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Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Gene

PPP2R2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

  • protein phosphatase type 2A regulator activity Source: UniProtKB

GO - Biological processi

  • regulation of protein phosphatase type 2A activity Source: GOC
  • signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Alternative name(s):
IMYPNO1
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma
Gene namesi
Name:PPP2R2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9306. PPP2R2C.

Subcellular locationi

GO - Cellular componenti

  • protein phosphatase type 2A complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33670.

Polymorphism and mutation databases

BioMutaiPPP2R2C.
DMDMi145559437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoformPRO_0000071428Add
BLAST

Proteomic databases

PaxDbiQ9Y2T4.
PRIDEiQ9Y2T4.

PTM databases

PhosphoSiteiQ9Y2T4.

Expressioni

Gene expression databases

BgeeiQ9Y2T4.
CleanExiHS_PPP2R2C.
ExpressionAtlasiQ9Y2T4. baseline and differential.
GenevestigatoriQ9Y2T4.

Organism-specific databases

HPAiHPA042122.
HPA042770.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP2CAP677753EBI-1774058,EBI-712311

Protein-protein interaction databases

BioGridi111514. 37 interactions.
IntActiQ9Y2T4. 14 interactions.
MINTiMINT-4832053.
STRINGi9606.ENSP00000335083.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T4.
SMRiQ9Y2T4. Positions 21-442.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 6140WD 1Add
BLAST
Repeati87 – 12842WD 2Add
BLAST
Repeati171 – 20939WD 3Add
BLAST
Repeati220 – 26041WD 4Add
BLAST
Repeati279 – 31739WD 5Add
BLAST
Repeati334 – 37542WD 6Add
BLAST
Repeati410 – 44637WD 7Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG5170.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiQ9Y2T4.
KOiK04354.
OMAiHSFLRDH.
OrthoDBiEOG7Q5HCZ.
PhylomeDBiQ9Y2T4.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2T4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI
60 70 80 90 100
FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ
110 120 130 140 150
QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV
160 170 180 190 200
PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH
210 220 230 240 250
LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC
260 270 280 290 300
DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
310 320 330 340 350
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD
360 370 380 390 400
SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR
410 420 430 440
RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH
Length:447
Mass (Da):51,515
Last modified:April 17, 2007 - v4
Checksum:iDB002C2384686BBD
GO
Isoform 2 (identifier: Q9Y2T4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGLSFFSKHLPIQEGQPWALKTP

Show »
Length:447
Mass (Da):51,376
Checksum:i3EEEDCCC0A023DCD
GO
Isoform 3 (identifier: Q9Y2T4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGKRDT

Show »
Length:430
Mass (Da):49,470
Checksum:iFC27804D310C6D93
GO
Isoform 4 (identifier: Q9Y2T4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MREADTLRPPQLMEVS

Note: No experimental confirmation available.

Show »
Length:440
Mass (Da):50,636
Checksum:i05512449DDA70BCF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661E → D in AAG39636 (PubMed:10945473).Curated
Sequence conflicti253 – 2531R → P in AAG39636 (PubMed:10945473).Curated
Sequence conflicti293 – 2931G → D in AAG39636 (PubMed:10945473).Curated
Sequence conflicti293 – 2931G → D in AAP97279 (Ref. 3) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MGEDT…SYVTE → MGLSFFSKHLPIQEGQPWAL KTP in isoform 2. 1 PublicationVSP_036457Add
BLAST
Alternative sequencei1 – 2323MGEDT…SYVTE → MGKRDT in isoform 3. 1 PublicationVSP_036458Add
BLAST
Alternative sequencei1 – 2323MGEDT…SYVTE → MREADTLRPPQLMEVS in isoform 4. 1 PublicationVSP_043380Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH007514 Genomic DNA. Translation: AAD20987.1.
AF086924 mRNA. Translation: AAG39636.1.
AF145027 mRNA. Translation: AAP97279.1.
AK093115 mRNA. Translation: BAG52658.1.
AK296474 mRNA. Translation: BAH12367.1.
AK316003 mRNA. Translation: BAH14374.1.
AC093323 Genomic DNA. No translation available.
AC114815 Genomic DNA. No translation available.
AC116317 Genomic DNA. No translation available.
AC122939 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82393.1.
CH471131 Genomic DNA. Translation: EAW82394.1.
CH471131 Genomic DNA. Translation: EAW82395.1.
BC032954 mRNA. Translation: AAH32954.1.
CCDSiCCDS3387.1. [Q9Y2T4-1]
CCDS3388.1. [Q9Y2T4-2]
CCDS56304.1. [Q9Y2T4-3]
CCDS56305.1. [Q9Y2T4-4]
PIRiJC7153.
RefSeqiNP_001193923.1. NM_001206994.1. [Q9Y2T4-4]
NP_001193924.1. NM_001206995.1. [Q9Y2T4-4]
NP_001193925.1. NM_001206996.1. [Q9Y2T4-3]
NP_065149.2. NM_020416.3. [Q9Y2T4-1]
NP_870991.1. NM_181876.2. [Q9Y2T4-2]
UniGeneiHs.479069.

Genome annotation databases

EnsembliENST00000335585; ENSP00000335083; ENSG00000074211. [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211. [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211. [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211. [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211. [Q9Y2T4-3]
GeneIDi5522.
KEGGihsa:5522.
UCSCiuc003gja.3. human. [Q9Y2T4-2]
uc003gjb.3. human. [Q9Y2T4-3]
uc003gjc.3. human. [Q9Y2T4-1]
uc011bwd.2. human. [Q9Y2T4-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH007514 Genomic DNA. Translation: AAD20987.1.
AF086924 mRNA. Translation: AAG39636.1.
AF145027 mRNA. Translation: AAP97279.1.
AK093115 mRNA. Translation: BAG52658.1.
AK296474 mRNA. Translation: BAH12367.1.
AK316003 mRNA. Translation: BAH14374.1.
AC093323 Genomic DNA. No translation available.
AC114815 Genomic DNA. No translation available.
AC116317 Genomic DNA. No translation available.
AC122939 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82393.1.
CH471131 Genomic DNA. Translation: EAW82394.1.
CH471131 Genomic DNA. Translation: EAW82395.1.
BC032954 mRNA. Translation: AAH32954.1.
CCDSiCCDS3387.1. [Q9Y2T4-1]
CCDS3388.1. [Q9Y2T4-2]
CCDS56304.1. [Q9Y2T4-3]
CCDS56305.1. [Q9Y2T4-4]
PIRiJC7153.
RefSeqiNP_001193923.1. NM_001206994.1. [Q9Y2T4-4]
NP_001193924.1. NM_001206995.1. [Q9Y2T4-4]
NP_001193925.1. NM_001206996.1. [Q9Y2T4-3]
NP_065149.2. NM_020416.3. [Q9Y2T4-1]
NP_870991.1. NM_181876.2. [Q9Y2T4-2]
UniGeneiHs.479069.

3D structure databases

ProteinModelPortaliQ9Y2T4.
SMRiQ9Y2T4. Positions 21-442.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111514. 37 interactions.
IntActiQ9Y2T4. 14 interactions.
MINTiMINT-4832053.
STRINGi9606.ENSP00000335083.

PTM databases

PhosphoSiteiQ9Y2T4.

Polymorphism and mutation databases

BioMutaiPPP2R2C.
DMDMi145559437.

Proteomic databases

PaxDbiQ9Y2T4.
PRIDEiQ9Y2T4.

Protocols and materials databases

DNASUi5522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335585; ENSP00000335083; ENSG00000074211. [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211. [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211. [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211. [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211. [Q9Y2T4-3]
GeneIDi5522.
KEGGihsa:5522.
UCSCiuc003gja.3. human. [Q9Y2T4-2]
uc003gjb.3. human. [Q9Y2T4-3]
uc003gjc.3. human. [Q9Y2T4-1]
uc011bwd.2. human. [Q9Y2T4-4]

Organism-specific databases

CTDi5522.
GeneCardsiGC04M006322.
HGNCiHGNC:9306. PPP2R2C.
HPAiHPA042122.
HPA042770.
MIMi605997. gene.
neXtProtiNX_Q9Y2T4.
PharmGKBiPA33670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5170.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiQ9Y2T4.
KOiK04354.
OMAiHSFLRDH.
OrthoDBiEOG7Q5HCZ.
PhylomeDBiQ9Y2T4.
TreeFamiTF105553.

Miscellaneous databases

ChiTaRSiPPP2R2C. human.
GeneWikiiPPP2R2C.
GenomeRNAii5522.
NextBioi21370.
PROiQ9Y2T4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2T4.
CleanExiHS_PPP2R2C.
ExpressionAtlasiQ9Y2T4. baseline and differential.
GenevestigatoriQ9Y2T4.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit."
    Torres R., Ide S.E., Dehejia A., Baras A., Polymeropoulos M.H.
    DNA Res. 6:323-327(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16."
    Hu P., Yu L., Zhang M., Zheng L., Zhao Y., Fu Q., Zhao S.
    Genomics 67:83-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of a new human cDNA homologous to Oryctolagus cuniculus protein phosphatase 2A1 B gamma subunit."
    Yu L., Zhao S.Y.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain, Testis and Thalamus.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry namei2ABG_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T4
Secondary accession number(s): A8MSY7
, B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: April 29, 2015
This is version 133 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The EMBL entry for PubMed:10574460 is not complete, the paper shows the rest of the sequence (residues 1 to 23).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.