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Q9Y2Q9

- RT28_HUMAN

UniProt

Q9Y2Q9 - RT28_HUMAN

Protein

28S ribosomal protein S28, mitochondrial

Gene

MRPS28

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 117 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Keywords - Molecular functioni

    Ribonucleoprotein, Ribosomal protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    28S ribosomal protein S28, mitochondrial
    Short name:
    MRP-S28
    Short name:
    S28mt
    Alternative name(s):
    28S ribosomal protein S35, mitochondrial
    Short name:
    MRP-S35
    Short name:
    S35mt
    Gene namesi
    Name:MRPS28
    Synonyms:MRPS35
    ORF Names:HSPC007
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:14513. MRPS28.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrial small ribosomal subunit Source: UniProtKB
    2. mitochondrion Source: HPA

    Keywords - Cellular componenti

    Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31016.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 7171MitochondrionBy similarityAdd
    BLAST
    Chaini72 – 18711628S ribosomal protein S28, mitochondrialPRO_0000087714Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei73 – 731PhosphoserineBy similarity
    Modified residuei133 – 1331N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ9Y2Q9.
    PaxDbiQ9Y2Q9.
    PRIDEiQ9Y2Q9.

    PTM databases

    PhosphoSiteiQ9Y2Q9.

    Expressioni

    Gene expression databases

    ArrayExpressiQ9Y2Q9.
    BgeeiQ9Y2Q9.
    CleanExiHS_MRPS28.
    HS_MRPS35.
    GenevestigatoriQ9Y2Q9.

    Organism-specific databases

    HPAiHPA027202.

    Interactioni

    Subunit structurei

    Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

    Protein-protein interaction databases

    BioGridi118784. 36 interactions.
    IntActiQ9Y2Q9. 7 interactions.
    MINTiMINT-8052210.
    STRINGi9606.ENSP00000276585.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2Q9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiNOG245406.
    HOGENOMiHOG000230806.
    HOVERGENiHBG036126.
    InParanoidiQ9Y2Q9.
    KOiK17407.
    OMAiCRTRAVT.
    OrthoDBiEOG7288SV.
    PhylomeDBiQ9Y2Q9.
    TreeFamiTF315097.

    Family and domain databases

    InterProiIPR019375. Ribosomal_S28_mit.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view]
    PfamiPF10246. MRP-S35. 1 hit.
    [Graphical view]
    SMARTiSM00316. S1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9Y2Q9-1 [UniParc]FASTAAdd to Basket

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    MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG    50
    GFASALERHS ELLQKVEPLQ KGSPKNVESF ASMLRHSPLT QMGPAKDKLV 100
    IGRIFHIVEN DLYIDFGGKF HCVCRRPEVD GEKYQKGTRV RLRLLDLELT 150
    SRFLGATTDT TVLEANAVLL GIQESKDSRS KEEHHEK 187
    Length:187
    Mass (Da):20,843
    Last modified:November 1, 1999 - v1
    Checksum:i2ED0EA43552B9B54
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti103 – 1031R → W.
    Corresponds to variant rs16919579 [ dbSNP | Ensembl ].
    VAR_052047

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070663 mRNA. Translation: AAD20969.1.
    AK315739 mRNA. Translation: BAG38094.1.
    CH471068 Genomic DNA. Translation: EAW87069.1.
    BC010150 mRNA. Translation: AAH10150.1.
    AB061209 Genomic DNA. Translation: BAB54959.1.
    CCDSiCCDS6226.1.
    RefSeqiNP_054737.1. NM_014018.2.
    UniGeneiHs.521124.

    Genome annotation databases

    EnsembliENST00000276585; ENSP00000276585; ENSG00000147586.
    GeneIDi28957.
    KEGGihsa:28957.
    UCSCiuc003ybp.3. human.

    Polymorphism databases

    DMDMi22001973.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF070663 mRNA. Translation: AAD20969.1 .
    AK315739 mRNA. Translation: BAG38094.1 .
    CH471068 Genomic DNA. Translation: EAW87069.1 .
    BC010150 mRNA. Translation: AAH10150.1 .
    AB061209 Genomic DNA. Translation: BAB54959.1 .
    CCDSi CCDS6226.1.
    RefSeqi NP_054737.1. NM_014018.2.
    UniGenei Hs.521124.

    3D structure databases

    ProteinModelPortali Q9Y2Q9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118784. 36 interactions.
    IntActi Q9Y2Q9. 7 interactions.
    MINTi MINT-8052210.
    STRINGi 9606.ENSP00000276585.

    PTM databases

    PhosphoSitei Q9Y2Q9.

    Polymorphism databases

    DMDMi 22001973.

    Proteomic databases

    MaxQBi Q9Y2Q9.
    PaxDbi Q9Y2Q9.
    PRIDEi Q9Y2Q9.

    Protocols and materials databases

    DNASUi 28957.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000276585 ; ENSP00000276585 ; ENSG00000147586 .
    GeneIDi 28957.
    KEGGi hsa:28957.
    UCSCi uc003ybp.3. human.

    Organism-specific databases

    CTDi 28957.
    GeneCardsi GC08M080830.
    HGNCi HGNC:14513. MRPS28.
    HPAi HPA027202.
    MIMi 611990. gene.
    neXtProti NX_Q9Y2Q9.
    PharmGKBi PA31016.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG245406.
    HOGENOMi HOG000230806.
    HOVERGENi HBG036126.
    InParanoidi Q9Y2Q9.
    KOi K17407.
    OMAi CRTRAVT.
    OrthoDBi EOG7288SV.
    PhylomeDBi Q9Y2Q9.
    TreeFami TF315097.

    Miscellaneous databases

    ChiTaRSi MRPS28. human.
    GeneWikii MRPS28.
    GenomeRNAii 28957.
    NextBioi 51779.
    PROi Q9Y2Q9.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2Q9.
    Bgeei Q9Y2Q9.
    CleanExi HS_MRPS28.
    HS_MRPS35.
    Genevestigatori Q9Y2Q9.

    Family and domain databases

    InterProi IPR019375. Ribosomal_S28_mit.
    IPR022967. RNA-binding_domain_S1.
    [Graphical view ]
    Pfami PF10246. MRP-S35. 1 hit.
    [Graphical view ]
    SMARTi SM00316. S1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Umbilical cord blood.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
      Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
      Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-71.
    6. "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins."
      Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.
      J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.
    7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRT28_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2Q9
    Secondary accession number(s): B2RDZ7, Q96Q21
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 26, 2002
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 117 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3