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Protein

Probable G-protein coupled receptor 52

Gene

GPR52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Orphan receptor.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Probable G-protein coupled receptor 52
Gene namesi
Name:GPR52
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:4508. GPR52.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 4444ExtracellularSequence analysisAdd
BLAST
Transmembranei45 – 6521Helical; Name=1Sequence analysisAdd
BLAST
Topological domaini66 – 8722CytoplasmicSequence analysisAdd
BLAST
Transmembranei88 – 10821Helical; Name=2Sequence analysisAdd
BLAST
Topological domaini109 – 1168ExtracellularSequence analysis
Transmembranei117 – 13721Helical; Name=3Sequence analysisAdd
BLAST
Topological domaini138 – 15922CytoplasmicSequence analysisAdd
BLAST
Transmembranei160 – 18021Helical; Name=4Sequence analysisAdd
BLAST
Topological domaini181 – 20323ExtracellularSequence analysisAdd
BLAST
Transmembranei204 – 22421Helical; Name=5Sequence analysisAdd
BLAST
Topological domaini225 – 26541CytoplasmicSequence analysisAdd
BLAST
Transmembranei266 – 28621Helical; Name=6Sequence analysisAdd
BLAST
Topological domaini287 – 29610ExtracellularSequence analysis
Transmembranei297 – 31721Helical; Name=7Sequence analysisAdd
BLAST
Topological domaini318 – 36144CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of plasma membrane Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28897.

Chemistry

ChEMBLiCHEMBL3297639.
GuidetoPHARMACOLOGYi108.

Polymorphism and mutation databases

BioMutaiGPR52.
DMDMi76803659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 361361Probable G-protein coupled receptor 52PRO_0000069576Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi2 – 21N-linked (GlcNAc...)Sequence analysis
Glycosylationi13 – 131N-linked (GlcNAc...)Sequence analysis
Glycosylationi20 – 201N-linked (GlcNAc...)Sequence analysis
Disulfide bondi114 ↔ 193PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ9Y2T5.
PRIDEiQ9Y2T5.

Expressioni

Gene expression databases

BgeeiQ9Y2T5.
CleanExiHS_GPR52.
ExpressionAtlasiQ9Y2T5. baseline and differential.
GenevisibleiQ9Y2T5. HS.

Organism-specific databases

HPAiHPA028575.

Interactioni

Protein-protein interaction databases

BioGridi114707. 31 interactions.
IntActiQ9Y2T5. 1 interaction.
STRINGi9606.ENSP00000356658.

Chemistry

BindingDBiQ9Y2T5.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T5.
SMRiQ9Y2T5. Positions 50-331.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ9Y2T5.
KOiK08407.
OMAiSAVDVCI.
OrthoDBiEOG7B05D5.
PhylomeDBiQ9Y2T5.
TreeFamiTF332372.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNESRWTEWR ILNMSSGIVN VSERHSCPLG FGHYSVVDVC IFETVVIVLL
60 70 80 90 100
TFLIIAGNLT VIFVFHCAPL LHHYTTSYFI QTMAYADLFV GVSCLVPTLS
110 120 130 140 150
LLHYSTGVHE SLTCQVFGYI ISVLKSVSMA CLACISVDRY LAITKPLSYN
160 170 180 190 200
QLVTPCRLRI CIILIWIYSC LIFLPSFFGW GKPGYHGDIF EWCATSWLTS
210 220 230 240 250
AYFTGFIVCL LYAPAAFVVC FTYFHIFKIC RQHTKEINDR RARFPSHEVD
260 270 280 290 300
SSRETGHSPD RRYAMVLFRI TSVFYMLWLP YIIYFLLESS RVLDNPTLSF
310 320 330 340 350
LTTWLAISNS FCNCVIYSLS NSVFRLGLRR LSETMCTSCM CVKDQEAQEP
360
KPRKRANSCS I
Length:361
Mass (Da):41,354
Last modified:September 27, 2005 - v2
Checksum:i4888D58CEBB2D725
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti18 – 181I → V in AAH95532 (PubMed:15489334).Curated
Sequence conflicti21 – 211V → A in AAD22409 (PubMed:9931487).Curated
Sequence conflicti64 – 641V → A in AAD22409 (PubMed:9931487).Curated
Sequence conflicti115 – 1151Q → R in AAD22409 (PubMed:9931487).Curated
Sequence conflicti264 – 2641A → T in AAH95532 (PubMed:15489334).Curated
Sequence conflicti307 – 3071I → V in AAD22409 (PubMed:9931487).Curated
Sequence conflicti322 – 3221S → G in AAD22409 (PubMed:9931487).Curated
Sequence conflicti332 – 3321S → F in AAD22409 (PubMed:9931487).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096784 Genomic DNA. Translation: AAD22409.1.
AL022171 Genomic DNA. Translation: CAA18160.1.
BC067456 mRNA. Translation: AAH67456.1.
BC067457 mRNA. Translation: AAH67457.1.
BC067458 mRNA. Translation: AAH67458.1.
BC067459 mRNA. Translation: AAH67459.1.
BC067460 mRNA. Translation: AAH67460.1.
BC069460 mRNA. Translation: AAH69460.1.
BC095532 mRNA. Translation: AAH95532.1.
CCDSiCCDS30941.1.
RefSeqiNP_005675.3. NM_005684.4.
UniGeneiHs.673850.

