Q9Y2R9 (RT07_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S7, mitochondrial
Short name=MRP-S7
Short name=S7mt

Alternative name(s):
bMRP-27a
Short name=bMRP27a

Gene names

Name:

MRPS7

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	242 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins By similarity.
Subcellular location	Mitochondrion By similarity.
Sequence similarities	Belongs to the ribosomal protein S7P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Coding sequence diversity	Polymorphism
Domain	Transit peptide
Molecular function	Ribonucleoprotein Ribosomal protein
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	cytosolic small ribosomal subunit Inferred from sequence or structural similarity. Source: UniProtKB mitochondrion Inferred from direct assay. Source: HPA
Molecular_function	RNA binding Inferred from sequence or structural similarity. Source: UniProtKB structural constituent of ribosome Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 37	37	Mitochondrion Potential
	Chain	38 – 242	205	28S ribosomal protein S7, mitochondrial		PRO_0000273056
Amino acid modifications
	Modified residue	208	1	N6-acetyllysine Ref.9
	Modified residue	228	1	N6-acetyllysine Ref.9
Natural variations
	Natural variant	2	1	A → V. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs8075276 [ dbSNP | Ensembl ].		VAR_030076
Experimental info
	Sequence conflict	223	1	K → S in BAD96715. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2R9 [UniParc]. Last modified May 18, 2010. Version 2. Checksum: 945BC3E948B41CCA	FASTA	242	28,134
	10 20 30 40 50 60 MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY YRKPVEELTE 70 80 90 100 110 120 EEKYVRELKK TQLIKAAPAG KTSSVFEDPV ISKFTNMMMI GGNKVLARSL MIQTLEAVKR 130 140 150 160 170 180 KQFEKYHAAS AEEQATIERN PYTIFHQALK NCEPMIGLVP ILKGGRFYQV PVPLPDRRRR 190 200 210 220 230 240 FLAMKWMITE CRDKKHQRTL MPEKLSHKLL EAFHNQGPVI KRKHDLHKMA EANRALAHYR WW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells." Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. , Gu J., Chen S.-J., Chen Z. Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2. Tissue: Umbilical cord blood.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2. Tissue: Skeletal muscle.
[3]	Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S. Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2. Tissue: Small intestine.
[4]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2. Tissue: Eye.
[6]	"Identification of a mammalian mitochondrial homolog of ribosomal protein S7." Koc E.C., Blackburn K., Burkhart W., Spremulli L.L. Biochem. Biophys. Res. Commun. 266:141-146(1999) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[7]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[8]	"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
[9]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-208 AND LYS-228, MASS SPECTROMETRY.
[10]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF077042 mRNA. Translation: AAD27775.1. AK222995 mRNA. Translation: BAD96715.1. AK313854 mRNA. Translation: BAG36582.1. AC022211 Genomic DNA. No translation available. BC000241 mRNA. Translation: AAH00241.1.
IPI	IPI00006440.
PIR	JC7165.
RefSeq	NP_057055.2. NM_015971.3.
UniGene	Hs.71787.
3D structure databases
ProteinModelPortal	Q9Y2R9.
SMR	Q9Y2R9. Positions 85-241.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2R9. 4 interactions.
MINT	MINT-3084952.
STRING	9606.ENSP00000245539.
PTM databases
PhosphoSite	Q9Y2R9.
Polymorphism databases
DMDM	296452884.
Proteomic databases
PaxDb	Q9Y2R9.
PRIDE	Q9Y2R9.
Protocols and materials databases
DNASU	51081.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000245539; ENSP00000245539; ENSG00000125445.
GeneID	51081.
KEGG	hsa:51081.
UCSC	uc002jnm.4. human.
Organism-specific databases
CTD	51081.
GeneCards	GC17P073254.
H-InvDB	HIX0014167.
HGNC	HGNC:14499. MRPS7.
HPA	HPA022522. HPA023007.
MIM	611974. gene.
neXtProt	NX_Q9Y2R9.
PharmGKB	PA31026.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0049.
HOGENOM	HOG000039065.
HOVERGEN	HBG080152.
InParanoid	Q9Y2R9.
KO	K02992.
OMA	SKFINMM.
OrthoDB	EOG48D0W5.
PhylomeDB	Q9Y2R9.
Gene expression databases
ArrayExpress	Q9Y2R9.
Bgee	Q9Y2R9.
CleanEx	HS_MRPS7.
Genevestigator	Q9Y2R9.
Family and domain databases
Gene3D	1.10.455.10. 1 hit.
InterPro	IPR000235. Ribosomal_S5/S7. IPR023798. Ribosomal_S7_dom. [Graphical view]
PANTHER	PTHR11205. PTHR11205. 1 hit.
Pfam	PF00177. Ribosomal_S7. 1 hit. [Graphical view]
SUPFAM	SSF47973. Ribosomal_S7. 1 hit.
PROSITE	PS00052. RIBOSOMAL_S7. False negative. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	51081.
NextBio	53723.
SOURCE	Search...

Entry information

Entry name

RT07_HUMAN

Accession

Primary (citable) accession number: Q9Y2R9
Secondary accession number(s): B2R9N5, Q53GD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 23, 2007
Last sequence update:	May 18, 2010
Last modified:	May 29, 2013
This is version 92 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.