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Protein

AP-3 complex subunit mu-1

Gene

AP3M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

GO - Molecular functioni

  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • protein targeting to lysosome Source: ProtInc

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-390471. Association of TriC/CCT with target proteins during biosynthesis.
SignaLinkiQ9Y2T2.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit mu-1
Alternative name(s):
AP-3 adaptor complex mu3A subunit
Adaptor-related protein complex 3 subunit mu-1
Mu-adaptin 3A
Mu3A-adaptin
Gene namesi
Name:AP3M1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:569. AP3M1.

Subcellular locationi

GO - Cellular componenti

  • axon cytoplasm Source: GOC
  • clathrin adaptor complex Source: InterPro
  • cytoplasmic vesicle membrane Source: UniProtKB-SubCell
  • Golgi apparatus Source: UniProtKB-SubCell
  • lysosomal membrane Source: UniProtKB
  • lysosome Source: ProtInc

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26985.
OpenTargetsiENSG00000185009.
PharmGKBiPA24860.

Polymorphism and mutation databases

BioMutaiAP3M1.
DMDMi13123952.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937811 – 418AP-3 complex subunit mu-1Add BLAST418

Proteomic databases

EPDiQ9Y2T2.
MaxQBiQ9Y2T2.
PaxDbiQ9Y2T2.
PeptideAtlasiQ9Y2T2.
PRIDEiQ9Y2T2.

PTM databases

iPTMnetiQ9Y2T2.
PhosphoSitePlusiQ9Y2T2.

Expressioni

Gene expression databases

BgeeiENSG00000185009.
CleanExiHS_AP3M1.
ExpressionAtlasiQ9Y2T2. baseline and differential.
GenevisibleiQ9Y2T2. HS.

Organism-specific databases

HPAiHPA045591.
HPA048380.

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rab GTPase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi117938. 66 interactors.
IntActiQ9Y2T2. 29 interactors.
STRINGi9606.ENSP00000347408.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T2.
SMRiQ9Y2T2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 417MHDPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2740. Eukaryota.
ENOG410XT7B. LUCA.
GeneTreeiENSGT00530000062779.
HOGENOMiHOG000234366.
HOVERGENiHBG104910.
InParanoidiQ9Y2T2.
KOiK12398.
OMAiHMPKAVL.
OrthoDBiEOG091G088V.
PhylomeDBiQ9Y2T2.
TreeFamiTF315187.

Family and domain databases

InterProiView protein in InterPro
IPR022775. AP_mu_sigma_su.
IPR001392. Clathrin_mu.
IPR018240. Clathrin_mu_CS.
IPR011012. Longin-like_dom.
IPR028565. MHD.
PfamiView protein in Pfam
PF00928. Adap_comp_sub. 1 hit.
PF01217. Clat_adaptor_s. 1 hit.
PIRSFiPIRSF005992. Clathrin_mu. 1 hit.
PRINTSiPR00314. CLATHRINADPT.
SUPFAMiSSF49447. SSF49447. 1 hit.
SSF64356. SSF64356. 1 hit.
PROSITEiView protein in PROSITE
PS00990. CLAT_ADAPTOR_M_1. 1 hit.
PS00991. CLAT_ADAPTOR_M_2. 1 hit.
PS51072. MHD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y2T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS
60 70 80 90 100
TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA
110 120 130 140 150
AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS
160 170 180 190 200
SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA
210 220 230 240 250
EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF
260 270 280 290 300
IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN
310 320 330 340 350
MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLT WDVGKITPQK
360 370 380 390 400
LPSLKGLVNL QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK
410
PFKGVKYVTK AGKFQVRT
Length:418
Mass (Da):46,939
Last modified:November 1, 1999 - v1
Checksum:i533E189C320C4C48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160G → V in BAB15614 (PubMed:14702039).Curated1
Sequence conflicti285N → D in BAB15614 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092092 mRNA. Translation: AAD20446.1.
AK026983 mRNA. Translation: BAB15614.1.
AL731576 Genomic DNA. No translation available.
BC026232 mRNA. Translation: AAH26232.1.
BC067127 mRNA. Translation: AAH67127.1.
CCDSiCCDS7342.1.
RefSeqiNP_001307192.1. NM_001320263.1.
NP_001307193.1. NM_001320264.1.
NP_036227.1. NM_012095.5.
NP_996895.1. NM_207012.3.
UniGeneiHs.500104.

Genome annotation databases

EnsembliENST00000355264; ENSP00000347408; ENSG00000185009.
ENST00000372745; ENSP00000361831; ENSG00000185009.
GeneIDi26985.
KEGGihsa:26985.
UCSCiuc001jwg.4. human.

Similar proteinsi

Entry informationi

Entry nameiAP3M1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T2
Secondary accession number(s): Q5JQ12, Q9H5L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: August 30, 2017
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families