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Protein

RNA 3'-terminal phosphate cyclase-like protein

Gene

RCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processRibosome biogenesis

Enzyme and pathway databases

ReactomeiR-HSA-6790901 rRNA modification in the nucleus and cytosol
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol

Names & Taxonomyi

Protein namesi
Recommended name:
RNA 3'-terminal phosphate cyclase-like protein
Gene namesi
Name:RCL1
Synonyms:RNAC, RPC2, RPCL1, RTC2
ORF Names:HSPC338
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000120158.11
HGNCiHGNC:17687 RCL1
MIMi611405 gene
neXtProtiNX_Q9Y2P8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi10171
OpenTargetsiENSG00000120158
PharmGKBiPA134894364

Polymorphism and mutation databases

DMDMi90103518

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001564381 – 373RNA 3'-terminal phosphate cyclase-like proteinAdd BLAST373

Proteomic databases

EPDiQ9Y2P8
PaxDbiQ9Y2P8
PeptideAtlasiQ9Y2P8
PRIDEiQ9Y2P8

PTM databases

iPTMnetiQ9Y2P8
PhosphoSitePlusiQ9Y2P8

Expressioni

Gene expression databases

BgeeiENSG00000120158
CleanExiHS_RCL1
ExpressionAtlasiQ9Y2P8 baseline and differential
GenevisibleiQ9Y2P8 HS

Organism-specific databases

HPAiHPA071308

Interactioni

Protein-protein interaction databases

BioGridi115473, 30 interactors
IntActiQ9Y2P8, 12 interactors
MINTiQ9Y2P8
STRINGi9606.ENSP00000371169

Structurei

3D structure databases

ProteinModelPortaliQ9Y2P8
SMRiQ9Y2P8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3980 Eukaryota
COG0430 LUCA
GeneTreeiENSGT00530000063404
HOGENOMiHOG000110352
HOVERGENiHBG014327
KOiK11108
OMAiGEVFFSC
OrthoDBiEOG091G092A
PhylomeDBiQ9Y2P8
TreeFamiTF300831

Family and domain databases

CDDicd00875 RNA_Cyclase_Class_I, 1 hit
Gene3Di3.30.360.20, 1 hit
3.65.10.20, 2 hits
InterProiView protein in InterPro
IPR013791 RNA3'-term_phos_cycl_insert
IPR023797 RNA3'_phos_cyclase_dom
IPR037136 RNA3'_phos_cyclase_dom_sf
IPR000228 RNA3'_term_phos_cyc
IPR016443 RNA3'_term_phos_cyc_type_2
IPR020719 RNA3'_term_phos_cycl-like_CS
IPR013792 RNA3'P_cycl/enolpyr_Trfase_a/b
IPR036553 RPTC_insert
PANTHERiPTHR11096 PTHR11096, 1 hit
PTHR11096:SF1 PTHR11096:SF1, 1 hit
PfamiView protein in Pfam
PF01137 RTC, 1 hit
PF05189 RTC_insert, 1 hit
PIRSFiPIRSF005378 RNA3'_term_phos_cycl_euk, 1 hit
SUPFAMiSSF55205 SSF55205, 1 hit
TIGRFAMsiTIGR03400 18S_RNA_Rcl1p, 1 hit
PROSITEiView protein in PROSITE
PS01287 RTC, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2P8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATQAHSLSY AGCNFLRQRL VLSTLSGRPV KIRKIRARDD NPGLRDFEAS
60 70 80 90 100
FIRLLDKITN GSRIEINQTG TTLYYQPGLL YGGSVEHDCS VLRGIGYYLE
110 120 130 140 150
SLLCLAPFMK HPLKIVLRGV TNDQVDPSVD VLKATALPLL KQFGIDGESF
160 170 180 190 200
ELKIVRRGMP PGGGGEVVFS CPVRKVLKPI QLTDPGKIKR IRGMAYSVRV
210 220 230 240 250
SPQMANRIVD SARSILNKFI PDIYIYTDHM KGVNSGKSPG FGLSLVAETT
260 270 280 290 300
SGTFLSAELA SNPQGQGAAV LPEDLGRNCA RLLLEEIYRG GCVDSTNQSL
310 320 330 340 350
ALLLMTLGQQ DVSKVLLGPL SPYTIEFLRH LKSFFQIMFK IETKPCGEEL
360 370
KGGDKVLMTC VGIGFSNLSK TLK
Length:373
Mass (Da):40,843
Last modified:March 7, 2006 - v3
Checksum:i533FAE8420AF93CB
GO
Isoform 2 (identifier: Q9Y2P8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-9: MATQAHSLS → MTSLTPGCR
     10-195: Missing.

Note: No experimental confirmation available.
Show »
Length:187
Mass (Da):20,284
Checksum:iA9BF3D695E5E6A1B
GO

Sequence cautioni

The sequence AAD32456 differs from that shown. Reason: Frameshift at positions 13 and 58.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6H → Y in BAB14300 (PubMed:14702039).Curated1
Sequence conflicti46D → S in AAF29016 (Ref. 8) Curated1
Sequence conflicti49A → S in AAF29016 (Ref. 8) Curated1
Sequence conflicti153K → N in BAB14300 (PubMed:14702039).Curated1
Sequence conflicti310Q → R in CAB89811 (PubMed:10790377).Curated1
Sequence conflicti310Q → R in AAD32456 (PubMed:11042152).Curated1
Sequence conflicti310Q → R in AAF29016 (Ref. 8) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0564521 – 9MATQAHSLS → MTSLTPGCR in isoform 2. 1 Publication9
Alternative sequenceiVSP_05645310 – 195Missing in isoform 2. 1 PublicationAdd BLAST186

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ276894 mRNA Translation: CAB89811.1
AK022904 mRNA Translation: BAB14300.1
EF553527 mRNA Translation: ABQ66271.1
AL158147 Genomic DNA No translation available.
AL353151 Genomic DNA No translation available.
CH471071 Genomic DNA Translation: EAW58776.1
CH471071 Genomic DNA Translation: EAW58777.1
BC001025 mRNA Translation: AAH01025.1
AF067172 mRNA Translation: AAD32456.1 Frameshift.
AF161456 mRNA Translation: AAF29016.1
CCDSiCCDS6456.1 [Q9Y2P8-1]
CCDS69565.1 [Q9Y2P8-2]
RefSeqiNP_001273628.1, NM_001286699.1
NP_001273629.1, NM_001286700.1
NP_001273630.1, NM_001286701.1 [Q9Y2P8-2]
NP_005763.3, NM_005772.4 [Q9Y2P8-1]
XP_011515975.1, XM_011517673.2 [Q9Y2P8-2]
XP_016869665.1, XM_017014176.1 [Q9Y2P8-2]
UniGeneiHs.194121

Genome annotation databases

EnsembliENST00000381728; ENSP00000371147; ENSG00000120158 [Q9Y2P8-2]
ENST00000381730; ENSP00000371149; ENSG00000120158 [Q9Y2P8-2]
ENST00000381750; ENSP00000371169; ENSG00000120158 [Q9Y2P8-1]
ENST00000448872; ENSP00000388096; ENSG00000120158 [Q9Y2P8-2]
GeneIDi10171
KEGGihsa:10171
UCSCiuc003zis.4 human [Q9Y2P8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRCL1_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2P8
Secondary accession number(s): D3DRI2
, Q5VYW9, Q5VZU1, Q9H9D0, Q9NY00, Q9P044
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: March 7, 2006
Last modified: May 23, 2018
This is version 166 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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