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Protein

28S ribosomal protein S28, mitochondrial

Gene

MRPS28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB

GO - Biological processi

  1. mitochondrial translation Source: Reactome
  2. mitochondrial translational elongation Source: Reactome
  3. mitochondrial translational initiation Source: Reactome
  4. mitochondrial translational termination Source: Reactome
  5. organelle organization Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S28, mitochondrial
Short name:
MRP-S28
Short name:
S28mt
Alternative name(s):
28S ribosomal protein S35, mitochondrial
Short name:
MRP-S35
Short name:
S35mt
Gene namesi
Name:MRPS28
Synonyms:MRPS35
ORF Names:HSPC007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14513. MRPS28.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial small ribosomal subunit Source: UniProtKB
  3. mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31016.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 7171MitochondrionBy similarityAdd
BLAST
Chaini72 – 18711628S ribosomal protein S28, mitochondrialPRO_0000087714Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei73 – 731PhosphoserineBy similarity
Modified residuei133 – 1331N6-acetyllysine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ9Y2Q9.
PaxDbiQ9Y2Q9.
PRIDEiQ9Y2Q9.

PTM databases

PhosphoSiteiQ9Y2Q9.

Expressioni

Gene expression databases

BgeeiQ9Y2Q9.
CleanExiHS_MRPS28.
HS_MRPS35.
ExpressionAtlasiQ9Y2Q9. baseline and differential.
GenevestigatoriQ9Y2Q9.

Organism-specific databases

HPAiHPA027202.

Interactioni

Subunit structurei

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Protein-protein interaction databases

BioGridi118784. 42 interactions.
IntActiQ9Y2Q9. 7 interactions.
MINTiMINT-8052210.
STRINGi9606.ENSP00000276585.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiNOG245406.
GeneTreeiENSGT00390000001057.
HOGENOMiHOG000230806.
HOVERGENiHBG036126.
InParanoidiQ9Y2Q9.
KOiK17407.
OMAiKANDVEN.
OrthoDBiEOG7288SV.
PhylomeDBiQ9Y2Q9.
TreeFamiTF315097.

Family and domain databases

InterProiIPR019375. Ribosomal_S28_mit.
IPR022967. S1_dom.
[Graphical view]
PfamiPF10246. MRP-S35. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG
60 70 80 90 100
GFASALERHS ELLQKVEPLQ KGSPKNVESF ASMLRHSPLT QMGPAKDKLV
110 120 130 140 150
IGRIFHIVEN DLYIDFGGKF HCVCRRPEVD GEKYQKGTRV RLRLLDLELT
160 170 180
SRFLGATTDT TVLEANAVLL GIQESKDSRS KEEHHEK
Length:187
Mass (Da):20,843
Last modified:November 1, 1999 - v1
Checksum:i2ED0EA43552B9B54
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti103 – 1031R → W.
Corresponds to variant rs16919579 [ dbSNP | Ensembl ].
VAR_052047

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070663 mRNA. Translation: AAD20969.1.
AK315739 mRNA. Translation: BAG38094.1.
CH471068 Genomic DNA. Translation: EAW87069.1.
BC010150 mRNA. Translation: AAH10150.1.
AB061209 Genomic DNA. Translation: BAB54959.1.
CCDSiCCDS6226.1.
RefSeqiNP_054737.1. NM_014018.2.
UniGeneiHs.521124.

Genome annotation databases

EnsembliENST00000276585; ENSP00000276585; ENSG00000147586.
GeneIDi28957.
KEGGihsa:28957.
UCSCiuc003ybp.3. human.

Polymorphism databases

DMDMi22001973.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070663 mRNA. Translation: AAD20969.1.
AK315739 mRNA. Translation: BAG38094.1.
CH471068 Genomic DNA. Translation: EAW87069.1.
BC010150 mRNA. Translation: AAH10150.1.
AB061209 Genomic DNA. Translation: BAB54959.1.
CCDSiCCDS6226.1.
RefSeqiNP_054737.1. NM_014018.2.
UniGeneiHs.521124.

3D structure databases

ProteinModelPortaliQ9Y2Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118784. 42 interactions.
IntActiQ9Y2Q9. 7 interactions.
MINTiMINT-8052210.
STRINGi9606.ENSP00000276585.

PTM databases

PhosphoSiteiQ9Y2Q9.

Polymorphism databases

DMDMi22001973.

Proteomic databases

MaxQBiQ9Y2Q9.
PaxDbiQ9Y2Q9.
PRIDEiQ9Y2Q9.

Protocols and materials databases

DNASUi28957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276585; ENSP00000276585; ENSG00000147586.
GeneIDi28957.
KEGGihsa:28957.
UCSCiuc003ybp.3. human.

Organism-specific databases

CTDi28957.
GeneCardsiGC08M080830.
HGNCiHGNC:14513. MRPS28.
HPAiHPA027202.
MIMi611990. gene.
neXtProtiNX_Q9Y2Q9.
PharmGKBiPA31016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG245406.
GeneTreeiENSGT00390000001057.
HOGENOMiHOG000230806.
HOVERGENiHBG036126.
InParanoidiQ9Y2Q9.
KOiK17407.
OMAiKANDVEN.
OrthoDBiEOG7288SV.
PhylomeDBiQ9Y2Q9.
TreeFamiTF315097.

Enzyme and pathway databases

ReactomeiREACT_267634. Mitochondrial translation initiation.
REACT_268133. Mitochondrial translation elongation.
REACT_268261. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS28. human.
GeneWikiiMRPS28.
GenomeRNAii28957.
NextBioi51779.
PROiQ9Y2Q9.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2Q9.
CleanExiHS_MRPS28.
HS_MRPS35.
ExpressionAtlasiQ9Y2Q9. baseline and differential.
GenevestigatoriQ9Y2Q9.

Family and domain databases

InterProiIPR019375. Ribosomal_S28_mit.
IPR022967. S1_dom.
[Graphical view]
PfamiPF10246. MRP-S35. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Umbilical cord blood.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Uterus.
  5. "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
    Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
    Genomics 77:65-70(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-71.
  6. "A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins."
    Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.
    J. Biol. Chem. 275:32585-32591(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiRT28_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Q9
Secondary accession number(s): B2RDZ7, Q96Q21
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: April 1, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.