Genome annotation databases

EnsembliENST00000367685; ENSP00000356658; ENSG00000203737.
GeneIDi9293.
KEGGihsa:9293.
UCSCiuc001gka.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF096784 Genomic DNA. Translation: AAD22409.1.
AL022171 Genomic DNA. Translation: CAA18160.1.
BC067456 mRNA. Translation: AAH67456.1.
BC067457 mRNA. Translation: AAH67457.1.
BC067458 mRNA. Translation: AAH67458.1.
BC067459 mRNA. Translation: AAH67459.1.
BC067460 mRNA. Translation: AAH67460.1.
BC069460 mRNA. Translation: AAH69460.1.
BC095532 mRNA. Translation: AAH95532.1.
CCDSiCCDS30941.1.
RefSeqiNP_005675.3. NM_005684.4.
UniGeneiHs.673850.

3D structure databases

ProteinModelPortaliQ9Y2T5.
SMRiQ9Y2T5. Positions 50-331.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114707. 31 interactions.
IntActiQ9Y2T5. 1 interaction.
STRINGi9606.ENSP00000356658.

Chemistry

BindingDBiQ9Y2T5.
ChEMBLiCHEMBL3297639.
GuidetoPHARMACOLOGYi108.

Protein family/group databases

GPCRDBiSearch...

Polymorphism and mutation databases

BioMutaiGPR52.
DMDMi76803659.

Proteomic databases

PaxDbiQ9Y2T5.
PRIDEiQ9Y2T5.

Protocols and materials databases

DNASUi9293.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367685; ENSP00000356658; ENSG00000203737.
GeneIDi9293.
KEGGihsa:9293.
UCSCiuc001gka.2. human.

Organism-specific databases

CTDi9293.
GeneCardsiGPR52.
HGNCiHGNC:4508. GPR52.
HPAiHPA028575.
MIMi604106. gene.
neXtProtiNX_Q9Y2T5.
PharmGKBiPA28897.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
GeneTreeiENSGT00790000123085.
HOGENOMiHOG000261615.
HOVERGENiHBG051801.
InParanoidiQ9Y2T5.
KOiK08407.
OMAiSAVDVCI.
OrthoDBiEOG7B05D5.
PhylomeDBiQ9Y2T5.
TreeFamiTF332372.

Miscellaneous databases

GenomeRNAii9293.
NextBioi34819.
PROiQ9Y2T5.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2T5.
CleanExiHS_GPR52.
ExpressionAtlasiQ9Y2T5. baseline and differential.
GenevisibleiQ9Y2T5. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain."
    Sawzdargo M., Nguyen T., Lee D.K., Lynch K.R., Cheng R., Heng H.H.Q., George S.R., O'Dowd B.F.
    Brain Res. Mol. Brain Res. 64:193-198(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiGPR52_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T5
Secondary accession number(s): O75654, Q4VBL6, Q6ISM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: September 27, 2005
Last modified: March 16, 2016
This is version 118 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.