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Q9Y2T6

- GPR55_HUMAN

UniProt

Q9Y2T6 - GPR55_HUMAN

Protein

G-protein coupled receptor 55

Gene

GPR55

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 108 (01 Oct 2014)
      Sequence version 2 (10 May 2005)
      Previous versions | rss
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    Functioni

    May be involved in hyperalgesia associated with inflammatory and neuropathic pain By similarity. Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.By similarity1 Publication

    GO - Molecular functioni

    1. cannabinoid receptor activity Source: UniProtKB
    2. G-protein coupled receptor activity Source: ProtInc

    GO - Biological processi

    1. activation of phospholipase C activity Source: UniProtKB
    2. bone resorption Source: UniProtKB
    3. cannabinoid signaling pathway Source: GOC
    4. G-protein coupled receptor signaling pathway Source: ProtInc
    5. negative regulation of osteoclast differentiation Source: UniProtKB
    6. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    7. positive regulation of Rho protein signal transduction Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G-protein coupled receptor 55
    Gene namesi
    Name:GPR55
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:4511. GPR55.

    Subcellular locationi

    Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

    GO - Cellular componenti

    1. integral component of plasma membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28900.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 319319G-protein coupled receptor 55PRO_0000069577Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi5 – 51N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi171 – 1711N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ9Y2T6.
    PRIDEiQ9Y2T6.

    PTM databases

    PhosphoSiteiQ9Y2T6.

    Expressioni

    Tissue specificityi

    Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.2 Publications

    Gene expression databases

    ArrayExpressiQ9Y2T6.
    BgeeiQ9Y2T6.
    CleanExiHS_GPR55.
    GenevestigatoriQ9Y2T6.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000375893.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2T6.
    SMRiQ9Y2T6. Positions 25-296.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2121ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini43 – 5816CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini80 – 9415ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini116 – 13722CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini159 – 18022ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini202 – 23130CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini253 – 27119ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini293 – 31927CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei59 – 7921Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei138 – 15821Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 20121Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei232 – 25221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei272 – 29221Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG145477.
    HOGENOMiHOG000013155.
    HOVERGENiHBG096388.
    InParanoidiQ9Y2T6.
    KOiK08413.
    OMAiCFHNMSD.
    OrthoDBiEOG7327PC.
    PhylomeDBiQ9Y2T6.
    TreeFamiTF335700.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028334. GPR55.
    [Graphical view]
    PANTHERiPTHR24232:SF8. PTHR24232:SF8. 1 hit.
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2T6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSQQNTSGDC LFDGVNELMK TLQFAVHIPT FVLGLLLNLL AIHGFSTFLK    50
    NRWPDYAATS IYMINLAVFD LLLVLSLPFK MVLSQVQSPF PSLCTLVECL 100
    YFVSMYGSVF TICFISMDRF LAIRYPLLVS HLRSPRKIFG ICCTIWVLVW 150
    TGSIPIYSFH GKVEKYMCFH NMSDDTWSAK VFFPLEVFGF LLPMGIMGFC 200
    CSRSIHILLG RRDHTQDWVQ QKACIYSIAA SLAVFVVSFL PVHLGFFLQF 250
    LVRNSFIVEC RAKQSISFFL QLSMCFSNVN CCLDVFCYYF VIKEFRMNIR 300
    AHRPSRVQLV LQDTTISRG 319
    Length:319
    Mass (Da):36,637
    Last modified:May 10, 2005 - v2
    Checksum:iD6E5C6CA8426E7D5
    GO

    Sequence cautioni

    The sequence AAD22410.1 differs from that shown. Reason: Frameshift at positions 132 and 142.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti195 – 1951G → V.
    Corresponds to variant rs3749073 [ dbSNP | Ensembl ].
    VAR_024257
    Natural varianti215 – 2151T → N.
    Corresponds to variant rs34229723 [ dbSNP | Ensembl ].
    VAR_049395

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096786 Genomic DNA. Translation: AAD22410.1. Frameshift.
    CR541776 mRNA. Translation: CAG46575.1.
    BC032694 mRNA. Translation: AAH32694.1.
    CCDSiCCDS2480.1.
    RefSeqiNP_005674.2. NM_005683.3.
    XP_005247009.1. XM_005246952.1.
    UniGeneiHs.114545.

