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Protein

Probable ATP-dependent RNA helicase DDX52

Gene

DDX52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 216ATP8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus and cytosol.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus and cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX52 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent RNA helicase ROK1-like
DEAD box protein 52
Gene namesi
Name:DDX52
Synonyms:ROK1
ORF Names:HUSSY-19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20038. DDX52.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • membrane Source: UniProtKB
  • nucleolus Source: GO_Central
  • nucleoplasm Source: Reactome

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11056.
PharmGKBiPA134904836.

Polymorphism and mutation databases

BioMutaiDDX52.
DMDMi296439375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550601 – 599Probable ATP-dependent RNA helicase DDX52Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei39PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2R4.
MaxQBiQ9Y2R4.
PaxDbiQ9Y2R4.
PeptideAtlasiQ9Y2R4.
PRIDEiQ9Y2R4.

2D gel databases

SWISS-2DPAGEiQ9Y2R4.

PTM databases

iPTMnetiQ9Y2R4.
PhosphoSitePlusiQ9Y2R4.
SwissPalmiQ9Y2R4.

Expressioni

Gene expression databases

BgeeiENSG00000141141.
CleanExiHS_DDX52.
ExpressionAtlasiQ9Y2R4. baseline and differential.
GenevisibleiQ9Y2R4. HS.

Organism-specific databases

HPAiHPA056173.

Interactioni

Protein-protein interaction databases

BioGridi116241. 37 interactors.
IntActiQ9Y2R4. 13 interactors.
MINTiMINT-2823243.
STRINGi9606.ENSP00000268854.

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi139 – 146Combined sources8
Beta strandi149 – 155Combined sources7
Helixi163 – 170Combined sources8
Helixi174 – 182Combined sources9
Helixi190 – 200Combined sources11
Beta strandi205 – 208Combined sources4
Helixi215 – 227Combined sources13
Beta strandi232 – 234Combined sources3
Beta strandi237 – 240Combined sources4
Helixi244 – 257Combined sources14
Turni258 – 260Combined sources3
Helixi270 – 275Combined sources6
Turni276 – 278Combined sources3
Beta strandi288 – 291Combined sources4
Helixi293 – 301Combined sources9
Beta strandi302 – 304Combined sources3
Beta strandi314 – 319Combined sources6
Helixi320 – 326Combined sources7
Helixi331 – 341Combined sources11
Beta strandi348 – 355Combined sources8
Helixi358 – 367Combined sources10
Beta strandi368 – 370Combined sources3
Beta strandi372 – 376Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DKPX-ray2.10A139-381[»]
ProteinModelPortaliQ9Y2R4.
SMRiQ9Y2R4.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2R4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 374Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST179
Domaini385 – 546Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi165 – 193Q motifAdd BLAST29
Motifi318 – 321DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi543 – 592Lys-richAdd BLAST50

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0344. Eukaryota.
ENOG410XQS8. LUCA.
HOGENOMiHOG000242486.
HOVERGENiHBG051332.
InParanoidiQ9Y2R4.
KOiK14779.
OrthoDBiEOG091G06V2.
PhylomeDBiQ9Y2R4.
TreeFamiTF314448.

Family and domain databases

InterProiView protein in InterPro
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
PfamiView protein in Pfam
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
SMARTiView protein in SMART
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiView protein in PROSITE
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9Y2R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVHDLFRRL GAGAKFDTRR FSADAARFQI GKRKYDFDSS EVLQGLDFFG
60 70 80 90 100
NKKSVPGVCG ASQTHQKPQN GEKKEESLTE RKREQSKKKR KTMTSEIASQ
110 120 130 140 150
EEGATIQWMS SVEAKIEDKK VQRESKLTSG KLENLRKEKI NFLRNKHKIH
160 170 180 190 200
VQGTDLPDPI ATFQQLDQEY KINSRLLQNI LDAGFQMPTP IQMQAIPVML
210 220 230 240 250
HGRELLASAP TGSGKTLAFS IPILMQLKQP ANKGFRALII SPTRELASQI
260 270 280 290 300
HRELIKISEG TGFRIHMIHK AAVAAKKFGP KSSKKFDILV TTPNRLIYLL
310 320 330 340 350
KQDPPGIDLA SVEWLVVDES DKLFEDGKTG FRDQLASIFL ACTSHKVRRA
360 370 380 390 400
MFSATFAYDV EQWCKLNLDN VISVSIGARN SAVETVEQEL LFVGSETGKL
410 420 430 440 450
LAMRELVKKG FNPPVLVFVQ SIERAKELFH ELIYEGINVD VIHAERTQQQ
460 470 480 490 500
RDNTVHSFRA GKIWVLICTA LLARGIDFKG VNLVINYDFP TSSVEYIHRI
510 520 530 540 550
GRTGRAGNKG KAITFFTEDD KPLLRSVANV IQQAGCPVPE YIKGFQKLLS
560 570 580 590
KQKKKMIKKP LERESISTTP KCFLEKAKDK QKKVTGQNSK KKVALEDKS
Length:599
Mass (Da):67,498
Last modified:May 18, 2010 - v3
Checksum:iF31EA34AC478EE21
GO

Sequence cautioni

The sequence AAD27766 differs from that shown. Reason: Frameshift at positions 324, 327, 330, 350, 365 and 377.Curated
The sequence AK093661 differs from that shown. Cloning artifact.Curated
The sequence BAA91812 differs from that shown. Cloning artifact.Curated
The sequence CAA09374 differs from that shown. Reason: Frameshift at positions 355 and 377.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299L → S in AK093661 (PubMed:14702039).Curated1
Sequence conflicti582K → R in BAA91812 (PubMed:14702039).Curated1
Sequence conflicti584V → F in CAA09374 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060235403M → V4 PublicationsCorresponds to variant dbSNP:rs7216445Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077033 mRNA. Translation: AAD27766.1. Frameshift.
AK001652 mRNA. Translation: BAA91812.1. Sequence problems.
AK093661 mRNA. No translation available.
AC091199 Genomic DNA. No translation available.
BC041785 mRNA. Translation: AAH41785.1.
AJ010840 mRNA. Translation: CAA09374.1. Frameshift.
CCDSiCCDS11323.1.
RefSeqiNP_001278405.1. NM_001291476.1.
NP_008941.3. NM_007010.4.
UniGeneiHs.590937.

Genome annotation databases

EnsembliENST00000615769; ENSP00000480030; ENSG00000277594.
ENST00000617633; ENSP00000479504; ENSG00000278053.
GeneIDi11056.
KEGGihsa:11056.
UCSCiuc002hoi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDDX52_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2R4
Secondary accession number(s): Q86YG1
, Q8N213, Q9NVE0, Q9Y482
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: May 18, 2010
Last modified: July 5, 2017
This is version 153 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families