Q9Y2T4 (2ABG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Alternative name(s):
IMYPNO1
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma

Gene names

Name:

PPP2R2C

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	447 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.
Subunit structure	PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.
Sequence similarities	Belongs to the phosphatase 2A regulatory subunit B family. Contains 7 WD repeats.
Caution	The EMBL entry for Ref.1 is not complete, the paper shows the rest of the sequence (residues 1 to 23).

Ontologies

Keywords
Coding sequence diversity	Alternative splicing
Domain	Repeat WD repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	signal transduction Non-traceable author statement. Source: UniProtKB
Cellular_component	protein phosphatase type 2A complex Non-traceable author statement Ref.2. Source: UniProtKB
Molecular_function	protein phosphatase type 2A regulator activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2T4-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2T4-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGLSFFSKHLPIQEGQPWALKTP

Isoform 3 (identifier: Q9Y2T4-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGKRDT

Isoform 4 (identifier: Q9Y2T4-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MREADTLRPPQLMEVS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 447	447	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform		PRO_0000071428
Regions
	Repeat	22 – 61	40	WD 1
	Repeat	87 – 128	42	WD 2
	Repeat	171 – 209	39	WD 3
	Repeat	220 – 260	41	WD 4
	Repeat	279 – 317	39	WD 5
	Repeat	334 – 375	42	WD 6
	Repeat	410 – 446	37	WD 7
Natural variations
	Alternative sequence	1 – 23	23	MGEDT…SYVTE → MGLSFFSKHLPIQEGQPWAL KTP in isoform 2.		VSP_036457
	Alternative sequence	1 – 23	23	MGEDT…SYVTE → MGKRDT in isoform 3.		VSP_036458
	Alternative sequence	1 – 23	23	MGEDT…SYVTE → MREADTLRPPQLMEVS in isoform 4.		VSP_043380
Experimental info
	Sequence conflict	66	1	E → D in AAG39636. Ref.2
	Sequence conflict	253	1	R → P in AAG39636. Ref.2
	Sequence conflict	293	1	G → D in AAG39636. Ref.2
	Sequence conflict	293	1	G → D in AAP97279. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified April 17, 2007. Version 4. Checksum: DB002C2384686BBD	FASTA	447	51,515
	10 20 30 40 50 60 MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 70 80 90 100 110 120 PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 130 140 150 160 170 180 TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS 190 200 210 220 230 240 VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY 250 260 270 280 290 300 SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 310 320 330 340 350 360 YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN 370 380 390 400 410 420 FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW 430 440 HPAENIIAIA ATNNLYIFQD KVNSDMH
	Isoform 2 [UniParc]. Checksum: 3EEEDCCC0A023DCD	FASTA	447	51,376
	10 20 30 40 50 60 MGLSFFSKHL PIQEGQPWAL KTPADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA 70 80 90 100 110 120 PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI 130 140 150 160 170 180 TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS 190 200 210 220 230 240 VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY 250 260 270 280 290 300 SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 310 320 330 340 350 360 YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN 370 380 390 400 410 420 FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW 430 440 HPAENIIAIA ATNNLYIFQD KVNSDMH
	Isoform 3 [UniParc]. Checksum: FC27804D310C6D93	FASTA	430	49,470
	10 20 30 40 50 60 MGKRDTADII STVEFNHTGE LLATGDKGGR VVIFQREPES KNAPHSQGEY DVYSTFQSHE 70 80 90 100 110 120 PEFDYLKSLE IEEKINKIKW LPQQNAAHSL LSTNDKTIKL WKITERDKRP EGYNLKDEEG 130 140 150 160 170 180 KLKDLSTVTS LQVPVLKPMD LMVEVSPRRI FANGHTYHIN SISVNSDCET YMSADDLRIN 190 200 210 220 230 240 LWHLAITDRS FNIVDIKPAN MEDLTEVITA SEFHPHHCNL FVYSSSKGSL RLCDMRAAAL 250 260 270 280 290 300 CDKHSKLFEE PEDPSNRSFF SEIISSVSDV KFSHSGRYML TRDYLTVKVW DLNMEARPIE 310 320 330 340 350 360 TYQVHDYLRS KLCSLYENDC IFDKFECAWN GSDSVIMTGA YNNFFRMFDR NTKRDVTLEA 370 380 390 400 410 420 SRESSKPRAV LKPRRVCVGG KRRRDDISVD SLDFTKKILH TAWHPAENII AIAATNNLYI 430 FQDKVNSDMH
	Isoform 4 [UniParc]. Checksum: 05512449DDA70BCF	FASTA	440	50,636
	10 20 30 40 50 60 MREADTLRPP QLMEVSADII STVEFNHTGE LLATGDKGGR VVIFQREPES KNAPHSQGEY 70 80 90 100 110 120 DVYSTFQSHE PEFDYLKSLE IEEKINKIKW LPQQNAAHSL LSTNDKTIKL WKITERDKRP 130 140 150 160 170 180 EGYNLKDEEG KLKDLSTVTS LQVPVLKPMD LMVEVSPRRI FANGHTYHIN SISVNSDCET 190 200 210 220 230 240 YMSADDLRIN LWHLAITDRS FNIVDIKPAN MEDLTEVITA SEFHPHHCNL FVYSSSKGSL 250 260 270 280 290 300 RLCDMRAAAL CDKHSKLFEE PEDPSNRSFF SEIISSVSDV KFSHSGRYML TRDYLTVKVW 310 320 330 340 350 360 DLNMEARPIE TYQVHDYLRS KLCSLYENDC IFDKFECAWN GSDSVIMTGA YNNFFRMFDR 370 380 390 400 410 420 NTKRDVTLEA SRESSKPRAV LKPRRVCVGG KRRRDDISVD SLDFTKKILH TAWHPAENII 430 440 AIAATNNLYI FQDKVNSDMH

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit." Torres R., Ide S.E., Dehejia A., Baras A., Polymeropoulos M.H. DNA Res. 6:323-327(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16." Hu P., Yu L., Zhang M., Zheng L., Zhao Y., Fu Q., Zhao S. Genomics 67:83-86(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Cloning of a new human cDNA homologous to Oryctolagus cuniculus protein phosphatase 2A1 B gamma subunit." Yu L., Zhao S.Y. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4). Tissue: Brain, Testis and Thalamus.
[5]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Testis.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AH007514 Genomic DNA. Translation: AAD20987.1. AF086924 mRNA. Translation: AAG39636.1. AF145027 mRNA. Translation: AAP97279.1. AK093115 mRNA. Translation: BAG52658.1. AK296474 mRNA. Translation: BAH12367.1. AK316003 mRNA. Translation: BAH14374.1. AC093323 Genomic DNA. No translation available. AC114815 Genomic DNA. No translation available. AC116317 Genomic DNA. No translation available. AC122939 Genomic DNA. No translation available. CH471131 Genomic DNA. Translation: EAW82393.1. CH471131 Genomic DNA. Translation: EAW82394.1. CH471131 Genomic DNA. Translation: EAW82395.1. BC032954 mRNA. Translation: AAH32954.1.
IPI	IPI00032462. IPI00178803. IPI00871687. IPI00964437.
PIR	JC7153.
RefSeq	NP_001193923.1. NM_001206994.1. NP_001193924.1. NM_001206995.1. NP_001193925.1. NM_001206996.1. NP_870991.1. NM_181876.2.
UniGene	Hs.479069.
3D structure databases
ProteinModelPortal	Q9Y2T4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2T4. 14 interactions.
STRING	9606.ENSP00000335083.
PTM databases
PhosphoSite	Q9Y2T4.
Polymorphism databases
DMDM	145559437.
Proteomic databases
PaxDb	Q9Y2T4.
PRIDE	Q9Y2T4.
Protocols and materials databases
DNASU	5522.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000335585; ENSP00000335083; ENSG00000074211. ENST00000382599; ENSP00000372042; ENSG00000074211. ENST00000506140; ENSP00000423649; ENSG00000074211. ENST00000507294; ENSP00000425247; ENSG00000074211. ENST00000515571; ENSP00000422374; ENSG00000074211.
GeneID	5522.
KEGG	hsa:5522.
UCSC	uc003gja.3. human. uc003gjb.3. human. uc003gjc.3. human.
Organism-specific databases
CTD	5522.
GeneCards	GC04M006322.
HGNC	HGNC:9306. PPP2R2C.
MIM	605997. gene.
neXtProt	NX_Q9Y2T4.
PharmGKB	PA33670.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5170.
HOGENOM	HOG000089745.
HOVERGEN	HBG000012.
KO	K04354.
OMA	GTEANGN.
OrthoDB	EOG4M0F1K.
Gene expression databases
ArrayExpress	Q9Y2T4.
Bgee	Q9Y2T4.
CleanEx	HS_PPP2R2C.
Genevestigator	Q9Y2T4.
GermOnline	ENSG00000074211. Homo sapiens.
Family and domain databases
Gene3D	2.130.10.10. 1 hit.
InterPro	IPR000009. PP2A_PR55. IPR018067. PP2A_PR55_CS. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR017986. WD40_repeat_dom. [Graphical view]
PANTHER	PTHR11871. PTHR11871. 1 hit.
PIRSF	PIRSF037309. PP2A_PR55. 1 hit.
PRINTS	PR00600. PP2APR55.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS01024. PR55_1. 1 hit. PS01025. PR55_2. 1 hit. PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. False negative. PS50294. WD_REPEATS_REGION. False negative. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q9Y2T4.
ChEMBL	CHEMBL2507.
ChiTaRS	PPP2R2C. human.
GenomeRNAi	5522.
NextBio	21370.
SOURCE	Search...

Entry information

Entry name

2ABG_HUMAN

Accession

Primary (citable) accession number: Q9Y2T4
Secondary accession number(s): A8MSY7 , B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	April 17, 2007
Last modified:	May 1, 2013
This is version 113 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.