Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9Y2T1

- AXIN2_HUMAN

UniProt

Q9Y2T1 - AXIN2_HUMAN

Protein

Axin-2

Gene

AXIN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 140 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Inhibitor of the Wnt signaling pathway. Down-regulates beta-catenin. Probably facilitate the phosphorylation of beta-catenin and APC by GSK3B By similarity.By similarity

    GO - Molecular functioni

    1. armadillo repeat domain binding Source: RefGenome
    2. beta-catenin binding Source: BHF-UCL
    3. enzyme binding Source: UniProtKB
    4. GTPase activator activity Source: RefGenome
    5. protein binding Source: IntAct
    6. protein kinase binding Source: RefGenome
    7. signal transducer activity Source: InterPro
    8. ubiquitin protein ligase binding Source: UniProtKB

    GO - Biological processi

    1. bone mineralization Source: Ensembl
    2. cell proliferation Source: Ensembl
    3. cellular protein localization Source: BHF-UCL
    4. cellular response to organic cyclic compound Source: RefGenome
    5. chondrocyte differentiation involved in endochondral bone morphogenesis Source: Ensembl
    6. dorsal/ventral axis specification Source: RefGenome
    7. intramembranous ossification Source: RefGenome
    8. maintenance of DNA repeat elements Source: BHF-UCL
    9. mRNA stabilization Source: BHF-UCL
    10. negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
    11. negative regulation of catenin import into nucleus Source: BHF-UCL
    12. negative regulation of cell proliferation Source: BHF-UCL
    13. negative regulation of osteoblast differentiation Source: RefGenome
    14. odontogenesis Source: BHF-UCL
    15. positive regulation of cell death Source: BHF-UCL
    16. positive regulation of epithelial to mesenchymal transition Source: BHF-UCL
    17. positive regulation of GTPase activity Source: GOC
    18. positive regulation of protein phosphorylation Source: BHF-UCL
    19. regulation of centromeric sister chromatid cohesion Source: BHF-UCL
    20. regulation of chondrocyte development Source: Ensembl
    21. regulation of mismatch repair Source: BHF-UCL
    22. termination of G-protein coupled receptor signaling pathway Source: InterPro
    23. Wnt signaling pathway involved in somitogenesis Source: RefGenome

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Wnt signaling pathway

    Enzyme and pathway databases

    ReactomeiREACT_200766. degradation of AXIN.
    REACT_200777. TCF dependent signaling in response to WNT.
    REACT_200799. binding of TCF/LEF:CTNNB1 to target gene promoters.
    SignaLinkiQ9Y2T1.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Axin-2
    Alternative name(s):
    Axin-like protein
    Short name:
    Axil
    Axis inhibition protein 2
    Conductin
    Gene namesi
    Name:AXIN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:904. AXIN2.

    Subcellular locationi

    GO - Cellular componenti

    1. beta-catenin destruction complex Source: BHF-UCL
    2. cell cortex Source: RefGenome
    3. centrosome Source: BHF-UCL
    4. cytoplasm Source: UniProtKB
    5. cytoplasmic membrane-bounded vesicle Source: RefGenome
    6. cytoplasmic microtubule Source: RefGenome
    7. nucleus Source: UniProtKB
    8. plasma membrane Source: RefGenome
    9. postsynaptic density Source: RefGenome

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.1 Publication
    Note: The gene represented in this entry is involved in disease pathogenesis.
    Oligodontia-colorectal cancer syndrome (ODCRCS) [MIM:608615]: Affected individuals manifest severe tooth agenesis and colorectal cancer or precancerous lesions of variable types.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Organism-specific databases

    MIMi114500. phenotype.
    608615. phenotype.
    Orphaneti2227. Hypodontia.
    99798. Oligodontia.
    300576. Oligodontia - cancer predisposition syndrome.
    PharmGKBiPA25196.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 843843Axin-2PRO_0000220895Add
    BLAST

    Post-translational modificationi

    Probably phosphorylated by GSK3B and dephosphorylated by PP2A.By similarity
    ADP-ribosylated by tankyrase TNKS and TNKS2. Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination and subsequent activation of the Wnt signaling pathway.1 Publication
    Ubiquitinated by RNF146 when poly-ADP-ribosylated, leading to its degradation and subsequent activation of the Wnt signaling pathway. Deubiquitinated by USP34, deubiquitinated downstream of beta-catenin stabilization step: deubiquitination is important Wnt signaling to positively regulate beta-catenin (CTNBB1)-mediated transcription.1 Publication

    Keywords - PTMi

    ADP-ribosylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ9Y2T1.
    PaxDbiQ9Y2T1.
    PRIDEiQ9Y2T1.

    PTM databases

    PhosphoSiteiQ9Y2T1.

    Expressioni

    Tissue specificityi

    Expressed in brain and lymphoblast.

    Gene expression databases

    ArrayExpressiQ9Y2T1.
    BgeeiQ9Y2T1.
    CleanExiHS_AXIN2.
    GenevestigatoriQ9Y2T1.

    Organism-specific databases

    HPAiCAB012283.
    CAB017783.
    HPA042344.

    Interactioni

    Subunit structurei

    Interacts with glycogen synthase kinase-3 beta (GSK3B) and beta-catenin. The interaction between axin and beta-catenin occurs via the armadillo repeats contained in beta-catenin By similarity. Interacts with SMAD7 and RNF111. Interacts with ANKRD6.By similarity3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    AMER3Q8N9442EBI-4400025,EBI-8869590
    PPP2CBP627144EBI-4400025,EBI-1044367

    Protein-protein interaction databases

    BioGridi113910. 10 interactions.
    DIPiDIP-59293N.
    IntActiQ9Y2T1. 10 interactions.
    MINTiMINT-3085018.
    STRINGi9606.ENSP00000302625.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2T1.
    SMRiQ9Y2T1. Positions 74-199, 764-843.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini81 – 200120RGSPROSITE-ProRule annotationAdd
    BLAST
    Domaini761 – 84383DIXPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni327 – 41387Interaction with GSK3BBy similarityAdd
    BLAST
    Regioni413 – 47664Interaction with beta-cateninBy similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi21 – 3010Tankyrase-binding motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi469 – 4746Poly-His

    Domaini

    The tankyrase-binding motif (also named TBD) is required for interaction with tankyrase TNKS and TNKS2.By similarity

    Sequence similaritiesi

    Contains 1 DIX domain.PROSITE-ProRule annotation
    Contains 1 RGS domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG238205.
    HOVERGENiHBG004324.
    InParanoidiQ9Y2T1.
    KOiK04385.
    OrthoDBiEOG79PJQ0.
    PhylomeDBiQ9Y2T1.
    TreeFamiTF315454.

    Family and domain databases

    Gene3Di1.10.196.10. 2 hits.
    InterProiIPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PfamiPF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view]
    PRINTSiPR01301. RGSPROTEIN.
    SMARTiSM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEiPS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2T1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSAMLVTCL PDPSSSFRED APRPPVPGEE GETPPCQPGV GKGQVTKPMS    50
    VSSNTRRNED GLGEPEGRAS PDSPLTRWTK SLHSLLGDQD GAYLFRTFLE 100
    REKCVDTLDF WFACNGFRQM NLKDTKTLRV AKAIYKRYIE NNSIVSKQLK 150
    PATKTYIRDG IKKQQIDSIM FDQAQTEIQS VMEENAYQMF LTSDIYLEYV 200
    RSGGENTAYM SNGGLGSLKV VCGYLPTLNE EEEWTCADFK CKLSPTVVGL 250
    SSKTLRATAS VRSTETVDSG YRSFKRSDPV NPYHIGSGYV FAPATSANDS 300
    EISSDALTDD SMSMTDSSVD GIPPYRVGSK KQLQREMHRS VKANGQVSLP 350
    HFPRTHRLPK EMTPVEPATF AAELISRLEK LKLELESRHS LEERLQQIRE 400
    DEEREGSELT LNSREGAPTQ HPLSLLPSGS YEEDPQTILD DHLSRVLKTP 450
    GCQSPGVGRY SPRSRSPDHH HHHHSQYHSL LPPGGKLPPA AASPGACPLL 500
    GGKGFVTKQT TKHVHHHYIH HHAVPKTKEE IEAEATQRVH CFCPGGSEYY 550
    CYSKCKSHSK APETMPSEQF GGSRGSTLPK RNGKGTEPGL ALPAREGGAP 600
    GGAGALQLPR EEGDRSQDVW QWMLESERQS KPKPHSAQST KKAYPLESAR 650
    SSPGERASRH HLWGGNSGHP RTTPRAHLFT QDPAMPPLTP PNTLAQLEEA 700
    CRRLAEVSKP PKQRCCVASQ QRDRNHSATV QTGATPFSNP SLAPEDHKEP 750
    KKLAGVHALQ ASELVVTYFF CGEEIPYRRM LKAQSLTLGH FKEQLSKKGN 800
    YRYYFKKASD EFACGAVFEE IWEDETVLPM YEGRILGKVE RID 843
    Length:843
    Mass (Da):93,558
    Last modified:November 1, 1999 - v1
    Checksum:iF7B62BED6AB4664D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti37 – 6226QPGVG…NEDGL → HHGGQGPGHQTHVCLFQHQA ERRWV in AAF22799. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti346 – 3461Q → R in AAF22799. 1 PublicationCurated
    Sequence conflicti572 – 63665Missing in AAF22799. 1 PublicationCuratedAdd
    BLAST
    Sequence conflicti687 – 6871P → S in AAF22799. 1 PublicationCurated
    Sequence conflicti696 – 6961Q → H in AAF22799. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti50 – 501S → P in polymorphism associated with increased risk of lung cancer. 1 Publication
    Corresponds to variant rs2240308 [ dbSNP | Ensembl ].
    VAR_054860

