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Protein

Polymerase delta-interacting protein 2

Gene

POLDIP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Polymerase delta-interacting protein 2
Alternative name(s):
38 kDa DNA polymerase delta interaction protein
Short name:
p38
Gene namesi
Name:POLDIP2
Synonyms:PDIP38, POLD4
ORF Names:HSPC017
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:23781. POLDIP2.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial nucleoid Source: BHF-UCL
  • mitochondrion Source: LIFEdb
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134866227.

Polymorphism and mutation databases

BioMutaiPOLDIP2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 368368Polymerase delta-interacting protein 2PRO_0000197975Add
BLAST

Proteomic databases

EPDiQ9Y2S7.
MaxQBiQ9Y2S7.
PRIDEiQ9Y2S7.

PTM databases

iPTMnetiQ9Y2S7.
PhosphoSiteiQ9Y2S7.

Expressioni

Gene expression databases

CleanExiHS_POLD4.
HS_POLDIP2.
ExpressionAtlasiQ9Y2S7. baseline and differential.
GenevisibleiQ9Y2S7. HS.

Interactioni

Subunit structurei

Interacts with PCNA and POLD2.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ALAS1P131964EBI-713000,EBI-3905054
MTUS2Q5JR593EBI-713000,EBI-742948

Protein-protein interaction databases

BioGridi117531. 25 interactions.
IntActiQ9Y2S7. 16 interactions.
MINTiMINT-1383241.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2S7.
SMRiQ9Y2S7. Positions 240-355.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini235 – 360126ApaGPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 apaG domain.PROSITE-ProRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000010198.
HOVERGENiHBG053549.
InParanoidiQ9Y2S7.
KOiK17809.
OMAiFYMGCRE.
PhylomeDBiQ9Y2S7.

Family and domain databases

Gene3Di2.60.40.1470. 1 hit.
InterProiIPR007474. ApaG_domain.
IPR011722. Hemimethylated_DNA-bd_dom.
[Graphical view]
PfamiPF04379. DUF525. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF110069. SSF110069. 1 hit.
SSF141255. SSF141255. 2 hits.
PROSITEiPS51087. APAG. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2S7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAACTARRAL AVGSRWWSRS LTGARWPRPL CAAAGAGAFS PASTTTTRRH
60 70 80 90 100
LSSRNRPEGK VLETVGVFEV PKQNGKYETG QLFLHSIFGY RGVVLFPWQA
110 120 130 140 150
RLYDRDVASA APEKAENPAG HGSKEVKGKT HTYYQVLIDA RDCPHISQRS
160 170 180 190 200
QTEAVTFLAN HDDSRALYAI PGLDYVSHED ILPYTSTDQV PIQHELFERF
210 220 230 240 250
LLYDQTKAPP FVARETLRAW QEKNHPWLEL SDVHRETTEN IRVTVIPFYM
260 270 280 290 300
GMREAQNSHV YWWRYCIRLE NLDSDVVQLR ERHWRIFSLS GTLETVRGRG
310 320 330 340 350
VVGREPVLSK EQPAFQYSSH VSLQASSGHM WGTFRFERPD GSHFDVRIPP
360
FSLESNKDEK TPPSGLHW
Length:368
Mass (Da):42,033
Last modified:November 1, 1999 - v1
Checksum:i1882F93273542CCF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91A → P in AAK92018 (PubMed:12522211).Curated
Sequence conflicti28 – 281R → K in AAK92018 (PubMed:12522211).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179891 mRNA. Translation: AAK92018.1.
AF077203 mRNA. Translation: AAD26998.1.
AK313232 mRNA. Translation: BAG36043.1.
BC000655 mRNA. Translation: AAH00655.1.
BC009265 mRNA. Translation: AAH09265.1.
CCDSiCCDS74018.1.
RefSeqiNP_001277074.1. NM_001290145.1.
NP_056399.1. NM_015584.4.
UniGeneiHs.241543.

Genome annotation databases

EnsembliENST00000540200; ENSP00000475924; ENSG00000004142.
GeneIDi26073.
KEGGihsa:26073.
UCSCiuc032ezc.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF179891 mRNA. Translation: AAK92018.1.
AF077203 mRNA. Translation: AAD26998.1.
AK313232 mRNA. Translation: BAG36043.1.
BC000655 mRNA. Translation: AAH00655.1.
BC009265 mRNA. Translation: AAH09265.1.
CCDSiCCDS74018.1.
RefSeqiNP_001277074.1. NM_001290145.1.
NP_056399.1. NM_015584.4.
UniGeneiHs.241543.

3D structure databases

ProteinModelPortaliQ9Y2S7.
SMRiQ9Y2S7. Positions 240-355.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117531. 25 interactions.
IntActiQ9Y2S7. 16 interactions.
MINTiMINT-1383241.

PTM databases

iPTMnetiQ9Y2S7.
PhosphoSiteiQ9Y2S7.

Polymorphism and mutation databases

BioMutaiPOLDIP2.

Proteomic databases

EPDiQ9Y2S7.
MaxQBiQ9Y2S7.
PRIDEiQ9Y2S7.

Protocols and materials databases

DNASUi26073.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000540200; ENSP00000475924; ENSG00000004142.
GeneIDi26073.
KEGGihsa:26073.
UCSCiuc032ezc.2. human.

Organism-specific databases

CTDi26073.
GeneCardsiPOLDIP2.
HGNCiHGNC:23781. POLDIP2.
MIMi611519. gene.
neXtProtiNX_Q9Y2S7.
PharmGKBiPA134866227.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00390000010198.
HOVERGENiHBG053549.
InParanoidiQ9Y2S7.
KOiK17809.
OMAiFYMGCRE.
PhylomeDBiQ9Y2S7.

Miscellaneous databases

GeneWikiiPOLDIP2.
GenomeRNAii26073.
NextBioi47983.
PROiQ9Y2S7.
SOURCEiSearch...

Gene expression databases

CleanExiHS_POLD4.
HS_POLDIP2.
ExpressionAtlasiQ9Y2S7. baseline and differential.
GenevisibleiQ9Y2S7. HS.

Family and domain databases

Gene3Di2.60.40.1470. 1 hit.
InterProiIPR007474. ApaG_domain.
IPR011722. Hemimethylated_DNA-bd_dom.
[Graphical view]
PfamiPF04379. DUF525. 1 hit.
PF08755. YccV-like. 1 hit.
[Graphical view]
SMARTiSM00992. YccV-like. 1 hit.
[Graphical view]
SUPFAMiSSF110069. SSF110069. 1 hit.
SSF141255. SSF141255. 2 hits.
PROSITEiPS51087. APAG. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen."
    Liu L., Rodriguez-Belmonte E.M., Mazloum N., Xie B., Lee M.Y.W.T.
    J. Biol. Chem. 278:10041-10047(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], INTERACTION WITH PCNA AND POLD2.
    Tissue: Placenta.
  2. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Colon and Lung.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPDIP2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2S7
Secondary accession number(s): B2R846, Q96JE4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.