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Q9Y2P7 (ZN256_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 124. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein 256
Alternative name(s):
Bone marrow zinc finger 3
Short name=BMZF-3
Gene names
Name:ZNF256
Synonyms:BMZF3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length627 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor that plays a role in cell proliferation. Requires TRIM28 for its activity. Ref.6

Subunit structure

Interacts with TRIM28. Ref.6

Subcellular location

Nucleus Ref.6.

Induction

By GDNF/glial cell line-derived neurotrophic factor. Ref.6

Domain

The KRAB domain mediates interaction with TRIM28 and is required for transcriptional repressor activity. Ref.6

Sequence similarities

Belongs to the krueppel C2H2-type zinc-finger protein family.

Contains 15 C2H2-type zinc fingers.

Contains 1 KRAB domain.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q9Y2P7-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q9Y2P7-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 627627Zinc finger protein 256
PRO_0000047489

Regions

Domain14 – 9683KRAB
Zinc finger90 – 11223C2H2-type 1
Zinc finger239 – 26123C2H2-type 2
Zinc finger267 – 28923C2H2-type 3
Zinc finger295 – 31723C2H2-type 4
Zinc finger323 – 34523C2H2-type 5
Zinc finger351 – 37323C2H2-type 6
Zinc finger379 – 40123C2H2-type 7
Zinc finger407 – 42923C2H2-type 8
Zinc finger435 – 45723C2H2-type 9
Zinc finger463 – 48523C2H2-type 10
Zinc finger491 – 51323C2H2-type 11
Zinc finger519 – 54123C2H2-type 12
Zinc finger547 – 56923C2H2-type 13
Zinc finger575 – 59723C2H2-type 14
Zinc finger603 – 62523C2H2-type 15

Natural variations

Alternative sequence1 – 153153Missing in isoform 2.
VSP_037721
Natural variant3041F → I.
Corresponds to variant rs953619 [ dbSNP | Ensembl ].
VAR_058326

Experimental info

Sequence conflict2541L → P in BAG36789. Ref.3
Sequence conflict5521C → F in BAG36789. Ref.3
Sequence conflict5741P → L in AAD32449. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 28, 2009. Version 2.
Checksum: F03506B03E4A6E86

FASTA62771,871
        10         20         30         40         50         60 
MAAAELTAPA QGIVTFEDVA VYFSWKEWGL LDEAQKCLYH DVMLENLTLT TSLGGSGAGD 

        70         80         90        100        110        120 
EEAPYQQSTS PQRVSQVRIP KALPSPQKTN PCEICGPVLR QILHLVEHQG THHGQKLYTD 

       130        140        150        160        170        180 
GACRKQLQFT AYLHQHQKQH VGQKHFRSNG GRDMFLSSCT FEVSGKPFTC KEVGKDFLVR 

       190        200        210        220        230        240 
SRFLQQQAAH TRKKSNRTKS AVAFHSVKNH YNWGECVKAF SYKHVRVQHQ GDLIRERSYM 

       250        260        270        280        290        300 
CSECGKSFST SCSLSDHLRV HTSEKPYTCG ECGKSYRQSS SLITHRRIHT GVRPHQCDEC 

       310        320        330        340        350        360 
GKLFNRKYDL LIHQRVHTGE RPYKCSECGK SFSHSSSLIT HQRIHTGMRP YECSECGKSF 

       370        380        390        400        410        420 
IHSSSLITHQ RVHTGTRPYM CSECGKSFSQ SCHLIKHRRL HIGEGPYECS ECGKLFTYRS 

       430        440        450        460        470        480 
RFFQHQRVHT GVRSHECHEC GKLFSRKFDL IVHERVHTGE RPYECSECGK SFTCKSYLIS 

       490        500        510        520        530        540 
HWKVHTGARP YECGECGKSF THSSTLLQHQ RVHTGERPYE CNECGKFFSQ SSSLIRHRRS 

       550        560        570        580        590        600 
HTGERPYECS ECWKSFSNHS SLVKHRRVHT GERPYECSEC GKSFSQSSNL TNHQRIHSGE 

       610        620 
RPYECSDCGK FFTFNSNLLK HQNVHKG 

« Hide

Isoform 2 [UniParc].

Checksum: 304E4C25742FD014
Show »

FASTA47454,856

References

« Hide 'large scale' references
[1]"Molecular cloning of six novel Kruppel-like zinc finger genes from hematopoietic cells and identification of a novel transregulatory domain KRNB."
Han Z.-G., Zhang Q.-H., Ye M., Kan L.-X., Gu B.-W., He K.-L., Shi S.-L., Zhou J., Fu G., Mao M., Chen S.-J., Yu L., Chen Z.
J. Biol. Chem. 274:35741-35748(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Tissue: Bone marrow.
[2]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[3]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Tongue.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
Tissue: Placenta.
[6]"A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1."
Suzuki C., Murakumo Y., Kawase Y., Sato T., Morinaga T., Fukuda N., Enomoto A., Ichihara M., Takahashi M.
Biochem. Biophys. Res. Commun. 366:226-232(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION, SUBCELLULAR LOCATION, DOMAIN, INTERACTION WITH TRIM28.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF067165 mRNA. Translation: AAD32449.1.
BT006853 mRNA. Translation: AAP35499.1.
AK314094 mRNA. Translation: BAG36789.1.
AC008969 Genomic DNA. No translation available.
AC010326 Genomic DNA. No translation available.
BC001438 mRNA. Translation: AAH01438.2.
RefSeqNP_005764.2. NM_005773.2.
XP_005258464.1. XM_005258407.1.
UniGeneHs.596242.

3D structure databases

ProteinModelPortalQ9Y2P7.
SMRQ9Y2P7. Positions 8-62, 99-626.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid115474. 2 interactions.

PTM databases

PhosphoSiteQ9Y2P7.

Polymorphism databases

DMDM254763378.

Proteomic databases

PaxDbQ9Y2P7.
PRIDEQ9Y2P7.

Protocols and materials databases

DNASU10172.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000282308; ENSP00000282308; ENSG00000152454. [Q9Y2P7-1]
GeneID10172.
KEGGhsa:10172.
UCSCuc002qqu.3. human. [Q9Y2P7-1]

Organism-specific databases

CTD10172.
GeneCardsGC19M058452.
HGNCHGNC:13049. ZNF256.
HPAHPA055390.
MIM606956. gene.
neXtProtNX_Q9Y2P7.
PharmGKBPA37627.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5048.
HOGENOMHOG000234617.
HOVERGENHBG018163.
InParanoidQ9Y2P7.
KOK09228.
OMAYDLLIHQ.
OrthoDBEOG7KSX7Q.
PhylomeDBQ9Y2P7.
TreeFamTF339848.

Enzyme and pathway databases

ReactomeREACT_71. Gene Expression.

Gene expression databases

ArrayExpressQ9Y2P7.
BgeeQ9Y2P7.
CleanExHS_ZNF256.
GenevestigatorQ9Y2P7.

Family and domain databases

Gene3D3.30.160.60. 14 hits.
InterProIPR001909. Krueppel-associated_box.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamPF01352. KRAB. 1 hit.
[Graphical view]
SMARTSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 15 hits.
[Graphical view]
SUPFAMSSF109640. SSF109640. 1 hit.
PROSITEPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 15 hits.
PS50157. ZINC_FINGER_C2H2_2. 15 hits.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi10172.
NextBio38516.
PROQ9Y2P7.
SOURCESearch...

Entry information

Entry nameZN256_HUMAN
AccessionPrimary (citable) accession number: Q9Y2P7
Secondary accession number(s): B2RA92, Q53Y85, Q9BV71
Entry history
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: July 28, 2009
Last modified: March 19, 2014
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM