Q9Y2Q0 (AT8A1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phospholipid-transporting ATPase IA
EC=3.6.3.1

Alternative name(s):
ATPase class I type 8A member 1
Chromaffin granule ATPase II

Gene names

Name:	ATP8A1
Synonyms:	ATPIA

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1164 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the transport of aminophospholipids from the outer to the inner leaflet of various membranes and the maintenance of asymmetric distribution of phospholipids, mainly in secretory vesicles.
Catalytic activity	ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).
Subcellular location	Cytoplasmic vesicle › secretory vesicle › chromaffin granule membrane; Multi-pass membrane protein By similarity.
Tissue specificity	Found in most adult tissues except liver, testis and placenta. Most abundant in heart, brain and skeletal muscle. Also detected in fetal tissues. Isoform 1 is only detected in brain, skeletal muscle and heart and is the most abundant form in skeletal muscle.
Sequence similarities	Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]
Sequence caution	The sequence AAI09318.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA77248.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Cytoplasmic vesicle Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid translocation Non-traceable author statement. Source: UniProtKB
Cellular component	chromaffin granule membrane Inferred from electronic annotation. Source: UniProtKB-SubCell endoplasmic reticulum Inferred from direct assay. Source: UniProtKB integral to membrane Non-traceable author statement. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular function	ATP binding Non-traceable author statement. Source: UniProtKB ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism Inferred from electronic annotation. Source: InterPro aminophospholipid transporter activity Non-traceable author statement. Source: UniProtKB cation-transporting ATPase activity Non-traceable author statement Ref.1. Source: UniProtKB magnesium ion binding Inferred from electronic annotation. Source: InterPro phospholipid-translocating ATPase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2Q0-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2Q0-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     433-447: Missing.

Isoform 3 (identifier: Q9Y2Q0-3)

The sequence of this isoform differs from the canonical sequence as follows:
     152-171: AVGEIVKVTNGEHLPADLIS → NVGDIVIIKGKEYIPADTVL
     433-447: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1164	1164	Probable phospholipid-transporting ATPase IA		PRO_0000046360
Regions
	Topological domain	1 – 65	65	Cytoplasmic Potential
	Transmembrane	66 – 86	21	Helical; Potential
	Topological domain	87 – 92	6	Extracellular Potential
	Transmembrane	93 – 115	23	Helical; Potential
	Topological domain	116 – 297	182	Cytoplasmic Potential
	Transmembrane	298 – 319	22	Helical; Potential
	Topological domain	320 – 344	25	Extracellular Potential
	Transmembrane	345 – 366	22	Helical; Potential
	Topological domain	367 – 857	491	Cytoplasmic Potential
	Transmembrane	858 – 878	21	Helical; Potential
	Topological domain	879 – 890	12	Extracellular Potential
	Transmembrane	891 – 910	20	Helical; Potential
	Topological domain	911 – 940	30	Cytoplasmic Potential
	Transmembrane	941 – 962	22	Helical; Potential
	Topological domain	963 – 976	14	Extracellular Potential
	Transmembrane	977 – 999	23	Helical; Potential
	Topological domain	1000 – 1005	6	Cytoplasmic Potential
	Transmembrane	1006 – 1026	21	Helical; Potential
	Topological domain	1027 – 1044	18	Extracellular Potential
	Transmembrane	1045 – 1070	26	Helical; Potential
	Topological domain	1071 – 1164	94	Cytoplasmic Potential
	Nucleotide binding	741 – 748	8	ATP Potential
	Nucleotide binding	1095 – 1102	8	ATP Potential
Sites
	Active site	409	1	4-aspartylphosphate intermediate By similarity
	Metal binding	801	1	Magnesium By similarity
	Metal binding	805	1	Magnesium By similarity
Amino acid modifications
	Modified residue	9	1	Phosphoserine By similarity
	Modified residue	25	1	Phosphoserine Ref.5
	Modified residue	28	1	Phosphothreonine Ref.5
	Modified residue	29	1	Phosphoserine Ref.5
	Modified residue	269	1	Phosphotyrosine By similarity
Natural variations
	Alternative sequence	152 – 171	20	AVGEI…ADLIS → NVGDIVIIKGKEYIPADTVL in isoform 3.		VSP_040977
	Alternative sequence	433 – 447	15	Missing in isoform 2 and isoform 3.		VSP_000431
	Natural variant	673	1	T → M. Corresponds to variant rs3792687 [ dbSNP | Ensembl ].		VAR_022003
Experimental info
	Sequence conflict	364	1	E → K in BAA77248. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (Long) [UniParc]. Last modified November 1, 1999. Version 1. Checksum: CE1EAF0206CD36F7	FASTA	1,164	131,369
	10 20 30 40 50 60 MPTMRRTVSE IRSRAEGYEK TDDVSEKTSL ADQEEVRTIF INQPQLTKFC NNHVSTAKYN 70 80 90 100 110 120 IITFLPRFLY SQFRRAANSF FLFIALLQQI PDVSPTGRYT TLVPLLFILA VAAIKEIIED 130 140 150 160 170 180 IKRHKADNAV NKKQTQVLRN GAWEIVHWEK VAVGEIVKVT NGEHLPADLI SLSSSEPQAM 190 200 210 220 230 240 CYIETSNLDG ETNLKIRQGL PATSDIKDVD SLMRISGRIE CESPNRHLYD FVGNIRLDGH 250 260 270 280 290 300 GTVPLGADQI LLRGAQLRNT QWVHGIVVYT GHDTKLMQNS TSPPLKLSNV ERITNVQILI 310 320 330 340 350 360 LFCILIAMSL VCSVGSAIWN RRHSGKDWYL NLNYGGASNF GLNFLTFIIL FNNLIPISLL 370 380 390 400 410 420 VTLEVVKFTQ AYFINWDLDM HYEPTDTAAM ARTSNLNEEL GQVKYIFSDK TGTLTCNVMQ 430 440 450 460 470 480 FKKCTIAGVA YGHVPEPEDY GCSPDEWQNS QFGDEKTFSD SSLLENLQNN HPTAPIICEF 490 500 510 520 530 540 LTMMAVCHTA VPEREGDKII YQAASPDEGA LVRAAKQLNF VFTGRTPDSV IIDSLGQEER 550 560 570 580 590 600 YELLNVLEFT SARKRMSVIV RTPSGKLRLY CKGADTVIYD RLAETSKYKE ITLKHLEQFA 610 620 630 640 650 660 TEGLRTLCFA VAEISESDFQ EWRAVYQRAS TSVQNRLLKL EESYELIEKN LQLLGATAIE 670 680 690 700 710 720 DKLQDQVPET IETLMKADIK IWILTGDKQE TAINIGHSCK LLKKNMGMIV INEGSLDGTR 730 740 750 760 770 780 ETLSRHCTTL GDALRKENDF ALIIDGKTLK YALTFGVRQY FLDLALSCKA VICCRVSPLQ 790 800 810 820 830 840 KSEVVEMVKK QVKVVTLAIG DGANDVSMIQ TAHVGVGISG NEGLQAANSS DYSIAQFKYL 850 860 870 880 890 900 KNLLMIHGAW NYNRVSKCIL YCFYKNIVLY IIEIWFAFVN GFSGQILFER WCIGLYNVMF 910 920 930 940 950 960 TAMPPLTLGI FERSCRKENM LKYPELYKTS QNALDFNTKV FWVHCLNGLF HSVILFWFPL 970 980 990 1000 1010 1020 KALQYGTAFG NGKTSDYLLL GNFVYTFVVI TVCLKAGLET SYWTWFSHIA IWGSIALWVV 1030 1040 1050 1060 1070 1080 FFGIYSSLWP AIPMAPDMSG EAAMLFSSGV FWMGLLFIPV ASLLLDVVYK VIKRTAFKTL 1090 1100 1110 1120 1130 1140 VDEVQELEAK SQDPGAVVLG KSLTERAQLL KNVFKKNHVN LYRSESLQQN LLHGYAFSQD 1150 1160 ENGIVSQSEV IRAYDTTKQR PDEW
