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Protein

Long-chain fatty acid transport protein 6

Gene

SLC27A6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi221 – 23212AMPSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. long-chain fatty acid-CoA ligase activity Source: ProtInc
  2. nucleotide binding Source: UniProtKB-KW
  3. very long-chain fatty acid-CoA ligase activity Source: Ensembl

GO - Biological processi

  1. long-chain fatty acid metabolic process Source: GOC
  2. long-chain fatty acid transport Source: Reactome
  3. transmembrane transport Source: Reactome
  4. very long-chain fatty acid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_23892. Transport of fatty acids.

Protein family/group databases

TCDBi4.C.1.1.11. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 6
Short name:
FATP-6
Short name:
Fatty acid transport protein 6
Alternative name(s):
Fatty-acid-coenzyme A ligase, very long-chain 2
Solute carrier family 27 member 6
Very long-chain acyl-CoA synthetase homolog 1
Short name:
VLCSH1
Short name:
hVLCS-H1
Gene namesi
Name:SLC27A6
Synonyms:ACSVL2, FACVL2, FATP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:11000. SLC27A6.

Subcellular locationi

Membrane Curated; Multi-pass membrane protein Curated. Cell membranesarcolemma By similarity
Note: In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221HelicalSequence AnalysisAdd
BLAST
Transmembranei119 – 13921HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
  3. sarcolemma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Long-chain fatty acid transport protein 6PRO_0000193216Add
BLAST

Proteomic databases

PaxDbiQ9Y2P4.
PeptideAtlasiQ9Y2P4.
PRIDEiQ9Y2P4.

PTM databases

PhosphoSiteiQ9Y2P4.

Expressioni

Tissue specificityi

Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.1 Publication

Gene expression databases

BgeeiQ9Y2P4.
CleanExiHS_SLC27A6.
ExpressionAtlasiQ9Y2P4. baseline and differential.
GenevestigatoriQ9Y2P4.

Organism-specific databases

HPAiHPA008987.

Interactioni

Protein-protein interaction databases

BioGridi118790. 12 interactions.
MINTiMINT-1375094.
STRINGi9606.ENSP00000262462.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2P4.
SMRiQ9Y2P4. Positions 56-579.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiQ9Y2P4.
KOiK08749.
OMAiSSISFMN.
OrthoDBiEOG7W6WKB.
PhylomeDBiQ9Y2P4.
TreeFamiTF313430.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030309. FATP6.
[Graphical view]
PANTHERiPTHR24096:SF98. PTHR24096:SF98. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2P4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR
60 70 80 90 100
GELVTVLDKF LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS
110 120 130 140 150
SLKKGDTVAL LMSNEPDFVH VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA
160 170 180 190 200
CGPRALVVGA DLLGTVEEIL PSLSENISVW GMKDSVPQGV ISLKEKLSTS
210 220 230 240 250
PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ VLRGSAVLWA
260 270 280 290 300
FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC
310 320 330 340 350
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD
360 370 380 390 400
RFGNIKVCEL YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF
410 420 430 440 450
QKDEPMRNEQ GWCIHVKKGE PGLLISRVNA KNPFFGYAGP YKHTKDKLLC
460 470 480 490 500
DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT GDTFRWKGEN VATTEVADVI
510 520 530 540 550
GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK VYEQVVTFLP
560 570 580 590 600
AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS
610
YVLLTRELYD QIMLGEIKL
Length:619
Mass (Da):70,112
Last modified:November 1, 1999 - v1
Checksum:i20264CE3FBB44FF5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251P → T in AAH41945 (PubMed:15489334).Curated
Sequence conflicti207 – 2071R → H in CAD97625 (PubMed:17974005).Curated
Sequence conflicti215 – 2151L → I in AAH41945 (PubMed:15489334).Curated
Sequence conflicti231 – 2311P → S in CAG33410 (Ref. 3) Curated
Sequence conflicti432 – 4321N → S in CAD97625 (PubMed:17974005).Curated
Sequence conflicti596 – 5961N → D in CAD97625 (PubMed:17974005).Curated
Sequence conflicti618 – 6181K → N in CAG33410 (Ref. 3) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191L → V.1 Publication
Corresponds to variant rs2526247 [ dbSNP | Ensembl ].
VAR_048245

