Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

28S ribosomal protein S17, mitochondrial

Gene

MRPS17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-5368286 Mitochondrial translation initiation
R-HSA-5389840 Mitochondrial translation elongation
R-HSA-5419276 Mitochondrial translation termination

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S17, mitochondrial
Short name:
MRP-S17
Short name:
S17mt
Alternative name(s):
Mitochondrial small ribosomal subunit protein uS17m1 Publication
Gene namesi
Name:MRPS17
Synonyms:RPMS17
ORF Names:HSPC011
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000239789.5
HGNCiHGNC:14047 MRPS17
MIMi611980 gene
neXtProtiNX_Q9Y2R5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000239789
PharmGKBiPA31002

Polymorphism and mutation databases

BioMutaiMRPS17
DMDMi13633951

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 20MitochondrionSequence analysisAdd BLAST20
ChainiPRO_000003062321 – 13028S ribosomal protein S17, mitochondrialAdd BLAST110

Proteomic databases

EPDiQ9Y2R5
MaxQBiQ9Y2R5
PaxDbiQ9Y2R5
PeptideAtlasiQ9Y2R5
PRIDEiQ9Y2R5
TopDownProteomicsiQ9Y2R5

PTM databases

iPTMnetiQ9Y2R5
PhosphoSitePlusiQ9Y2R5

Expressioni

Gene expression databases

BgeeiENSG00000239789
CleanExiHS_MRPS17
ExpressionAtlasiQ9Y2R5 baseline and differential
GenevisibleiQ9Y2R5 HS

Organism-specific databases

HPAiHPA047159

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi119506, 16 interactors
CORUMiQ9Y2R5
IntActiQ9Y2R5, 9 interactors
MINTiQ9Y2R5
STRINGi9606.ENSP00000285298

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AN1-130[»]
ProteinModelPortaliQ9Y2R5
SMRiQ9Y2R5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG3447 Eukaryota
ENOG4111N11 LUCA
GeneTreeiENSGT00530000064130
HOGENOMiHOG000126812
HOVERGENiHBG002498
InParanoidiQ9Y2R5
KOiK02961
OrthoDBiEOG091G0QS6
PhylomeDBiQ9Y2R5
TreeFamiTF326484

Family and domain databases

InterProiView protein in InterPro
IPR012340 NA-bd_OB-fold
IPR000266 Ribosomal_S17/S11
PfamiView protein in Pfam
PF00366 Ribosomal_S17, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD001295 Ribosomal_S17, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2R5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVVRSSVHA RWIVGKVIGT KMQKTAKVRV TRLVLDPYLL KYFNKRKTYF
60 70 80 90 100
AHDALQQCTV GDIVLLRALP VPRAKHVKHE LAEIVFKVGK VIDPVTGKPC
110 120 130
AGTTYLESPL SSETTQLSKN LEELNISSAQ
Length:130
Mass (Da):14,502
Last modified:November 1, 1999 - v1
Checksum:i5346917E78F7C6C3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077035 mRNA Translation: AAD27768.1
AB049950 mRNA Translation: BAB41003.1
BC047445 mRNA Translation: AAH47445.2
BC054031 mRNA Translation: AAH54031.1
CCDSiCCDS5520.1
RefSeqiNP_057053.1, NM_015969.2
UniGeneiHs.44298

Genome annotation databases

EnsembliENST00000285298; ENSP00000285298; ENSG00000239789
GeneIDi51373
KEGGihsa:51373
UCSCiuc003trd.4 human

Similar proteinsi

Entry informationi

Entry nameiRT17_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2R5
Secondary accession number(s): Q86X15
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1999
Last modified: March 28, 2018
This is version 156 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health