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Protein

28S ribosomal protein S28, mitochondrial

Gene

MRPS28

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • RNA binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Names & Taxonomyi

Protein namesi
Recommended name:
28S ribosomal protein S28, mitochondrial
Short name:
MRP-S28
Short name:
S28mt
Alternative name(s):
28S ribosomal protein S35, mitochondrial
Short name:
MRP-S35
Short name:
S35mt
Mitochondrial small ribosomal subunit protein bS1m1 Publication
Gene namesi
Name:MRPS28
Synonyms:MRPS35
ORF Names:HSPC007
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:14513. MRPS28.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial inner membrane Source: Reactome
  • mitochondrial small ribosomal subunit Source: UniProtKB
  • mitochondrion Source: HPA

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi28957.
PharmGKBiPA31016.

Polymorphism and mutation databases

BioMutaiMRPS28.
DMDMi22001973.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 71MitochondrionBy similarityAdd BLAST71
ChainiPRO_000008771472 – 18728S ribosomal protein S28, mitochondrialAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei73PhosphoserineBy similarity1
Modified residuei133N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ9Y2Q9.
MaxQBiQ9Y2Q9.
PaxDbiQ9Y2Q9.
PeptideAtlasiQ9Y2Q9.
PRIDEiQ9Y2Q9.
TopDownProteomicsiQ9Y2Q9.

PTM databases

iPTMnetiQ9Y2Q9.
PhosphoSitePlusiQ9Y2Q9.

Expressioni

Gene expression databases

BgeeiENSG00000147586.
CleanExiHS_MRPS28.
HS_MRPS35.
ExpressionAtlasiQ9Y2Q9. baseline and differential.
GenevisibleiQ9Y2Q9. HS.

Organism-specific databases

HPAiHPA027202.

Interactioni

Subunit structurei

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.1 Publication

Protein-protein interaction databases

BioGridi118784. 52 interactors.
IntActiQ9Y2Q9. 12 interactors.
MINTiMINT-8052210.
STRINGi9606.ENSP00000276585.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AW1-187[»]
ProteinModelPortaliQ9Y2Q9.
SMRiQ9Y2Q9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG4078. Eukaryota.
ENOG4111RYH. LUCA.
GeneTreeiENSGT00390000001057.
HOGENOMiHOG000230806.
HOVERGENiHBG036126.
InParanoidiQ9Y2Q9.
KOiK17407.
OMAiCRTRAVT.
OrthoDBiEOG091G0VHY.
PhylomeDBiQ9Y2Q9.
TreeFamiTF315097.

Family and domain databases

InterProiView protein in InterPro
IPR019375. Ribosomal_S28_mit.
PANTHERiPTHR13447:SF3. PTHR13447:SF3. 1 hit.
PfamiView protein in Pfam
PF10246. MRP-S35. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9Y2Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG
60 70 80 90 100
GFASALERHS ELLQKVEPLQ KGSPKNVESF ASMLRHSPLT QMGPAKDKLV
110 120 130 140 150
IGRIFHIVEN DLYIDFGGKF HCVCRRPEVD GEKYQKGTRV RLRLLDLELT
160 170 180
SRFLGATTDT TVLEANAVLL GIQESKDSRS KEEHHEK
Length:187
Mass (Da):20,843
Last modified:November 1, 1999 - v1
Checksum:i2ED0EA43552B9B54
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052047103R → W. Corresponds to variant dbSNP:rs16919579Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070663 mRNA. Translation: AAD20969.1.
AK315739 mRNA. Translation: BAG38094.1.
CH471068 Genomic DNA. Translation: EAW87069.1.
BC010150 mRNA. Translation: AAH10150.1.
AB061209 Genomic DNA. Translation: BAB54959.1.
CCDSiCCDS6226.1.
RefSeqiNP_054737.1. NM_014018.2.
UniGeneiHs.521124.

Genome annotation databases

EnsembliENST00000276585; ENSP00000276585; ENSG00000147586.
GeneIDi28957.
KEGGihsa:28957.
UCSCiuc003ybp.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070663 mRNA. Translation: AAD20969.1.
AK315739 mRNA. Translation: BAG38094.1.
CH471068 Genomic DNA. Translation: EAW87069.1.
BC010150 mRNA. Translation: AAH10150.1.
AB061209 Genomic DNA. Translation: BAB54959.1.
CCDSiCCDS6226.1.
RefSeqiNP_054737.1. NM_014018.2.
UniGeneiHs.521124.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3J9Melectron microscopy3.50AW1-187[»]
ProteinModelPortaliQ9Y2Q9.
SMRiQ9Y2Q9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118784. 52 interactors.
IntActiQ9Y2Q9. 12 interactors.
MINTiMINT-8052210.
STRINGi9606.ENSP00000276585.

PTM databases

iPTMnetiQ9Y2Q9.
PhosphoSitePlusiQ9Y2Q9.

Polymorphism and mutation databases

BioMutaiMRPS28.
DMDMi22001973.

Proteomic databases

EPDiQ9Y2Q9.
MaxQBiQ9Y2Q9.
PaxDbiQ9Y2Q9.
PeptideAtlasiQ9Y2Q9.
PRIDEiQ9Y2Q9.
TopDownProteomicsiQ9Y2Q9.

Protocols and materials databases

DNASUi28957.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000276585; ENSP00000276585; ENSG00000147586.
GeneIDi28957.
KEGGihsa:28957.
UCSCiuc003ybp.4. human.

Organism-specific databases

CTDi28957.
DisGeNETi28957.
GeneCardsiMRPS28.
HGNCiHGNC:14513. MRPS28.
HPAiHPA027202.
MIMi611990. gene.
neXtProtiNX_Q9Y2Q9.
PharmGKBiPA31016.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4078. Eukaryota.
ENOG4111RYH. LUCA.
GeneTreeiENSGT00390000001057.
HOGENOMiHOG000230806.
HOVERGENiHBG036126.
InParanoidiQ9Y2Q9.
KOiK17407.
OMAiCRTRAVT.
OrthoDBiEOG091G0VHY.
PhylomeDBiQ9Y2Q9.
TreeFamiTF315097.

Enzyme and pathway databases

ReactomeiR-HSA-5368286. Mitochondrial translation initiation.
R-HSA-5389840. Mitochondrial translation elongation.
R-HSA-5419276. Mitochondrial translation termination.

Miscellaneous databases

ChiTaRSiMRPS28. human.
GeneWikiiMRPS28.
GenomeRNAii28957.
PROiPR:Q9Y2Q9.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000147586.
CleanExiHS_MRPS28.
HS_MRPS35.
ExpressionAtlasiQ9Y2Q9. baseline and differential.
GenevisibleiQ9Y2Q9. HS.

Family and domain databases

InterProiView protein in InterPro
IPR019375. Ribosomal_S28_mit.
PANTHERiPTHR13447:SF3. PTHR13447:SF3. 1 hit.
PfamiView protein in Pfam
PF10246. MRP-S35. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRT28_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Q9
Secondary accession number(s): B2RDZ7, Q96Q21
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: April 12, 2017
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Ribosomal proteins
    Ribosomal proteins families and list of entries
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.