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064254 mRNA. Translation: AAD29443.1.
CR457129 mRNA. Translation: CAG33410.1.
BX537383 mRNA. Translation: CAD97625.1.
BC041945 mRNA. Translation: AAH41945.1.
CCDSiCCDS4145.1.
RefSeqiNP_001017372.1. NM_001017372.1.
NP_054750.1. NM_014031.3.
XP_005272024.1. XM_005271967.1.
XP_005272025.1. XM_005271968.2.
XP_005272026.1. XM_005271969.2.
XP_005272027.1. XM_005271970.2.
XP_005272028.1. XM_005271971.1.
UniGeneiHs.49765.

Genome annotation databases

EnsembliENST00000262462; ENSP00000262462; ENSG00000113396.
ENST00000395266; ENSP00000378684; ENSG00000113396.
ENST00000506176; ENSP00000421024; ENSG00000113396.
GeneIDi28965.
KEGGihsa:28965.
UCSCiuc003kuy.3. human.

Polymorphism databases

DMDMi74725713.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF064254 mRNA. Translation: AAD29443.1.
CR457129 mRNA. Translation: CAG33410.1.
BX537383 mRNA. Translation: CAD97625.1.
BC041945 mRNA. Translation: AAH41945.1.
CCDSiCCDS4145.1.
RefSeqiNP_001017372.1. NM_001017372.1.
NP_054750.1. NM_014031.3.
XP_005272024.1. XM_005271967.1.
XP_005272025.1. XM_005271968.2.
XP_005272026.1. XM_005271969.2.
XP_005272027.1. XM_005271970.2.
XP_005272028.1. XM_005271971.1.
UniGeneiHs.49765.

3D structure databases

ProteinModelPortaliQ9Y2P4.
SMRiQ9Y2P4. Positions 56-579.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi118790. 12 interactions.
MINTiMINT-1375094.
STRINGi9606.ENSP00000262462.

Protein family/group databases

TCDBi4.C.1.1.11. the proposed fatty acid transporter (fat) family.

PTM databases

PhosphoSiteiQ9Y2P4.

Polymorphism databases

DMDMi74725713.

Proteomic databases

PaxDbiQ9Y2P4.
PeptideAtlasiQ9Y2P4.
PRIDEiQ9Y2P4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262462; ENSP00000262462; ENSG00000113396.
ENST00000395266; ENSP00000378684; ENSG00000113396.
ENST00000506176; ENSP00000421024; ENSG00000113396.
GeneIDi28965.
KEGGihsa:28965.
UCSCiuc003kuy.3. human.

Organism-specific databases

CTDi28965.
GeneCardsiGC05P127873.
HGNCiHGNC:11000. SLC27A6.
HPAiHPA008987.
MIMi604196. gene.
neXtProtiNX_Q9Y2P4.
PharmGKBiPA35874.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0318.
GeneTreeiENSGT00550000074420.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiQ9Y2P4.
KOiK08749.
OMAiSSISFMN.
OrthoDBiEOG7W6WKB.
PhylomeDBiQ9Y2P4.
TreeFamiTF313430.

Enzyme and pathway databases

ReactomeiREACT_23892. Transport of fatty acids.

Miscellaneous databases

ChiTaRSiSLC27A6. human.
GeneWikiiSLC27A6.
GenomeRNAii28965.
NextBioi51813.
PROiQ9Y2P4.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2P4.
CleanExiHS_SLC27A6.
ExpressionAtlasiQ9Y2P4. baseline and differential.
GenevestigatoriQ9Y2P4.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
IPR030309. FATP6.
[Graphical view]
PANTHERiPTHR24096:SF98. PTHR24096:SF98. 1 hit.
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a heart-specific fatty acid transport protein."
    Gimeno R.E., Ortegon A.M., Patel S., Punreddy S., Ge P., Sun Y., Lodish H.F., Stahl A.
    J. Biol. Chem. 278:16039-16044(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Human very long-chain acyl-CoA synthetase homolog 1."
    Steinberg S.J., Watkins P.A.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-19.
    Tissue: Brain.

Entry informationi

Entry nameiS27A6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2P4
Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1999
Last modified: January 7, 2015
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.