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Protein

Probable ATP-dependent RNA helicase DDX52

Gene

DDX52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi209 – 216ATP8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX52 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent RNA helicase ROK1-like
DEAD box protein 52
Gene namesi
Name:DDX52
Synonyms:ROK1
ORF Names:HUSSY-19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000278053.4
HGNCiHGNC:20038 DDX52
MIMi612500 gene
neXtProtiNX_Q9Y2R4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi11056
PharmGKBiPA134904836

Polymorphism and mutation databases

BioMutaiDDX52
DMDMi296439375

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550601 – 599Probable ATP-dependent RNA helicase DDX52Add BLAST599

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei15N6-acetyllysineCombined sources1
Modified residuei39PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2R4
MaxQBiQ9Y2R4
PaxDbiQ9Y2R4
PeptideAtlasiQ9Y2R4
PRIDEiQ9Y2R4

2D gel databases

SWISS-2DPAGEiQ9Y2R4

PTM databases

iPTMnetiQ9Y2R4
PhosphoSitePlusiQ9Y2R4
SwissPalmiQ9Y2R4

Expressioni

Gene expression databases

BgeeiENSG00000278053
CleanExiHS_DDX52
ExpressionAtlasiQ9Y2R4 baseline and differential
GenevisibleiQ9Y2R4 HS

Organism-specific databases

HPAiHPA056173

Interactioni

Protein-protein interaction databases

BioGridi116241, 43 interactors
IntActiQ9Y2R4, 13 interactors
MINTiQ9Y2R4
STRINGi9606.ENSP00000268854

Structurei

Secondary structure

1599
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi139 – 146Combined sources8
Beta strandi149 – 155Combined sources7
Helixi163 – 170Combined sources8
Helixi174 – 182Combined sources9
Helixi190 – 200Combined sources11
Beta strandi205 – 208Combined sources4
Helixi215 – 227Combined sources13
Beta strandi232 – 234Combined sources3
Beta strandi237 – 240Combined sources4
Helixi244 – 257Combined sources14
Turni258 – 260Combined sources3
Helixi270 – 275Combined sources6
Turni276 – 278Combined sources3
Beta strandi288 – 291Combined sources4
Helixi293 – 301Combined sources9
Beta strandi302 – 304Combined sources3
Beta strandi314 – 319Combined sources6
Helixi320 – 326Combined sources7
Helixi331 – 341Combined sources11
Beta strandi348 – 355Combined sources8
Helixi358 – 367Combined sources10
Beta strandi368 – 370Combined sources3
Beta strandi372 – 376Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3DKPX-ray2.10A139-381[»]
ProteinModelPortaliQ9Y2R4
SMRiQ9Y2R4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2R4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini196 – 374Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST179
Domaini385 – 546Helicase C-terminalPROSITE-ProRule annotationAdd BLAST162

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi165 – 193Q motifAdd BLAST29
Motifi318 – 321DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi543 – 592Lys-richAdd BLAST50

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0344 Eukaryota
ENOG410XQS8 LUCA
HOGENOMiHOG000242486
HOVERGENiHBG051332
InParanoidiQ9Y2R4
KOiK14779
OrthoDBiEOG091G06V2
PhylomeDBiQ9Y2R4
TreeFamiTF314448

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR014014 RNA_helicase_DEAD_Q_motif
PfamiView protein in Pfam
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
SMARTiView protein in SMART
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q9Y2R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVHDLFRRL GAGAKFDTRR FSADAARFQI GKRKYDFDSS EVLQGLDFFG
60 70 80 90 100
NKKSVPGVCG ASQTHQKPQN GEKKEESLTE RKREQSKKKR KTMTSEIASQ
110 120 130 140 150
EEGATIQWMS SVEAKIEDKK VQRESKLTSG KLENLRKEKI NFLRNKHKIH
160 170 180 190 200
VQGTDLPDPI ATFQQLDQEY KINSRLLQNI LDAGFQMPTP IQMQAIPVML
210 220 230 240 250
HGRELLASAP TGSGKTLAFS IPILMQLKQP ANKGFRALII SPTRELASQI
260 270 280 290 300
HRELIKISEG TGFRIHMIHK AAVAAKKFGP KSSKKFDILV TTPNRLIYLL
310 320 330 340 350
KQDPPGIDLA SVEWLVVDES DKLFEDGKTG FRDQLASIFL ACTSHKVRRA
360 370 380 390 400
MFSATFAYDV EQWCKLNLDN VISVSIGARN SAVETVEQEL LFVGSETGKL
410 420 430 440 450
LAMRELVKKG FNPPVLVFVQ SIERAKELFH ELIYEGINVD VIHAERTQQQ
460 470 480 490 500
RDNTVHSFRA GKIWVLICTA LLARGIDFKG VNLVINYDFP TSSVEYIHRI
510 520 530 540 550
GRTGRAGNKG KAITFFTEDD KPLLRSVANV IQQAGCPVPE YIKGFQKLLS
560 570 580 590
KQKKKMIKKP LERESISTTP KCFLEKAKDK QKKVTGQNSK KKVALEDKS
Length:599
Mass (Da):67,498
Last modified:May 18, 2010 - v3
Checksum:iF31EA34AC478EE21
GO

Sequence cautioni

The sequence AAD27766 differs from that shown. Reason: Frameshift at positions 324, 327, 330, 350, 365 and 377.Curated
The sequence AK093661 differs from that shown. Cloning artifact.Curated
The sequence BAA91812 differs from that shown. Cloning artifact.Curated
The sequence CAA09374 differs from that shown. Reason: Frameshift at positions 355 and 377.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti299L → S in AK093661 (PubMed:14702039).Curated1
Sequence conflicti582K → R in BAA91812 (PubMed:14702039).Curated1
Sequence conflicti584V → F in CAA09374 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_060235403M → V4 PublicationsCorresponds to variant dbSNP:rs7216445Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077033 mRNA Translation: AAD27766.1 Frameshift.
AK001652 mRNA Translation: BAA91812.1 Sequence problems.
AK093661 mRNA No translation available.
AC091199 Genomic DNA No translation available.
BC041785 mRNA Translation: AAH41785.1
AJ010840 mRNA Translation: CAA09374.1 Frameshift.
CCDSiCCDS11323.1
RefSeqiNP_001278405.1, NM_001291476.1
NP_008941.3, NM_007010.4
UniGeneiHs.590937

Genome annotation databases

EnsembliENST00000615769; ENSP00000480030; ENSG00000277594
ENST00000617633; ENSP00000479504; ENSG00000278053
GeneIDi11056
KEGGihsa:11056
UCSCiuc002hoi.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiDDX52_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2R4
Secondary accession number(s): Q86YG1
, Q8N213, Q9NVE0, Q9Y482
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: May 18, 2010
Last modified: March 28, 2018
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health