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Q9Y2P4

- S27A6_HUMAN

UniProt

Q9Y2P4 - S27A6_HUMAN

Protein

Long-chain fatty acid transport protein 6

Gene

SLC27A6

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 1 (01 Nov 1999)
      Previous versions | rss
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    Functioni

    Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi221 – 23212AMPSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. long-chain fatty acid-CoA ligase activity Source: ProtInc
    2. nucleotide binding Source: UniProtKB-KW
    3. very long-chain fatty acid-CoA ligase activity Source: Ensembl

    GO - Biological processi

    1. long-chain fatty acid metabolic process Source: GOC
    2. long-chain fatty acid transport Source: Reactome
    3. transmembrane transport Source: Reactome
    4. very long-chain fatty acid metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    Fatty acid metabolism, Lipid metabolism, Lipid transport, Transport

    Keywords - Ligandi

    Nucleotide-binding

    Enzyme and pathway databases

    ReactomeiREACT_23892. Transport of fatty acids.

    Protein family/group databases

    TCDBi4.C.1.1.11. the proposed fatty acid transporter (fat) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Long-chain fatty acid transport protein 6
    Short name:
    FATP-6
    Short name:
    Fatty acid transport protein 6
    Alternative name(s):
    Fatty-acid-coenzyme A ligase, very long-chain 2
    Solute carrier family 27 member 6
    Very long-chain acyl-CoA synthetase homolog 1
    Short name:
    VLCSH1
    Short name:
    hVLCS-H1
    Gene namesi
    Name:SLC27A6
    Synonyms:ACSVL2, FACVL2, FATP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 5

    Organism-specific databases

    HGNCiHGNC:11000. SLC27A6.

    Subcellular locationi

    Membrane Curated; Multi-pass membrane protein Curated. Cell membranesarcolemma By similarity
    Note: In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36.By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome
    3. sarcolemma Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA35874.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 619619Long-chain fatty acid transport protein 6PRO_0000193216Add
    BLAST

    Proteomic databases

    PaxDbiQ9Y2P4.
    PeptideAtlasiQ9Y2P4.
    PRIDEiQ9Y2P4.

    PTM databases

    PhosphoSiteiQ9Y2P4.

    Expressioni

    Tissue specificityi

    Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus.1 Publication

    Gene expression databases

    ArrayExpressiQ9Y2P4.
    BgeeiQ9Y2P4.
    CleanExiHS_SLC27A6.
    GenevestigatoriQ9Y2P4.

    Organism-specific databases

    HPAiHPA008987.

    Interactioni

    Protein-protein interaction databases

    BioGridi118790. 7 interactions.
    MINTiMINT-1375094.
    STRINGi9606.ENSP00000262462.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9Y2P4.
    SMRiQ9Y2P4. Positions 56-579.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei22 – 4221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei119 – 13921HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0318.
    HOGENOMiHOG000044189.
    HOVERGENiHBG005642.
    InParanoidiQ9Y2P4.
    KOiK08749.
    OMAiRELYDQI.
    OrthoDBiEOG7W6WKB.
    PhylomeDBiQ9Y2P4.
    TreeFamiTF313430.

    Family and domain databases

    InterProiIPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view]
    PfamiPF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view]
    PROSITEiPS00455. AMP_BINDING. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9Y2P4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR    50
    GELVTVLDKF LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS 100
    SLKKGDTVAL LMSNEPDFVH VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA 150
    CGPRALVVGA DLLGTVEEIL PSLSENISVW GMKDSVPQGV ISLKEKLSTS 200
    PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ VLRGSAVLWA 250
    FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC 300
    KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD 350
    RFGNIKVCEL YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF 400
    QKDEPMRNEQ GWCIHVKKGE PGLLISRVNA KNPFFGYAGP YKHTKDKLLC 450
    DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT GDTFRWKGEN VATTEVADVI 500
    GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK VYEQVVTFLP 550
    AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS 600
    YVLLTRELYD QIMLGEIKL 619
    Length:619
    Mass (Da):70,112
    Last modified:November 1, 1999 - v1
    Checksum:i20264CE3FBB44FF5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti25 – 251P → T in AAH41945. (PubMed:15489334)Curated
    Sequence conflicti207 – 2071R → H in CAD97625. (PubMed:17974005)Curated
    Sequence conflicti215 – 2151L → I in AAH41945. (PubMed:15489334)Curated
    Sequence conflicti231 – 2311P → S in CAG33410. 1 PublicationCurated
    Sequence conflicti432 – 4321N → S in CAD97625. (PubMed:17974005)Curated
    Sequence conflicti596 – 5961N → D in CAD97625. (PubMed:17974005)Curated
    Sequence conflicti618 – 6181K → N in CAG33410. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti19 – 191L → V.1 Publication
    Corresponds to variant rs2526247 [ dbSNP | Ensembl ].
    VAR_048245

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064254 mRNA. Translation: AAD29443.1.
    CR457129 mRNA. Translation: CAG33410.1.
    BX537383 mRNA. Translation: CAD97625.1.
    BC041945 mRNA. Translation: AAH41945.1.
    CCDSiCCDS4145.1.
    RefSeqiNP_001017372.1. NM_001017372.1.
    NP_054750.1. NM_014031.3.
    XP_005272024.1. XM_005271967.1.
    XP_005272025.1. XM_005271968.2.
    XP_005272026.1. XM_005271969.2.
    XP_005272027.1. XM_005271970.2.
    XP_005272028.1. XM_005271971.1.
    UniGeneiHs.49765.

    Genome annotation databases

    EnsembliENST00000262462; ENSP00000262462; ENSG00000113396.
    ENST00000395266; ENSP00000378684; ENSG00000113396.
    ENST00000506176; ENSP00000421024; ENSG00000113396.
    GeneIDi28965.
    KEGGihsa:28965.
    UCSCiuc003kuy.3. human.

    Polymorphism databases

    DMDMi74725713.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF064254 mRNA. Translation: AAD29443.1 .
    CR457129 mRNA. Translation: CAG33410.1 .
    BX537383 mRNA. Translation: CAD97625.1 .
    BC041945 mRNA. Translation: AAH41945.1 .
    CCDSi CCDS4145.1.
    RefSeqi NP_001017372.1. NM_001017372.1.
    NP_054750.1. NM_014031.3.
    XP_005272024.1. XM_005271967.1.
    XP_005272025.1. XM_005271968.2.
    XP_005272026.1. XM_005271969.2.
    XP_005272027.1. XM_005271970.2.
    XP_005272028.1. XM_005271971.1.
    UniGenei Hs.49765.

    3D structure databases

    ProteinModelPortali Q9Y2P4.
    SMRi Q9Y2P4. Positions 56-579.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 118790. 7 interactions.
    MINTi MINT-1375094.
    STRINGi 9606.ENSP00000262462.

    Protein family/group databases

    TCDBi 4.C.1.1.11. the proposed fatty acid transporter (fat) family.

    PTM databases

    PhosphoSitei Q9Y2P4.

    Polymorphism databases

    DMDMi 74725713.

    Proteomic databases

    PaxDbi Q9Y2P4.
    PeptideAtlasi Q9Y2P4.
    PRIDEi Q9Y2P4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000262462 ; ENSP00000262462 ; ENSG00000113396 .
    ENST00000395266 ; ENSP00000378684 ; ENSG00000113396 .
    ENST00000506176 ; ENSP00000421024 ; ENSG00000113396 .
    GeneIDi 28965.
    KEGGi hsa:28965.
    UCSCi uc003kuy.3. human.

    Organism-specific databases

    CTDi 28965.
    GeneCardsi GC05P127873.
    HGNCi HGNC:11000. SLC27A6.
    HPAi HPA008987.
    MIMi 604196. gene.
    neXtProti NX_Q9Y2P4.
    PharmGKBi PA35874.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0318.
    HOGENOMi HOG000044189.
    HOVERGENi HBG005642.
    InParanoidi Q9Y2P4.
    KOi K08749.
    OMAi RELYDQI.
    OrthoDBi EOG7W6WKB.
    PhylomeDBi Q9Y2P4.
    TreeFami TF313430.

    Enzyme and pathway databases

    Reactomei REACT_23892. Transport of fatty acids.

    Miscellaneous databases

    GeneWikii SLC27A6.
    GenomeRNAii 28965.
    NextBioi 51813.
    PROi Q9Y2P4.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q9Y2P4.
    Bgeei Q9Y2P4.
    CleanExi HS_SLC27A6.
    Genevestigatori Q9Y2P4.

    Family and domain databases

    InterProi IPR025110. AMP-bd_C.
    IPR020845. AMP-binding_CS.
    IPR000873. AMP-dep_Synth/Lig.
    [Graphical view ]
    Pfami PF00501. AMP-binding. 1 hit.
    PF13193. AMP-binding_C. 1 hit.
    [Graphical view ]
    PROSITEi PS00455. AMP_BINDING. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a heart-specific fatty acid transport protein."
      Gimeno R.E., Ortegon A.M., Patel S., Punreddy S., Ge P., Sun Y., Lodish H.F., Stahl A.
      J. Biol. Chem. 278:16039-16044(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    2. "Human very long-chain acyl-CoA synthetase homolog 1."
      Steinberg S.J., Watkins P.A.
      Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-19.
      Tissue: Brain.

    Entry informationi

    Entry nameiS27A6_HUMAN
    AccessioniPrimary (citable) accession number: Q9Y2P4
    Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: November 1, 1999
    Last modified: October 1, 2014
    This is version 99 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3