ID   2ABG_HUMAN              Reviewed;         447 AA.
AC   Q9Y2T4; A8MSY7; B7Z3Y1; Q7Z4V7; Q8NEC4; Q9H3G7;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   17-APR-2007, sequence version 4.
DT   27-MAR-2024, entry version 189.
DE   RecName: Full=Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform;
DE   AltName: Full=IMYPNO1;
DE   AltName: Full=PP2A subunit B isoform B55-gamma;
DE   AltName: Full=PP2A subunit B isoform PR55-gamma;
DE   AltName: Full=PP2A subunit B isoform R2-gamma;
DE   AltName: Full=PP2A subunit B isoform gamma;
GN   Name=PPP2R2C;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=10574460; DOI=10.1093/dnares/6.5.323;
RA   Torres R., Ide S.E., Dehejia A., Baras A., Polymeropoulos M.H.;
RT   "Genomic structure and localization of the human phosphatase 2A BR gamma
RT   regulatory subunit.";
RL   DNA Res. 6:323-327(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX   PubMed=10945473; DOI=10.1006/geno.2000.6219;
RA   Hu P., Yu L., Zhang M., Zheng L., Zhao Y., Fu Q., Zhao S.;
RT   "Molecular cloning and mapping of the brain-abundant B1gamma subunit of
RT   protein phosphatase 2A, PPP2R2C, to human chromosome 4p16.";
RL   Genomics 67:83-86(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA   Yu L., Zhao S.Y.;
RT   "Cloning of a new human cDNA homologous to Oryctolagus cuniculus protein
RT   phosphatase 2A1 B gamma subunit.";
RL   Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC   TISSUE=Brain, Testis, and Thalamus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [8]
RP   INTERACTION WITH IER5.
RX   PubMed=25816751; DOI=10.1016/j.febslet.2015.03.019;
RA   Ishikawa Y., Kawabata S., Sakurai H.;
RT   "HSF1 transcriptional activity is modulated by IER5 and PP2A/B55.";
RL   FEBS Lett. 589:1150-1155(2015).
CC   -!- FUNCTION: The B regulatory subunit might modulate substrate selectivity
CC       and catalytic activity, and also might direct the localization of the
CC       catalytic enzyme to a particular subcellular compartment.
CC   -!- SUBUNIT: PP2A consists of a common heterodimeric core enzyme, composed
CC       of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant
CC       regulatory subunit (PR65 or subunit A), that associates with a variety
CC       of regulatory subunits. Proteins that associate with the core dimer
CC       include three families of regulatory subunits B (the R2/B/PR55/B55,
CC       R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable
CC       regulatory subunit, viral proteins, and cell signaling molecules (By
CC       similarity). Interacts with IER5 (PubMed:25816751). {ECO:0000250,
CC       ECO:0000269|PubMed:25816751}.
CC   -!- INTERACTION:
CC       Q9Y2T4; P67775: PPP2CA; NbExp=3; IntAct=EBI-1774058, EBI-712311;
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=4;
CC       Name=1;
CC         IsoId=Q9Y2T4-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q9Y2T4-2; Sequence=VSP_036457;
CC       Name=3;
CC         IsoId=Q9Y2T4-3; Sequence=VSP_036458;
CC       Name=4;
CC         IsoId=Q9Y2T4-4; Sequence=VSP_043380;
CC   -!- SIMILARITY: Belongs to the phosphatase 2A regulatory subunit B family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The EMBL entry for PubMed:10574460 is not complete, the paper
CC       shows the rest of the sequence (residues 1 to 23). {ECO:0000305}.
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DR   EMBL; AH007514; AAD20987.1; -; Genomic_DNA.
DR   EMBL; AF086924; AAG39636.1; -; mRNA.
DR   EMBL; AF145027; AAP97279.1; -; mRNA.
DR   EMBL; AK093115; BAG52658.1; -; mRNA.
DR   EMBL; AK296474; BAH12367.1; -; mRNA.
