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Q9Y2U2

- KCNK7_HUMAN

UniProt

Q9Y2U2 - KCNK7_HUMAN

Protein

Potassium channel subfamily K member 7

Gene

KCNK7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

    GO - Molecular functioni

    1. potassium channel activity Source: ProtInc
    2. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. potassium ion transport Source: ProtInc
    2. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Potassium channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Potassium channel subfamily K member 7
    Gene namesi
    Name:KCNK7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:6282. KCNK7.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30064.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 307307Potassium channel subfamily K member 7PRO_0000101751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y2U2.
    PRIDEiQ9Y2U2.

    Expressioni

    Gene expression databases

    BgeeiQ9Y2U2.
    CleanExiHS_KCNK7.
    GenevestigatoriQ9Y2U2.

    Interactioni

    Subunit structurei

    Homodimer.Curated

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2U2.
    SMRiQ9Y2U2. Positions 10-269.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1010CytoplasmicSequence Analysis
    Topological domaini141 – 17030CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini254 – 30754CytoplasmicSequence AnalysisAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei92 – 11928Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
    BLAST
    Intramembranei199 – 22729Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei120 – 14021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei171 – 19121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG265536.
    HOGENOMiHOG000286014.
    HOVERGENiHBG052237.
    InParanoidiQ9Y2U2.
    KOiK04918.
    OMAiYGACLPP.
    PhylomeDBiQ9Y2U2.
    TreeFamiTF313947.

    Family and domain databases

    InterProiIPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005408. 2pore_dom_K_chnl_TWIK.
    [Graphical view]
    PfamiPF07885. Ion_trans_2. 2 hits.
    [Graphical view]
    PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSiPR01333. 2POREKCHANEL.
    PR01586. TWIKCHANNEL.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform A (identifier: Q9Y2U2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF    50
    QAEHRACLPP GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA 100
    SILTTTGYGH MAPLSPGGKA FCMVYAALGL PASLALVATL RHCLLPVLSR 150
    PRAWVAVHWQ LSPARAALLQ AVALGLLVAS SFVLLPALVL WGLQGDCSLL 200
    GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG YLLLGLLAML 250
    LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA 300
    SGQAPAC 307
    Length:307
    Mass (Da):31,947
    Last modified:November 1, 1999 - v1
    Checksum:iBD4A36DD9591ADAC
    GO
    Isoform B (identifier: Q9Y2U2-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         241-252: YLLLGLLAMLLA → GGTSLQGTAWEG
         253-307: Missing.

    Show »
    Length:252
    Mass (Da):26,212
    Checksum:iA0C93A5D690C3295
    GO
    Isoform C (identifier: Q9Y2U2-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         241-257: YLLLGLLAMLLAVETFS → KSSHLTACGGRGKRSLD
         258-307: Missing.

    Show »
    Length:257
    Mass (Da):26,822
    Checksum:i73FBC250F69D67FB
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei241 – 25717YLLLG…VETFS → KSSHLTACGGRGKRSLD in isoform C. 1 PublicationVSP_006695Add
    BLAST
    Alternative sequencei241 – 25212YLLLG…AMLLA → GGTSLQGTAWEG in isoform B. 2 PublicationsVSP_006693Add
    BLAST
    Alternative sequencei253 – 30755Missing in isoform B. 2 PublicationsVSP_006694Add
    BLAST
    Alternative sequencei258 – 30750Missing in isoform C. 1 PublicationVSP_006696Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110522 mRNA. Translation: AAD29578.1.
    AF110524 mRNA. Translation: AAD29580.1.
    AF110523 mRNA. Translation: AAD29579.1.
    CH471076 Genomic DNA. Translation: EAW74413.1.
    BC103809 mRNA. Translation: AAI03810.1.
    CCDSiCCDS31608.1. [Q9Y2U2-1]
    CCDS41673.1. [Q9Y2U2-3]
    CCDS8106.1. [Q9Y2U2-2]
    RefSeqiNP_005705.1. NM_005714.1. [Q9Y2U2-3]
    NP_203133.1. NM_033347.1. [Q9Y2U2-1]
    NP_203134.1. NM_033348.1. [Q9Y2U2-2]
    NP_258416.1. NM_033455.1. [Q9Y2U2-2]
    UniGeneiHs.175218.

    Genome annotation databases

    EnsembliENST00000340313; ENSP00000344820; ENSG00000173338. [Q9Y2U2-1]
    ENST00000342202; ENSP00000343923; ENSG00000173338. [Q9Y2U2-2]
    ENST00000394216; ENSP00000377764; ENSG00000173338. [Q9Y2U2-3]
    ENST00000394217; ENSP00000377765; ENSG00000173338. [Q9Y2U2-2]
    GeneIDi10089.
    KEGGihsa:10089.
    UCSCiuc001oeq.3. human. [Q9Y2U2-2]
    uc001oes.3. human. [Q9Y2U2-1]
    uc001oeu.3. human. [Q9Y2U2-3]

    Polymorphism databases

    DMDMi13124109.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF110522 mRNA. Translation: AAD29578.1 .
    AF110524 mRNA. Translation: AAD29580.1 .
    AF110523 mRNA. Translation: AAD29579.1 .
    CH471076 Genomic DNA. Translation: EAW74413.1 .
    BC103809 mRNA. Translation: AAI03810.1 .
    CCDSi CCDS31608.1. [Q9Y2U2-1 ]
    CCDS41673.1. [Q9Y2U2-3 ]
    CCDS8106.1. [Q9Y2U2-2 ]
    RefSeqi NP_005705.1. NM_005714.1. [Q9Y2U2-3 ]
    NP_203133.1. NM_033347.1. [Q9Y2U2-1 ]
    NP_203134.1. NM_033348.1. [Q9Y2U2-2 ]
    NP_258416.1. NM_033455.1. [Q9Y2U2-2 ]
    UniGenei Hs.175218.

    3D structure databases

    ProteinModelPortali Q9Y2U2.
    SMRi Q9Y2U2. Positions 10-269.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 13124109.

    Proteomic databases

    PaxDbi Q9Y2U2.
    PRIDEi Q9Y2U2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000340313 ; ENSP00000344820 ; ENSG00000173338 . [Q9Y2U2-1 ]
    ENST00000342202 ; ENSP00000343923 ; ENSG00000173338 . [Q9Y2U2-2 ]
    ENST00000394216 ; ENSP00000377764 ; ENSG00000173338 . [Q9Y2U2-3 ]
    ENST00000394217 ; ENSP00000377765 ; ENSG00000173338 . [Q9Y2U2-2 ]
    GeneIDi 10089.
    KEGGi hsa:10089.
    UCSCi uc001oeq.3. human. [Q9Y2U2-2 ]
    uc001oes.3. human. [Q9Y2U2-1 ]
    uc001oeu.3. human. [Q9Y2U2-3 ]

    Organism-specific databases

    CTDi 10089.
    GeneCardsi GC11M065360.
    HGNCi HGNC:6282. KCNK7.
    MIMi 603940. gene.
    neXtProti NX_Q9Y2U2.
    PharmGKBi PA30064.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG265536.
    HOGENOMi HOG000286014.
    HOVERGENi HBG052237.
    InParanoidi Q9Y2U2.
    KOi K04918.
    OMAi YGACLPP.
    PhylomeDBi Q9Y2U2.
    TreeFami TF313947.

    Enzyme and pathway databases

    Reactomei REACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

    Miscellaneous databases

    GeneWikii KCNK7.
    GenomeRNAii 10089.
    NextBioi 38151.
    PROi Q9Y2U2.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q9Y2U2.
    CleanExi HS_KCNK7.
    Genevestigatori Q9Y2U2.

    Family and domain databases

    InterProi IPR003280. 2pore_dom_K_chnl.
    IPR013099. 2pore_dom_K_chnl_dom.
    IPR003092. 2pore_dom_K_chnl_TASK.
    IPR005408. 2pore_dom_K_chnl_TWIK.
    [Graphical view ]
    Pfami PF07885. Ion_trans_2. 2 hits.
    [Graphical view ]
    PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
    PRINTSi PR01333. 2POREKCHANEL.
    PR01586. TWIKCHANNEL.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure."
      Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G., Lazdunski M.
      J. Biol. Chem. 274:11751-11760(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).

    Entry informationi

    Entry nameiKCNK7_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2U2
    Secondary accession number(s): Q3SYI2, Q9Y2U3, Q9Y2U4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2001
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 113 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3