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Protein

Glutathione S-transferase kappa 1

Gene

GSTK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53Glutathione1 Publication1
Binding sitei183Glutathione; via amide nitrogen and carbonyl oxygen1 Publication1

GO - Molecular functioni

  • glutathione peroxidase activity Source: UniProtKB
  • glutathione transferase activity Source: UniProtKB
  • protein disulfide oxidoreductase activity Source: InterPro
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionTransferase

Enzyme and pathway databases

ReactomeiR-HSA-156590 Glutathione conjugation
R-HSA-9033241 Peroxisomal protein import

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase kappa 1 (EC:2.5.1.18)
Alternative name(s):
GST 13-13
GST class-kappa
GSTK1-1
Short name:
hGSTK1
Glutathione S-transferase subunit 13
Gene namesi
Name:GSTK1
ORF Names:HDCMD47P
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000197448.13
HGNCiHGNC:16906 GSTK1
MIMi602321 gene
neXtProtiNX_Q9Y2Q3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

Pathology & Biotechi

Organism-specific databases

DisGeNETi373156
OpenTargetsiENSG00000197448
PharmGKBiPA134948237

Chemistry databases

ChEMBLiCHEMBL4491
DrugBankiDB00143 Glutathione
DB04700 GLUTATHIONE SULFINATE

Polymorphism and mutation databases

BioMutaiGSTK1
DMDMi12643338

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001858911 – 226Glutathione S-transferase kappa 1Add BLAST226

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei49N6-succinyllysineBy similarity1
Modified residuei71N6-acetyllysineCombined sources1
Modified residuei85N6-acetyllysineBy similarity1
Modified residuei116N6-acetyllysine; alternateBy similarity1
Modified residuei116N6-succinyllysine; alternateBy similarity1
Modified residuei144N6-succinyllysineBy similarity1
Modified residuei158N6-acetyllysine; alternateBy similarity1
Modified residuei158N6-succinyllysine; alternateBy similarity1
Modified residuei165N6-acetyllysineBy similarity1
Modified residuei169N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ9Y2Q3
PeptideAtlasiQ9Y2Q3
PRIDEiQ9Y2Q3
TopDownProteomicsiQ9Y2Q3-1 [Q9Y2Q3-1]
Q9Y2Q3-2 [Q9Y2Q3-2]
Q9Y2Q3-4 [Q9Y2Q3-4]

PTM databases

iPTMnetiQ9Y2Q3
PhosphoSitePlusiQ9Y2Q3
SwissPalmiQ9Y2Q3

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000197448
CleanExiHS_GSTK1
ExpressionAtlasiQ9Y2Q3 baseline and differential
GenevisibleiQ9Y2Q3 HS

Organism-specific databases

HPAiHPA006311
HPA022904

Interactioni

Subunit structurei

Homodimer.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi131875, 54 interactors
DIPiDIP-46924N
IntActiQ9Y2Q3, 14 interactors
MINTiQ9Y2Q3

Chemistry databases

BindingDBiQ9Y2Q3

Structurei

Secondary structure

1226
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 12Combined sources7
Helixi17 – 29Combined sources13
Turni30 – 32Combined sources3
Beta strandi33 – 41Combined sources9
Helixi44 – 47Combined sources4
Beta strandi57 – 59Combined sources3
Helixi61 – 77Combined sources17
Helixi88 – 94Combined sources7
Helixi97 – 109Combined sources13
Helixi111 – 113Combined sources3
Helixi114 – 126Combined sources13
Helixi135 – 144Combined sources10
Helixi149 – 156Combined sources8
Turni157 – 160Combined sources4
Helixi162 – 177Combined sources16
Beta strandi181 – 183Combined sources3
Beta strandi185 – 190Combined sources6
Beta strandi193 – 201Combined sources9
Helixi203 – 210Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YZXX-ray1.93A/B1-226[»]
3RPNX-ray1.90A/B/C/D/E/F1-226[»]
3RPPX-ray1.80A/B/C1-226[»]
ProteinModelPortaliQ9Y2Q3
SMRiQ9Y2Q3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2Q3

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni16 – 18Glutathione binding3
Regioni200 – 201Glutathione binding2

Sequence similaritiesi

Belongs to the GST superfamily. Kappa family.Curated

Phylogenomic databases

GeneTreeiENSGT00440000033697
HOGENOMiHOG000219769
HOVERGENiHBG051852
InParanoidiQ9Y2Q3
KOiK13299
OMAiETEGFWG
OrthoDBiEOG091G0LCM
PhylomeDBiQ9Y2Q3
TreeFamiTF105323

