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Q9Y2U2

- KCNK7_HUMAN

UniProt

Q9Y2U2 - KCNK7_HUMAN

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Protein

Potassium channel subfamily K member 7

Gene

KCNK7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Probable potassium channel subunit. No channel activity observed in vitro as protein remains in the endoplasmic reticulum. May need to associate with an as yet unknown partner in order to reach the plasma membrane.

GO - Molecular functioni

  1. potassium channel activity Source: ProtInc
  2. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. potassium ion transport Source: ProtInc
  2. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Potassium channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Names & Taxonomyi

Protein namesi
Recommended name:
Potassium channel subfamily K member 7
Gene namesi
Name:KCNK7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:6282. KCNK7.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1010CytoplasmicSequence Analysis
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST
Intramembranei92 – 11928Pore-forming; Name=Pore-forming 1Sequence AnalysisAdd
BLAST
Transmembranei120 – 14021HelicalSequence AnalysisAdd
BLAST
Topological domaini141 – 17030CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence AnalysisAdd
BLAST
Intramembranei199 – 22729Pore-forming; Name=Pore-forming 2Sequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Topological domaini254 – 30754CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 307307Potassium channel subfamily K member 7PRO_0000101751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y2U2.
PRIDEiQ9Y2U2.

Expressioni

Gene expression databases

BgeeiQ9Y2U2.
CleanExiHS_KCNK7.
GenevestigatoriQ9Y2U2.

Interactioni

Subunit structurei

Homodimer.Curated

Structurei

3D structure databases

ProteinModelPortaliQ9Y2U2.
SMRiQ9Y2U2. Positions 10-269.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG265536.
GeneTreeiENSGT00760000118858.
HOGENOMiHOG000286014.
HOVERGENiHBG052237.
InParanoidiQ9Y2U2.
KOiK04918.
OMAiYGACLPP.
PhylomeDBiQ9Y2U2.
TreeFamiTF313947.

Family and domain databases

InterProiIPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
[Graphical view]
PfamiPF07885. Ion_trans_2. 2 hits.
[Graphical view]
PIRSFiPIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSiPR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform A (identifier: Q9Y2U2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGLRPWSRY GLLVVAHLLA LGLGAVVFQA LEGPPACRLQ AELRAELAAF
60 70 80 90 100
QAEHRACLPP GALEELLGTA LATQAHGVST LGNSSEGRTW DLPSALLFAA
110 120 130 140 150
SILTTTGYGH MAPLSPGGKA FCMVYAALGL PASLALVATL RHCLLPVLSR
160 170 180 190 200
PRAWVAVHWQ LSPARAALLQ AVALGLLVAS SFVLLPALVL WGLQGDCSLL
210 220 230 240 250
GAVYFCFSSL STIGLEDLLP GRGRSLHPVI YHLGQLALLG YLLLGLLAML
260 270 280 290 300
LAVETFSELP QVRAMGKFFR PSGPVTAEDQ GGILGQDELA LSTLPPAAPA

SGQAPAC
Length:307
Mass (Da):31,947
Last modified:November 1, 1999 - v1
Checksum:iBD4A36DD9591ADAC
GO
Isoform B (identifier: Q9Y2U2-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-252: YLLLGLLAMLLA → GGTSLQGTAWEG
     253-307: Missing.

Show »
Length:252
Mass (Da):26,212
Checksum:iA0C93A5D690C3295
GO
Isoform C (identifier: Q9Y2U2-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-257: YLLLGLLAMLLAVETFS → KSSHLTACGGRGKRSLD
     258-307: Missing.

Show »
Length:257
Mass (Da):26,822
Checksum:i73FBC250F69D67FB
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei241 – 25717YLLLG…VETFS → KSSHLTACGGRGKRSLD in isoform C. 1 PublicationVSP_006695Add
BLAST
Alternative sequencei241 – 25212YLLLG…AMLLA → GGTSLQGTAWEG in isoform B. 2 PublicationsVSP_006693Add
BLAST
Alternative sequencei253 – 30755Missing in isoform B. 2 PublicationsVSP_006694Add
BLAST
Alternative sequencei258 – 30750Missing in isoform C. 1 PublicationVSP_006696Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110522 mRNA. Translation: AAD29578.1.
AF110524 mRNA. Translation: AAD29580.1.
AF110523 mRNA. Translation: AAD29579.1.
CH471076 Genomic DNA. Translation: EAW74413.1.
BC103809 mRNA. Translation: AAI03810.1.
CCDSiCCDS31608.1. [Q9Y2U2-1]
CCDS41673.1. [Q9Y2U2-3]
CCDS8106.1. [Q9Y2U2-2]
RefSeqiNP_005705.1. NM_005714.1. [Q9Y2U2-3]
NP_203133.1. NM_033347.1. [Q9Y2U2-1]
NP_203134.1. NM_033348.1. [Q9Y2U2-2]
NP_258416.1. NM_033455.1. [Q9Y2U2-2]
UniGeneiHs.175218.

Genome annotation databases

EnsembliENST00000340313; ENSP00000344820; ENSG00000173338. [Q9Y2U2-1]
ENST00000342202; ENSP00000343923; ENSG00000173338. [Q9Y2U2-2]
ENST00000394216; ENSP00000377764; ENSG00000173338. [Q9Y2U2-3]
ENST00000394217; ENSP00000377765; ENSG00000173338. [Q9Y2U2-2]
GeneIDi10089.
KEGGihsa:10089.
UCSCiuc001oeq.3. human. [Q9Y2U2-2]
uc001oes.3. human. [Q9Y2U2-1]
uc001oeu.3. human. [Q9Y2U2-3]

Polymorphism databases

DMDMi13124109.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF110522 mRNA. Translation: AAD29578.1 .
AF110524 mRNA. Translation: AAD29580.1 .
AF110523 mRNA. Translation: AAD29579.1 .
CH471076 Genomic DNA. Translation: EAW74413.1 .
BC103809 mRNA. Translation: AAI03810.1 .
CCDSi CCDS31608.1. [Q9Y2U2-1 ]
CCDS41673.1. [Q9Y2U2-3 ]
CCDS8106.1. [Q9Y2U2-2 ]
RefSeqi NP_005705.1. NM_005714.1. [Q9Y2U2-3 ]
NP_203133.1. NM_033347.1. [Q9Y2U2-1 ]
NP_203134.1. NM_033348.1. [Q9Y2U2-2 ]
NP_258416.1. NM_033455.1. [Q9Y2U2-2 ]
UniGenei Hs.175218.

3D structure databases

ProteinModelPortali Q9Y2U2.
SMRi Q9Y2U2. Positions 10-269.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 13124109.

Proteomic databases

PaxDbi Q9Y2U2.
PRIDEi Q9Y2U2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000340313 ; ENSP00000344820 ; ENSG00000173338 . [Q9Y2U2-1 ]
ENST00000342202 ; ENSP00000343923 ; ENSG00000173338 . [Q9Y2U2-2 ]
ENST00000394216 ; ENSP00000377764 ; ENSG00000173338 . [Q9Y2U2-3 ]
ENST00000394217 ; ENSP00000377765 ; ENSG00000173338 . [Q9Y2U2-2 ]
GeneIDi 10089.
KEGGi hsa:10089.
UCSCi uc001oeq.3. human. [Q9Y2U2-2 ]
uc001oes.3. human. [Q9Y2U2-1 ]
uc001oeu.3. human. [Q9Y2U2-3 ]

Organism-specific databases

CTDi 10089.
GeneCardsi GC11M065360.
HGNCi HGNC:6282. KCNK7.
MIMi 603940. gene.
neXtProti NX_Q9Y2U2.
PharmGKBi PA30064.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG265536.
GeneTreei ENSGT00760000118858.
HOGENOMi HOG000286014.
HOVERGENi HBG052237.
InParanoidi Q9Y2U2.
KOi K04918.
OMAi YGACLPP.
PhylomeDBi Q9Y2U2.
TreeFami TF313947.

Enzyme and pathway databases

Reactomei REACT_75779. Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK).

Miscellaneous databases

GeneWikii KCNK7.
GenomeRNAii 10089.
NextBioi 38151.
PROi Q9Y2U2.
SOURCEi Search...

Gene expression databases

Bgeei Q9Y2U2.
CleanExi HS_KCNK7.
Genevestigatori Q9Y2U2.

Family and domain databases

InterProi IPR003280. 2pore_dom_K_chnl.
IPR013099. 2pore_dom_K_chnl_dom.
IPR003092. 2pore_dom_K_chnl_TASK.
IPR005408. 2pore_dom_K_chnl_TWIK.
[Graphical view ]
Pfami PF07885. Ion_trans_2. 2 hits.
[Graphical view ]
PIRSFi PIRSF038061. K_channel_subfamily_K_type. 1 hit.
PRINTSi PR01333. 2POREKCHANEL.
PR01586. TWIKCHANNEL.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure."
    Salinas M., Reyes R., Lesage F., Fosset M., Heurteaux C., Romey G., Lazdunski M.
    J. Biol. Chem. 274:11751-11760(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS A; B AND C).
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM B).

Entry informationi

Entry nameiKCNK7_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2U2
Secondary accession number(s): Q3SYI2, Q9Y2U3, Q9Y2U4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: October 29, 2014
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3