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Q9Y2T6

- GPR55_HUMAN

UniProt

Q9Y2T6 - GPR55_HUMAN

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Protein

G-protein coupled receptor 55

Gene
GPR55
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May be involved in hyperalgesia associated with inflammatory and neuropathic pain By similarity. Receptor for L-alpha-lysophosphatidylinositol (LPI). LPI induces Ca2+ release from intracellular stores via the heterotrimeric G protein GNA13 and RHOA. Putative cannabinoid receptor. May play a role in bone physiology by regulating osteoclast number and function.1 Publication

GO - Molecular functioni

  1. cannabinoid receptor activity Source: UniProtKB
  2. G-protein coupled receptor activity Source: ProtInc

GO - Biological processi

  1. activation of phospholipase C activity Source: UniProtKB
  2. bone resorption Source: UniProtKB
  3. cannabinoid signaling pathway Source: GOC
  4. G-protein coupled receptor signaling pathway Source: ProtInc
  5. negative regulation of osteoclast differentiation Source: UniProtKB
  6. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
  7. positive regulation of Rho protein signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor 55
Gene namesi
Name:GPR55
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:4511. GPR55.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2121Extracellular Reviewed predictionAdd
BLAST
Transmembranei22 – 4221Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini43 – 5816Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei59 – 7921Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini80 – 9415Extracellular Reviewed predictionAdd
BLAST
Transmembranei95 – 11521Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini116 – 13722Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei138 – 15821Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini159 – 18022Extracellular Reviewed predictionAdd
BLAST
Transmembranei181 – 20121Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini202 – 23130Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei232 – 25221Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini253 – 27119Extracellular Reviewed predictionAdd
BLAST
Transmembranei272 – 29221Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini293 – 31927Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of plasma membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 319319G-protein coupled receptor 55PRO_0000069577Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi5 – 51N-linked (GlcNAc...) Reviewed prediction
Glycosylationi171 – 1711N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9Y2T6.
PRIDEiQ9Y2T6.

PTM databases

PhosphoSiteiQ9Y2T6.

Expressioni

Tissue specificityi

Expressed in the caudate nucleus and putamen, but not detected in the hippocampus, thalamus, pons cerebellum, frontal cortex of the brain or in the liver. Expressed in osteoclasts and osteoblasts.2 Publications

Gene expression databases

ArrayExpressiQ9Y2T6.
BgeeiQ9Y2T6.
CleanExiHS_GPR55.
GenevestigatoriQ9Y2T6.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000375893.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T6.
SMRiQ9Y2T6. Positions 25-296.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG145477.
HOGENOMiHOG000013155.
HOVERGENiHBG096388.
InParanoidiQ9Y2T6.
KOiK08413.
OMAiCFHNMSD.
OrthoDBiEOG7327PC.
PhylomeDBiQ9Y2T6.
TreeFamiTF335700.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view]
PANTHERiPTHR24232:SF8. PTHR24232:SF8. 1 hit.
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2T6-1 [UniParc]FASTAAdd to Basket

« Hide

MSQQNTSGDC LFDGVNELMK TLQFAVHIPT FVLGLLLNLL AIHGFSTFLK    50
NRWPDYAATS IYMINLAVFD LLLVLSLPFK MVLSQVQSPF PSLCTLVECL 100
YFVSMYGSVF TICFISMDRF LAIRYPLLVS HLRSPRKIFG ICCTIWVLVW 150
TGSIPIYSFH GKVEKYMCFH NMSDDTWSAK VFFPLEVFGF LLPMGIMGFC 200
CSRSIHILLG RRDHTQDWVQ QKACIYSIAA SLAVFVVSFL PVHLGFFLQF 250
LVRNSFIVEC RAKQSISFFL QLSMCFSNVN CCLDVFCYYF VIKEFRMNIR 300
AHRPSRVQLV LQDTTISRG 319
Length:319
Mass (Da):36,637
Last modified:May 10, 2005 - v2
Checksum:iD6E5C6CA8426E7D5
GO

Sequence cautioni

The sequence AAD22410.1 differs from that shown. Reason: Frameshift at positions 132 and 142.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti195 – 1951G → V.
Corresponds to variant rs3749073 [ dbSNP | Ensembl ].
VAR_024257
Natural varianti215 – 2151T → N.
Corresponds to variant rs34229723 [ dbSNP | Ensembl ].
VAR_049395

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096786 Genomic DNA. Translation: AAD22410.1. Frameshift.
CR541776 mRNA. Translation: CAG46575.1.
BC032694 mRNA. Translation: AAH32694.1.
CCDSiCCDS2480.1.
RefSeqiNP_005674.2. NM_005683.3.
XP_005247009.1. XM_005246952.1.
UniGeneiHs.114545.

