH MAPLSPGGKA FCMVYAALGL PASLALVATL RHCLLPVLSR 150
PRAWVAVHWQ LSPARAALLQ AVALGLLVAS SFVLLPALVL WGLQGDCSLL 200
GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG YLLLGLLAML 250
LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA 300
SGQAPAC 307
Length:307
Mass (Da):31,947
Last modified:November 1, 1999 - v1
Checksum:iBD4A36DD9591ADAC
GO
Isoform B (identifier: Q9Y2U2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-252: YLLLGLLAMLLA → GGTSLQGTAWEG
     253-307: Missing.

Show »
Length:252
Mass (Da):26,212
Checksum:iA0C93A5D690C3295
GO
Isoform C (identifier: Q9Y2U2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-257: YLLLGLLAMLLAVETFS → KSSHLTACGGRGKRSLD
     258-307: Missing.

Show »
Length:257
Mass (Da):26,822
Checksum:i73FBC250F69D67FB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei241 – 25717YLLLG…VETFS → KSSHLTACGGRGKRSLD in isoform C.
VSP_006695Add
BLAST
Alternative sequencei241 – 25212YLLLG…AMLLA → GGTSLQGTAWEG in isoform B.
VSP_006693Add
BLAST
Alternative sequencei253 – 30755Missing in isoform B.
VSP_006694Add
BLAST
Alternative sequencei258 – 30750Missing in isoform C.
VSP_006696Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110522 mRNA. Translation: AAD29578.1.
AF110524 mRNA. Translation: AAD29580.1.
AF110523 mRNA. Translation: AAD29579.1.
CH471076 Genomic DNA. Translation: EAW74413.1.
BC103809 mRNA. Translation: AAI03810.1.
CCDSiCCDS31608.1. [Q9Y2U2-1]
CCDS41673.1. [Q9Y2U2-3]
CCDS8106.1. [Q9Y2U2-2]
RefSeqiNP_005705.1. NM_005714.1. [Q9Y2U2-3]
NP_203133.1. NM_033347.1. [Q9Y2U2-1]
NP_203134.1. NM_033348.1. [Q9Y2U2-2]
NP_258416.1. NM_033455.1. [Q9Y2U2-2]
UniGeneiHs.175218.

Genome annotation databases

EnsembliENST00000340313; ENSP00000344820; ENSG00000173338. [Q9Y2U2-1]
ENST00000342202; ENSP00000343923; ENSG00000173338. [Q9Y2U2-2]
ENST00000394216; ENSP00000377764; ENSG00000173338. [Q9Y2U2-3]
ENST00000394217; ENSP00000377765; ENSG00000173338. [Q9Y2U2-2]
GeneIDi10089.
KEGGihsa:10089.
UCSCiuc001oeq.3. human. [Q9Y2U2-2]
uc001oes.3. human. [Q9Y2U2-1]
uc001oeu.3. human. [Q9Y2U2-3]

Polymorphism databases

DMDMi13124109.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF110522 mRNA. Translation: AAD29578.1 .
AF110524 mRNA. Translation: AAD29580.1 .
AF110523 mRNA. Translation: AAD29579.1 .
CH471076 Genomic DNA. Translation: EAW74413.1 .
BC103809 mRNA. Translation: AAI03810.1 .
CCDSi CCDS31608.1. [Q9Y2U2-1 ]
CCDS41673.1. [Q9Y2U2-3 ]
CCDS8106.1. [Q9Y2U2-2 ]
RefSeqi NP_005705.1. NM_005714.1. [Q9Y2U2-3 ]
NP_203133.1. NM_033347.1. [Q9Y2U2-1 ]
NP_203134.1. NM_033348.1. [Q9Y2U2-2 ]
NP_258416.1. NM_033455.1. [Q9Y2U2-2 ]
UniGenei Hs.175218.

3D structure databases

ProteinModelPortali Q9Y2U2.
SMRi Q9Y2U2. Positions 10-269.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 13124109.

Proteomic databases

PaxDbi Q9Y2U2.
PRIDEi Q9Y2U2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340313 ; ENSP00000344820 ; ENSG00000173338 . [Q9Y2U2-1 ]
ENST00000342202 ; ENSP00000343923 ; ENSG00000173338 . [Q9Y2U2-2 ]
ENST00000394216 ; ENSP00000377764 ; ENSG00000173338 . [Q9Y2U2-3 ]
ENST00000394217 ; ENSP00000377765 ; ENSG00000173338 . [Q9Y2U2-2 ]
GeneIDi 10089.
KEGGi hsa:10089.
UCSCi uc001oeq.3. human. [Q9Y2U2-2 ]
uc001oes.3. human. [Q9Y2U2-1 ]
uc001oeu.3. human. [Q9Y2U2-3 ]

Organism-specific databases

CTDi 10089.
GeneCardsi GC11M065360.
HGNCi HGNC:6282. KCNK7.
MIMi 603940. gene.
neXtProti NX_Q9Y2U2.
PharmGKBi PA30064.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265536.
HOGENOMi HOG000286014.
HOVERGENi HBG052237.
InParanoidi Q9Y2U2.
KOi K04918.
OMAi YGACLPP.
PhylomeDBi Q9Y2U2.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Miscellaneous databases

GeneWikii KCNK7.
GenomeRNAii 10089.
NextBioi 38151.
PROi Q9Y2U2.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2U2.
CleanExi HS_KCNK7.
Genevestigatori Q9Y2U2.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSi PR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure."
    Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G., Lazdunski M.
    J. Biol. Chem. 274:11751-11760(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).

Entry informationi

Entry nameiKCNK7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2U2
Secondary accession number(s): Q3SYI2, Q9Y2U3, Q9Y2U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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