    Genome annotation databases

    EnsembliENST00000392039; ENSP00000375893; ENSG00000135898.
    ENST00000392040; ENSP00000375894; ENSG00000135898.
    ENST00000444078; ENSP00000410267; ENSG00000135898.
    GeneIDi9290.
    KEGGihsa:9290.
    UCSCiuc002vrg.3. human.

    Polymorphism databases

    DMDMi71159390.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF096786 Genomic DNA. Translation: AAD22410.1 . Frameshift.
    CR541776 mRNA. Translation: CAG46575.1 .
    BC032694 mRNA. Translation: AAH32694.1 .
    CCDSi CCDS2480.1.
    RefSeqi NP_005674.2. NM_005683.3.
    XP_005247009.1. XM_005246952.1.
    UniGenei Hs.114545.

    3D structure databases

    ProteinModelPortali Q9Y2T6.
    SMRi Q9Y2T6. Positions 25-296.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000375893.

    Chemistry

    BindingDBi Q9Y2T6.
    ChEMBLi CHEMBL1075322.
    GuidetoPHARMACOLOGYi 109.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q9Y2T6.

    Polymorphism databases

    DMDMi 71159390.

    Proteomic databases

    PaxDbi Q9Y2T6.
    PRIDEi Q9Y2T6.

    Protocols and materials databases

    DNASUi 9290.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000392039 ; ENSP00000375893 ; ENSG00000135898 .
    ENST00000392040 ; ENSP00000375894 ; ENSG00000135898 .
    ENST00000444078 ; ENSP00000410267 ; ENSG00000135898 .
    GeneIDi 9290.
    KEGGi hsa:9290.
    UCSCi uc002vrg.3. human.

    Organism-specific databases

    CTDi 9290.
    GeneCardsi GC02M231736.
    HGNCi HGNC:4511. GPR55.
    MIMi 604107. gene.
    neXtProti NX_Q9Y2T6.
    PharmGKBi PA28900.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145477.
    HOGENOMi HOG000013155.
    HOVERGENi HBG096388.
    InParanoidi Q9Y2T6.
    KOi K08413.
    OMAi CFHNMSD.
    OrthoDBi EOG7327PC.
    PhylomeDBi Q9Y2T6.
    TreeFami TF335700.

    Enzyme and pathway databases

    Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GeneWikii GPR55.
    GenomeRNAii 9290.
    NextBioi 34813.
    PROi Q9Y2T6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2T6.
    Bgeei Q9Y2T6.
    CleanExi HS_GPR55.
    Genevestigatori Q9Y2T6.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR028334. GPR55.
    [Graphical view ]
    PANTHERi PTHR24232:SF8. PTHR24232:SF8. 1 hit.
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain."
      Sawzdargo M., Nguyen T., Lee D.K., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
      Brain Res. Mol. Brain Res. 64:193-198(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Pancreas.
    4. "Identification of GPR55 as a lysophosphatidylinositol receptor."
      Oka S., Nakajima K., Yamashita A., Kishimoto S., Sugiura T.
      Biochem. Biophys. Res. Commun. 362:928-934(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING.
    5. "The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation."
      Henstridge C.M., Balenga N.A., Ford L.A., Ross R.A., Waldhoer M., Irving A.J.
      FASEB J. 23:183-193(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, CHARACTERIZATION, LIGAND-BINDING.
    6. "Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands."
      Kapur A., Zhao P., Sharir H., Bai Y., Caron M.G., Barak L.S., Abood M.E.
      J. Biol. Chem. 284:29817-29827(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: LIGAND-BINDING.
    7. "The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo."
      Whyte L.S., Ryberg E., Sims N.A., Ridge S.A., Mackie K., Greasley P.J., Ross R.A., Rogers M.J.
      Proc. Natl. Acad. Sci. U.S.A. 106:16511-16516(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY, FUNCTION.

    Entry informationi

    Entry nameiGPR55_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2T6
    Secondary accession number(s): Q8N580
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 10, 2005
    Last sequence update: May 10, 2005
    Last modified: October 1, 2014
    This is version 108 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3