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Q9Y2S0

- RPAC2_HUMAN

UniProt

Q9Y2S0 - RPAC2_HUMAN

Protein

DNA-directed RNA polymerases I and III subunit RPAC2

Gene

POLR1D

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common core component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively.

    GO - Molecular functioni

    1. DNA binding Source: InterPro
    2. DNA-directed RNA polymerase activity Source: UniProtKB-KW

    GO - Biological processi

    1. gene expression Source: Reactome
    2. innate immune response Source: Reactome
    3. positive regulation of type I interferon production Source: Reactome
    4. termination of RNA polymerase III transcription Source: Reactome
    5. termination of RNA polymerase I transcription Source: Reactome
    6. transcription elongation from RNA polymerase III promoter Source: Reactome
    7. transcription elongation from RNA polymerase I promoter Source: Reactome
    8. transcription from RNA polymerase III promoter Source: Reactome
    9. transcription from RNA polymerase I promoter Source: Reactome
    10. transcription initiation from RNA polymerase I promoter Source: Reactome

    Keywords - Biological processi

    Transcription

    Enzyme and pathway databases

    ReactomeiREACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    DNA-directed RNA polymerases I and III subunit RPAC2
    Short name:
    RNA polymerases I and III subunit AC2
    Alternative name(s):
    AC19
    DNA-directed RNA polymerase I subunit D
    RNA polymerase I 16 kDa subunit
    Short name:
    RPA16
    RPC16
    hRPA19
    Gene namesi
    Name:POLR1D
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 13

    Organism-specific databases

    HGNCiHGNC:20422. POLR1D.

    Subcellular locationi

    Nucleus By similarity

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. DNA-directed RNA polymerase I complex Source: RefGenome
    3. DNA-directed RNA polymerase III complex Source: RefGenome
    4. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    DNA-directed RNA polymerase, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    Treacher Collins syndrome 2 (TCS2) [MIM:613717]: A form of Treacher Collins syndrome, a disorder of craniofacial development. Treacher Collins syndrome is characterized by a combination of bilateral downward slanting of the palpebral fissures, colobomas of the lower eyelids with a paucity of eyelashes medial to the defect, hypoplasia of the facial bones, cleft palate, malformation of the external ears, atresia of the external auditory canals, and bilateral conductive hearing loss.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471E → K in TCS2. 1 Publication
    VAR_064892
    Natural varianti50 – 501T → I in TCS2. 1 Publication
    VAR_064893
    Natural varianti51 – 511L → R in TCS2. 1 Publication
    VAR_064894
    Natural varianti52 – 521G → E in TCS2. 1 Publication
    VAR_064895
    Natural varianti56 – 561R → C in TCS2. 1 Publication
    VAR_064896
    Natural varianti82 – 821L → S in TCS2. 1 Publication
    VAR_064897
    Natural varianti99 – 991G → S in TCS2. 1 Publication
    VAR_064898

    Keywords - Diseasei

    Disease mutation

    Organism-specific databases

    MIMi613717. phenotype.
    Orphaneti861. Treacher-Collins syndrome.
    PharmGKBiPA134914527.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 133133DNA-directed RNA polymerases I and III subunit RPAC2PRO_0000149316Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine4 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y2S0.
    PaxDbiQ9Y2S0.
    PeptideAtlasiQ9Y2S0.
    PRIDEiQ9Y2S0.

    2D gel databases

    SWISS-2DPAGEQ9Y2S0.

    PTM databases

    PhosphoSiteiQ9Y2S0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2S0.
    BgeeiQ9Y2S0.
    CleanExiHS_POLR1D.
    GenevestigatoriQ9Y2S0.

    Organism-specific databases

    HPAiHPA039337.

    Interactioni

    Subunit structurei

    Component of the RNA polymerase I (Pol I) and RNA polymerase III (Pol III) complexes consisting of at least 13 and 17 subunits, respectively.By similarity

    Protein-protein interaction databases

    BioGridi119272. 23 interactions.
    DIPiDIP-27598N.
    IntActiQ9Y2S0. 15 interactions.
    MINTiMINT-1149665.
    STRINGi9606.ENSP00000302478.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2S0.
    SMRiQ9Y2S0. Positions 22-119.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG1761.
    HOGENOMiHOG000179862.
    HOVERGENiHBG001176.
    KOiK03020.
    OMAiPVLEMVQ.
    OrthoDBiEOG7J9VRX.
    PhylomeDBiQ9Y2S0.
    TreeFamiTF103035.

    Family and domain databases

    InterProiIPR009025. RBP11-like_dimer.
    IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
    [Graphical view]
    SUPFAMiSSF55257. SSF55257. 1 hit.
    PROSITEiPS01154. RNA_POL_L_13KD. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q9Y2S0-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEEDQELERK ISGLKTSMAE GERKTALEMV QAAGTDRHCV TFVLHEEDHT    50
    LGNSLRYMIM KNPEVEFCGY TTTHPSESKI NLRIQTRGTL PAVEPFQRGL 100
    NELMNVCQHV LDKFEASIKD YKDQKASRNE STF 133
    Length:133
    Mass (Da):15,237
    Last modified:November 1, 1999 - v1
    Checksum:i715DAEF2B22B1C76
    GO
    Isoform 2 (identifier: Q9Y2S0-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         11-133: ISGLKTSMAE...QKASRNESTF → AIEELLKEAK...DKYEKRSNRR

    Note: Contains a phosphoserine at position 104.

    Show »
    Length:122
    Mass (Da):14,332
    Checksum:iF6F1FAF28BB89E3A
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti47 – 471E → K in TCS2. 1 Publication
    VAR_064892
    Natural varianti50 – 501T → I in TCS2. 1 Publication
    VAR_064893
    Natural varianti51 – 511L → R in TCS2. 1 Publication
    VAR_064894
    Natural varianti52 – 521G → E in TCS2. 1 Publication
    VAR_064895
    Natural varianti56 – 561R → C in TCS2. 1 Publication
    VAR_064896
    Natural varianti82 – 821L → S in TCS2. 1 Publication
    VAR_064897
    Natural varianti99 – 991G → S in TCS2. 1 Publication
    VAR_064898

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei11 – 133123ISGLK…NESTF → AIEELLKEAKRGKTRAETMG PMGWMKCPLASTNKRFLINT IKNTLPSHKEQDHEQKEGDK EPAKSQAQKEENPKKHRSHP YKHSFRARGSASYSPPRKRS SQDKYEKRSNRR in isoform 2. 2 PublicationsVSP_035416Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077044 mRNA. Translation: AAD27777.1.
    AK311833 mRNA. Translation: BAG34775.1.
    AL136439 Genomic DNA. Translation: CAI16933.1.
    AL136439 Genomic DNA. Translation: CAI16934.1.
    CH471075 Genomic DNA. Translation: EAX08416.1.
    BC000889 mRNA. Translation: AAH00889.1.
    BC015319 mRNA. Translation: AAH15319.1.
    BC018528 mRNA. Translation: AAH18528.1.
    CCDSiCCDS9324.1. [Q9Y2S0-2]
    CCDS9325.1. [Q9Y2S0-1]
    RefSeqiNP_001193488.1. NM_001206559.1.
    NP_057056.1. NM_015972.3. [Q9Y2S0-1]
    NP_689918.1. NM_152705.2. [Q9Y2S0-2]
    XP_005266469.1. XM_005266412.1. [Q9Y2S0-1]
    XP_005266471.1. XM_005266414.1. [Q9Y2S0-2]
    UniGeneiHs.507584.
    Hs.735744.

    Genome annotation databases

    EnsembliENST00000302979; ENSP00000302478; ENSG00000186184. [Q9Y2S0-1]
    ENST00000399696; ENSP00000382603; ENSG00000186184. [Q9Y2S0-1]
    ENST00000399697; ENSP00000382604; ENSG00000186184. [Q9Y2S0-2]
    GeneIDi51082.
    KEGGihsa:51082.
    UCSCiuc001uro.3. human. [Q9Y2S0-1]
    uc001urp.3. human. [Q9Y2S0-2]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077044 mRNA. Translation: AAD27777.1 .
    AK311833 mRNA. Translation: BAG34775.1 .
    AL136439 Genomic DNA. Translation: CAI16933.1 .
    AL136439 Genomic DNA. Translation: CAI16934.1 .
    CH471075 Genomic DNA. Translation: EAX08416.1 .
    BC000889 mRNA. Translation: AAH00889.1 .
    BC015319 mRNA. Translation: AAH15319.1 .
    BC018528 mRNA. Translation: AAH18528.1 .
    CCDSi CCDS9324.1. [Q9Y2S0-2 ]
    CCDS9325.1. [Q9Y2S0-1 ]
    RefSeqi NP_001193488.1. NM_001206559.1.
    NP_057056.1. NM_015972.3. [Q9Y2S0-1 ]
    NP_689918.1. NM_152705.2. [Q9Y2S0-2 ]
    XP_005266469.1. XM_005266412.1. [Q9Y2S0-1 ]
    XP_005266471.1. XM_005266414.1. [Q9Y2S0-2 ]
    UniGenei Hs.507584.
    Hs.735744.

    3D structure databases

    ProteinModelPortali Q9Y2S0.
    SMRi Q9Y2S0. Positions 22-119.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119272. 23 interactions.
    DIPi DIP-27598N.
    IntActi Q9Y2S0. 15 interactions.
    MINTi MINT-1149665.
    STRINGi 9606.ENSP00000302478.

    PTM databases

    PhosphoSitei Q9Y2S0.

    2D gel databases

    SWISS-2DPAGE Q9Y2S0.

    Proteomic databases

    MaxQBi Q9Y2S0.
    PaxDbi Q9Y2S0.
    PeptideAtlasi Q9Y2S0.
    PRIDEi Q9Y2S0.

    Protocols and materials databases

    DNASUi 51082.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000302979 ; ENSP00000302478 ; ENSG00000186184 . [Q9Y2S0-1 ]
    ENST00000399696 ; ENSP00000382603 ; ENSG00000186184 . [Q9Y2S0-1 ]
    ENST00000399697 ; ENSP00000382604 ; ENSG00000186184 . [Q9Y2S0-2 ]
    GeneIDi 51082.
    KEGGi hsa:51082.
    UCSCi uc001uro.3. human. [Q9Y2S0-1 ]
    uc001urp.3. human. [Q9Y2S0-2 ]

    Organism-specific databases

    CTDi 51082.
    GeneCardsi GC13P028194.
    GeneReviewsi POLR1D.
    HGNCi HGNC:20422. POLR1D.
    HPAi HPA039337.
    MIMi 613715. gene.
    613717. phenotype.
    neXtProti NX_Q9Y2S0.
    Orphaneti 861. Treacher-Collins syndrome.
    PharmGKBi PA134914527.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1761.
    HOGENOMi HOG000179862.
    HOVERGENi HBG001176.
    KOi K03020.
    OMAi PVLEMVQ.
    OrthoDBi EOG7J9VRX.
    PhylomeDBi Q9Y2S0.
    TreeFami TF103035.

    Enzyme and pathway databases

    Reactomei REACT_1036. RNA Polymerase III Transcription Initiation From Type 2 Promoter.
    REACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_347. RNA Polymerase III Transcription Initiation From Type 1 Promoter.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    REACT_63. RNA Polymerase III Transcription Termination.
    REACT_756. RNA Polymerase III Chain Elongation.
    REACT_953. RNA Polymerase I Transcription Initiation.

    Miscellaneous databases

    ChiTaRSi POLR1D. human.
    GeneWikii POLR1D.
    GenomeRNAii 51082.
    NextBioi 53727.
    PROi Q9Y2S0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2S0.
    Bgeei Q9Y2S0.
    CleanExi HS_POLR1D.
    Genevestigatori Q9Y2S0.

    Family and domain databases

    InterProi IPR009025. RBP11-like_dimer.
    IPR008193. RNA_pol_Rpb11_13-16kDa_CS.
    [Graphical view ]
    SUPFAMi SSF55257. SSF55257. 1 hit.
    PROSITEi PS01154. RNA_POL_L_13KD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human RNA polymerase I 16-kDa subunit."
      Ye M., Zhang Q., Fu G., Zhou J., Yu Y., Shen Y., Wu J., He K., Chen S., Mao M., Chen Z.
      Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Cerebellum.
    3. "The DNA sequence and analysis of human chromosome 13."
      Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L., Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S., Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P., Ambrose K.D., Andrews D.T.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P., Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C., Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P., Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L., Frankish A.G., Frankland J., French L., Garner P., Garnett J., Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M., Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D., Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D., Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S., Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S., Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R., Rogers J., Ross M.T.
      Nature 428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Cervix, Colon and Eye.
    6. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-9 AND 88-98, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    7. "Characterization of human RNA polymerase III identifies orthologues for Saccharomyces cerevisiae RNA polymerase III subunits."
      Hu P., Wu S., Sun Y., Yuan C.-C., Kobayashi R., Myers M.P., Hernandez N.
      Mol. Cell. Biol. 22:8044-8055(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE RNA POL III COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
    8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-104 (ISOFORM 2), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    11. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: VARIANTS TCS2 LYS-47; ILE-50; ARG-51; GLU-52; CYS-56; SER-82 AND SER-99.

    Entry informationi

    Entry nameiRPAC2_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2S0
    Secondary accession number(s): Q5TBX2, Q96BR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 129 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 13
      Human chromosome 13: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3