Q9Y2U2 (KCNK7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Potassium channel subfamily K member 7

Gene names

Name:

KCNK7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	307 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.
Subunit structure	Homodimer Potential.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the two pore domain potassium channel (TC 1.A.1.8) family. [View classification]

Ontologies

Keywords
Biological process	Ion transport Potassium transport Transport
Cellular component	Membrane
Coding sequence diversity	Alternative splicing
Domain	Transmembrane Transmembrane helix
Ligand	Potassium
Molecular function	Ion channel Potassium channel Voltage-gated channel
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	synaptic transmission Traceable author statement. Source: Reactome
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome
Molecular_function	potassium channel activity Traceable author statement Ref.1. Source: ProtInc voltage-gated ion channel activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: Q9Y2U2-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: Q9Y2U2-2)

The sequence of this isoform differs from the canonical sequence as follows:
     241-252: YLLLGLLAMLLA → GGTSLQGTAWEG
     253-307: Missing.

Isoform C (identifier: Q9Y2U2-3)

The sequence of this isoform differs from the canonical sequence as follows:
     241-257: YLLLGLLAMLLAVETFS → KSSHLTACGGRGKRSLD
     258-307: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 307	307	Potassium channel subfamily K member 7		PRO_0000101751
Regions
	Topological domain	1 – 10	10	Cytoplasmic Potential
	Transmembrane	11 – 31	21	Helical; Potential
	Intramembrane	92 – 119	28	Pore-forming; Name=Pore-forming 1; Potential
	Transmembrane	120 – 140	21	Helical; Potential
	Topological domain	141 – 170	30	Cytoplasmic Potential
	Transmembrane	171 – 191	21	Helical; Potential
	Intramembrane	199 – 227	29	Pore-forming; Name=Pore-forming 2; Potential
	Transmembrane	233 – 253	21	Helical; Potential
	Topological domain	254 – 307	54	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	83	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	241 – 257	17	YLLLG…VETFS → KSSHLTACGGRGKRSLD in isoform C.		VSP_006695
	Alternative sequence	241 – 252	12	YLLLG…AMLLA → GGTSLQGTAWEG in isoform B.		VSP_006693
	Alternative sequence	253 – 307	55	Missing in isoform B.		VSP_006694
	Alternative sequence	258 – 307	50	Missing in isoform C.		VSP_006696

Sequences

	Sequence		Length	Mass (Da)
	Isoform A [UniParc]. Last modified November 1, 1999. Version 1. Checksum: BD4A36DD9591ADAC	FASTA	307	31,947
	10 20 30 40 50 60 MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF QAEHRACLPP 70 80 90 100 110 120 GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA SILTTTGYGH MAPLSPGGKA 130 140 150 160 170 180 FCMVYAALGL PASLALVATL RHCLLPVLSR PRAWVAVHWQ LSPARAALLQ AVALGLLVAS 190 200 210 220 230 240 SFVLLPALVL WGLQGDCSLL GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG 250 260 270 280 290 300 YLLLGLLAML LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA SGQAPAC
	Isoform B [UniParc]. Checksum: A0C93A5D690C3295	FASTA	252	26,212
	10 20 30 40 50 60 MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF QAEHRACLPP 70 80 90 100 110 120 GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA SILTTTGYGH MAPLSPGGKA 130 140 150 160 170 180 FCMVYAALGL PASLALVATL RHCLLPVLSR PRAWVAVHWQ LSPARAALLQ AVALGLLVAS 190 200 210 220 230 240 SFVLLPALVL WGLQGDCSLL GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG 250 GGTSLQGTAW EG
	Isoform C [UniParc]. Checksum: 73FBC250F69D67FB	FASTA	257	26,822
	10 20 30 40 50 60 MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF QAEHRACLPP 70 80 90 100 110 120 GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA SILTTTGYGH MAPLSPGGKA 130 140 150 160 170 180 FCMVYAALGL PASLALVATL RHCLLPVLSR PRAWVAVHWQ LSPARAALLQ AVALGLLVAS 190 200 210 220 230 240 SFVLLPALVL WGLQGDCSLL GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG 250 KSSHLTACGG RGKRSLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure." Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G., Lazdunski M. J. Biol. Chem. 274:11751-11760(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C). Tissue: Brain.
[2]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF110522 mRNA. Translation: AAD29578.1. AF110524 mRNA. Translation: AAD29580.1. AF110523 mRNA. Translation: AAD29579.1. CH471076 Genomic DNA. Translation: EAW74413.1. BC103809 mRNA. Translation: AAI03810.1.
IPI	IPI00032486. IPI00217046. IPI00217050.
RefSeq	NP_005705.1. NM_005714.1. NP_203133.1. NM_033347.1. NP_203134.1. NM_033348.1. NP_258416.1. NM_033455.1.
UniGene	Hs.175218.
3D structure databases
ProteinModelPortal	Q9Y2U2.
ModBase	Search...
Polymorphism databases
DMDM	13124109.
Proteomic databases
PaxDb	Q9Y2U2.
PRIDE	Q9Y2U2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340313; ENSP00000344820; ENSG00000173338. ENST00000342202; ENSP00000343923; ENSG00000173338. ENST00000394216; ENSP00000377764; ENSG00000173338. ENST00000394217; ENSP00000377765; ENSG00000173338.
GeneID	10089.
KEGG	hsa:10089.
UCSC	uc001oeq.3. human. uc001oes.3. human. uc001oeu.3. human.
Organism-specific databases
CTD	10089.
GeneCards	GC11M065360.
HGNC	HGNC:6282. KCNK7.
MIM	603940. gene.
neXtProt	NX_Q9Y2U2.
PharmGKB	PA30064.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG265536.
HOGENOM	HOG000286014.
HOVERGEN	HBG052237.
InParanoid	Q9Y2U2.
KO	K04918.
OMA	YGACLPP.
OrthoDB	EOG42V8HD.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
Bgee	Q9Y2U2.
CleanEx	HS_KCNK7.
Genevestigator	Q9Y2U2.
GermOnline	ENSG00000173338. Homo sapiens.
Family and domain databases
InterPro	IPR003280. 2pore_dom_K_chnl. IPR022306. 2pore_dom_K_chnl_TASK/TWIK. IPR005408. 2pore_dom_K_chnl_TWIK. IPR013099. Ion_trans_2. [Graphical view]
Pfam	PF07885. Ion_trans_2. 2 hits. [Graphical view]
PIRSF	PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTS	PR01333. 2POREKCHANEL. PR01586. TWIKCHANNEL.
ProtoNet	Search...
Other
GenomeRNAi	10089.
NextBio	38151.
SOURCE	Search...

Entry information

Entry name

KCNK7_HUMAN

Accession

Primary (citable) accession number: Q9Y2U2
Secondary accession number(s): Q3SYI2, Q9Y2U3, Q9Y2U4

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 21, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.