DR   EMBL; AK316003; BAH14374.1; -; mRNA.
DR   EMBL; AC093323; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC114815; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC116317; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC122939; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471131; EAW82393.1; -; Genomic_DNA.
DR   EMBL; CH471131; EAW82394.1; -; Genomic_DNA.
DR   EMBL; CH471131; EAW82395.1; -; Genomic_DNA.
DR   EMBL; BC032954; AAH32954.1; -; mRNA.
DR   CCDS; CCDS3387.1; -. [Q9Y2T4-1]
DR   CCDS; CCDS3388.1; -. [Q9Y2T4-2]
DR   CCDS; CCDS56304.1; -. [Q9Y2T4-3]
DR   CCDS; CCDS56305.1; -. [Q9Y2T4-4]
DR   PIR; JC7153; JC7153.
DR   RefSeq; NP_001193923.1; NM_001206994.1. [Q9Y2T4-4]
DR   RefSeq; NP_001193924.1; NM_001206995.1. [Q9Y2T4-4]
DR   RefSeq; NP_001193925.1; NM_001206996.1. [Q9Y2T4-3]
DR   RefSeq; NP_065149.2; NM_020416.3. [Q9Y2T4-1]
DR   RefSeq; NP_870991.1; NM_181876.2. [Q9Y2T4-2]
DR   AlphaFoldDB; Q9Y2T4; -.
DR   SMR; Q9Y2T4; -.
DR   BioGRID; 111514; 67.
DR   IntAct; Q9Y2T4; 41.
DR   MINT; Q9Y2T4; -.
DR   STRING; 9606.ENSP00000372042; -.
DR   iPTMnet; Q9Y2T4; -.
DR   PhosphoSitePlus; Q9Y2T4; -.
DR   BioMuta; PPP2R2C; -.
DR   DMDM; 145559437; -.
DR   EPD; Q9Y2T4; -.
DR   jPOST; Q9Y2T4; -.
DR   MassIVE; Q9Y2T4; -.
DR   MaxQB; Q9Y2T4; -.
DR   PaxDb; 9606-ENSP00000335083; -.
DR   PeptideAtlas; Q9Y2T4; -.
DR   ProteomicsDB; 85893; -.
DR   ProteomicsDB; 85894; -. [Q9Y2T4-2]
DR   ProteomicsDB; 85895; -. [Q9Y2T4-3]
DR   ProteomicsDB; 85896; -. [Q9Y2T4-4]
DR   Antibodypedia; 22656; 121 antibodies from 25 providers.
DR   DNASU; 5522; -.
DR   Ensembl; ENST00000335585.9; ENSP00000335083.5; ENSG00000074211.14. [Q9Y2T4-2]
DR   Ensembl; ENST00000382599.9; ENSP00000372042.4; ENSG00000074211.14. [Q9Y2T4-1]
DR   Ensembl; ENST00000506140.5; ENSP00000423649.1; ENSG00000074211.14. [Q9Y2T4-4]
DR   Ensembl; ENST00000507294.1; ENSP00000425247.1; ENSG00000074211.14. [Q9Y2T4-4]
DR   Ensembl; ENST00000515571.5; ENSP00000422374.1; ENSG00000074211.14. [Q9Y2T4-3]
DR   GeneID; 5522; -.
DR   KEGG; hsa:5522; -.
DR   MANE-Select; ENST00000382599.9; ENSP00000372042.4; NM_020416.4; NP_065149.2.
DR   UCSC; uc003gja.3; human. [Q9Y2T4-1]
DR   AGR; HGNC:9306; -.
DR   CTD; 5522; -.
DR   DisGeNET; 5522; -.
DR   GeneCards; PPP2R2C; -.
DR   HGNC; HGNC:9306; PPP2R2C.
DR   HPA; ENSG00000074211; Tissue enhanced (brain).
DR   MIM; 605997; gene.
DR   neXtProt; NX_Q9Y2T4; -.
