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Protein

G-protein coupled receptor 55

Gene

GPR55

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in hyperalgesia associated with inflammatory and neuropathic pain (By similarity). Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.By similarity1 Publication

Miscellaneous

The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

GO - Molecular functioni

  • cannabinoid receptor activity Source: UniProtKB
  • G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  • activation of phospholipase C activity Source: UniProtKB
  • bone resorption Source: UniProtKB
  • G-protein coupled receptor signaling pathway Source: ProtInc
  • negative regulation of osteoclast differentiation Source: UniProtKB
  • positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: GO_Central
  • positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • positive regulation of Rho protein signal transduction Source: UniProtKB

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076. Class A/1 (Rhodopsin-like receptors).
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 55
Gene namesi
Name:GPR55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000135898.9.
HGNCiHGNC:4511. GPR55.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 21ExtracellularSequence analysisAdd BLAST21
Transmembranei22 – 42Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini43 – 58CytoplasmicSequence analysisAdd BLAST16
Transmembranei59 – 79Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini80 – 94ExtracellularSequence analysisAdd BLAST15
Transmembranei95 – 115Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini116 – 137CytoplasmicSequence analysisAdd BLAST22
Transmembranei138 – 158Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini159 – 180ExtracellularSequence analysisAdd BLAST22
Transmembranei181 – 201Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini202 – 231CytoplasmicSequence analysisAdd BLAST30
Transmembranei232 – 252Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini253 – 271ExtracellularSequence analysisAdd BLAST19
Transmembranei272 – 292Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini293 – 319CytoplasmicSequence analysisAdd BLAST27

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9290.
OpenTargetsiENSG00000135898.
PharmGKBiPA28900.

Chemistry databases

ChEMBLiCHEMBL1075322.
GuidetoPHARMACOLOGYi109.

Polymorphism and mutation databases

BioMutaiGPR55.
DMDMi71159390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695771 – 319G-protein coupled receptor 55Add BLAST319

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi5N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi171N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y2T6.
PRIDEiQ9Y2T6.

PTM databases

PhosphoSitePlusiQ9Y2T6.

Expressioni

Tissue specificityi

Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.2 Publications

Gene expression databases

BgeeiENSG00000135898.
CleanExiHS_GPR55.
ExpressionAtlasiQ9Y2T6. baseline and differential.
GenevisibleiQ9Y2T6. HS.

Interactioni

Protein-protein interaction databases

BioGridi114705. 4 interactors.
STRINGi9606.ENSP00000375893.

Chemistry databases

BindingDBiQ9Y2T6.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IEJJ. Eukaryota.
ENOG4111H9D. LUCA.
GeneTreeiENSGT00730000110768.
HOGENOMiHOG000013155.
HOVERGENiHBG096388.
InParanoidiQ9Y2T6.
KOiK08413.
OMAiCFHNMSD.
OrthoDBiEOG091G0CP3.
PhylomeDBiQ9Y2T6.
TreeFamiTF335700.

Family and domain databases

InterProiView protein in InterPro
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
PANTHERiPTHR24232:SF56. PTHR24232:SF56. 1 hit.
PfamiView protein in Pfam
PF00001. 7tm_1. 1 hit.
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiView protein in PROSITE
PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y2T6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQQNTSGDC LFDGVNELMK TLQFAVHIPT FVLGLLLNLL AIHGFSTFLK
60 70 80 90 100
NRWPDYAATS IYMINLAVFD LLLVLSLPFK MVLSQVQSPF PSLCTLVECL
110 120 130 140 150
YFVSMYGSVF TICFISMDRF LAIRYPLLVS HLRSPRKIFG ICCTIWVLVW
160 170 180 190 200
TGSIPIYSFH GKVEKYMCFH NMSDDTWSAK VFFPLEVFGF LLPMGIMGFC
210 220 230 240 250
CSRSIHILLG RRDHTQDWVQ QKACIYSIAA SLAVFVVSFL PVHLGFFLQF
260 270 280 290 300
LVRNSFIVEC RAKQSISFFL QLSMCFSNVN CCLDVFCYYF VIKEFRMNIR
310
AHRPSRVQLV LQDTTISRG
Length:319
Mass (Da):36,637
Last modified:May 10, 2005 - v2
Checksum:iD6E5C6CA8426E7D5
GO

Sequence cautioni

The sequence AAD22410 differs from that shown. Reason: Frameshift at positions 132 and 142.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024257195G → V. Corresponds to variant dbSNP:rs3749073Ensembl.1
Natural variantiVAR_049395215T → N. Corresponds to variant dbSNP:rs34229723Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096786 Genomic DNA. Translation: AAD22410.1. Frameshift.
CR541776 mRNA. Translation: CAG46575.1.
BC032694 mRNA. Translation: AAH32694.1.
CCDSiCCDS2480.1.
RefSeqiNP_005674.2. NM_005683.3.
XP_005247009.1. XM_005246952.3.
XP_011510477.1. XM_011512175.2.
XP_011510478.1. XM_011512176.2.
UniGeneiHs.114545.

Genome annotation databases

EnsembliENST00000392039; ENSP00000375893; ENSG00000135898.
ENST00000392040; ENSP00000375894; ENSG00000135898.
ENST00000444078; ENSP00000410267; ENSG00000135898.
ENST00000622008; ENSP00000482381; ENSG00000135898.
GeneIDi9290.
KEGGihsa:9290.
UCSCiuc002vrf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGPR55_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T6
Secondary accession number(s): Q8N580
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: October 25, 2017
This is version 128 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families