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Protein

Zinc finger protein 257

Gene

ZNF257

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 31026C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42526C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 257
Alternative name(s):
Bone marrow zinc finger 4
Short name:
BMZF-4
Gene namesi
Name:ZNF257
Synonyms:BMZF4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:13498. ZNF257.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37786.

Polymorphism and mutation databases

BioMutaiZNF257.
DMDMi327478547.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 563563Zinc finger protein 257PRO_0000047490Add
BLAST

Proteomic databases

EPDiQ9Y2Q1.
PaxDbiQ9Y2Q1.
PRIDEiQ9Y2Q1.

PTM databases

iPTMnetiQ9Y2Q1.
PhosphoSiteiQ9Y2Q1.

Expressioni

Gene expression databases

BgeeiQ9Y2Q1.
CleanExiHS_ZNF257.
ExpressionAtlasiQ9Y2Q1. baseline and differential.
GenevisibleiQ9Y2Q1. HS.

Interactioni

Protein-protein interaction databases

BioGridi125264. 1 interaction.
STRINGi9606.ENSP00000470209.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2Q1.
SMRiQ9Y2Q1. Positions 143-561.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 7572KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri173 – 19523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri201 – 22323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri229 – 25123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri257 – 27923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri285 – 31026C2H2-type 5; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri316 – 33823C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri344 – 36623C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri372 – 39423C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri400 – 42526C2H2-type 9; degeneratePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri431 – 45323C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri459 – 48123C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri487 – 50923C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri515 – 53723C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y2Q1.
KOiK09228.
OMAiGKPFNRF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y2Q1.
TreeFamiTF342117.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2Q1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGPLTIRDVT VEFSLEEWHC LDTAQQNLYR DVMLENYRNL VFLGIAVSKP
60 70 80 90 100
DLITCLEQGK EPCNMKRHEM VAKPPVMCSH IAEDLCPERD IKYFFQKVIL
110 120 130 140 150
RRYDKCEHEN LQLRKGCKSV DECKVCKGGY NGLNQCLITT QSKMYQCDKY
160 170 180 190 200
VKVFYKFSNS DRHKIRHTEK KTCKCKECGK SFCMLSQLTR HKRIHIRENS
210 220 230 240 250
HKCEECGKAF NQSSALTRHK MTHTGEKPYK CEECGKAFNR SSHLTQHKVI
260 270 280 290 300
HTREKPYKCE ECGKAFNRSS HITQHKRIHN REKPFKYDEC CKAFKWSSAL
310 320 330 340 350
TTLTQHKRIH TGEKPYKCEE CGKAFNQSSA LTRHKMIHTG EKPFQCEECG
360 370 380 390 400
KAFNRSSHLT QHKIIHTKEK PYKCEECGKA FNRSSHLTKH KRIHTREKAY
410 420 430 440 450
KCDEYCKAFN WSSALTTLTQ HKIIHTGEKP YKCEECGKAF NRSSYLIRHK
460 470 480 490 500
IIHTGEKPYK CEECGKAFNQ SSHLTQHKII HTGEKPYKCE ECGKAFNRSS
510 520 530 540 550
HLSQHKIIHT GEKPYKCEEC GKPFNRFSYL TVHKRIHAGE NPNKYEECGK
560
ACNHSSNLTK HNS
Length:563
Mass (Da):65,779
Last modified:April 5, 2011 - v2
Checksum:i19440275324E119B
GO
Isoform 2 (identifier: Q9Y2Q1-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     177-204: Missing.

Show »
Length:535
Mass (Da):62,426
Checksum:i28C39BD95F13431D
GO
Isoform 3 (identifier: Q9Y2Q1-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-32: Missing.

Show »
Length:531
Mass (Da):62,017
Checksum:iCB9C3942B06AA3A4
GO
Isoform 4 (identifier: Q9Y2Q1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     51-83: Missing.

Show »
Length:530
Mass (Da):62,058
Checksum:iBC4FAEE8D2905E21
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti355 – 3551R → G in AAH36446 (PubMed:15489334).Curated
Sequence conflicti450 – 4501K → E in AAD20957 (PubMed:10585455).Curated
Sequence conflicti501 – 5022HL → QP in AAD20957 (PubMed:10585455).Curated
Sequence conflicti506 – 5061K → R in AAD20957 (PubMed:10585455).Curated
Sequence conflicti523 – 5231P → A in AAD20957 (PubMed:10585455).Curated
Sequence conflicti526 – 5261R → T in AAD20957 (PubMed:10585455).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 3232Missing in isoform 3. 1 PublicationVSP_040858Add
BLAST
Alternative sequencei51 – 8333Missing in isoform 4. 1 PublicationVSP_040859Add
BLAST
Alternative sequencei177 – 20428Missing in isoform 2. 1 PublicationVSP_040860Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070651 mRNA. Translation: AAD20957.1.
AK056694 mRNA. Translation: BAG51786.1.
AC003973 Genomic DNA. No translation available.
AC011482 Genomic DNA. No translation available.
BC036446 mRNA. Translation: AAH36446.1.
CCDSiCCDS46030.1. [Q9Y2Q1-1]
RefSeqiNP_001303925.1. NM_001316996.1. [Q9Y2Q1-3]
NP_001303926.1. NM_001316997.1.
NP_001303927.1. NM_001316998.1.
NP_258429.2. NM_033468.3. [Q9Y2Q1-1]
UniGeneiHs.283900.

Genome annotation databases

EnsembliENST00000594947; ENSP00000470209; ENSG00000197134. [Q9Y2Q1-1]
GeneIDi113835.
KEGGihsa:113835.
UCSCiuc010ecx.4. human. [Q9Y2Q1-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF070651 mRNA. Translation: AAD20957.1.
AK056694 mRNA. Translation: BAG51786.1.
AC003973 Genomic DNA. No translation available.
AC011482 Genomic DNA. No translation available.
BC036446 mRNA. Translation: AAH36446.1.
CCDSiCCDS46030.1. [Q9Y2Q1-1]
RefSeqiNP_001303925.1. NM_001316996.1. [Q9Y2Q1-3]
NP_001303926.1. NM_001316997.1.
NP_001303927.1. NM_001316998.1.
NP_258429.2. NM_033468.3. [Q9Y2Q1-1]
UniGeneiHs.283900.

3D structure databases

ProteinModelPortaliQ9Y2Q1.
SMRiQ9Y2Q1. Positions 143-561.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi125264. 1 interaction.
STRINGi9606.ENSP00000470209.

PTM databases

iPTMnetiQ9Y2Q1.
PhosphoSiteiQ9Y2Q1.

Polymorphism and mutation databases

BioMutaiZNF257.
DMDMi327478547.

Proteomic databases

EPDiQ9Y2Q1.
PaxDbiQ9Y2Q1.
PRIDEiQ9Y2Q1.

Protocols and materials databases

DNASUi113835.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000594947; ENSP00000470209; ENSG00000197134. [Q9Y2Q1-1]
GeneIDi113835.
KEGGihsa:113835.
UCSCiuc010ecx.4. human. [Q9Y2Q1-1]

Organism-specific databases

CTDi113835.
GeneCardsiZNF257.
HGNCiHGNC:13498. ZNF257.
MIMi606957. gene.
neXtProtiNX_Q9Y2Q1.
PharmGKBiPA37786.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00790000122969.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y2Q1.
KOiK09228.
OMAiGKPFNRF.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y2Q1.
TreeFamiTF342117.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii113835.
NextBioi78924.
PROiQ9Y2Q1.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2Q1.
CleanExiHS_ZNF257.
ExpressionAtlasiQ9Y2Q1. baseline and differential.
GenevisibleiQ9Y2Q1. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 9 hits.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 13 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 11 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB."
    Han Z.-G., Zhang Q.-H., Ye M., Kan L.-X., Gu B.-W., He K.-L., Shi S.-L., Zhou J., Fu G., Mao M., Chen S.-J., Yu L., Chen Z.
    J. Biol. Chem. 274:35741-35748(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Tissue: Bone marrow.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    Tissue: Testis.

Entry informationi

Entry nameiZN257_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2Q1
Secondary accession number(s): B3KPS4, E9PG34, Q8NE34
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 5, 2011
Last modified: April 13, 2016
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.