Long-chain fatty acid transport protein 6

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Q9Y2P4 (S27A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 87. History...

Clusters with 100%, 90%, 50% identity |

Documents (5) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Long-chain fatty acid transport protein 6
Short name=FATP-6
Short name=Fatty acid transport protein 6

Alternative name(s):
Fatty-acid-coenzyme A ligase, very long-chain 2
Solute carrier family 27 member 6
Very long-chain acyl-CoA synthetase homolog 1
Short name=VLCSH1
Short name=hVLCS-H1

Gene names

Name:	SLC27A6
Synonyms:	ACSVL2, FACVL2, FATP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	619 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. Ref.1
Subcellular location	Membrane; Multi-pass membrane protein Potential. Cell membrane › sarcolemma By similarity. Note: In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36 By similarity. Ref.1
Tissue specificity	Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. Ref.1
Sequence similarities	Belongs to the ATP-dependent AMP-binding enzyme family.

Ontologies

Keywords
Biological process	Fatty acid metabolism Lipid metabolism Lipid transport Transport
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Ligand	Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	long-chain fatty acid transport Traceable author statement. Source: Reactome transmembrane transport Traceable author statement. Source: Reactome very long-chain fatty acid metabolic process Traceable author statement PubMed 10471116. Source: ProtInc
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Traceable author statement. Source: Reactome sarcolemma Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	long-chain fatty acid-CoA ligase activity Traceable author statement PubMed 10471116. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW very long-chain fatty acid-CoA ligase activity Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 619

619

Long-chain fatty acid transport protein 6

PRO_0000193216

Regions

Transmembrane

22 – 42

Helical; Potential

Transmembrane

119 – 139

Helical; Potential

Nucleotide binding

221 – 232

AMP Potential

Natural variations

Natural variant

L → V. Ref.5
Corresponds to variant rs2526247 [ dbSNP | Ensembl ].

VAR_048245

Experimental info

Sequence conflict

P → T in AAH41945. Ref.5

Sequence conflict

207

R → H in CAD97625. Ref.4

Sequence conflict

215

L → I in AAH41945. Ref.5

Sequence conflict

231

P → S in CAG33410. Ref.3

Sequence conflict

432

N → S in CAD97625. Ref.4

Sequence conflict

596

N → D in CAD97625. Ref.4

Sequence conflict

618

K → N in CAG33410. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q9Y2P4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 20264CE3FBB44FF5
Show »

FASTA

619

70,112

        10         20         30         40         50         60 
MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR GELVTVLDKF 

        70         80         90        100        110        120 
LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS SLKKGDTVAL LMSNEPDFVH 

       130        140        150        160        170        180 
VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA CGPRALVVGA DLLGTVEEIL PSLSENISVW 

       190        200        210        220        230        240 
GMKDSVPQGV ISLKEKLSTS PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ 

       250        260        270        280        290        300 
VLRGSAVLWA FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC 

       310        320        330        340        350        360 
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD RFGNIKVCEL 

       370        380        390        400        410        420 
YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF QKDEPMRNEQ GWCIHVKKGE 

       430        440        450        460        470        480 
PGLLISRVNA KNPFFGYAGP YKHTKDKLLC DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT 

       490        500        510        520        530        540 
GDTFRWKGEN VATTEVADVI GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK 

       550        560        570        580        590        600 
VYEQVVTFLP AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS 

       610 
YVLLTRELYD QIMLGEIKL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a heart-specific fatty acid transport protein." Gimeno R.E., Ortegon A.M., Patel S., Punreddy S., Ge P., Sun Y., Lodish H.F., Stahl A. J. Biol. Chem. 278:16039-16044(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]	"Human very long-chain acyl-CoA synthetase homolog 1." Steinberg S.J., Watkins P.A. Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-19. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF064254 mRNA. Translation: AAD29443.1. CR457129 mRNA. Translation: CAG33410.1. BX537383 mRNA. Translation: CAD97625.1. BC041945 mRNA. Translation: AAH41945.1.
IPI	IPI00470637.
RefSeq	NP_001017372.1. NM_001017372.1. NP_054750.1. NM_014031.3.
UniGene	Hs.49765.
3D structure databases
ProteinModelPortal	Q9Y2P4.
ModBase	Search...
Protein-protein interaction databases
MINT	MINT-1375094.
STRING	9606.ENSP00000262462.
PTM databases
PhosphoSite	Q9Y2P4.
Polymorphism databases
DMDM	74725713.
Proteomic databases
PaxDb	Q9Y2P4.
PeptideAtlas	Q9Y2P4.
PRIDE	Q9Y2P4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262462; ENSP00000262462; ENSG00000113396. ENST00000395266; ENSP00000378684; ENSG00000113396. ENST00000506176; ENSP00000421024; ENSG00000113396.
GeneID	28965.
KEGG	hsa:28965.
UCSC	uc003kuy.3. human.
Organism-specific databases
CTD	28965.
GeneCards	GC05P127873.
HGNC	HGNC:11000. SLC27A6.
HPA	HPA008987.
MIM	604196. gene.
neXtProt	NX_Q9Y2P4.
PharmGKB	PA35874.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG0318.
HOGENOM	HOG000044189.
HOVERGEN	HBG005642.
InParanoid	Q9Y2P4.
KO	K08749.
OMA	DKRSSRV.
OrthoDB	EOG4DZ1V3.
PhylomeDB	Q9Y2P4.
Enzyme and pathway databases
Reactome	REACT_15518. Transmembrane transport of small molecules.
Gene expression databases
ArrayExpress	Q9Y2P4.
Bgee	Q9Y2P4.
CleanEx	HS_SLC27A6.
Genevestigator	Q9Y2P4.
GermOnline	ENSG00000113396. Homo sapiens.
Family and domain databases
InterPro	IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view]
Pfam	PF00501. AMP-binding. 1 hit. [Graphical view]
PROSITE	PS00455. AMP_BINDING. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	28965.
NextBio	51813.
SOURCE	Search...

Entry information

Entry name

S27A6_HUMAN

Accession

Primary (citable) accession number: Q9Y2P4
Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 22, 2005
Last sequence update:	November 1, 1999
Last modified:	May 1, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents