Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Gene

PPP2R2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

  • protein phosphatase type 2A regulator activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074211-MONOMER.
SIGNORiQ9Y2T4.

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Alternative name(s):
IMYPNO1
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma
Gene namesi
Name:PPP2R2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:9306. PPP2R2C.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: GO_Central
  • protein phosphatase type 2A complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi5522.
OpenTargetsiENSG00000074211.
PharmGKBiPA33670.

Polymorphism and mutation databases

BioMutaiPPP2R2C.
DMDMi145559437.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000714282 – 447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoformAdd BLAST446

Proteomic databases

PaxDbiQ9Y2T4.
PeptideAtlasiQ9Y2T4.
PRIDEiQ9Y2T4.

PTM databases

iPTMnetiQ9Y2T4.
PhosphoSitePlusiQ9Y2T4.

Expressioni

Gene expression databases

BgeeiENSG00000074211.
CleanExiHS_PPP2R2C.
ExpressionAtlasiQ9Y2T4. baseline and differential.
GenevisibleiQ9Y2T4. HS.

Organism-specific databases

HPAiHPA042122.
HPA042770.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP2CAP677753EBI-1774058,EBI-712311

Protein-protein interaction databases

BioGridi111514. 39 interactors.
IntActiQ9Y2T4. 14 interactors.
MINTiMINT-4832053.
STRINGi9606.ENSP00000335083.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T4.
SMRiQ9Y2T4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 61WD 1Add BLAST40
Repeati87 – 128WD 2Add BLAST42
Repeati171 – 209WD 3Add BLAST39
Repeati220 – 260WD 4Add BLAST41
Repeati279 – 317WD 5Add BLAST39
Repeati334 – 375WD 6Add BLAST42
Repeati410 – 446WD 7Add BLAST37

Sequence similaritiesi

Contains 7 WD repeats.Curated

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiQ9Y2T4.
KOiK04354.
OMAiQEGQPWA.
OrthoDBiEOG091G09BB.
PhylomeDBiQ9Y2T4.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2T4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI
60 70 80 90 100
FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ
110 120 130 140 150
QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV
160 170 180 190 200
PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH
210 220 230 240 250
LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC
260 270 280 290 300
DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD
310 320 330 340 350
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD
360 370 380 390 400
SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR
410 420 430 440
RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH
Length:447
Mass (Da):51,515
Last modified:April 17, 2007 - v4
Checksum:iDB002C2384686BBD
GO
Isoform 2 (identifier: Q9Y2T4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGLSFFSKHLPIQEGQPWALKTP

Show »
Length:447
Mass (Da):51,376
Checksum:i3EEEDCCC0A023DCD
GO
Isoform 3 (identifier: Q9Y2T4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGKRDT

Show »
Length:430
Mass (Da):49,470
Checksum:iFC27804D310C6D93
GO
Isoform 4 (identifier: Q9Y2T4-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MREADTLRPPQLMEVS

Note: No experimental confirmation available.
Show »
Length:440
Mass (Da):50,636
Checksum:i05512449DDA70BCF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti66E → D in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti253R → P in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti293G → D in AAG39636 (PubMed:10945473).Curated1
Sequence conflicti293G → D in AAP97279 (Ref. 3) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0364571 – 23MGEDT…SYVTE → MGLSFFSKHLPIQEGQPWAL KTP in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0364581 – 23MGEDT…SYVTE → MGKRDT in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_0433801 – 23MGEDT…SYVTE → MREADTLRPPQLMEVS in isoform 4. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH007514 Genomic DNA. Translation: AAD20987.1.
AF086924 mRNA. Translation: AAG39636.1.
AF145027 mRNA. Translation: AAP97279.1.
AK093115 mRNA. Translation: BAG52658.1.
AK296474 mRNA. Translation: BAH12367.1.
AK316003 mRNA. Translation: BAH14374.1.
AC093323 Genomic DNA. No translation available.
AC114815 Genomic DNA. No translation available.
AC116317 Genomic DNA. No translation available.
AC122939 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82393.1.
CH471131 Genomic DNA. Translation: EAW82394.1.
CH471131 Genomic DNA. Translation: EAW82395.1.
BC032954 mRNA. Translation: AAH32954.1.
CCDSiCCDS3387.1. [Q9Y2T4-1]
CCDS3388.1. [Q9Y2T4-2]
CCDS56304.1. [Q9Y2T4-3]
CCDS56305.1. [Q9Y2T4-4]
PIRiJC7153.
RefSeqiNP_001193923.1. NM_001206994.1. [Q9Y2T4-4]
NP_001193924.1. NM_001206995.1. [Q9Y2T4-4]
NP_001193925.1. NM_001206996.1. [Q9Y2T4-3]
NP_065149.2. NM_020416.3. [Q9Y2T4-1]
NP_870991.1. NM_181876.2. [Q9Y2T4-2]
UniGeneiHs.479069.

Genome annotation databases

EnsembliENST00000335585; ENSP00000335083; ENSG00000074211. [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211. [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211. [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211. [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211. [Q9Y2T4-3]
GeneIDi5522.
KEGGihsa:5522.
UCSCiuc003gja.3. human. [Q9Y2T4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AH007514 Genomic DNA. Translation: AAD20987.1.
AF086924 mRNA. Translation: AAG39636.1.
AF145027 mRNA. Translation: AAP97279.1.
AK093115 mRNA. Translation: BAG52658.1.
AK296474 mRNA. Translation: BAH12367.1.
AK316003 mRNA. Translation: BAH14374.1.
AC093323 Genomic DNA. No translation available.
AC114815 Genomic DNA. No translation available.
AC116317 Genomic DNA. No translation available.
AC122939 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82393.1.
CH471131 Genomic DNA. Translation: EAW82394.1.
CH471131 Genomic DNA. Translation: EAW82395.1.
BC032954 mRNA. Translation: AAH32954.1.
CCDSiCCDS3387.1. [Q9Y2T4-1]
CCDS3388.1. [Q9Y2T4-2]
CCDS56304.1. [Q9Y2T4-3]
CCDS56305.1. [Q9Y2T4-4]
PIRiJC7153.
RefSeqiNP_001193923.1. NM_001206994.1. [Q9Y2T4-4]
NP_001193924.1. NM_001206995.1. [Q9Y2T4-4]
NP_001193925.1. NM_001206996.1. [Q9Y2T4-3]
NP_065149.2. NM_020416.3. [Q9Y2T4-1]
NP_870991.1. NM_181876.2. [Q9Y2T4-2]
UniGeneiHs.479069.

3D structure databases

ProteinModelPortaliQ9Y2T4.
SMRiQ9Y2T4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111514. 39 interactors.
IntActiQ9Y2T4. 14 interactors.
MINTiMINT-4832053.
STRINGi9606.ENSP00000335083.

PTM databases

iPTMnetiQ9Y2T4.
PhosphoSitePlusiQ9Y2T4.

Polymorphism and mutation databases

BioMutaiPPP2R2C.
DMDMi145559437.

Proteomic databases

PaxDbiQ9Y2T4.
PeptideAtlasiQ9Y2T4.
PRIDEiQ9Y2T4.

Protocols and materials databases

DNASUi5522.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000335585; ENSP00000335083; ENSG00000074211. [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211. [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211. [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211. [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211. [Q9Y2T4-3]
GeneIDi5522.
KEGGihsa:5522.
UCSCiuc003gja.3. human. [Q9Y2T4-1]

Organism-specific databases

CTDi5522.
DisGeNETi5522.
GeneCardsiPPP2R2C.
HGNCiHGNC:9306. PPP2R2C.
HPAiHPA042122.
HPA042770.
MIMi605997. gene.
neXtProtiNX_Q9Y2T4.
OpenTargetsiENSG00000074211.
PharmGKBiPA33670.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1354. Eukaryota.
COG5170. LUCA.
GeneTreeiENSGT00390000006311.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
InParanoidiQ9Y2T4.
KOiK04354.
OMAiQEGQPWA.
OrthoDBiEOG091G09BB.
PhylomeDBiQ9Y2T4.
TreeFamiTF105553.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000074211-MONOMER.
SIGNORiQ9Y2T4.

Miscellaneous databases

ChiTaRSiPPP2R2C. human.
GeneWikiiPPP2R2C.
GenomeRNAii5522.
PROiQ9Y2T4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000074211.
CleanExiHS_PPP2R2C.
ExpressionAtlasiQ9Y2T4. baseline and differential.
GenevisibleiQ9Y2T4. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei2ABG_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T4
Secondary accession number(s): A8MSY7
, B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: November 2, 2016
This is version 145 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The EMBL entry for PubMed:10574460 is not complete, the paper shows the rest of the sequence (residues 1 to 23).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.