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Q9Y2T6 (GPR55_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
G-protein coupled receptor 55
Gene names
Name:GPR55
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length319 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May be involved in hyperalgesia associated with inflammatory and neuropathic pain By similarity. Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function. Ref.7

Subcellular location

Cell membrane; Multi-pass membrane protein Ref.5.

Tissue specificity

Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts. Ref.1 Ref.7

Miscellaneous

The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAD22410.1 differs from that shown. Reason: Frameshift at positions 132 and 142.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 319319G-protein coupled receptor 55
PRO_0000069577

Regions

Topological domain1 – 2121Extracellular Potential
Transmembrane22 – 4221Helical; Name=1; Potential
Topological domain43 – 5816Cytoplasmic Potential
Transmembrane59 – 7921Helical; Name=2; Potential
Topological domain80 – 9415Extracellular Potential
Transmembrane95 – 11521Helical; Name=3; Potential
Topological domain116 – 13722Cytoplasmic Potential
Transmembrane138 – 15821Helical; Name=4; Potential
Topological domain159 – 18022Extracellular Potential
Transmembrane181 – 20121Helical; Name=5; Potential
Topological domain202 – 23130Cytoplasmic Potential
Transmembrane232 – 25221Helical; Name=6; Potential
Topological domain253 – 27119Extracellular Potential
Transmembrane272 – 29221Helical; Name=7; Potential
Topological domain293 – 31927Cytoplasmic Potential

Amino acid modifications

Glycosylation51N-linked (GlcNAc...) Potential
Glycosylation1711N-linked (GlcNAc...) Potential

Natural variations

Natural variant1951G → V.
Corresponds to variant rs3749073 [ dbSNP | Ensembl ].
VAR_024257
Natural variant2151T → N.
Corresponds to variant rs34229723 [ dbSNP | Ensembl ].
VAR_049395

Sequences

Sequence LengthMass (Da)Tools
Q9Y2T6 [UniParc].

Last modified May 10, 2005. Version 2.
Checksum: D6E5C6CA8426E7D5

FASTA31936,637
        10         20         30         40         50         60 
MSQQNTSGDC LFDGVNELMK TLQFAVHIPT FVLGLLLNLL AIHGFSTFLK NRWPDYAATS 

        70         80         90        100        110        120 
IYMINLAVFD LLLVLSLPFK MVLSQVQSPF PSLCTLVECL YFVSMYGSVF TICFISMDRF 

       130        140        150        160        170        180 
LAIRYPLLVS HLRSPRKIFG ICCTIWVLVW TGSIPIYSFH GKVEKYMCFH NMSDDTWSAK 

       190        200        210        220        230        240 
VFFPLEVFGF LLPMGIMGFC CSRSIHILLG RRDHTQDWVQ QKACIYSIAA SLAVFVVSFL 

       250        260        270        280        290        300 
PVHLGFFLQF LVRNSFIVEC RAKQSISFFL QLSMCFSNVN CCLDVFCYYF VIKEFRMNIR 

       310 
AHRPSRVQLV LQDTTISRG 

« Hide

References

« Hide 'large scale' references
[1]"Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain."
Sawzdargo M., Nguyen T., Lee D.K., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
Brain Res. Mol. Brain Res. 64:193-198(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Pancreas.
[4]"Identification of GPR55 as a lysophosphatidylinositol receptor."
Oka S., Nakajima K., Yamashita A., Kishimoto S., Sugiura T.
Biochem. Biophys. Res. Commun. 362:928-934(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING.
[5]"The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation."
Henstridge C.M., Balenga N.A., Ford L.A., Ross R.A., Waldhoer M., Irving A.J.
FASEB J. 23:183-193(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, CHARACTERIZATION, LIGAND-BINDING.
[6]"Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands."
Kapur A., Zhao P., Sharir H., Bai Y., Caron M.G., Barak L.S., Abood M.E.
J. Biol. Chem. 284:29817-29827(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: LIGAND-BINDING.
[7]"The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo."
Whyte L.S., Ryberg E., Sims N.A., Ridge S.A., Mackie K., Greasley P.J., Ross R.A., Rogers M.J.
Proc. Natl. Acad. Sci. U.S.A. 106:16511-16516(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY, FUNCTION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF096786 Genomic DNA. Translation: AAD22410.1. Frameshift.
CR541776 mRNA. Translation: CAG46575.1.
BC032694 mRNA. Translation: AAH32694.1.
CCDSCCDS2480.1.
RefSeqNP_005674.2. NM_005683.3.
XP_005247009.1. XM_005246952.1.
UniGeneHs.114545.

3D structure databases

ProteinModelPortalQ9Y2T6.
SMRQ9Y2T6. Positions 25-296.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000375893.

Chemistry

BindingDBQ9Y2T6.
ChEMBLCHEMBL1075322.
GuidetoPHARMACOLOGY109.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ9Y2T6.

Polymorphism databases

DMDM71159390.

Proteomic databases

PaxDbQ9Y2T6.
PRIDEQ9Y2T6.

Protocols and materials databases

DNASU9290.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000392039; ENSP00000375893; ENSG00000135898.
ENST00000392040; ENSP00000375894; ENSG00000135898.
ENST00000444078; ENSP00000410267; ENSG00000135898.
GeneID9290.
KEGGhsa:9290.
UCSCuc002vrg.3. human.

Organism-specific databases

CTD9290.
GeneCardsGC02M231736.
HGNCHGNC:4511. GPR55.
MIM604107. gene.
neXtProtNX_Q9Y2T6.
PharmGKBPA28900.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145477.
HOGENOMHOG000013155.
HOVERGENHBG096388.
InParanoidQ9Y2T6.
KOK08413.
OMACFHNMSD.
OrthoDBEOG7327PC.
PhylomeDBQ9Y2T6.
TreeFamTF335700.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ9Y2T6.
BgeeQ9Y2T6.
CleanExHS_GPR55.
GenevestigatorQ9Y2T6.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view]
PANTHERPTHR24232:SF8. PTHR24232:SF8. 1 hit.
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiGPR55.
GenomeRNAi9290.
NextBio34813.
PROQ9Y2T6.
SOURCESearch...

Entry information

Entry nameGPR55_HUMAN
AccessionPrimary (citable) accession number: Q9Y2T6
Secondary accession number(s): Q8N580
Entry history
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: July 9, 2014
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries