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Protein

Axin-2

Gene

AXIN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B (By similarity).By similarity

GO - Molecular functioni

  • armadillo repeat domain binding Source: GO_Central
  • beta-catenin binding Source: BHF-UCL
  • enzyme binding Source: UniProtKB
  • GTPase activator activity Source: GO_Central
  • protein kinase binding Source: GO_Central
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

  • bone mineralization Source: Ensembl
  • cell death Source: GO_Central
  • cell differentiation Source: GO_Central
  • cell proliferation Source: Ensembl
  • cellular protein localization Source: BHF-UCL
  • cellular response to organic cyclic compound Source: GO_Central
  • chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
  • dorsal/ventral axis specification Source: GO_Central
  • intramembranous ossification Source: GO_Central
  • maintenance of DNA repeat elements Source: BHF-UCL
  • mRNA stabilization Source: BHF-UCL
  • negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
  • negative regulation of catenin import into nucleus Source: BHF-UCL
  • negative regulation of cell proliferation Source: BHF-UCL
  • negative regulation of osteoblast differentiation Source: GO_Central
  • odontogenesis Source: BHF-UCL
  • positive regulation of canonical Wnt signaling pathway Source: Reactome
  • positive regulation of cell death Source: BHF-UCL
  • positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
  • positive regulation of GTPase activity Source: GOC
  • positive regulation of protein phosphorylation Source: BHF-UCL
  • regulation of centromeric sister chromatid cohesion Source: BHF-UCL
  • regulation of chondrocyte development Source: Ensembl
  • regulation of mismatch repair Source: BHF-UCL
  • regulation of transcription, DNA-templated Source: GO_Central
  • secondary heart field specification Source: Ensembl
  • termination of G-protein coupled receptor signaling pathway Source: InterPro
  • Wnt signaling pathway involved in somitogenesis Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Wnt signaling pathway

Enzyme and pathway databases

ReactomeiREACT_263873. degradation of AXIN.
REACT_264532. binding of TCF/LEF:CTNNB1 to target gene promoters.
REACT_264596. TCF dependent signaling in response to WNT.
SignaLinkiQ9Y2T1.

Names & Taxonomyi

Protein namesi
Recommended name:
Axin-2
Alternative name(s):
Axin-like protein
Short name:
Axil
Axis inhibition protein 2
Conductin
Gene namesi
Name:AXIN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:904. AXIN2.

Subcellular locationi

GO - Cellular componenti

  • beta-catenin destruction complex Source: BHF-UCL
  • cell cortex Source: GO_Central
  • centrosome Source: BHF-UCL
  • cytoplasm Source: UniProtKB
  • cytoplasmic membrane-bounded vesicle Source: GO_Central
  • cytoplasmic microtubule Source: GO_Central
  • cytosol Source: Reactome
  • Golgi apparatus Source: HPA
  • microtubule cytoskeleton Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • plasma membrane Source: GO_Central
  • postsynaptic density Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

Colorectal cancer (CRC)1 Publication

The gene represented in this entry is involved in disease pathogenesis.

Disease descriptionA complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.

See also OMIM:114500
Oligodontia-colorectal cancer syndrome (ODCRCS)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionAffected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.

See also OMIM:608615

Organism-specific databases

MIMi114500. phenotype.
608615. phenotype.
Orphaneti401911. AXIN2-related attenuated familial adenomatous polyposis.
2227. Hypodontia.
99798. Oligodontia.
300576. Oligodontia - cancer predisposition syndrome.
PharmGKBiPA25196.

Polymorphism and mutation databases

BioMutaiAXIN2.
DMDMi12643949.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 843843Axin-2PRO_0000220895Add
BLAST

Post-translational modificationi

Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity
ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.1 Publication
Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.1 Publication

Keywords - PTMi

ADP-ribosylation, Phosphoprotein, Ubl conjugation

Proteomic databases

MaxQBiQ9Y2T1.
PaxDbiQ9Y2T1.
PRIDEiQ9Y2T1.

PTM databases

PhosphoSiteiQ9Y2T1.

Expressioni

Tissue specificityi

Expressed in brain and lymphoblast.

Gene expression databases

BgeeiQ9Y2T1.
CleanExiHS_AXIN2.
ExpressionAtlasiQ9Y2T1. baseline and differential.
GenevisibleiQ9Y2T1. HS.

Organism-specific databases

HPAiCAB012283.
CAB017783.
HPA042344.

Interactioni

Subunit structurei

Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin (By similarity). Interacts with SMAD7 and RNF111. Interacts with ANKRD6.By similarity3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
AMER3Q8N9442EBI-4400025,EBI-8869590
PPP2CBP627144EBI-4400025,EBI-1044367

Protein-protein interaction databases

BioGridi113910. 11 interactions.
DIPiDIP-59293N.
IntActiQ9Y2T1. 19 interactions.
MINTiMINT-3085018.
STRINGi9606.ENSP00000302625.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2T1.
SMRiQ9Y2T1. Positions 74-199, 764-843.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini81 – 200120RGSPROSITE-ProRule annotationAdd
BLAST
Domaini761 – 84383DIXPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni327 – 41387Interaction with GSK3BBy similarityAdd
BLAST
Regioni413 – 47664Interaction with beta-cateninBy similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi21 – 3010Tankyrase-binding motif

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi469 – 4746Poly-His

Domaini

The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.By similarity

Sequence similaritiesi

Contains 1 DIX domain.PROSITE-ProRule annotation
Contains 1 RGS domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG238205.
HOVERGENiHBG004324.
InParanoidiQ9Y2T1.
KOiK04385.
OrthoDBiEOG79PJQ0.
PhylomeDBiQ9Y2T1.
TreeFamiTF315454.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2T1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSAMLVTCL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGQVTKPMS
60 70 80 90 100
VSSNTRRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE
110 120 130 140 150
REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSIVSKQLK
160 170 180 190 200
PATKTYIRDG IKKQQIDSIM FDQAQTEIQS VMEENAYQMF LTSDIYLEYV
210 220 230 240 250
RSGGENTAYM SNGGLGSLKV VCGYLPTLNE EEEWTCADFK CKLSPTVVGL
260 270 280 290 300
SSKTLRATAS VRSTETVDSG YRSFKRSDPV NPYHIGSGYV FAPATSANDS
310 320 330 340 350
EISSDALTDD SMSMTDSSVD GIPPYRVGSK KQLQREMHRS VKANGQVSLP
360 370 380 390 400
HFPRTHRLPK EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE
410 420 430 440 450
DEEREGSELT LNSREGAPTQ HPLSLLPSGS YEEDPQTILD DHLSRVLKTP
460 470 480 490 500
GCQSPGVGRY SPRSRSPDHH HHHHSQYHSL LPPGGKLPPA AASPGACPLL
510 520 530 540 550
GGKGFVTKQT TKHVHHHYIH HHAVPKTKEE IEAEATQRVH CFCPGGSEYY
560 570 580 590 600
CYSKCKSHSK APETMPSEQF GGSRGSTLPK RNGKGTEPGL ALPAREGGAP
610 620 630 640 650
GGAGALQLPR EEGDRSQDVW QWMLESERQS KPKPHSAQST KKAYPLESAR
660 670 680 690 700
SSPGERASRH HLWGGNSGHP RTTPRAHLFT QDPAMPPLTP PNTLAQLEEA
710 720 730 740 750
CRRLAEVSKP PKQRCCVASQ QRDRNHSATV QTGATPFSNP SLAPEDHKEP
760 770 780 790 800
KKLAGVHALQ ASELVVTYFF CGEEIPYRRM LKAQSLTLGH FKEQLSKKGN
810 820 830 840
YRYYFKKASD EFACGAVFEE IWEDETVLPM YEGRILGKVE RID
Length:843
Mass (Da):93,558
Last modified:November 1, 1999 - v1
Checksum:iF7B62BED6AB4664D
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti37 – 6226QPGVG…NEDGL → HHGGQGPGHQTHVCLFQHQA ERRWV in AAF22799 (Ref. 2) CuratedAdd
BLAST
Sequence conflicti346 – 3461Q → R in AAF22799 (Ref. 2) Curated
Sequence conflicti572 – 63665Missing in AAF22799 (Ref. 2) CuratedAdd
BLAST
Sequence conflicti687 – 6871P → S in AAF22799 (Ref. 2) Curated
Sequence conflicti696 – 6961Q → H in AAF22799 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti50 – 501S → P in polymorphism associated with increased risk of lung cancer. 1 Publication
Corresponds to variant rs2240308 [ dbSNP | Ensembl ].
VAR_054860

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078165 mRNA. Translation: AAD20976.1.
AF205888 mRNA. Translation: AAF22799.1.
AC115994 Genomic DNA. No translation available.
BC101533 mRNA. Translation: AAI01534.1.
AB052751 mRNA. Translation: BAB19762.1.
CCDSiCCDS11662.1.
RefSeqiNP_004646.3. NM_004655.3.
UniGeneiHs.156527.

Genome annotation databases

EnsembliENST00000307078; ENSP00000302625; ENSG00000168646.
GeneIDi8313.
KEGGihsa:8313.
UCSCiuc002jfi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF078165 mRNA. Translation: AAD20976.1.
AF205888 mRNA. Translation: AAF22799.1.
AC115994 Genomic DNA. No translation available.
BC101533 mRNA. Translation: AAI01534.1.
AB052751 mRNA. Translation: BAB19762.1.
CCDSiCCDS11662.1.
RefSeqiNP_004646.3. NM_004655.3.
UniGeneiHs.156527.

3D structure databases

ProteinModelPortaliQ9Y2T1.
SMRiQ9Y2T1. Positions 74-199, 764-843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113910. 11 interactions.
DIPiDIP-59293N.
IntActiQ9Y2T1. 19 interactions.
MINTiMINT-3085018.
STRINGi9606.ENSP00000302625.

Chemistry

BindingDBiQ9Y2T1.
ChEMBLiCHEMBL1255167.

PTM databases

PhosphoSiteiQ9Y2T1.

Polymorphism and mutation databases

BioMutaiAXIN2.
DMDMi12643949.

Proteomic databases

MaxQBiQ9Y2T1.
PaxDbiQ9Y2T1.
PRIDEiQ9Y2T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307078; ENSP00000302625; ENSG00000168646.
GeneIDi8313.
KEGGihsa:8313.
UCSCiuc002jfi.3. human.

Organism-specific databases

CTDi8313.
GeneCardsiGC17M063524.
HGNCiHGNC:904. AXIN2.
HPAiCAB012283.
CAB017783.
HPA042344.
MIMi114500. phenotype.
604025. gene.
608615. phenotype.
neXtProtiNX_Q9Y2T1.
Orphaneti401911. AXIN2-related attenuated familial adenomatous polyposis.
2227. Hypodontia.
99798. Oligodontia.
300576. Oligodontia - cancer predisposition syndrome.
PharmGKBiPA25196.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG238205.
HOVERGENiHBG004324.
InParanoidiQ9Y2T1.
KOiK04385.
OrthoDBiEOG79PJQ0.
PhylomeDBiQ9Y2T1.
TreeFamiTF315454.

Enzyme and pathway databases

ReactomeiREACT_263873. degradation of AXIN.
REACT_264532. binding of TCF/LEF:CTNNB1 to target gene promoters.
REACT_264596. TCF dependent signaling in response to WNT.
SignaLinkiQ9Y2T1.

Miscellaneous databases

ChiTaRSiAXIN2. human.
GeneWikiiAXIN2.
GenomeRNAii8313.
NextBioi31133.
PROiQ9Y2T1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2T1.
CleanExiHS_AXIN2.
ExpressionAtlasiQ9Y2T1. baseline and differential.
GenevisibleiQ9Y2T1. HS.

Family and domain databases

Gene3Di1.10.196.10. 2 hits.
InterProiIPR014936. Axin_b-cat-bd.
IPR001158. DIX.
IPR016137. RGS.
IPR024066. RGS_subdom1.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF08833. Axin_b-cat_bind. 1 hit.
PF00778. DIX. 1 hit.
PF00615. RGS. 1 hit.
[Graphical view]
PRINTSiPR01301. RGSPROTEIN.
SMARTiSM00021. DAX. 1 hit.
SM00315. RGS. 1 hit.
[Graphical view]
SUPFAMiSSF48097. SSF48097. 1 hit.
SSF54236. SSF54236. 1 hit.
PROSITEiPS50841. DIX. 1 hit.
PS50132. RGS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24."
    Mai M., Qian C., Yokomizo A., Smith D.I., Liu W.
    Genomics 55:341-344(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Properties of mouse Axin2 and human AXIN2: chromosomal location, expression pattern, interaction with Axin and effects on embryonic axis formation."
    Zhang T., Fagotto F., Hsu W., Zeng L., Gilbert D., Copeland N.G., Jenkins N.A., Warburton D., Costantini F.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain and Lymphoblast.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Identification of 3' UTR of Axin2."
    Takahashi M., Furukawa Y.
    Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 697-843.
  6. "Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling."
    Liu W., Dong X., Mai M., Seelan R.S., Taniguchi K., Krishnadath K.K., Halling K.C., Cunningham J.M., Qian C., Christensen E., Roches P.C., Smith D.I., Thibodeau S.N.
    Nat. Genet. 26:146-147(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN COLORECTAL CANCER.
  7. "Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer."
    Lammi L., Arte S., Somer M., Jarvinen H., Lahermo P., Thesleff I., Pirinen S., Nieminen P.
    Am. J. Hum. Genet. 74:1043-1050(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN ODCRCS.
  8. "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
    Liu W., Rui H., Wang J., Lin S., He Y., Chen M., Li Q., Ye Z., Zhang S., Chan S.C., Chen Y.-G., Han J., Lin S.-C.
    EMBO J. 25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SMAD7 AND RNF111.
  9. Cited for: ADP-RIBOSYLATION, UBIQUITINATION, INTERACTION WITH TNKS AND TNKS2.
  10. "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
    Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S.
    Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION, DEUBIQUITINATION BY USP34.
  11. "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
    Zhang Y., Liu S., Mickanin C., Feng Y., Charlat O., Michaud G.A., Schirle M., Shi X., Hild M., Bauer A., Myer V.E., Finan P.M., Porter J.A., Huang S.M., Cong F.
    Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: ADP-RIBOSYLATION, UBIQUITINATION, INTERACTION WITH RNF146; TNKS AND TNKS2.
  12. "Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population."
    Kanzaki H., Ouchida M., Hanafusa H., Yano M., Suzuki H., Aoe M., Imai K., Shimizu N., Nakachi K., Shimizu K.
    Int. J. Mol. Med. 18:279-284(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PRO-50.

Entry informationi

Entry nameiAXIN2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2T1
Secondary accession number(s): Q3MJ88, Q9H3M6, Q9UH84
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: July 22, 2015
This is version 149 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.