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Protein

28S ribosomal protein S17, mitochondrial

Gene

MRPS17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • rRNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: UniProtKB

GO - Biological processi

  • mitochondrial translation Source: UniProtKB
  • mitochondrial translational elongation Source: Reactome
  • mitochondrial translational termination Source: Reactome
  • translation Source: UniProtKB

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S17, mitochondrial
Short name:
MRP-S17
Short name:
S17mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS17m1 Publication
Gene namesi
Name:MRPS17
Synonyms:RPMS17
ORF Names:HSPC011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000239789.5.
HGNCiHGNC:14047. MRPS17.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000239789.
PharmGKBiPA31002.

Polymorphism and mutation databases

BioMutaiMRPS17.
DMDMi13633951.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000003062321 – 13028S ribosomal protein S17, mitochondrialAdd BLAST110

Proteomic databases

EPDiQ9Y2R5.
MaxQBiQ9Y2R5.
PaxDbiQ9Y2R5.
PeptideAtlasiQ9Y2R5.
PRIDEiQ9Y2R5.
TopDownProteomicsiQ9Y2R5.

PTM databases

iPTMnetiQ9Y2R5.
PhosphoSitePlusiQ9Y2R5.

Expressioni

Gene expression databases

BgeeiENSG00000239789.
CleanExiHS_MRPS17.
ExpressionAtlasiQ9Y2R5. baseline and differential.
GenevisibleiQ9Y2R5. HS.

Organism-specific databases

HPAiHPA047159.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi119506. 14 interactors.
CORUMiQ9Y2R5.
IntActiQ9Y2R5. 9 interactors.
MINTiMINT-3084934.
STRINGi9606.ENSP00000285298.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AN1-130[»]
ProteinModelPortaliQ9Y2R5.
SMRiQ9Y2R5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3447. Eukaryota.
ENOG4111N11. LUCA.
GeneTreeiENSGT00530000064130.
HOGENOMiHOG000126812.
HOVERGENiHBG002498.
InParanoidiQ9Y2R5.
KOiK02961.
OrthoDBiEOG091G0QS6.
PhylomeDBiQ9Y2R5.
TreeFamiTF326484.

Family and domain databases

InterProiView protein in InterPro
IPR012340. NA-bd_OB-fold.
IPR000266. Ribosomal_S17/S11.
PfamiView protein in Pfam
PF00366. Ribosomal_S17. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001295. Ribosomal_S17. 1 hit.
SUPFAMiSSF50249. SSF50249. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF
60 70 80 90 100
AHDALQQCTV GDIVLLRALP VPRAKHVKHE LAEIVFKVGK VIDPVTGKPC
110 120 130
AGTTYLESPL SSETTQLSKN LEELNISSAQ
Length:130
Mass (Da):14,502
Last modified:November 1, 1999 - v1
Checksum:i5346917E78F7C6C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077035 mRNA. Translation: AAD27768.1.
AB049950 mRNA. Translation: BAB41003.1.
BC047445 mRNA. Translation: AAH47445.2.
BC054031 mRNA. Translation: AAH54031.1.
CCDSiCCDS5520.1.
RefSeqiNP_057053.1. NM_015969.2.
UniGeneiHs.44298.

Genome annotation databases

EnsembliENST00000285298; ENSP00000285298; ENSG00000239789.
GeneIDi51373.
KEGGihsa:51373.
UCSCiuc003trd.4. human.

Similar proteinsi

Entry informationi

Entry nameiRT17_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2R5
Secondary accession number(s): Q86X15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: September 27, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families