Family and domain databases

InterProiView protein in InterPro
IPR001853 DSBA-like_thioredoxin_dom
IPR014440 HCCAis_GSTk
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF01323 DSBA, 1 hit
PIRSFiPIRSF006386 HCCAis_GSTk, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2Q3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLPRTVEL FYDVLSPYSW LGFEILCRYQ NIWNINLQLR PSLITGIMKD
60 70 80 90 100
SGNKPPGLLP RKGLYMANDL KLLRHHLQIP IHFPKDFLSV MLEKGSLSAM
110 120 130 140 150
RFLTAVNLEH PEMLEKASRE LWMRVWSRNE DITEPQSILA AAEKAGMSAE
160 170 180 190 200
QAQGLLEKIA TPKVKNQLKE TTEAACRYGA FGLPITVAHV DGQTHMLFGS
210 220
DRMELLAHLL GEKWMGPIPP AVNARL
Length:226
Mass (Da):25,497
Last modified:January 23, 2007 - v3
Checksum:iD3FDAFD1533B58A4
GO
Isoform 2 (identifier: Q9Y2Q3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     128-128: R → RVSVGLWESSGRTLDDFLTFPRHVFRVMILPPPGGSTVLPVTPLSPHRLPAVFSSSQ

Show »
Length:282
Mass (Da):31,566
Checksum:i6F88B28A6081324D
GO
Isoform 3 (identifier: Q9Y2Q3-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     129-140: Missing.

Show »
Length:214
Mass (Da):24,185
Checksum:iFA98AC407CF8FB7B
GO
Isoform 4 (identifier: Q9Y2Q3-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     52-94: Missing.

Show »
Length:183
Mass (Da):20,538
Checksum:i2AA664FBDBB510C9
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti51S → R in BAG61794 (PubMed:14702039).Curated1
Sequence conflicti171T → A in BAG61794 (PubMed:14702039).Curated1
Sequence conflicti179G → R in AAF65506 (Ref. 4) Curated1
Sequence conflicti206L → V in AAP97160 (Ref. 5) Curated1
Sequence conflicti220P → S in AAF65506 (Ref. 4) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_04097852 – 94Missing in isoform 4. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_040025128R → RVSVGLWESSGRTLDDFLTF PRHVFRVMILPPPGGSTVLP VTPLSPHRLPAVFSSSQ in isoform 2. 2 Publications1
Alternative sequenceiVSP_040979129 – 140Missing in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY520571 mRNA Translation: AAS00610.1
AY486465 Genomic DNA Translation: AAS01180.1
AF070657 mRNA Translation: AAD20963.1
AF068287 mRNA Translation: AAF65506.1
AF087849 mRNA Translation: AAP97160.1
AL136938 mRNA Translation: CAB66872.1
AK289570 mRNA Translation: BAF82259.1
AK295592 mRNA Translation: BAG58483.1
AK299968 mRNA Translation: BAG61794.1
AC073342 Genomic DNA No translation available.
CH471198 Genomic DNA Translation: EAW51877.1
BC001231 mRNA Translation: AAH01231.1
BC050715 mRNA Translation: AAH50715.1
BC063425 mRNA Translation: AAH63425.1
CCDSiCCDS47730.1 [Q9Y2Q3-2]
CCDS47731.1 [Q9Y2Q3-3]
CCDS47732.1 [Q9Y2Q3-4]
CCDS5877.1 [Q9Y2Q3-1]
RefSeqiNP_001137151.1, NM_001143679.1 [Q9Y2Q3-2]
NP_001137152.1, NM_001143680.1 [Q9Y2Q3-3]
NP_001137153.1, NM_001143681.1 [Q9Y2Q3-4]
NP_057001.1, NM_015917.2 [Q9Y2Q3-1]
UniGeneiHs.390667

Genome annotation databases

EnsembliENST00000358406; ENSP00000351181; ENSG00000197448 [Q9Y2Q3-1]
ENST00000409500; ENSP00000386944; ENSG00000197448 [Q9Y2Q3-3]
ENST00000443571; ENSP00000415813; ENSG00000197448 [Q9Y2Q3-4]
ENST00000479303; ENSP00000431049; ENSG00000197448 [Q9Y2Q3-2]
GeneIDi373156
KEGGihsa:373156
UCSCiuc003wci.4 human [Q9Y2Q3-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiGSTK1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Q3
Secondary accession number(s): B4DIH1
, B4DSY2, Q6P4H0, Q7Z520, Q9P1S4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 164 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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