DR   OpenTargets; ENSG00000074211; -.
DR   PharmGKB; PA33670; -.
DR   VEuPathDB; HostDB:ENSG00000074211; -.
DR   eggNOG; KOG1354; Eukaryota.
DR   GeneTree; ENSGT00950000182864; -.
DR   HOGENOM; CLU_021713_3_3_1; -.
DR   InParanoid; Q9Y2T4; -.
DR   OMA; LVPMELI; -.
DR   OrthoDB; 397100at2759; -.
DR   PhylomeDB; Q9Y2T4; -.
DR   TreeFam; TF105553; -.
DR   PathwayCommons; Q9Y2T4; -.
DR   SignaLink; Q9Y2T4; -.
DR   SIGNOR; Q9Y2T4; -.
DR   BioGRID-ORCS; 5522; 11 hits in 1144 CRISPR screens.
DR   ChiTaRS; PPP2R2C; human.
DR   GeneWiki; PPP2R2C; -.
DR   GenomeRNAi; 5522; -.
DR   Pharos; Q9Y2T4; Tbio.
DR   PRO; PR:Q9Y2T4; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q9Y2T4; Protein.
DR   Bgee; ENSG00000074211; Expressed in middle temporal gyrus and 162 other cell types or tissues.
DR   ExpressionAtlas; Q9Y2T4; baseline and differential.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000159; C:protein phosphatase type 2A complex; IBA:GO_Central.
DR   GO; GO:0019888; F:protein phosphatase regulator activity; IBA:GO_Central.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR000009; PP2A_PR55.
DR   InterPro; IPR018067; PP2A_PR55_CS.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR11871; PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B; 1.
DR   PANTHER; PTHR11871:SF5; SERINE_THREONINE-PROTEIN PHOSPHATASE 2A 55 KDA REGULATORY SUBUNIT B GAMMA ISOFORM; 1.
DR   PIRSF; PIRSF037309; PP2A_PR55; 1.
DR   PRINTS; PR00600; PP2APR55.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS01024; PR55_1; 1.
DR   PROSITE; PS01025; PR55_2; 1.
DR   Genevisible; Q9Y2T4; HS.
PE   1: Evidence at protein level;
KW   Alternative splicing; Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..447
FT                   /note="Serine/threonine-protein phosphatase 2A 55 kDa
FT                   regulatory subunit B gamma isoform"
FT                   /id="PRO_0000071428"
FT   REPEAT          22..61
FT                   /note="WD 1"
FT   REPEAT          87..128
FT                   /note="WD 2"
FT   REPEAT          171..209
FT                   /note="WD 3"
FT   REPEAT          220..260
FT                   /note="WD 4"
FT   REPEAT          279..317
FT                   /note="WD 5"
FT   REPEAT          334..375
FT                   /note="WD 6"
FT   REPEAT          410..446
FT                   /note="WD 7"
FT   VAR_SEQ         1..23
FT                   /note="MGEDTDTRKINHSFLRDHSYVTE -> MGLSFFSKHLPIQEGQPWALKTP
FT                   (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_036457"
FT   VAR_SEQ         1..23
FT                   /note="MGEDTDTRKINHSFLRDHSYVTE -> MGKRDT (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:15489334"
FT                   /id="VSP_036458"
FT   VAR_SEQ         1..23
FT                   /note="MGEDTDTRKINHSFLRDHSYVTE -> MREADTLRPPQLMEVS (in
FT                   isoform 4)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_043380"
FT   CONFLICT        66
FT                   /note="E -> D (in Ref. 2; AAG39636)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        253
FT                   /note="R -> P (in Ref. 2; AAG39636)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        293
FT                   /note="G -> D (in Ref. 2; AAG39636 and 3; AAP97279)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   447 AA;  51515 MW;  DB002C2384686BBD CRC64;
     MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA
     PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI
     TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS
     VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY
     SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
     YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN
     FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW
     HPAENIIAIA ATNNLYIFQD KVNSDMH
//