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Q9Y2P4 (S27A6_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Long-chain fatty acid transport protein 6

Short name=FATP-6
Short name=Fatty acid transport protein 6
Alternative name(s):
Fatty-acid-coenzyme A ligase, very long-chain 2
Solute carrier family 27 member 6
Very long-chain acyl-CoA synthetase homolog 1
Short name=VLCSH1
Short name=hVLCS-H1
Gene names
Name:SLC27A6
Synonyms:ACSVL2, FACVL2, FATP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length619 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. Thought to function as the predominant fatty acid protein transporter in heart. Ref.1

Subcellular location

Membrane; Multi-pass membrane protein Potential. Cell membranesarcolemma By similarity. Note: In heart is exclusively located on the sarcolemma in areas juxtaposed with small blood vessels where it colocalizes CD36 By similarity. Ref.1

Tissue specificity

Strongly expressed in heart and localizes to cardiac myocytes. Expressed at moderate levels in placenta, testis, and adrenal glands. Expressed at very low levels in kidney, bladder and uterus. Ref.1

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 619619Long-chain fatty acid transport protein 6
PRO_0000193216

Regions

Transmembrane22 – 4221Helical; Potential
Transmembrane119 – 13921Helical; Potential
Nucleotide binding221 – 23212AMP Potential

Natural variations

Natural variant191L → V. Ref.5
Corresponds to variant rs2526247 [ dbSNP | Ensembl ].
VAR_048245

Experimental info

Sequence conflict251P → T in AAH41945. Ref.5
Sequence conflict2071R → H in CAD97625. Ref.4
Sequence conflict2151L → I in AAH41945. Ref.5
Sequence conflict2311P → S in CAG33410. Ref.3
Sequence conflict4321N → S in CAD97625. Ref.4
Sequence conflict5961N → D in CAD97625. Ref.4
Sequence conflict6181K → N in CAG33410. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9Y2P4 [UniParc].

Last modified November 1, 1999. Version 1.
Checksum: 20264CE3FBB44FF5

FASTA61970,112
        10         20         30         40         50         60 
MLLSWLTVLG AGMVVLHFLQ KLLFPYFWDD FWFVLKVVLI IIRLKKYEKR GELVTVLDKF 

        70         80         90        100        110        120 
LSHAKRQPRK PFIIYEGDIY TYQDVDKRSS RVAHVFLNHS SLKKGDTVAL LMSNEPDFVH 

       130        140        150        160        170        180 
VWFGLAKLGC VVAFLNTNIR SNSLLNCIRA CGPRALVVGA DLLGTVEEIL PSLSENISVW 

       190        200        210        220        230        240 
GMKDSVPQGV ISLKEKLSTS PDEPVPRSHH VVSLLKSTCL YIFTSGTTGL PKAAVISQLQ 

       250        260        270        280        290        300 
VLRGSAVLWA FGCTAHDIVY ITLPLYHSSA AILGISGCVE LGATCVLKKK FSASQFWSDC 

       310        320        330        340        350        360 
KKYDVTVFQY IGELCRYLCK QSKREGEKDH KVRLAIGNGI RSDVWREFLD RFGNIKVCEL 

       370        380        390        400        410        420 
YAATESSISF MNYTGRIGAI GRTNLFYKLL STFDLIKYDF QKDEPMRNEQ GWCIHVKKGE 

       430        440        450        460        470        480 
PGLLISRVNA KNPFFGYAGP YKHTKDKLLC DVFKKGDVYL NTGDLIVQDQ DNFLYFWDRT 

       490        500        510        520        530        540 
GDTFRWKGEN VATTEVADVI GMLDFIQEAN VYGVAISGYE GRAGMASIIL KPNTSLDLEK 

       550        560        570        580        590        600 
VYEQVVTFLP AYACPRFLRI QEKMEATGTF KLLKHQLVED GFNPLKISEP LYFMDNLKKS 

       610 
YVLLTRELYD QIMLGEIKL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of a heart-specific fatty acid transport protein."
Gimeno R.E., Ortegon A.M., Patel S., Punreddy S., Ge P., Sun Y., Lodish H.F., Stahl A.
J. Biol. Chem. 278:16039-16044(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[2]"Human very long-chain acyl-CoA synthetase homolog 1."
Steinberg S.J., Watkins P.A.
Submitted (MAY-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT VAL-19.
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF064254 mRNA. Translation: AAD29443.1.
CR457129 mRNA. Translation: CAG33410.1.
BX537383 mRNA. Translation: CAD97625.1.
BC041945 mRNA. Translation: AAH41945.1.
RefSeqNP_001017372.1. NM_001017372.1.
NP_054750.1. NM_014031.3.
XP_005272024.1. XM_005271967.1.
XP_005272025.1. XM_005271968.2.
XP_005272026.1. XM_005271969.2.
XP_005272027.1. XM_005271970.2.
XP_005272028.1. XM_005271971.1.
UniGeneHs.49765.

3D structure databases

ProteinModelPortalQ9Y2P4.
SMRQ9Y2P4. Positions 56-579.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid118790. 7 interactions.
MINTMINT-1375094.
STRING9606.ENSP00000262462.

Protein family/group databases

TCDB4.C.1.1.11. the proposed fatty acid transporter (fat) family.

PTM databases

PhosphoSiteQ9Y2P4.

Polymorphism databases

DMDM74725713.

Proteomic databases

PaxDbQ9Y2P4.
PeptideAtlasQ9Y2P4.
PRIDEQ9Y2P4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000262462; ENSP00000262462; ENSG00000113396.
ENST00000395266; ENSP00000378684; ENSG00000113396.
ENST00000506176; ENSP00000421024; ENSG00000113396.
GeneID28965.
KEGGhsa:28965.
UCSCuc003kuy.3. human.

Organism-specific databases

CTD28965.
GeneCardsGC05P127873.
HGNCHGNC:11000. SLC27A6.
HPAHPA008987.
MIM604196. gene.
neXtProtNX_Q9Y2P4.
PharmGKBPA35874.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG0318.
HOGENOMHOG000044189.
HOVERGENHBG005642.
InParanoidQ9Y2P4.
KOK08749.
OMASDCKKYD.
OrthoDBEOG7W6WKB.
PhylomeDBQ9Y2P4.
TreeFamTF313430.

Enzyme and pathway databases

ReactomeREACT_15518. Transmembrane transport of small molecules.

Gene expression databases

ArrayExpressQ9Y2P4.
BgeeQ9Y2P4.
CleanExHS_SLC27A6.
GenevestigatorQ9Y2P4.

Family and domain databases

InterProIPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSLC27A6.
GenomeRNAi28965.
NextBio51813.
PROQ9Y2P4.
SOURCESearch...

Entry information

Entry nameS27A6_HUMAN
AccessionPrimary (citable) accession number: Q9Y2P4
Secondary accession number(s): Q6IAM5, Q7Z6E6, Q86YF6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: November 1, 1999
Last modified: April 16, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM