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Q9Y2R9

- RT07_HUMAN

UniProt

Q9Y2R9 - RT07_HUMAN

Protein

28S ribosomal protein S7, mitochondrial

Gene

MRPS7

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB
    2. RNA binding Source: UniProtKB
    3. structural constituent of ribosome Source: UniProtKB

    GO - Biological processi

    1. translation Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S7, mitochondrial
    Short name:
    MRP-S7
    Short name:
    S7mt
    Alternative name(s):
    bMRP-27a
    Short name:
    bMRP27a
    Gene namesi
    Name:MRPS7
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:14499. MRPS7.

    Subcellular locationi

    Mitochondrion By similarity

    GO - Cellular componenti

    1. cytosolic small ribosomal subunit Source: UniProtKB
    2. mitochondrion Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31026.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 3737MitochondrionSequence AnalysisAdd
    BLAST
    Chaini38 – 24220528S ribosomal protein S7, mitochondrialPRO_0000273056Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei208 – 2081N6-acetyllysine1 Publication
    Modified residuei228 – 2281N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ9Y2R9.
    PaxDbiQ9Y2R9.
    PRIDEiQ9Y2R9.

    PTM databases

    PhosphoSiteiQ9Y2R9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2R9.
    BgeeiQ9Y2R9.
    CleanExiHS_MRPS7.
    GenevestigatoriQ9Y2R9.

    Organism-specific databases

    HPAiHPA022522.
    HPA023007.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.By similarity

    Protein-protein interaction databases

    BioGridi119271. 22 interactions.
    IntActiQ9Y2R9. 5 interactions.
    MINTiMINT-3084952.
    STRINGi9606.ENSP00000245539.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2R9.
    SMRiQ9Y2R9. Positions 85-241.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ribosomal protein S7P family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0049.
    HOGENOMiHOG000039065.
    HOVERGENiHBG080152.
    InParanoidiQ9Y2R9.
    KOiK02992.
    OMAiREYLICI.
    PhylomeDBiQ9Y2R9.
    TreeFamiTF105978.

    Family and domain databases

    Gene3Di1.10.455.10. 1 hit.
    InterProiIPR000235. Ribosomal_S5/S7.
    IPR023798. Ribosomal_S7_dom.
    [Graphical view]
    PANTHERiPTHR11205. PTHR11205. 1 hit.
    PfamiPF00177. Ribosomal_S7. 1 hit.
    [Graphical view]
    SUPFAMiSSF47973. SSF47973. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y2R9-1 [UniParc]FASTAAdd to Basket

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    MAAPAVKVAR GWSGLALGVR RAVLQLPGLT QVRWSRYSPE FKDPLIDKEY    50
    YRKPVEELTE EEKYVRELKK TQLIKAAPAG KTSSVFEDPV ISKFTNMMMI 100
    GGNKVLARSL MIQTLEAVKR KQFEKYHAAS AEEQATIERN PYTIFHQALK 150
    NCEPMIGLVP ILKGGRFYQV PVPLPDRRRR FLAMKWMITE CRDKKHQRTL 200
    MPEKLSHKLL EAFHNQGPVI KRKHDLHKMA EANRALAHYR WW 242
    Length:242
    Mass (Da):28,134
    Last modified:May 18, 2010 - v2
    Checksum:i945BC3E948B41CCA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti223 – 2231K → S in BAD96715. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti2 – 21A → V.4 Publications
    Corresponds to variant rs8075276 [ dbSNP | Ensembl ].
    VAR_030076

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077042 mRNA. Translation: AAD27775.1.
    AK222995 mRNA. Translation: BAD96715.1.
    AK313854 mRNA. Translation: BAG36582.1.
    AC022211 Genomic DNA. No translation available.
    BC000241 mRNA. Translation: AAH00241.1.
    CCDSiCCDS11718.1.
    PIRiJC7165.
    RefSeqiNP_057055.2. NM_015971.3.
    XP_005257481.1. XM_005257424.2.
    UniGeneiHs.71787.

    Genome annotation databases

    EnsembliENST00000245539; ENSP00000245539; ENSG00000125445.
    GeneIDi51081.
    KEGGihsa:51081.
    UCSCiuc002jnm.4. human.

    Polymorphism databases

    DMDMi296452884.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF077042 mRNA. Translation: AAD27775.1 .
    AK222995 mRNA. Translation: BAD96715.1 .
    AK313854 mRNA. Translation: BAG36582.1 .
    AC022211 Genomic DNA. No translation available.
    BC000241 mRNA. Translation: AAH00241.1 .
    CCDSi CCDS11718.1.
    PIRi JC7165.
    RefSeqi NP_057055.2. NM_015971.3.
    XP_005257481.1. XM_005257424.2.
    UniGenei Hs.71787.

    3D structure databases

    ProteinModelPortali Q9Y2R9.
    SMRi Q9Y2R9. Positions 85-241.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119271. 22 interactions.
    IntActi Q9Y2R9. 5 interactions.
    MINTi MINT-3084952.
    STRINGi 9606.ENSP00000245539.

    PTM databases

    PhosphoSitei Q9Y2R9.

    Polymorphism databases

    DMDMi 296452884.

    Proteomic databases

    MaxQBi Q9Y2R9.
    PaxDbi Q9Y2R9.
    PRIDEi Q9Y2R9.

    Protocols and materials databases

    DNASUi 51081.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000245539 ; ENSP00000245539 ; ENSG00000125445 .
    GeneIDi 51081.
    KEGGi hsa:51081.
    UCSCi uc002jnm.4. human.

    Organism-specific databases

    CTDi 51081.
    GeneCardsi GC17P073254.
    H-InvDB HIX0014167.
    HGNCi HGNC:14499. MRPS7.
    HPAi HPA022522.
    HPA023007.
    MIMi 611974. gene.
    neXtProti NX_Q9Y2R9.
    PharmGKBi PA31026.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0049.
    HOGENOMi HOG000039065.
    HOVERGENi HBG080152.
    InParanoidi Q9Y2R9.
    KOi K02992.
    OMAi REYLICI.
    PhylomeDBi Q9Y2R9.
    TreeFami TF105978.

    Miscellaneous databases

    GeneWikii MRPS7.
    GenomeRNAii 51081.
    NextBioi 53723.
    PROi Q9Y2R9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2R9.
    Bgeei Q9Y2R9.
    CleanExi HS_MRPS7.
    Genevestigatori Q9Y2R9.

    Family and domain databases

    Gene3Di 1.10.455.10. 1 hit.
    InterProi IPR000235. Ribosomal_S5/S7.
    IPR023798. Ribosomal_S7_dom.
    [Graphical view ]
    PANTHERi PTHR11205. PTHR11205. 1 hit.
    Pfami PF00177. Ribosomal_S7. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47973. SSF47973. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
      Tissue: Umbilical cord blood.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
      Tissue: Skeletal muscle.
    3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
      Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
      Tissue: Small intestine.
    4. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-2.
      Tissue: Eye.
    6. "Identification of a mammalian mitochondrial homolog of ribosomal protein S7."
      Koc E.C., Blackburn K., Burkhart W., Spremulli L.L.
      Biochem. Biophys. Res. Commun. 266:141-146(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L.
      J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    8. "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit."
      Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K.
      J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    9. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-208 AND LYS-228, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT07_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2R9
    Secondary accession number(s): B2R9N5, Q53GD6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 23, 2007
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. Ribosomal proteins
      Ribosomal proteins families and list of entries
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3