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Protein

28S ribosomal protein S7, mitochondrial

Gene

MRPS7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
  2. RNA binding Source: UniProtKB
  3. structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
  6. translation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S7, mitochondrial
Short name:
MRP-S7
Short name:
S7mt
Alternative name(s):
bMRP-27a
Short name:
bMRP27a
Gene namesi
Name:MRPS7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:14499. MRPS7.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. cytosolic small ribosomal subunit Source: UniProtKB
  2. mitochondrial inner membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31026.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3737MitochondrionSequence AnalysisAdd
BLAST
Chaini38 – 24220528S ribosomal protein S7, mitochondrialPRO_0000273056Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei208 – 2081N6-acetyllysine1 Publication
Modified residuei228 – 2281N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ9Y2R9.
PaxDbiQ9Y2R9.
PRIDEiQ9Y2R9.

PTM databases

PhosphoSiteiQ9Y2R9.

Expressioni

Gene expression databases

BgeeiQ9Y2R9.
CleanExiHS_MRPS7.
ExpressionAtlasiQ9Y2R9. baseline and differential.
GenevestigatoriQ9Y2R9.

Organism-specific databases

HPAiHPA022522.
HPA023007.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

Protein-protein interaction databases

BioGridi119271. 38 interactions.
IntActiQ9Y2R9. 5 interactions.
MINTiMINT-3084952.
STRINGi9606.ENSP00000245539.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2R9.
SMRiQ9Y2R9. Positions 39-242.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ribosomal protein S7P family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0049.
GeneTreeiENSGT00390000014620.
HOGENOMiHOG000039065.
HOVERGENiHBG080152.
InParanoidiQ9Y2R9.
KOiK02992.
OMAiITECREK.
PhylomeDBiQ9Y2R9.
TreeFamiTF105978.

Family and domain databases

Gene3Di1.10.455.10. 1 hit.
InterProiIPR000235. Ribosomal_S5/S7.
IPR023798. Ribosomal_S7_dom.
[Graphical view]
PANTHERiPTHR11205. PTHR11205. 1 hit.
PfamiPF00177. Ribosomal_S7. 1 hit.
[Graphical view]
SUPFAMiSSF47973. SSF47973. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2R9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY
60 70 80 90 100
YRKPVEELTE EEKYVRELKK TQLIKAAPAG KTSSVFEDPV ISKFTNMMMI
110 120 130 140 150
GGNKVLARSL MIQTLEAVKR KQFEKYHAAS AEEQATIERN PYTIFHQALK
160 170 180 190 200
NCEPMIGLVP ILKGGRFYQV PVPLPDRRRR FLAMKWMITE CRDKKHQRTL
210 220 230 240
MPEKLSHKLL EAFHNQGPVI KRKHDLHKMA EANRALAHYR WW
Length:242
Mass (Da):28,134
Last modified:May 18, 2010 - v2
Checksum:i945BC3E948B41CCA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti223 – 2231K → S in BAD96715 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21A → V.4 Publications
Corresponds to variant rs8075276 [ dbSNP | Ensembl ].
VAR_030076

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077042 mRNA. Translation: AAD27775.1.
AK222995 mRNA. Translation: BAD96715.1.
AK313854 mRNA. Translation: BAG36582.1.
AC022211 Genomic DNA. No translation available.
BC000241 mRNA. Translation: AAH00241.1.
CCDSiCCDS11718.1.
PIRiJC7165.
RefSeqiNP_057055.2. NM_015971.3.
XP_005257481.1. XM_005257424.2.
UniGeneiHs.71787.

Genome annotation databases

EnsembliENST00000245539; ENSP00000245539; ENSG00000125445.
GeneIDi51081.
KEGGihsa:51081.
UCSCiuc002jnm.4. human.

Polymorphism databases

DMDMi296452884.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077042 mRNA. Translation: AAD27775.1.
AK222995 mRNA. Translation: BAD96715.1.
AK313854 mRNA. Translation: BAG36582.1.
AC022211 Genomic DNA. No translation available.
BC000241 mRNA. Translation: AAH00241.1.
CCDSiCCDS11718.1.
PIRiJC7165.
RefSeqiNP_057055.2. NM_015971.3.
XP_005257481.1. XM_005257424.2.
UniGeneiHs.71787.

3D structure databases

ProteinModelPortaliQ9Y2R9.
SMRiQ9Y2R9. Positions 39-242.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119271. 38 interactions.
IntActiQ9Y2R9. 5 interactions.
MINTiMINT-3084952.
STRINGi9606.ENSP00000245539.

PTM databases

PhosphoSiteiQ9Y2R9.

Polymorphism databases

DMDMi296452884.

Proteomic databases

MaxQBiQ9Y2R9.
PaxDbiQ9Y2R9.
PRIDEiQ9Y2R9.

Protocols and materials databases

DNASUi51081.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000245539; ENSP00000245539; ENSG00000125445.
GeneIDi51081.
KEGGihsa:51081.
UCSCiuc002jnm.4. human.

Organism-specific databases

CTDi51081.
GeneCardsiGC17P073254.
H-InvDBHIX0014167.
HGNCiHGNC:14499. MRPS7.
HPAiHPA022522.
HPA023007.
MIMi611974. gene.
neXtProtiNX_Q9Y2R9.
PharmGKBiPA31026.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0049.
GeneTreeiENSGT00390000014620.
HOGENOMiHOG000039065.
HOVERGENiHBG080152.
InParanoidiQ9Y2R9.
KOiK02992.
OMAiITECREK.
PhylomeDBiQ9Y2R9.
TreeFamiTF105978.

Enzyme and pathway databases

ReactomeiREACT_267602. Mitochondrial translation termination.
REACT_267677. Mitochondrial translation elongation.
REACT_267680. Mitochondrial translation initiation.

Miscellaneous databases

ChiTaRSiMRPS7. human.
GeneWikiiMRPS7.
GenomeRNAii51081.
NextBioi53723.
PROiQ9Y2R9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2R9.
CleanExiHS_MRPS7.
ExpressionAtlasiQ9Y2R9. baseline and differential.
GenevestigatoriQ9Y2R9.

Family and domain databases

Gene3Di1.10.455.10. 1 hit.
InterProiIPR000235. Ribosomal_S5/S7.
IPR023798. Ribosomal_S7_dom.
[Graphical view]
PANTHERiPTHR11205. PTHR11205. 1 hit.
PfamiPF00177. Ribosomal_S7. 1 hit.
[Graphical view]
SUPFAMiSSF47973. SSF47973. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
    Tissue: Umbilical cord blood.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
    Tissue: Skeletal muscle.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
    Tissue: Small intestine.
  4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
    Tissue: Eye.
  6. "Identification of a mammalian mitochondrial homolog of ribosomal protein S7."
    Koc E.C., Blackburn K., Burkhart W., Spremulli L.L.
    Biochem. Biophys. Res. Commun. 266:141-146(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
    J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  8. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
    Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
    J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-208 AND LYS-228, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT07_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2R9
Secondary accession number(s): B2R9N5, Q53GD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2007
Last sequence update: May 18, 2010
Last modified: March 4, 2015
This is version 108 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Ribosomal proteins
    Ribosomal proteins families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.