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Q9Y2P4

- S27A6_HUMAN

UniProt

Q9Y2P4 - S27A6_HUMAN

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Protein

Long-chain fatty acid transport protein 6

Gene
SLC27A6, ACSVL2, FACVL2, FATP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi221 – 23212AMP Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. long-chain fatty acid-CoA ligase activity Source: ProtInc
  2. nucleotide binding Source: UniProtKB-KW
  3. very long-chain fatty acid-CoA ligase activity Source: Ensembl

GO - Biological processi

  1. long-chain fatty acid metabolic process Source: GOC
  2. long-chain fatty acid transport Source: Reactome
  3. transmembrane transport Source: Reactome
  4. very long-chain fatty acid metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

Keywords - Ligandi

Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_23892. Transport of fatty acids.

Protein family/group databases

TCDBi4.C.1.1.11. the proposed fatty acid transporter (fat) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Long-chain fatty acid transport protein 6
Short name:
FATP-6
Short name:
Fatty acid transport protein 6
Alternative name(s):
Fatty-acid-coenzyme A ligase, very long-chain 2
Solute carrier family 27 member 6
Very long-chain acyl-CoA synthetase homolog 1
Short name:
VLCSH1
Short name:
hVLCS-H1
Gene namesi
Name:SLC27A6
Synonyms:ACSVL2, FACVL2, FATP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 5

Organism-specific databases

HGNCiHGNC:11000. SLC27A6.

Subcellular locationi

Membrane; Multi-pass membrane protein Reviewed prediction. Cell membranesarcolemma By similarity
Note: In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36 By similarity.1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei22 – 4221Helical; Reviewed predictionAdd
BLAST
Transmembranei119 – 13921Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
  3. sarcolemma Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA35874.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 619619Long-chain fatty acid transport protein 6PRO_0000193216Add
BLAST

Proteomic databases

PaxDbiQ9Y2P4.
PeptideAtlasiQ9Y2P4.
PRIDEiQ9Y2P4.

PTM databases

PhosphoSiteiQ9Y2P4.

Expressioni

Tissue specificityi

Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.1 Publication

Gene expression databases

ArrayExpressiQ9Y2P4.
BgeeiQ9Y2P4.
CleanExiHS_SLC27A6.
GenevestigatoriQ9Y2P4.

Organism-specific databases

HPAiHPA008987.

Interactioni

Protein-protein interaction databases

BioGridi118790. 7 interactions.
MINTiMINT-1375094.
STRINGi9606.ENSP00000262462.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2P4.
SMRiQ9Y2P4. Positions 56-579.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0318.
HOGENOMiHOG000044189.
HOVERGENiHBG005642.
InParanoidiQ9Y2P4.
KOiK08749.
OMAiRELYDQI.
OrthoDBiEOG7W6WKB.
PhylomeDBiQ9Y2P4.
TreeFamiTF313430.

Family and domain databases

InterProiIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2P4-1 [UniParc]FASTAAdd to Basket

« Hide

MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR    50
GELVTVLDKF LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS 100
SLKKGDTVAL LMSNEPDFVH VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA 150
CGPRALVVGA DLLGTVEEIL PSLSENISVW GMKDSVPQGV ISLKEKLSTS 200
PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ VLRGSAVLWA 250
FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC 300
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD 350
RFGNIKVCEL YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF 400
QKDEPMRNEQ GWCIHVKKGE PGLLISRVNA KNPFFGYAGP YKHTKDKLLC 450
DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT GDTFRWKGEN VATTEVADVI 500
GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK VYEQVVTFLP 550
AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS 600
YVLLTRELYD QIMLGEIKL 619
Length:619
Mass (Da):70,112
Last modified:November 1, 1999 - v1
Checksum:i20264CE3FBB44FF5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191L → V.1 Publication
Corresponds to variant rs2526247 [ dbSNP | Ensembl ].
VAR_048245

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti25 – 251P → T in AAH41945. 1 Publication
Sequence conflicti207 – 2071R → H in CAD97625. 1 Publication
Sequence conflicti215 – 2151L → I in AAH41945. 1 Publication
Sequence conflicti231 – 2311P → S in CAG33410. 1 Publication
Sequence conflicti432 – 4321N → S in CAD97625. 1 Publication
Sequence conflicti596 – 5961N → D in CAD97625. 1 Publication
Sequence conflicti618 – 6181K → N in CAG33410. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064254 mRNA. Translation: AAD29443.1.
CR457129 mRNA. Translation: CAG33410.1.
BX537383 mRNA. Translation: CAD97625.1.
BC041945 mRNA. Translation: AAH41945.1.
CCDSiCCDS4145.1.
RefSeqiNP_001017372.1. NM_001017372.1.
NP_054750.1. NM_014031.3.
XP_005272024.1. XM_005271967.1.
XP_005272025.1. XM_005271968.2.
XP_005272026.1. XM_005271969.2.
XP_005272027.1. XM_005271970.2.
XP_005272028.1. XM_005271971.1.
UniGeneiHs.49765.

Genome annotation databases

EnsembliENST00000262462; ENSP00000262462; ENSG00000113396.
ENST00000395266; ENSP00000378684; ENSG00000113396.
ENST00000506176; ENSP00000421024; ENSG00000113396.
GeneIDi28965.
KEGGihsa:28965.
UCSCiuc003kuy.3. human.

Polymorphism databases

DMDMi74725713.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF064254 mRNA. Translation: AAD29443.1 .
CR457129 mRNA. Translation: CAG33410.1 .
BX537383 mRNA. Translation: CAD97625.1 .
BC041945 mRNA. Translation: AAH41945.1 .
CCDSi CCDS4145.1.
RefSeqi NP_001017372.1. NM_001017372.1.
NP_054750.1. NM_014031.3.
XP_005272024.1. XM_005271967.1.
XP_005272025.1. XM_005271968.2.
XP_005272026.1. XM_005271969.2.
XP_005272027.1. XM_005271970.2.
XP_005272028.1. XM_005271971.1.
UniGenei Hs.49765.

3D structure databases

ProteinModelPortali Q9Y2P4.
SMRi Q9Y2P4. Positions 56-579.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 118790. 7 interactions.
MINTi MINT-1375094.
STRINGi 9606.ENSP00000262462.

Protein family/group databases

TCDBi 4.C.1.1.11. the proposed fatty acid transporter (fat) family.

PTM databases

PhosphoSitei Q9Y2P4.

Polymorphism databases

DMDMi 74725713.

Proteomic databases

PaxDbi Q9Y2P4.
PeptideAtlasi Q9Y2P4.
PRIDEi Q9Y2P4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000262462 ; ENSP00000262462 ; ENSG00000113396 .
ENST00000395266 ; ENSP00000378684 ; ENSG00000113396 .
ENST00000506176 ; ENSP00000421024 ; ENSG00000113396 .
GeneIDi 28965.
KEGGi hsa:28965.
UCSCi uc003kuy.3. human.

Organism-specific databases

CTDi 28965.
GeneCardsi GC05P127873.
HGNCi HGNC:11000. SLC27A6.
HPAi HPA008987.
MIMi 604196. gene.
neXtProti NX_Q9Y2P4.
PharmGKBi PA35874.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0318.
HOGENOMi HOG000044189.
HOVERGENi HBG005642.
InParanoidi Q9Y2P4.
KOi K08749.
OMAi RELYDQI.
OrthoDBi EOG7W6WKB.
PhylomeDBi Q9Y2P4.
TreeFami TF313430.

Enzyme and pathway databases

Reactomei REACT_23892. Transport of fatty acids.

Miscellaneous databases

GeneWikii SLC27A6.
GenomeRNAii 28965.
NextBioi 51813.
PROi Q9Y2P4.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q9Y2P4.
Bgeei Q9Y2P4.
CleanExi HS_SLC27A6.
Genevestigatori Q9Y2P4.

Family and domain databases

InterProi IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a heart-specific fatty acid transport protein."
    Gimeno R.E., Ortegon A.M., Patel S., Punreddy S., Ge P., Sun Y., Lodish H.F., Stahl A.
    J. Biol. Chem. 278:16039-16044(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  2. "Human very long-chain acyl-CoA synthetase homolog 1."
    Steinberg S.J., Watkins P.A.
    Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-19.
    Tissue: Brain.

Entry informationi

Entry nameiS27A6_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2P4
Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1999
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi