Q9Y2R5 (RT17_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
28S ribosomal protein S17, mitochondrial
Short name=MRP-S17
Short name=S17mt

Gene names

Name:	MRPS17
Synonyms:	RPMS17
ORF Names:	HSPC011

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	130 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.
Subcellular location	Mitochondrion.
Sequence similarities	Belongs to the ribosomal protein S17P family.

Ontologies

Keywords
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	RNA-binding rRNA-binding
Molecular function	Ribonucleoprotein Ribosomal protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	translation Non-traceable author statement Ref.4. Source: UniProtKB
Cellular_component	mitochondrial small ribosomal subunit Non-traceable author statement Ref.4. Source: UniProtKB
Molecular_function	rRNA binding Inferred from electronic annotation. Source: UniProtKB-KW structural constituent of ribosome Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – 20	20	Mitochondrion Potential
	Chain	21 – 130	110	28S ribosomal protein S17, mitochondrial		PRO_0000030623

Sequences

	Sequence		Length	Mass (Da)
	Q9Y2R5 [UniParc]. Last modified November 1, 1999. Version 1. Checksum: 5346917E78F7C6C3	FASTA	130	14,502
	10 20 30 40 50 60 MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF AHDALQQCTV 70 80 90 100 110 120 GDIVLLRALP VPRAKHVKHE LAEIVFKVGK VIDPVTGKPC AGTTYLESPL SSETTQLSKN 130 LEELNISSAQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of genes expressed in human CD34(+) hematopoietic stem/progenitor cells by expressed sequence tags and efficient full-length cDNA cloning." Mao M., Fu G., Wu J.-S., Zhang Q.-H., Zhou J., Kan L.-X., Huang Q.-H., He K.-L., Gu B.-W., Han Z.-G., Shen Y., Gu J., Yu Y.-P., Xu S.-H., Wang Y.-X., Chen S.-J., Chen Z. Proc. Natl. Acad. Sci. U.S.A. 95:8175-8180(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Umbilical cord blood.
[2]	"Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28S small subunit." Suzuki T., Terasaki M., Takemoto-Hori C., Hanada T., Ueda T., Wada A., Watanabe K. J. Biol. Chem. 276:33181-33195(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Uterus.
[4]	"The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present." Koc E.C., Burkhart W., Blackburn K., Moseley A., Spremulli L.L. J. Biol. Chem. 276:19363-19374(2001) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF077035 mRNA. Translation: AAD27768.1. AB049950 mRNA. Translation: BAB41003.1. BC047445 mRNA. Translation: AAH47445.2. BC054031 mRNA. Translation: AAH54031.1.
IPI	IPI00744772.
RefSeq	NP_057053.1. NM_015969.2.
UniGene	Hs.44298.
3D structure databases
ProteinModelPortal	Q9Y2R5.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9Y2R5. 1 interaction.
STRING	9606.ENSP00000285298.
PTM databases
PhosphoSite	Q9Y2R5.
Polymorphism databases
DMDM	13633951.
Proteomic databases
PaxDb	Q9Y2R5.
PRIDE	Q9Y2R5.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000285298; ENSP00000285298; ENSG00000239789.
GeneID	51373.
KEGG	hsa:51373.
UCSC	uc003trd.3. human.
Organism-specific databases
CTD	51373.
GeneCards	GC07P056019.
HGNC	HGNC:14047. MRPS17.
HPA	HPA047159.
MIM	611980. gene.
neXtProt	NX_Q9Y2R5.
PharmGKB	PA31002.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG5048.
HOGENOM	HOG000126812.
HOVERGEN	HBG002498.
InParanoid	Q9Y2R5.
KO	K02961.
OrthoDB	EOG4FTW22.
PhylomeDB	Q9Y2R5.
Gene expression databases
ArrayExpress	Q9Y2R5.
Bgee	Q9Y2R5.
CleanEx	HS_MRPS17.
Genevestigator	Q9Y2R5.
GermOnline	ENSG00000154999. Homo sapiens.
Family and domain databases
Gene3D	2.40.50.140. 1 hit.
InterPro	IPR012340. NA-bd_OB-fold. IPR000266. Ribosomal_S17. [Graphical view]
Pfam	PF00366. Ribosomal_S17. 1 hit. [Graphical view]
ProDom	PD001295. Ribosomal_S17. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF50249. Nucleic_acid_OB. 1 hit.
PROSITE	PS00056. RIBOSOMAL_S17. False negative. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	mRpS17. human.
GenomeRNAi	51373.
NextBio	54859.
SOURCE	Search...

Entry information

Entry name

RT17_HUMAN

Accession

Primary (citable) accession number: Q9Y2R5
Secondary accession number(s): Q86X15

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 110 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.