	Isoform 2 (Short) [UniParc]. Checksum: DC609CEA87E9F9B1	FASTA	1,149	129,628
	10 20 30 40 50 60 MPTMRRTVSE IRSRAEGYEK TDDVSEKTSL ADQEEVRTIF INQPQLTKFC NNHVSTAKYN 70 80 90 100 110 120 IITFLPRFLY SQFRRAANSF FLFIALLQQI PDVSPTGRYT TLVPLLFILA VAAIKEIIED 130 140 150 160 170 180 IKRHKADNAV NKKQTQVLRN GAWEIVHWEK VAVGEIVKVT NGEHLPADLI SLSSSEPQAM 190 200 210 220 230 240 CYIETSNLDG ETNLKIRQGL PATSDIKDVD SLMRISGRIE CESPNRHLYD FVGNIRLDGH 250 260 270 280 290 300 GTVPLGADQI LLRGAQLRNT QWVHGIVVYT GHDTKLMQNS TSPPLKLSNV ERITNVQILI 310 320 330 340 350 360 LFCILIAMSL VCSVGSAIWN RRHSGKDWYL NLNYGGASNF GLNFLTFIIL FNNLIPISLL 370 380 390 400 410 420 VTLEVVKFTQ AYFINWDLDM HYEPTDTAAM ARTSNLNEEL GQVKYIFSDK TGTLTCNVMQ 430 440 450 460 470 480 FKKCTIAGVA YGQNSQFGDE KTFSDSSLLE NLQNNHPTAP IICEFLTMMA VCHTAVPERE 490 500 510 520 530 540 GDKIIYQAAS PDEGALVRAA KQLNFVFTGR TPDSVIIDSL GQEERYELLN VLEFTSARKR 550 560 570 580 590 600 MSVIVRTPSG KLRLYCKGAD TVIYDRLAET SKYKEITLKH LEQFATEGLR TLCFAVAEIS 610 620 630 640 650 660 ESDFQEWRAV YQRASTSVQN RLLKLEESYE LIEKNLQLLG ATAIEDKLQD QVPETIETLM 670 680 690 700 710 720 KADIKIWILT GDKQETAINI GHSCKLLKKN MGMIVINEGS LDGTRETLSR HCTTLGDALR 730 740 750 760 770 780 KENDFALIID GKTLKYALTF GVRQYFLDLA LSCKAVICCR VSPLQKSEVV EMVKKQVKVV 790 800 810 820 830 840 TLAIGDGAND VSMIQTAHVG VGISGNEGLQ AANSSDYSIA QFKYLKNLLM IHGAWNYNRV 850 860 870 880 890 900 SKCILYCFYK NIVLYIIEIW FAFVNGFSGQ ILFERWCIGL YNVMFTAMPP LTLGIFERSC 910 920 930 940 950 960 RKENMLKYPE LYKTSQNALD FNTKVFWVHC LNGLFHSVIL FWFPLKALQY GTAFGNGKTS 970 980 990 1000 1010 1020 DYLLLGNFVY TFVVITVCLK AGLETSYWTW FSHIAIWGSI ALWVVFFGIY SSLWPAIPMA 1030 1040 1050 1060 1070 1080 PDMSGEAAML FSSGVFWMGL LFIPVASLLL DVVYKVIKRT AFKTLVDEVQ ELEAKSQDPG 1090 1100 1110 1120 1130 1140 AVVLGKSLTE RAQLLKNVFK KNHVNLYRSE SLQQNLLHGY AFSQDENGIV SQSEVIRAYD TTKQRPDEW
	Isoform 3 [UniParc]. Checksum: 83D2F58984DDF966	FASTA	1,149	129,723
	10 20 30 40 50 60 MPTMRRTVSE IRSRAEGYEK TDDVSEKTSL ADQEEVRTIF INQPQLTKFC NNHVSTAKYN 70 80 90 100 110 120 IITFLPRFLY SQFRRAANSF FLFIALLQQI PDVSPTGRYT TLVPLLFILA VAAIKEIIED 130 140 150 160 170 180 IKRHKADNAV NKKQTQVLRN GAWEIVHWEK VNVGDIVIIK GKEYIPADTV LLSSSEPQAM 190 200 210 220 230 240 CYIETSNLDG ETNLKIRQGL PATSDIKDVD SLMRISGRIE CESPNRHLYD FVGNIRLDGH 250 260 270 280 290 300 GTVPLGADQI LLRGAQLRNT QWVHGIVVYT GHDTKLMQNS TSPPLKLSNV ERITNVQILI 310 320 330 340 350 360 LFCILIAMSL VCSVGSAIWN RRHSGKDWYL NLNYGGASNF GLNFLTFIIL FNNLIPISLL 370 380 390 400 410 420 VTLEVVKFTQ AYFINWDLDM HYEPTDTAAM ARTSNLNEEL GQVKYIFSDK TGTLTCNVMQ 430 440 450 460 470 480 FKKCTIAGVA YGQNSQFGDE KTFSDSSLLE NLQNNHPTAP IICEFLTMMA VCHTAVPERE 490 500 510 520 530 540 GDKIIYQAAS PDEGALVRAA KQLNFVFTGR TPDSVIIDSL GQEERYELLN VLEFTSARKR 550 560 570 580 590 600 MSVIVRTPSG KLRLYCKGAD TVIYDRLAET SKYKEITLKH LEQFATEGLR TLCFAVAEIS 610 620 630 640 650 660 ESDFQEWRAV YQRASTSVQN RLLKLEESYE LIEKNLQLLG ATAIEDKLQD QVPETIETLM 670 680 690 700 710 720 KADIKIWILT GDKQETAINI GHSCKLLKKN MGMIVINEGS LDGTRETLSR HCTTLGDALR 730 740 750 760 770 780 KENDFALIID GKTLKYALTF GVRQYFLDLA LSCKAVICCR VSPLQKSEVV EMVKKQVKVV 790 800 810 820 830 840 TLAIGDGAND VSMIQTAHVG VGISGNEGLQ AANSSDYSIA QFKYLKNLLM IHGAWNYNRV 850 860 870 880 890 900 SKCILYCFYK NIVLYIIEIW FAFVNGFSGQ ILFERWCIGL YNVMFTAMPP LTLGIFERSC 910 920 930 940 950 960 RKENMLKYPE LYKTSQNALD FNTKVFWVHC LNGLFHSVIL FWFPLKALQY GTAFGNGKTS 970 980 990 1000 1010 1020 DYLLLGNFVY TFVVITVCLK AGLETSYWTW FSHIAIWGSI ALWVVFFGIY SSLWPAIPMA 1030 1040 1050 1060 1070 1080 PDMSGEAAML FSSGVFWMGL LFIPVASLLL DVVYKVIKRT AFKTLVDEVQ ELEAKSQDPG 1090 1100 1110 1120 1130 1140 AVVLGKSLTE RAQLLKNVFK KNHVNLYRSE SLQQNLLHGY AFSQDENGIV SQSEVIRAYD TTKQRPDEW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning, expression, and chromosomal mapping of a human ATPase II gene, member of the third subfamily of P-type ATPases and orthologous to the presumed bovine and murine aminophospholipid translocase." Mouro I., Halleck M.S., Schlegel R.A., Mattei M.-G., Williamson P.L., Zachowski A., Devaux P., Cartron J.-P., Colin Y. Biochem. Biophys. Res. Commun. 257:333-339(1999) [PubMed: 10198212] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Skeletal muscle.
[2]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	"cDNA cloning of human ATPaseII." Osada S., Nakanishi Y. Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 2-1164 (ISOFORM 1). Tissue: Brain.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-1164 (ISOFORM 3).
[5]	"Phosphoproteome of resting human platelets." Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J., Schuetz C., Walter U., Gambaryan S., Sickmann A. J. Proteome Res. 7:526-534(2008) [PubMed: 18088087] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25; THR-28 AND SER-29, MASS SPECTROMETRY. Tissue: Platelet.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF067820 mRNA. Translation: AAD34706.1. AC084010 Genomic DNA. Translation: AAY40980.1. AC096734 Genomic DNA. Translation: AAY40924.1. AC110788 Genomic DNA. No translation available. AC139717 Genomic DNA. No translation available. AB013452 mRNA. Translation: BAA77248.1. Different initiation. BC109317 mRNA. Translation: AAI09318.1. Different initiation.
IPI	IPI00032402. IPI00221038. IPI00941654.
RefSeq	NP_001098999.1. NM_001105529.1. NP_006086.1. NM_006095.2.
UniGene	Hs.435052.
3D structure databases
ProteinModelPortal	Q9Y2Q0.
SMR	Q9Y2Q0. Positions 779-861.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9Y2Q0.
PTM databases
PhosphoSite	Q9Y2Q0.
Polymorphism databases
DMDM	8134331.
Proteomic databases
PRIDE	Q9Y2Q0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000264449; ENSP00000264449; ENSG00000124406. ENST00000381668; ENSP00000371084; ENSG00000124406.
GeneID	10396.
KEGG	hsa:10396.
UCSC	uc003gwr.2. human.
Organism-specific databases
CTD	10396.
GeneCards	GC04M042325.
HGNC	HGNC:13531. ATP8A1.
MIM	609542. gene.
neXtProt	NX_Q9Y2Q0.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00570000078774.
HOGENOM	HBG745019.
HOVERGEN	HBG050601.
InParanoid	Q9Y2Q0.
OMA	PAIPMAP.
OrthoDB	EOG4V9TPV.
PhylomeDB	Q9Y2Q0.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9Y2Q0.
Bgee	Q9Y2Q0.
CleanEx	HS_ATP8A1.
Genevestigator	Q9Y2Q0.
GermOnline	ENSG00000124406. Homo sapiens.
Family and domain databases
InterPro	IPR023306. ATPase_cation_domN. IPR008250. ATPase_P-typ_ATPase-assoc-dom. IPR023300. ATPase_P-typ_cyto_domA. IPR023299. ATPase_P-typ_cyto_domN. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_P_site. IPR006539. ATPase_P-typ_Plipid-transl. IPR023214. HAD-like_dom. [Graphical view]
Gene3D	G3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits. G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 1 hit. G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KO	K14802.
Pfam	PF00122. E1-E2_ATPase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE.
SUPFAM	SSF81660. ATPase_cation_domN. 1 hit. SSF56784. HAD-like_dom. 1 hit.
TIGRFAMs	TIGR01652. ATPase-Plipid. 1 hit. TIGR01494. ATPase_P-type. 3 hits.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00144. Phosphatidylserine.
NextBio	39390.
SOURCE	Search...

Entry information

Entry name

AT8A1_HUMAN

Accession

Primary (citable) accession number: Q9Y2Q0
Secondary accession number(s): Q32M36, Q4W5J7, Q4W5P2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1999
Last modified:	January 25, 2012
This is version 108 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.