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Q9Y2T4 (2ABG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 123. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Alternative name(s):
IMYPNO1
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma
Gene names
Name:PPP2R2C
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length447 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

Subunit structure

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Sequence similarities

Belongs to the phosphatase 2A regulatory subunit B family.

Contains 7 WD repeats.

Caution

The EMBL entry for Ref.1 is not complete, the paper shows the rest of the sequence (residues 1 to 23).

Binary interactions

With

Entry

#Exp.

IntAct

Notes

PPP2CAP677753EBI-1774058,EBI-712311

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y2T4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y2T4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGLSFFSKHLPIQEGQPWALKTP
Isoform 3 (identifier: Q9Y2T4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGKRDT
Isoform 4 (identifier: Q9Y2T4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MREADTLRPPQLMEVS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 447447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
PRO_0000071428

Regions

Repeat22 – 6140WD 1
Repeat87 – 12842WD 2
Repeat171 – 20939WD 3
Repeat220 – 26041WD 4
Repeat279 – 31739WD 5
Repeat334 – 37542WD 6
Repeat410 – 44637WD 7

Natural variations

Alternative sequence1 – 2323MGEDT…SYVTE → MGLSFFSKHLPIQEGQPWAL KTP in isoform 2.
VSP_036457
Alternative sequence1 – 2323MGEDT…SYVTE → MGKRDT in isoform 3.
VSP_036458
Alternative sequence1 – 2323MGEDT…SYVTE → MREADTLRPPQLMEVS in isoform 4.
VSP_043380

Experimental info

Sequence conflict661E → D in AAG39636. Ref.2
Sequence conflict2531R → P in AAG39636. Ref.2
Sequence conflict2931G → D in AAG39636. Ref.2
Sequence conflict2931G → D in AAP97279. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified April 17, 2007. Version 4.
Checksum: DB002C2384686BBD

FASTA44751,515
        10         20         30         40         50         60 
MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 

        70         80         90        100        110        120 
PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 

       130        140        150        160        170        180 
TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS 

       190        200        210        220        230        240 
VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY 

       250        260        270        280        290        300 
SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 

       310        320        330        340        350        360 
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN 

       370        380        390        400        410        420 
FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW 

       430        440 
HPAENIIAIA ATNNLYIFQD KVNSDMH 

« Hide

Isoform 2 [UniParc].

Checksum: 3EEEDCCC0A023DCD
Show »

FASTA44751,376
Isoform 3 [UniParc].

Checksum: FC27804D310C6D93
Show »

FASTA43049,470
Isoform 4 [UniParc].

Checksum: 05512449DDA70BCF
Show »

FASTA44050,636

References

« Hide 'large scale' references
[1]"Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit."
Torres R., Ide S.E., Dehejia A., Baras A., Polymeropoulos M.H.
DNA Res. 6:323-327(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16."
Hu P., Yu L., Zhang M., Zheng L., Zhao Y., Fu Q., Zhao S.
Genomics 67:83-86(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]"Cloning of a new human cDNA homologous to Oryctolagus cuniculus protein phosphatase 2A1 B gamma subunit."
Yu L., Zhao S.Y.
Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
Tissue: Brain, Testis and Thalamus.
[5]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
Tissue: Testis.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AH007514 Genomic DNA. Translation: AAD20987.1.
AF086924 mRNA. Translation: AAG39636.1.
AF145027 mRNA. Translation: AAP97279.1.
AK093115 mRNA. Translation: BAG52658.1.
AK296474 mRNA. Translation: BAH12367.1.
AK316003 mRNA. Translation: BAH14374.1.
AC093323 Genomic DNA. No translation available.
AC114815 Genomic DNA. No translation available.
AC116317 Genomic DNA. No translation available.
AC122939 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82393.1.
CH471131 Genomic DNA. Translation: EAW82394.1.
CH471131 Genomic DNA. Translation: EAW82395.1.
BC032954 mRNA. Translation: AAH32954.1.
PIRJC7153.
RefSeqNP_001193923.1. NM_001206994.1.
NP_001193924.1. NM_001206995.1.
NP_001193925.1. NM_001206996.1.
NP_870991.1. NM_181876.2.
XP_005248034.1. XM_005247977.1.
UniGeneHs.479069.

3D structure databases

ProteinModelPortalQ9Y2T4.
SMRQ9Y2T4. Positions 21-442.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111514. 20 interactions.
IntActQ9Y2T4. 14 interactions.
MINTMINT-4832053.
STRING9606.ENSP00000335083.

Chemistry

BindingDBQ9Y2T4.

PTM databases

PhosphoSiteQ9Y2T4.

Polymorphism databases

DMDM145559437.

Proteomic databases

PaxDbQ9Y2T4.
PRIDEQ9Y2T4.

Protocols and materials databases

DNASU5522.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000335585; ENSP00000335083; ENSG00000074211. [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211. [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211. [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211. [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211. [Q9Y2T4-3]
GeneID5522.
KEGGhsa:5522.
UCSCuc003gja.3. human. [Q9Y2T4-2]
uc003gjb.3. human. [Q9Y2T4-3]
uc003gjc.3. human. [Q9Y2T4-1]
uc011bwd.2. human. [Q9Y2T4-4]

Organism-specific databases

CTD5522.
GeneCardsGC04M006322.
HGNCHGNC:9306. PPP2R2C.
MIM605997. gene.
neXtProtNX_Q9Y2T4.
PharmGKBPA33670.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5170.
HOGENOMHOG000089745.
HOVERGENHBG000012.
KOK04354.
OMARKINHSF.
OrthoDBEOG7Q5HCZ.
PhylomeDBQ9Y2T4.
TreeFamTF105553.

Gene expression databases

ArrayExpressQ9Y2T4.
BgeeQ9Y2T4.
CleanExHS_PPP2R2C.
GenevestigatorQ9Y2T4.

Family and domain databases

Gene3D2.130.10.10. 1 hit.
InterProIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERPTHR11871. PTHR11871. 1 hit.
PIRSFPIRSF037309. PP2A_PR55. 1 hit.
PRINTSPR00600. PP2APR55.
SMARTSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMSSF50978. SSF50978. 3 hits.
PROSITEPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSPPP2R2C. human.
GeneWikiPPP2R2C.
GenomeRNAi5522.
NextBio21370.
PROQ9Y2T4.
SOURCESearch...

Entry information

Entry name2ABG_HUMAN
AccessionPrimary (citable) accession number: Q9Y2T4
Secondary accession number(s): A8MSY7 expand/collapse secondary AC list , B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: April 16, 2014
This is version 123 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM