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Q9Y2T4

- 2ABG_HUMAN

UniProt

Q9Y2T4 - 2ABG_HUMAN

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Protein
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Gene
PPP2R2C
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment.

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. protein phosphatase type 2A regulator activity Source: UniProtKB

GO - Biological processi

  1. regulation of catalytic activity Source: GOC
  2. signal transduction Source: InterPro
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
Alternative name(s):
IMYPNO1
PP2A subunit B isoform B55-gamma
PP2A subunit B isoform PR55-gamma
PP2A subunit B isoform R2-gamma
PP2A subunit B isoform gamma
Gene namesi
Name:PPP2R2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:9306. PPP2R2C.

Subcellular locationi

GO - Cellular componenti

  1. protein phosphatase type 2A complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33670.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 447447Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
PRO_0000071428Add
BLAST

Proteomic databases

PaxDbiQ9Y2T4.
PRIDEiQ9Y2T4.

PTM databases

PhosphoSiteiQ9Y2T4.

Expressioni

Gene expression databases

ArrayExpressiQ9Y2T4.
BgeeiQ9Y2T4.
CleanExiHS_PPP2R2C.
GenevestigatoriQ9Y2T4.

Interactioni

Subunit structurei

PP2A consists of a common heterodimeric core enzyme, composed of a 36 kDa catalytic subunit (subunit C) and a 65 kDa constant regulatory subunit (PR65 or subunit A), that associates with a variety of regulatory subunits. Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules.

Binary interactionsi

WithEntry#Exp.IntActNotes
PPP2CAP677753EBI-1774058,EBI-712311

Protein-protein interaction databases

BioGridi111514. 20 interactions.
IntActiQ9Y2T4. 14 interactions.
MINTiMINT-4832053.
STRINGi9606.ENSP00000335083.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T4.
SMRiQ9Y2T4. Positions 21-442.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati22 – 6140WD 1
Add
BLAST
Repeati87 – 12842WD 2
Add
BLAST
Repeati171 – 20939WD 3
Add
BLAST
Repeati220 – 26041WD 4
Add
BLAST
Repeati279 – 31739WD 5
Add
BLAST
Repeati334 – 37542WD 6
Add
BLAST
Repeati410 – 44637WD 7
Add
BLAST

Sequence similaritiesi

Contains 7 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG5170.
HOGENOMiHOG000089745.
HOVERGENiHBG000012.
KOiK04354.
OMAiRKINHSF.
OrthoDBiEOG7Q5HCZ.
PhylomeDBiQ9Y2T4.
TreeFamiTF105553.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR11871. PTHR11871. 1 hit.
PIRSFiPIRSF037309. PP2A_PR55. 1 hit.
PRINTSiPR00600. PP2APR55.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 3 hits.
PROSITEiPS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q9Y2T4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI    50
FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ 100
QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV 150
PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH 200
LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC 250
DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD 300
YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD 350
SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR 400
RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH 447
Length:447
Mass (Da):51,515
Last modified:April 17, 2007 - v4
Checksum:iDB002C2384686BBD
GO
Isoform 2 (identifier: Q9Y2T4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGLSFFSKHLPIQEGQPWALKTP

Show »
Length:447
Mass (Da):51,376
Checksum:i3EEEDCCC0A023DCD
GO
Isoform 3 (identifier: Q9Y2T4-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MGKRDT

Show »
Length:430
Mass (Da):49,470
Checksum:iFC27804D310C6D93
GO
Isoform 4 (identifier: Q9Y2T4-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-23: MGEDTDTRKINHSFLRDHSYVTE → MREADTLRPPQLMEVS

Note: No experimental confirmation available.

Show »
Length:440
Mass (Da):50,636
Checksum:i05512449DDA70BCF
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2323MGEDT…SYVTE → MGLSFFSKHLPIQEGQPWAL KTP in isoform 2.
VSP_036457Add
BLAST
Alternative sequencei1 – 2323MGEDT…SYVTE → MGKRDT in isoform 3.
VSP_036458Add
BLAST
Alternative sequencei1 – 2323MGEDT…SYVTE → MREADTLRPPQLMEVS in isoform 4.
VSP_043380Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti66 – 661E → D in AAG39636. 1 Publication
Sequence conflicti253 – 2531R → P in AAG39636. 1 Publication
Sequence conflicti293 – 2931G → D in AAG39636. 1 Publication
Sequence conflicti293 – 2931G → D in AAP97279. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AH007514 Genomic DNA. Translation: AAD20987.1.
AF086924 mRNA. Translation: AAG39636.1.
AF145027 mRNA. Translation: AAP97279.1.
AK093115 mRNA. Translation: BAG52658.1.
AK296474 mRNA. Translation: BAH12367.1.
AK316003 mRNA. Translation: BAH14374.1.
AC093323 Genomic DNA. No translation available.
AC114815 Genomic DNA. No translation available.
AC116317 Genomic DNA. No translation available.
AC122939 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82393.1.
CH471131 Genomic DNA. Translation: EAW82394.1.
CH471131 Genomic DNA. Translation: EAW82395.1.
BC032954 mRNA. Translation: AAH32954.1.
CCDSiCCDS3388.1. [Q9Y2T4-2]
CCDS56304.1. [Q9Y2T4-3]
CCDS56305.1. [Q9Y2T4-4]
PIRiJC7153.
RefSeqiNP_001193923.1. NM_001206994.1. [Q9Y2T4-4]
NP_001193924.1. NM_001206995.1. [Q9Y2T4-4]
NP_001193925.1. NM_001206996.1. [Q9Y2T4-3]
NP_870991.1. NM_181876.2. [Q9Y2T4-2]
XP_005248034.1. XM_005247977.1. [Q9Y2T4-1]
UniGeneiHs.479069.

Genome annotation databases

EnsembliENST00000335585; ENSP00000335083; ENSG00000074211. [Q9Y2T4-2]
ENST00000382599; ENSP00000372042; ENSG00000074211. [Q9Y2T4-1]
ENST00000506140; ENSP00000423649; ENSG00000074211. [Q9Y2T4-4]
ENST00000507294; ENSP00000425247; ENSG00000074211. [Q9Y2T4-4]
ENST00000515571; ENSP00000422374; ENSG00000074211. [Q9Y2T4-3]
GeneIDi5522.
KEGGihsa:5522.
UCSCiuc003gja.3. human. [Q9Y2T4-2]
uc003gjb.3. human. [Q9Y2T4-3]
uc003gjc.3. human. [Q9Y2T4-1]
uc011bwd.2. human. [Q9Y2T4-4]

Polymorphism databases

DMDMi145559437.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AH007514 Genomic DNA. Translation: AAD20987.1 .
AF086924 mRNA. Translation: AAG39636.1 .
AF145027 mRNA. Translation: AAP97279.1 .
AK093115 mRNA. Translation: BAG52658.1 .
AK296474 mRNA. Translation: BAH12367.1 .
AK316003 mRNA. Translation: BAH14374.1 .
AC093323 Genomic DNA. No translation available.
AC114815 Genomic DNA. No translation available.
AC116317 Genomic DNA. No translation available.
AC122939 Genomic DNA. No translation available.
CH471131 Genomic DNA. Translation: EAW82393.1 .
CH471131 Genomic DNA. Translation: EAW82394.1 .
CH471131 Genomic DNA. Translation: EAW82395.1 .
BC032954 mRNA. Translation: AAH32954.1 .
CCDSi CCDS3388.1. [Q9Y2T4-2 ]
CCDS56304.1. [Q9Y2T4-3 ]
CCDS56305.1. [Q9Y2T4-4 ]
PIRi JC7153.
RefSeqi NP_001193923.1. NM_001206994.1. [Q9Y2T4-4 ]
NP_001193924.1. NM_001206995.1. [Q9Y2T4-4 ]
NP_001193925.1. NM_001206996.1. [Q9Y2T4-3 ]
NP_870991.1. NM_181876.2. [Q9Y2T4-2 ]
XP_005248034.1. XM_005247977.1. [Q9Y2T4-1 ]
UniGenei Hs.479069.

3D structure databases

ProteinModelPortali Q9Y2T4.
SMRi Q9Y2T4. Positions 21-442.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111514. 20 interactions.
IntActi Q9Y2T4. 14 interactions.
MINTi MINT-4832053.
STRINGi 9606.ENSP00000335083.

Chemistry

BindingDBi Q9Y2T4.

PTM databases

PhosphoSitei Q9Y2T4.

Polymorphism databases

DMDMi 145559437.

Proteomic databases

PaxDbi Q9Y2T4.
PRIDEi Q9Y2T4.

Protocols and materials databases

DNASUi 5522.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000335585 ; ENSP00000335083 ; ENSG00000074211 . [Q9Y2T4-2 ]
ENST00000382599 ; ENSP00000372042 ; ENSG00000074211 . [Q9Y2T4-1 ]
ENST00000506140 ; ENSP00000423649 ; ENSG00000074211 . [Q9Y2T4-4 ]
ENST00000507294 ; ENSP00000425247 ; ENSG00000074211 . [Q9Y2T4-4 ]
ENST00000515571 ; ENSP00000422374 ; ENSG00000074211 . [Q9Y2T4-3 ]
GeneIDi 5522.
KEGGi hsa:5522.
UCSCi uc003gja.3. human. [Q9Y2T4-2 ]
uc003gjb.3. human. [Q9Y2T4-3 ]
uc003gjc.3. human. [Q9Y2T4-1 ]
uc011bwd.2. human. [Q9Y2T4-4 ]

Organism-specific databases

CTDi 5522.
GeneCardsi GC04M006322.
HGNCi HGNC:9306. PPP2R2C.
MIMi 605997. gene.
neXtProti NX_Q9Y2T4.
PharmGKBi PA33670.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5170.
HOGENOMi HOG000089745.
HOVERGENi HBG000012.
KOi K04354.
OMAi RKINHSF.
OrthoDBi EOG7Q5HCZ.
PhylomeDBi Q9Y2T4.
TreeFami TF105553.

Miscellaneous databases

ChiTaRSi PPP2R2C. human.
GeneWikii PPP2R2C.
GenomeRNAii 5522.
NextBioi 21370.
PROi Q9Y2T4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2T4.
Bgeei Q9Y2T4.
CleanExi HS_PPP2R2C.
Genevestigatori Q9Y2T4.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR000009. PP2A_PR55.
IPR018067. PP2A_PR55_CS.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view ]
PANTHERi PTHR11871. PTHR11871. 1 hit.
PIRSFi PIRSF037309. PP2A_PR55. 1 hit.
PRINTSi PR00600. PP2APR55.
SMARTi SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 3 hits.
PROSITEi PS01024. PR55_1. 1 hit.
PS01025. PR55_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic structure and localization of the human phosphatase 2A BR gamma regulatory subunit."
    Torres R., Ide S.E., Dehejia A., Baras A., Polymeropoulos M.H.
    DNA Res. 6:323-327(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Molecular cloning and mapping of the brain-abundant B1gamma subunit of protein phosphatase 2A, PPP2R2C, to human chromosome 4p16."
    Hu P., Yu L., Zhang M., Zheng L., Zhao Y., Fu Q., Zhao S.
    Genomics 67:83-86(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. "Cloning of a new human cDNA homologous to Oryctolagus cuniculus protein phosphatase 2A1 B gamma subunit."
    Yu L., Zhao S.Y.
    Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
    Tissue: Brain, Testis and Thalamus.
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry namei2ABG_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T4
Secondary accession number(s): A8MSY7
, B7Z3Y1, Q7Z4V7, Q8NEC4, Q9H3G7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: April 17, 2007
Last modified: July 9, 2014
This is version 126 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi