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Protein

AP-3 complex subunit mu-1

Gene

AP3M1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.

GO - Molecular functioni

  • Rab GTPase binding Source: ParkinsonsUK-UCL

GO - Biological processi

  • anterograde axonal transport Source: UniProtKB
  • anterograde synaptic vesicle transport Source: UniProtKB
  • protein targeting to lysosome Source: ProtInc

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
SignaLinkiQ9Y2T2

Names & Taxonomyi

Protein namesi
Recommended name:
AP-3 complex subunit mu-1
Alternative name(s):
AP-3 adaptor complex mu3A subunit
Adaptor-related protein complex 3 subunit mu-1
Mu-adaptin 3A
Mu3A-adaptin
Gene namesi
Name:AP3M1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000185009.12
HGNCiHGNC:569 AP3M1
MIMi610366 gene
neXtProtiNX_Q9Y2T2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi26985
OpenTargetsiENSG00000185009
PharmGKBiPA24860

Polymorphism and mutation databases

BioMutaiAP3M1
DMDMi13123952

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001937811 – 418AP-3 complex subunit mu-1Add BLAST418

Proteomic databases

EPDiQ9Y2T2
MaxQBiQ9Y2T2
PaxDbiQ9Y2T2
PeptideAtlasiQ9Y2T2
PRIDEiQ9Y2T2

PTM databases

iPTMnetiQ9Y2T2
PhosphoSitePlusiQ9Y2T2

Expressioni

Gene expression databases

BgeeiENSG00000185009
CleanExiHS_AP3M1
ExpressionAtlasiQ9Y2T2 baseline and differential
GenevisibleiQ9Y2T2 HS

Organism-specific databases

HPAiHPA045591
HPA048380

Interactioni

Subunit structurei

Adaptor protein complex 3 (AP-3) is a heterotetramer composed of two large adaptins (delta-type subunit AP3D1 and beta-type subunit AP3B1 or AP3B2), a medium adaptin (mu-type subunit AP3M1 or AP3M2) and a small adaptin (sigma-type subunit APS1 or AP3S2). Interacts with AGAP1. AP-3 associates with the BLOC-1 complex (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

  • Rab GTPase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi117938, 67 interactors
CORUMiQ9Y2T2
IntActiQ9Y2T2, 30 interactors
MINTiQ9Y2T2
STRINGi9606.ENSP00000347408

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T2
SMRiQ9Y2T2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini176 – 417MHDPROSITE-ProRule annotationAdd BLAST242

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2740 Eukaryota
ENOG410XT7B LUCA
GeneTreeiENSGT00530000062779
HOGENOMiHOG000234366
HOVERGENiHBG104910
InParanoidiQ9Y2T2
KOiK12398
OMAiHMPKAVL
OrthoDBiEOG091G088V
PhylomeDBiQ9Y2T2
TreeFamiTF315187

Family and domain databases

InterProiView protein in InterPro
IPR036168 AP2_Mu_C_sf
IPR022775 AP_mu_sigma_su
IPR001392 Clathrin_mu
IPR018240 Clathrin_mu_CS
IPR011012 Longin-like_dom_sf
IPR028565 MHD
PfamiView protein in Pfam
PF00928 Adap_comp_sub, 1 hit
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF005992 Clathrin_mu, 1 hit
PRINTSiPR00314 CLATHRINADPT
SUPFAMiSSF49447 SSF49447, 1 hit
SSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00990 CLAT_ADAPTOR_M_1, 1 hit
PS00991 CLAT_ADAPTOR_M_2, 1 hit
PS51072 MHD, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y2T2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS
60 70 80 90 100
TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA
110 120 130 140 150
AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS
160 170 180 190 200
SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA
210 220 230 240 250
EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF
260 270 280 290 300
IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN
310 320 330 340 350
MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLT WDVGKITPQK
360 370 380 390 400
LPSLKGLVNL QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK
410
PFKGVKYVTK AGKFQVRT
Length:418
Mass (Da):46,939
Last modified:November 1, 1999 - v1
Checksum:i533E189C320C4C48
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti160G → V in BAB15614 (PubMed:14702039).Curated1
Sequence conflicti285N → D in BAB15614 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF092092 mRNA Translation: AAD20446.1
AK026983 mRNA Translation: BAB15614.1
AL731576 Genomic DNA No translation available.
BC026232 mRNA Translation: AAH26232.1
BC067127 mRNA Translation: AAH67127.1
CCDSiCCDS7342.1
RefSeqiNP_001307192.1, NM_001320263.1
NP_001307193.1, NM_001320264.1
NP_036227.1, NM_012095.5
NP_996895.1, NM_207012.3
UniGeneiHs.500104

Genome annotation databases

EnsembliENST00000355264; ENSP00000347408; ENSG00000185009
ENST00000372745; ENSP00000361831; ENSG00000185009
GeneIDi26985
KEGGihsa:26985
UCSCiuc001jwg.4 human

Similar proteinsi

Entry informationi

Entry nameiAP3M1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T2
Secondary accession number(s): Q5JQ12, Q9H5L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2001
Last sequence update: November 1, 1999
Last modified: May 23, 2018
This is version 151 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health