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Protein

Probable ATP-dependent RNA helicase DDX52

Gene

DDX52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi209 – 2168ATP

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX52 (EC:3.6.4.13)
Alternative name(s):
ATP-dependent RNA helicase ROK1-like
DEAD box protein 52
Gene namesi
Name:DDX52
Synonyms:ROK1
ORF Names:HUSSY-19
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:20038. DDX52.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134904836.

Polymorphism and mutation databases

BioMutaiDDX52.
DMDMi296439375.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Probable ATP-dependent RNA helicase DDX52PRO_0000055060Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei15 – 151N6-acetyllysineCombined sources
Modified residuei39 – 391PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2R4.
MaxQBiQ9Y2R4.
PaxDbiQ9Y2R4.
PeptideAtlasiQ9Y2R4.
PRIDEiQ9Y2R4.

2D gel databases

SWISS-2DPAGEQ9Y2R4.

PTM databases

iPTMnetiQ9Y2R4.
PhosphoSiteiQ9Y2R4.
SwissPalmiQ9Y2R4.

Expressioni

Gene expression databases

BgeeiENSG00000141141.
CleanExiHS_DDX52.
ExpressionAtlasiQ9Y2R4. baseline and differential.
GenevisibleiQ9Y2R4. HS.

Organism-specific databases

HPAiHPA056173.

Interactioni

Protein-protein interaction databases

BioGridi116241. 37 interactions.
IntActiQ9Y2R4. 13 interactions.
MINTiMINT-2823243.
STRINGi9606.ENSP00000268854.

Structurei

Secondary structure

1
599
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi139 – 1468Combined sources
Beta strandi149 – 1557Combined sources
Helixi163 – 1708Combined sources
Helixi174 – 1829Combined sources
Helixi190 – 20011Combined sources
Beta strandi205 – 2084Combined sources
Helixi215 – 22713Combined sources
Beta strandi232 – 2343Combined sources
Beta strandi237 – 2404Combined sources
Helixi244 – 25714Combined sources
Turni258 – 2603Combined sources
Helixi270 – 2756Combined sources
Turni276 – 2783Combined sources
Beta strandi288 – 2914Combined sources
Helixi293 – 3019Combined sources
Beta strandi302 – 3043Combined sources
Beta strandi314 – 3196Combined sources
Helixi320 – 3267Combined sources
Helixi331 – 34111Combined sources
Beta strandi348 – 3558Combined sources
Helixi358 – 36710Combined sources
Beta strandi368 – 3703Combined sources
Beta strandi372 – 3765Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DKPX-ray2.10A139-381[»]
ProteinModelPortaliQ9Y2R4.
SMRiQ9Y2R4. Positions 139-543.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2R4.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini196 – 374179Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini385 – 546162Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi165 – 19329Q motifAdd
BLAST
Motifi318 – 3214DEAD box

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi543 – 59250Lys-richAdd
BLAST

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0344. Eukaryota.
ENOG410XQS8. LUCA.
HOGENOMiHOG000242486.
HOVERGENiHBG051332.
InParanoidiQ9Y2R4.
KOiK14779.
OMAiTKCVAFF.
OrthoDBiEOG091G06V2.
PhylomeDBiQ9Y2R4.
TreeFamiTF314448.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2R4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVHDLFRRL GAGAKFDTRR FSADAARFQI GKRKYDFDSS EVLQGLDFFG
60 70 80 90 100
NKKSVPGVCG ASQTHQKPQN GEKKEESLTE RKREQSKKKR KTMTSEIASQ
110 120 130 140 150
EEGATIQWMS SVEAKIEDKK VQRESKLTSG KLENLRKEKI NFLRNKHKIH
160 170 180 190 200
VQGTDLPDPI ATFQQLDQEY KINSRLLQNI LDAGFQMPTP IQMQAIPVML
210 220 230 240 250
HGRELLASAP TGSGKTLAFS IPILMQLKQP ANKGFRALII SPTRELASQI
260 270 280 290 300
HRELIKISEG TGFRIHMIHK AAVAAKKFGP KSSKKFDILV TTPNRLIYLL
310 320 330 340 350
KQDPPGIDLA SVEWLVVDES DKLFEDGKTG FRDQLASIFL ACTSHKVRRA
360 370 380 390 400
MFSATFAYDV EQWCKLNLDN VISVSIGARN SAVETVEQEL LFVGSETGKL
410 420 430 440 450
LAMRELVKKG FNPPVLVFVQ SIERAKELFH ELIYEGINVD VIHAERTQQQ
460 470 480 490 500
RDNTVHSFRA GKIWVLICTA LLARGIDFKG VNLVINYDFP TSSVEYIHRI
510 520 530 540 550
GRTGRAGNKG KAITFFTEDD KPLLRSVANV IQQAGCPVPE YIKGFQKLLS
560 570 580 590
KQKKKMIKKP LERESISTTP KCFLEKAKDK QKKVTGQNSK KKVALEDKS
Length:599
Mass (Da):67,498
Last modified:May 18, 2010 - v3
Checksum:iF31EA34AC478EE21
GO

Sequence cautioni

The sequence AAD27766 differs from that shown. Reason: Frameshift at positions 324, 327, 330, 350, 365 and 377. Curated
The sequence AK093661 differs from that shown.Cloning artifact.Curated
The sequence BAA91812 differs from that shown.Cloning artifact.Curated
The sequence CAA09374 differs from that shown. Reason: Frameshift at positions 355 and 377. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti299 – 2991L → S in AK093661 (PubMed:14702039).Curated
Sequence conflicti582 – 5821K → R in BAA91812 (PubMed:14702039).Curated
Sequence conflicti584 – 5841V → F in CAA09374 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti403 – 4031M → V.4 Publications
Corresponds to variant rs7216445 [ dbSNP | Ensembl ].
VAR_060235

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077033 mRNA. Translation: AAD27766.1. Frameshift.
AK001652 mRNA. Translation: BAA91812.1. Sequence problems.
AK093661 mRNA. No translation available.
AC091199 Genomic DNA. No translation available.
BC041785 mRNA. Translation: AAH41785.1.
AJ010840 mRNA. Translation: CAA09374.1. Frameshift.
CCDSiCCDS11323.1.
RefSeqiNP_001278405.1. NM_001291476.1.
NP_008941.3. NM_007010.4.
UniGeneiHs.590937.

Genome annotation databases

EnsembliENST00000615769; ENSP00000480030; ENSG00000277594.
ENST00000617633; ENSP00000479504; ENSG00000278053.
GeneIDi11056.
KEGGihsa:11056.
UCSCiuc002hoi.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF077033 mRNA. Translation: AAD27766.1. Frameshift.
AK001652 mRNA. Translation: BAA91812.1. Sequence problems.
AK093661 mRNA. No translation available.
AC091199 Genomic DNA. No translation available.
BC041785 mRNA. Translation: AAH41785.1.
AJ010840 mRNA. Translation: CAA09374.1. Frameshift.
CCDSiCCDS11323.1.
RefSeqiNP_001278405.1. NM_001291476.1.
NP_008941.3. NM_007010.4.
UniGeneiHs.590937.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3DKPX-ray2.10A139-381[»]
ProteinModelPortaliQ9Y2R4.
SMRiQ9Y2R4. Positions 139-543.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116241. 37 interactions.
IntActiQ9Y2R4. 13 interactions.
MINTiMINT-2823243.
STRINGi9606.ENSP00000268854.

PTM databases

iPTMnetiQ9Y2R4.
PhosphoSiteiQ9Y2R4.
SwissPalmiQ9Y2R4.

Polymorphism and mutation databases

BioMutaiDDX52.
DMDMi296439375.

2D gel databases

SWISS-2DPAGEQ9Y2R4.

Proteomic databases

EPDiQ9Y2R4.
MaxQBiQ9Y2R4.
PaxDbiQ9Y2R4.
PeptideAtlasiQ9Y2R4.
PRIDEiQ9Y2R4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000615769; ENSP00000480030; ENSG00000277594.
ENST00000617633; ENSP00000479504; ENSG00000278053.
GeneIDi11056.
KEGGihsa:11056.
UCSCiuc002hoi.3. human.

Organism-specific databases

CTDi11056.
GeneCardsiDDX52.
HGNCiHGNC:20038. DDX52.
HPAiHPA056173.
MIMi612500. gene.
neXtProtiNX_Q9Y2R4.
PharmGKBiPA134904836.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0344. Eukaryota.
ENOG410XQS8. LUCA.
HOGENOMiHOG000242486.
HOVERGENiHBG051332.
InParanoidiQ9Y2R4.
KOiK14779.
OMAiTKCVAFF.
OrthoDBiEOG091G06V2.
PhylomeDBiQ9Y2R4.
TreeFamiTF314448.

Enzyme and pathway databases

ReactomeiR-HSA-6790901. rRNA modification in the nucleus.
R-HSA-6791226. Major pathway of rRNA processing in the nucleolus.

Miscellaneous databases

ChiTaRSiDDX52. human.
EvolutionaryTraceiQ9Y2R4.
GeneWikiiDDX52.
GenomeRNAii11056.
PROiQ9Y2R4.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141141.
CleanExiHS_DDX52.
ExpressionAtlasiQ9Y2R4. baseline and differential.
GenevisibleiQ9Y2R4. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX52_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2R4
Secondary accession number(s): Q86YG1
, Q8N213, Q9NVE0, Q9Y482
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 9, 2003
Last sequence update: May 18, 2010
Last modified: September 7, 2016
This is version 146 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.