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078165 mRNA. Translation: AAD20976.1.
    AF205888 mRNA. Translation: AAF22799.1.
    AC115994 Genomic DNA. No translation available.
    BC101533 mRNA. Translation: AAI01534.1.
    AB052751 mRNA. Translation: BAB19762.1.
    CCDSiCCDS11662.1.
    RefSeqiNP_004646.3. NM_004655.3.
    UniGeneiHs.156527.

    Genome annotation databases

    EnsembliENST00000307078; ENSP00000302625; ENSG00000168646.
    GeneIDi8313.
    KEGGihsa:8313.
    UCSCiuc002jfi.3. human.

    Polymorphism databases

    DMDMi12643949.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF078165 mRNA. Translation: AAD20976.1 .
    AF205888 mRNA. Translation: AAF22799.1 .
    AC115994 Genomic DNA. No translation available.
    BC101533 mRNA. Translation: AAI01534.1 .
    AB052751 mRNA. Translation: BAB19762.1 .
    CCDSi CCDS11662.1.
    RefSeqi NP_004646.3. NM_004655.3.
    UniGenei Hs.156527.

    3D structure databases

    ProteinModelPortali Q9Y2T1.
    SMRi Q9Y2T1. Positions 74-199, 764-843.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113910. 10 interactions.
    DIPi DIP-59293N.
    IntActi Q9Y2T1. 10 interactions.
    MINTi MINT-3085018.
    STRINGi 9606.ENSP00000302625.

    Chemistry

    ChEMBLi CHEMBL1255167.

    PTM databases

    PhosphoSitei Q9Y2T1.

    Polymorphism databases

    DMDMi 12643949.

    Proteomic databases

    MaxQBi Q9Y2T1.
    PaxDbi Q9Y2T1.
    PRIDEi Q9Y2T1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000307078 ; ENSP00000302625 ; ENSG00000168646 .
    GeneIDi 8313.
    KEGGi hsa:8313.
    UCSCi uc002jfi.3. human.

    Organism-specific databases

    CTDi 8313.
    GeneCardsi GC17M063524.
    HGNCi HGNC:904. AXIN2.
    HPAi CAB012283.
    CAB017783.
    HPA042344.
    MIMi 114500. phenotype.
    604025. gene.
    608615. phenotype.
    neXtProti NX_Q9Y2T1.
    Orphaneti 2227. Hypodontia.
    99798. Oligodontia.
    300576. Oligodontia - cancer predisposition syndrome.
    PharmGKBi PA25196.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG238205.
    HOVERGENi HBG004324.
    InParanoidi Q9Y2T1.
    KOi K04385.
    OrthoDBi EOG79PJQ0.
    PhylomeDBi Q9Y2T1.
    TreeFami TF315454.

    Enzyme and pathway databases

    Reactomei REACT_200766. degradation of AXIN.
    REACT_200777. TCF dependent signaling in response to WNT.
    REACT_200799. binding of TCF/LEF:CTNNB1 to target gene promoters.
    SignaLinki Q9Y2T1.

    Miscellaneous databases

    ChiTaRSi AXIN2. human.
    GeneWikii AXIN2.
    GenomeRNAii 8313.
    NextBioi 31133.
    PROi Q9Y2T1.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2T1.
    Bgeei Q9Y2T1.
    CleanExi HS_AXIN2.
    Genevestigatori Q9Y2T1.

    Family and domain databases

    Gene3Di 1.10.196.10. 2 hits.
    InterProi IPR014936. Axin_b-cat-bd.
    IPR001158. DIX.
    IPR024066. Regulat_G_prot_signal_dom1.
    IPR016137. Regulat_G_prot_signal_superfam.
    IPR000342. RGS_dom.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    Pfami PF08833. Axin_b-cat_bind. 1 hit.
    PF00778. DIX. 1 hit.
    PF00615. RGS. 1 hit.
    [Graphical view ]
    PRINTSi PR01301. RGSPROTEIN.
    SMARTi SM00021. DAX. 1 hit.
    SM00315. RGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48097. SSF48097. 1 hit.
    SSF54236. SSF54236. 1 hit.
    PROSITEi PS50841. DIX. 1 hit.
    PS50132. RGS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24."
      Mai M., Qian C., Yokomizo A., Smith D.I., Liu W.
      Genomics 55:341-344(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Properties of mouse Axin2 and human AXIN2: chromosomal location, expression pattern, interaction with Axin and effects on embryonic axis formation."
      Zhang T., Fagotto F., Hsu W., Zeng L., Gilbert D., Copeland N.G., Jenkins N.A., Warburton D., Costantini F.
      Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain and Lymphoblast.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Identification of 3' UTR of Axin2."
      Takahashi M., Furukawa Y.
      Submitted (DEC-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 697-843.
    6. "Mutations in AXIN2 cause colorectal cancer with defective mismatch repair by activating beta-catenin/TCF signalling."
      Liu W., Dong X., Mai M., Seelan R.S., Taniguchi K., Krishnadath K.K., Halling K.C., Cunningham J.M., Qian C., Christensen E., Roches P.C., Smith D.I., Thibodeau S.N.
      Nat. Genet. 26:146-147(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN COLORECTAL CANCER.
    7. "Mutations in AXIN2 cause familial tooth agenesis and predispose to colorectal cancer."
      Lammi L., Arte S., Somer M., Jarvinen H., Lahermo P., Thesleff I., Pirinen S., Nieminen P.
      Am. J. Hum. Genet. 74:1043-1050(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN ODCRCS.
    8. "Axin is a scaffold protein in TGF-beta signaling that promotes degradation of Smad7 by Arkadia."
      Liu W., Rui H., Wang J., Lin S., He Y., Chen M., Li Q., Ye Z., Zhang S., Chan S.C., Chen Y.-G., Han J., Lin S.-C.
      EMBO J. 25:1646-1658(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SMAD7 AND RNF111.
    9. Cited for: ADP-RIBOSYLATION, UBIQUITINATION, INTERACTION WITH TNKS AND TNKS2.
    10. "The Ubiquitin specific protease USP34 regulates Axin stability and Wnt/beta-catenin signaling."
      Lui T.T., Lacroix C., Ahmed S.M., Goldenberg S.J., Leach C.A., Daulat A.M., Angers S.
      Mol. Cell. Biol. 31:2053-2065(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION, DEUBIQUITINATION BY USP34.
    11. "RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling."
      Zhang Y., Liu S., Mickanin C., Feng Y., Charlat O., Michaud G.A., Schirle M., Shi X., Hild M., Bauer A., Myer V.E., Finan P.M., Porter J.A., Huang S.M., Cong F.
      Nat. Cell Biol. 13:623-629(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: ADP-RIBOSYLATION, UBIQUITINATION, INTERACTION WITH RNF146; TNKS AND TNKS2.
    12. "Single nucleotide polymorphism of the AXIN2 gene is preferentially associated with human lung cancer risk in a Japanese population."
      Kanzaki H., Ouchida M., Hanafusa H., Yano M., Suzuki H., Aoe M., Imai K., Shimizu N., Nakachi K., Shimizu K.
      Int. J. Mol. Med. 18:279-284(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT PRO-50.

    Entry informationi

    Entry nameiAXIN2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2T1
    Secondary accession number(s): Q3MJ88, Q9H3M6, Q9UH84
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 140 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3