Genome annotation databases

EnsembliENST00000392039; ENSP00000375893; ENSG00000135898.
ENST00000392040; ENSP00000375894; ENSG00000135898.
ENST00000444078; ENSP00000410267; ENSG00000135898.
GeneIDi9290.
KEGGihsa:9290.
UCSCiuc002vrg.3. human.

Polymorphism databases

DMDMi71159390.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF096786 Genomic DNA. Translation: AAD22410.1 . Frameshift.
CR541776 mRNA. Translation: CAG46575.1 .
BC032694 mRNA. Translation: AAH32694.1 .
CCDSi CCDS2480.1.
RefSeqi NP_005674.2. NM_005683.3.
XP_005247009.1. XM_005246952.1.
UniGenei Hs.114545.

3D structure databases

ProteinModelPortali Q9Y2T6.
SMRi Q9Y2T6. Positions 25-296.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000375893.

Chemistry

BindingDBi Q9Y2T6.
ChEMBLi CHEMBL1075322.
GuidetoPHARMACOLOGYi 109.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q9Y2T6.

Polymorphism databases

DMDMi 71159390.

Proteomic databases

PaxDbi Q9Y2T6.
PRIDEi Q9Y2T6.

Protocols and materials databases

DNASUi 9290.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000392039 ; ENSP00000375893 ; ENSG00000135898 .
ENST00000392040 ; ENSP00000375894 ; ENSG00000135898 .
ENST00000444078 ; ENSP00000410267 ; ENSG00000135898 .
GeneIDi 9290.
KEGGi hsa:9290.
UCSCi uc002vrg.3. human.

Organism-specific databases

CTDi 9290.
GeneCardsi GC02M231736.
HGNCi HGNC:4511. GPR55.
MIMi 604107. gene.
neXtProti NX_Q9Y2T6.
PharmGKBi PA28900.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145477.
HOGENOMi HOG000013155.
HOVERGENi HBG096388.
InParanoidi Q9Y2T6.
KOi K08413.
OMAi CFHNMSD.
OrthoDBi EOG7327PC.
PhylomeDBi Q9Y2T6.
TreeFami TF335700.

Enzyme and pathway databases

Reactomei REACT_14828. Class A/1 (Rhodopsin-like receptors).
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GeneWikii GPR55.
GenomeRNAii 9290.
NextBioi 34813.
PROi Q9Y2T6.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2T6.
Bgeei Q9Y2T6.
CleanExi HS_GPR55.
Genevestigatori Q9Y2T6.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR028334. GPR55.
[Graphical view ]
PANTHERi PTHR24232:SF8. PTHR24232:SF8. 1 hit.
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain."
    Sawzdargo M., Nguyen T., Lee D.K., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
    Brain Res. Mol. Brain Res. 64:193-198(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Pancreas.
  4. "Identification of GPR55 as a lysophosphatidylinositol receptor."
    Oka S., Nakajima K., Yamashita A., Kishimoto S., Sugiura T.
    Biochem. Biophys. Res. Commun. 362:928-934(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.
  5. "The GPR55 ligand L-alpha-lysophosphatidylinositol promotes RhoA-dependent Ca2+ signaling and NFAT activation."
    Henstridge C.M., Balenga N.A., Ford L.A., Ross R.A., Waldhoer M., Irving A.J.
    FASEB J. 23:183-193(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, CHARACTERIZATION, LIGAND-BINDING.
  6. "Atypical responsiveness of the orphan receptor GPR55 to cannabinoid ligands."
    Kapur A., Zhao P., Sharir H., Bai Y., Caron M.G., Barak L.S., Abood M.E.
    J. Biol. Chem. 284:29817-29827(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: LIGAND-BINDING.
  7. "The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo."
    Whyte L.S., Ryberg E., Sims N.A., Ridge S.A., Mackie K., Greasley P.J., Ross R.A., Rogers M.J.
    Proc. Natl. Acad. Sci. U.S.A. 106:16511-16516(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY, FUNCTION.

Entry informationi

Entry nameiGPR55_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T6
Secondary accession number(s): Q8N580
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2005
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

The classification of this protein as a cannabinoid receptor remains a contentious issue due to conflicting pharmacological results.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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