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Q9Y2Q9 (RT28_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 115. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
28S ribosomal protein S28, mitochondrial

Short name=MRP-S28
Short name=S28mt
Alternative name(s):
28S ribosomal protein S35, mitochondrial
Short name=MRP-S35
Short name=S35mt
Gene names
Name:MRPS28
Synonyms:MRPS35
ORF Names:HSPC007
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length187 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins.

Subcellular location

Mitochondrion.

Ontologies

Keywords
   Cellular componentMitochondrion
   Coding sequence diversityPolymorphism
   DomainTransit peptide
   Molecular functionRibonucleoprotein
Ribosomal protein
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentmitochondrial small ribosomal subunit

Traceable author statement Ref.6. Source: UniProtKB

mitochondrion

Inferred from direct assay. Source: HPA

   Molecular_functionpoly(A) RNA binding

Inferred from direct assay PubMed 22658674PubMed 22681889. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 7171Mitochondrion By similarity
Chain72 – 18711628S ribosomal protein S28, mitochondrial
PRO_0000087714

Amino acid modifications

Modified residue731Phosphoserine By similarity
Modified residue1331N6-acetyllysine Ref.7

Natural variations

Natural variant1031R → W.
Corresponds to variant rs16919579 [ dbSNP | Ensembl ].
VAR_052047

Sequences

Sequence LengthMass (Da)Tools
Q9Y2Q9 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 2ED0EA43552B9B54

FASTA18720,843
        10         20         30         40         50         60 
MAALCRTRAV AAESHFLRVF LFFRPFRGVG TESGSESGSS NAKEPKTRAG GFASALERHS 

        70         80         90        100        110        120 
ELLQKVEPLQ KGSPKNVESF ASMLRHSPLT QMGPAKDKLV IGRIFHIVEN DLYIDFGGKF 

       130        140        150        160        170        180 
HCVCRRPEVD GEKYQKGTRV RLRLLDLELT SRFLGATTDT TVLEANAVLL GIQESKDSRS 


KEEHHEK 

« Hide

References

« Hide 'large scale' references
[1]"Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X. expand/collapse author list , Gu J., Chen S.-J., Chen Z.
Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Umbilical cord blood.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain.
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[5]"The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders."
Kenmochi N., Suzuki T., Uechi T., Magoori M., Kuniba M., Higa S., Watanabe K., Tanaka T.
Genomics 77:65-70(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 40-71.
[6]"A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins."
Koc E.C., Burkhart W., Blackburn K., Moseley A., Koc H., Spremulli L.L.
J. Biol. Chem. 275:32585-32591(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
[7]"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-133, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF070663 mRNA. Translation: AAD20969.1.
AK315739 mRNA. Translation: BAG38094.1.
CH471068 Genomic DNA. Translation: EAW87069.1.
BC010150 mRNA. Translation: AAH10150.1.
AB061209 Genomic DNA. Translation: BAB54959.1.
CCDSCCDS6226.1.
RefSeqNP_054737.1. NM_014018.2.
UniGeneHs.521124.

3D structure databases

ProteinModelPortalQ9Y2Q9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118784. 37 interactions.
IntActQ9Y2Q9. 7 interactions.
MINTMINT-8052210.
STRING9606.ENSP00000276585.

PTM databases

PhosphoSiteQ9Y2Q9.

Polymorphism databases

DMDM22001973.

Proteomic databases

MaxQBQ9Y2Q9.
PaxDbQ9Y2Q9.
PRIDEQ9Y2Q9.

Protocols and materials databases

DNASU28957.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000276585; ENSP00000276585; ENSG00000147586.
GeneID28957.
KEGGhsa:28957.
UCSCuc003ybp.3. human.

Organism-specific databases

CTD28957.
GeneCardsGC08M080830.
HGNCHGNC:14513. MRPS28.
HPAHPA027202.
MIM611990. gene.
neXtProtNX_Q9Y2Q9.
PharmGKBPA31016.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG245406.
HOGENOMHOG000230806.
HOVERGENHBG036126.
InParanoidQ9Y2Q9.
KOK17407.
OMACRTRAVT.
OrthoDBEOG7288SV.
PhylomeDBQ9Y2Q9.
TreeFamTF315097.

Gene expression databases

ArrayExpressQ9Y2Q9.
BgeeQ9Y2Q9.
CleanExHS_MRPS28.
HS_MRPS35.
GenevestigatorQ9Y2Q9.

Family and domain databases

InterProIPR019375. Ribosomal_S28_mit.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PfamPF10246. MRP-S35. 1 hit.
[Graphical view]
SMARTSM00316. S1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSMRPS28. human.
GeneWikiMRPS28.
GenomeRNAi28957.
NextBio51779.
PROQ9Y2Q9.
SOURCESearch...

Entry information

Entry nameRT28_HUMAN
AccessionPrimary (citable) accession number: Q9Y2Q9
Secondary accession number(s): B2RDZ7, Q96Q21
Entry history
Integrated into UniProtKB/Swiss-Prot: July 26, 2002
Last sequence update: November 1, 1999
Last modified: July 9, 2014
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM