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Protein

Zinc finger protein 835

Gene

ZNF835

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160597-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 835
Gene namesi
Name:ZNF835
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:34332. ZNF835.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000127903.
PharmGKBiPA162410787.

Polymorphism and mutation databases

BioMutaiZNF835.
DMDMi403314387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003191111 – 537Zinc finger protein 835Add BLAST537

Proteomic databases

PaxDbiQ9Y2P0.
PeptideAtlasiQ9Y2P0.
PRIDEiQ9Y2P0.

PTM databases

iPTMnetiQ9Y2P0.
PhosphoSitePlusiQ9Y2P0.

Expressioni

Gene expression databases

BgeeiENSG00000127903.
CleanExiHS_ZNF835.
ExpressionAtlasiQ9Y2P0. baseline and differential.
GenevisibleiQ9Y2P0. HS.

Organism-specific databases

HPAiHPA051136.

Interactioni

Protein-protein interaction databases

IntActiQ9Y2P0. 1 interactor.
STRINGi9606.ENSP00000444747.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2P0.
SMRiQ9Y2P0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 14 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri110 – 132C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri138 – 160C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri166 – 188C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri194 – 216C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri222 – 244C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri250 – 272C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri278 – 300C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri306 – 328C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri334 – 356C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri362 – 384C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri390 – 412C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri418 – 440C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri446 – 468C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri474 – 496C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y2P0.
OMAiQESCPEP.
OrthoDBiEOG091G02KC.
TreeFamiTF341817.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2P0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGLLSVALQ GAELEGNWKH EGQVEDLQEN QESCPEPEAV ACKGDPAGDS
60 70 80 90 100
MQERDEFSRI PRTISSPAAT QASVPDDSSS RRCSAPGESP KERHPDSRQR
110 120 130 140 150
ERGGGPKKPW KCGDCGKAFS YCSAFILHQR IHTGEKPFAC PECGKAFSQS
160 170 180 190 200
VHLTLHQRTH TGEKPYACHE CGKAFSQGSY LASHWRTHTG EKPHRCADCG
210 220 230 240 250
KAFTRVTHLT QHRRVHTGER PYACAQCAKA FRNRSSLIEH QRIHTGEKPY
260 270 280 290 300
ECSACAKAFR FSSALIRHQR IHTEEKPYRC GQCAKAFAQI AHLTQHRRVH
310 320 330 340 350
TGEKPYTCQD CGALFSQSAS LAEHRRIHTG EKPYACGQCA KAFTQVSHLT
360 370 380 390 400
QHQRTHTGER PYPCHDCGKR FSNRSHLLQH RLVHTGERPY RCLQCGAAFS
410 420 430 440 450
HVSSLIEHQK IHTGERPYKC GECGKAFSQG SSLALHQRTH TGERPYTCPE
460 470 480 490 500
CGKAFSNRSY LIQHHIVHTG EKPYECSGCG KAFSFSSALI RHQRTHADSS
510 520 530
GRLCPAPTPD STPGLSQGGE TCQQGCPGRN PRGPAED
Length:537
Mass (Da):59,631
Last modified:September 5, 2012 - v2
Checksum:i99746C9E4D456DAB
GO

Sequence cautioni

The sequence AAD23609 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti156H → R in BAH13066 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06197729E → K.1 PublicationCorresponds to variant rs12462469dbSNPEnsembl.1
Natural variantiVAR_06197888E → A.1 PublicationCorresponds to variant rs12460400dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023017 mRNA. No translation available.
AK299565 mRNA. Translation: BAH13066.1.
AC007228 Genomic DNA. Translation: AAD23609.1. Sequence problems.
CH471135 Genomic DNA. Translation: EAW72470.1.
CCDSiCCDS56105.1.
RefSeqiNP_001005850.2. NM_001005850.2.
XP_005259439.1. XM_005259382.2.
XP_005259440.1. XM_005259383.3.
UniGeneiHs.458438.

Genome annotation databases

EnsembliENST00000537055; ENSP00000444747; ENSG00000127903.
GeneIDi90485.
KEGGihsa:90485.
UCSCiuc010ygn.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK023017 mRNA. No translation available.
AK299565 mRNA. Translation: BAH13066.1.
AC007228 Genomic DNA. Translation: AAD23609.1. Sequence problems.
CH471135 Genomic DNA. Translation: EAW72470.1.
CCDSiCCDS56105.1.
RefSeqiNP_001005850.2. NM_001005850.2.
XP_005259439.1. XM_005259382.2.
XP_005259440.1. XM_005259383.3.
UniGeneiHs.458438.

3D structure databases

ProteinModelPortaliQ9Y2P0.
SMRiQ9Y2P0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9Y2P0. 1 interactor.
STRINGi9606.ENSP00000444747.

PTM databases

iPTMnetiQ9Y2P0.
PhosphoSitePlusiQ9Y2P0.

Polymorphism and mutation databases

BioMutaiZNF835.
DMDMi403314387.

Proteomic databases

PaxDbiQ9Y2P0.
PeptideAtlasiQ9Y2P0.
PRIDEiQ9Y2P0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000537055; ENSP00000444747; ENSG00000127903.
GeneIDi90485.
KEGGihsa:90485.
UCSCiuc010ygn.3. human.

Organism-specific databases

CTDi90485.
GeneCardsiZNF835.
HGNCiHGNC:34332. ZNF835.
HPAiHPA051136.
neXtProtiNX_Q9Y2P0.
OpenTargetsiENSG00000127903.
PharmGKBiPA162410787.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00860000133674.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiQ9Y2P0.
OMAiQESCPEP.
OrthoDBiEOG091G02KC.
TreeFamiTF341817.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000160597-MONOMER.

Miscellaneous databases

GenomeRNAii90485.
PROiQ9Y2P0.

Gene expression databases

BgeeiENSG00000127903.
CleanExiHS_ZNF835.
ExpressionAtlasiQ9Y2P0. baseline and differential.
GenevisibleiQ9Y2P0. HS.

Family and domain databases

Gene3Di3.30.160.60. 14 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 14 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 14 hits.
PS50157. ZINC_FINGER_C2H2_2. 14 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZN835_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2P0
Secondary accession number(s): B7Z5Y0, G3V1S0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: September 5, 2012
Last modified: November 30, 2016
This is version 124 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.