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UniProtKB - Q9Y2N7 (HIF3A_HUMAN)

UniProt

Q9Y2N7 - HIF3A_HUMAN

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Protein

Hypoxia-inducible factor 3-alpha

Gene

HIF3A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator in adaptive response to low oxygen tension. Acts as a regulator of hypoxia-inducible gene expression (PubMed:11573933, PubMed:16126907, PubMed:19694616, PubMed:20416395, PubMed:21069422). Functions as an inhibitor of angiogenesis in hypoxic cells of the cornea. Plays a role in the development of the cardiorespiratory system. May also be involved in apoptosis (By similarity).By similarity5 Publications
Isoform 2: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation. Also inhibits hypoxia-inducible ARNT-mediated gene expression.1 Publication
Isoform 3: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.3 Publications
isoform 4: Attenuates the ability of transcription factor HIF1A and EPAS1/HIF2A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation (PubMed:16126907, PubMed:17998805, PubMed:19694616, PubMed:20416395). May act as a tumor suppressor and inhibits malignant cell transformation (PubMed:17998805).4 Publications
Isoform 5: Attenuates the ability of transcription factor HIF1A to bind to hypoxia-responsive elements (HRE) located within the enhancer/promoter of hypoxia-inducible target genes and hence inhibits HRE-driven transcriptional activation.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Angiogenesis, Apoptosis, Stress response, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-452723. Transcriptional regulation of pluripotent stem cells.

Names & Taxonomyi

Protein namesi
Recommended name:
Hypoxia-inducible factor 3-alpha1 Publication
Short name:
HIF-3-alpha1 Publication
Short name:
HIF3-alpha
Alternative name(s):
Basic-helix-loop-helix-PAS protein MOP7
Class E basic helix-loop-helix protein 17
Short name:
bHLHe17
HIF3-alpha-1
Inhibitory PAS domain protein
Short name:
IPAS
Member of PAS protein 7
PAS domain-containing protein 7
Gene namesi
Name:HIF3AImported
Synonyms:BHLHE17, MOP7, PASD7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:15825. HIF3A.

Subcellular locationi

  • Nucleus 2 Publications
  • Cytoplasm 1 Publication
  • Nucleus speckle By similarity
  • Mitochondrion By similarity

    • Note: In the nuclei of all periportal and perivenous hepatocytes. In the distal perivenous zone, detected in the cytoplasm of the hepatocytes. Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner. Colocalizes with BAD in the cytoplasm. Colocalizes with EPAS1 and HIF1A in the nucleus and speckles (By similarity). Localized in the cytoplasm and nuclei under normoxia, but increased in the nucleus under hypoxic conditions (PubMed:19694616). Colocalized with HIF1A in kidney tumors (PubMed:19694616).By similarity1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Mitochondrion, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi467 – 4671K → R: No loss of ubiquitination. Reduced ubiquitination; when associated with R-570. 1 Publication
Mutagenesisi492 – 4921P → A: Reduced hydroxylation activity. Reduced ubiquitination. 1 Publication
Mutagenesisi570 – 5701K → R: No loss of ubiquitination. Reduced ubiquitination; when associated with R-467. 1 Publication

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

PharmGKBiPA29285.

Polymorphism and mutation databases

BioMutaiHIF3A.
DMDMi145558932.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 669669Hypoxia-inducible factor 3-alphaPRO_0000284414Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki467 – 467Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei492 – 49214-hydroxyproline1 Publication
Cross-linki570 – 570Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Post-translational modificationi

In normoxia, hydroxylated on Pro-492 in the oxygen-dependent degradation domain (ODD) by prolyl hydroxylase(s) (PHD). The hydroxylated proline promotes interaction with VHL, initiating rapid ubiquitination and subsequent proteasomal degradation.1 Publication
Ubiquitinated; ubiquitination occurs in a VHL- and oxygen-dependent pathway and subsequently targeted for proteasomal degradation.1 Publication

Keywords - PTMi

Hydroxylation, Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiQ9Y2N7.
PeptideAtlasiQ9Y2N7.
PRIDEiQ9Y2N7.

PTM databases

iPTMnetiQ9Y2N7.
PhosphoSiteiQ9Y2N7.

Expressioni

Tissue specificityi

Expressed in vascular cells (at protein level) (PubMed:21069422). Expressed in kidney (PubMed:11573933, PubMed:19694616). Expressed in lung epithelial cells (PubMed:16775626). Expressed in endothelial cells (venous and arterial cells from umbilical cord and aortic endothelial cells) and in vascular smooth muscle cells (aorta) (PubMed:21069422). Strongly expressed in the heart, placenta, and skeletal muscle, whereas a weak expression profile was found in the lung, liver, and kidney (PubMed:12538644). Expressed weakly in cell renal cell carcinoma (CC-RCC) compared to normal renal cells (PubMed:16126907). Expression is down-regulated in numerous kidney tumor cells compared to non tumor kidney tissues (PubMed:16126907). Isoform 2 is expressed in heart, placenta, lung, liver, skeletal muscle and pancreas and in numerous cancer cell lines (PubMed:20416395). Isoform 3 and isoform 4 are weakly expressed in heart, placenta, lung, liver, skeletal muscle and pancreas (PubMed:20416395). Isoform 4 is expressed in fetal tissues, such as heart, brain, thymus, lung, liver, skeletal kidney and spleen (PubMed:20416395). Isoform 3 is weakly expressed in fetal tissues, such as liver and kidney (PubMed:20416395).7 Publications

Inductioni

Up-regulated by hypoxia (at protein level) (PubMed:16775626). Induced by hypoxia (PubMed:16775626). Isoform 2, isoform 3, isoform 4 and isoform 5 are up-regulated by hypoxia in a HIF1A- and EPAS1/HIF2A-dependent manner (PubMed:19694616, PubMed:20416395, PubMed:21069422). Isoform 4 is down-regulated by hypoxia and up-regulated upon restoring normoxia in embryonic kidney cells (PubMed:16126907).5 Publications

Gene expression databases

BgeeiENSG00000124440.
CleanExiHS_HIF3A.
ExpressionAtlasiQ9Y2N7. baseline and differential.
GenevisibleiQ9Y2N7. HS.

Organism-specific databases

HPAiHPA041141.

Interactioni

Subunit structurei

Isoform 2 interacts (via ODD domain) with VHL (via beta domain) (PubMed:12538644). Isoform 4 interacts with HIF1A; the interaction inhibits the binding of HIF1A to hypoxia-responsive element (HRE) and HIF1A/ARNT-dependent transcriptional activation (PubMed:16126907). Isoform 4 interacts with ARNT; the interaction occurs in a HIF1A- and DNA-binding-independent manner and does not induce HIF1A/ARNT-dependent transcriptional activation (PubMed:16126907). Isoform 4 interacts with EPAS1 (PubMed:17998805). Interacts with BAD, BCL2L2 and MCL1 (By similarity).By similarity3 Publications

Protein-protein interaction databases

BioGridi122143. 2 interactions.
STRINGi9606.ENSP00000366898.

Structurei

Secondary structure

1
669
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi241 – 2455Combined sources
Beta strandi250 – 2545Combined sources
Helixi258 – 2625Combined sources
Helixi266 – 2694Combined sources
Helixi274 – 2774Combined sources
Turni280 – 2823Combined sources
Helixi283 – 29614Combined sources
Beta strandi297 – 3004Combined sources
Beta strandi304 – 3074Combined sources
Beta strandi313 – 32311Combined sources
Helixi329 – 3313Combined sources
Beta strandi333 – 34210Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WN5X-ray1.15A/B237-347[»]
ProteinModelPortaliQ9Y2N7.
SMRiQ9Y2N7. Positions 9-357.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini14 – 6754bHLHPROSITE-ProRule annotationAdd
BLAST
Domaini82 – 15473PAS 1PROSITE-ProRule annotationAdd
BLAST
Domaini227 – 29771PAS 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni77 – 10024Nuclear localization signalBy similarityAdd
BLAST
Regioni230 – 27445Nuclear export signalBy similarityAdd
BLAST
Regioni452 – 581130ODDAdd
BLAST
Regioni454 – 50653NTADAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi414 – 4185LRRLL
Motifi490 – 4978LAPYISMD

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation
Contains 2 PAS (PER-ARNT-SIM) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234306.
HOVERGENiHBG060456.
InParanoidiQ9Y2N7.
KOiK09096.
OMAiPMAGARK.
OrthoDBiEOG091G0486.
PhylomeDBiQ9Y2N7.
TreeFamiTF317772.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR021537. HIF_alpha_subunit.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF11413. HIF-1. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]

Sequences (7)i

Sequence statusi: Complete.

This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basket

Note: Additional isoforms seem to exist.2 Publications
Isoform 1 (identifier: Q9Y2N7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALGLQRARS TTELRKEKSR DAARSRRSQE TEVLYQLAHT LPFARGVSAH 
        60         70         80         90        100
LDKASIMRLT ISYLRMHRLC AAGEWNQVGA GGEPLDACYL KALEGFVMVL 
       110        120        130        140        150
TAEGDMAYLS ENVSKHLGLS QLELIGHSIF DFIHPCDQEE LQDALTPQQT 
       160        170        180        190        200
LSRRKVEAPT ERCFSLRMKS TLTSRGRTLN LKAATWKVLN CSGHMRAYKP 
       210        220        230        240        250
PAQTSPAGSP DSEPPLQCLV LICEAIPHPG SLEPPLGRGA FLSRHSLDMK 
       260        270        280        290        300
FTYCDDRIAE VAGYSPDDLI GCSAYEYIHA LDSDAVSKSI HTLLSKGQAV 
       310        320        330        340        350
TGQYRFLARS GGYLWTQTQA TVVSGGRGPQ SESIVCVHFL ISQVEETGVV 
       360        370        380        390        400
LSLEQTEQHS RRPIQRGAPS QKDTPNPGDS LDTPGPRILA FLHPPSLSEA 
       410        420        430        440        450
ALAADPRRFC SPDLRRLLGP ILDGASVAAT PSTPLATRHP QSPLSADLPD 
       460        470        480        490        500
ELPVGTENVH RLFTSGKDTE AVETDLDIAQ DADALDLEML APYISMDDDF 
       510        520        530        540        550
QLNASEQLPR AYHRPLGAVP RPRARSFHGL SPPALEPSLL PRWGSDPRLS 
       560        570        580        590        600
CSSPSRGDPS ASSPMAGARK RTLAQSSEDE DEGVELLGVR PPKRSPSPEH 
       610        620        630        640        650
ENFLLFPLSL SFLLTGGPAP GSLQDPSTPL LNLNEPLGLG PSLLSPYSDE 
       660 
DTTQPGGPFQ PRAGSAQAD
Length:669
Mass (Da):72,433
Last modified:April 17, 2007 - v2
Checksum:i81C4C84517000DE2
GO
Isoform 2 (identifier: Q9Y2N7-2) [UniParc]FASTAAdd to basket
Also known as: HIF-3alpha11 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-8: MALGLQRA → MDWQDH

Show »
Length:667
Mass (Da):72,405
Checksum:i67B8794FF9DCCF4B
GO
Isoform 3 (identifier: Q9Y2N7-3) [UniParc]FASTAAdd to basket
Also known as: HIF-3alpha21 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     611-669: SFLLTGGPAP...QPRAGSAQAD → VCWGINGILWPSLPSWLKPTVL

Show »
Length:632
Mass (Da):68,964
Checksum:i9665B0AF3998F8EF
GO
Isoform 4 (identifier: Q9Y2N7-4) [UniParc]FASTAAdd to basket
Also known as: HIF-3alpha41 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     293-363: LLSKGQAVTG...EQTEQHSRRP → CMYPISPGAK...FSPHLPPWWP
     364-669: Missing.

Show »
Length:363
Mass (Da):39,962
Checksum:i66CE5B85A2C50A15
GO
Isoform 5 (identifier: Q9Y2N7-5) [UniParc]FASTAAdd to basket
Also known as: HIF-3alpha31 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-56: Missing.

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:613
Mass (Da):66,142
Checksum:i4F2122D0D17C55A6
GO
Isoform 6 (identifier: Q9Y2N7-6) [UniParc]FASTAAdd to basket
Also known as: HIF-3alpha61 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     1-86: Missing.
     87-137: ACYLKALEGF...SIFDFIHPCD → MRPAAGAARR...ATCACTASAP

Note: Incomplete sequence. No experimental confirmation available.
Show »
Length:583
Mass (Da):62,393
Checksum:i04D6B8408073EEB4
GO
Isoform 7 (identifier: Q9Y2N7-7) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-120: MALGLQRARS...ENVSKHLGLS → MRPAAGAARR...ATCACTASAP

Note: No experimental confirmation available.
Show »
Length:600
Mass (Da):64,359
Checksum:i822B55E0513AF129
GO

Sequence cautioni

The sequence AAL69947 differs from that shown.Intron retention.Curated
The sequence BAB13865 differs from that shown.Aberrant splicing site.Curated
The sequence BAB14824 differs from that shown.Unlikely isoform. Aberrant splice sites.Curated
The sequence BAB55324 differs from that shown.Intron retention.Curated
The sequence BAD93355 differs from that shown.Intron retention.Curated
The sequence BAG07185 differs from that shown.Intron retention.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti202 – 2021A → V in BAB55324 (PubMed:14702039).Curated
Sequence conflicti497 – 4971D → G in BAB55324 (PubMed:14702039).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti343 – 3431Q → R.1 Publication
Corresponds to variant rs3764609 [ dbSNP | Ensembl ].		VAR_031731
Natural varianti463 – 4631F → L.
Corresponds to variant rs7253301 [ dbSNP | Ensembl ].		VAR_031732

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 120120MALGL…HLGLS → MRPAAGAARRPRCCTSWLTR CPSPAASAPTWTRPLSCASP SATCACTASAP in isoform 7. 1 PublicationVSP_043429Add
BLAST
Alternative sequencei1 – 8686Missing in isoform 6. CuratedVSP_024518Add
BLAST
Alternative sequencei1 – 5656Missing in isoform 5. 1 PublicationVSP_024519Add
BLAST
Alternative sequencei1 – 88MALGLQRA → MDWQDH in isoform 2. 1 PublicationVSP_024520
Alternative sequencei87 – 13751ACYLK…IHPCD → MRPAAGAARRPRCCTSWLTR CPSPAASAPTWTRPLSCASP SATCACTASAP in isoform 6. CuratedVSP_024521Add
BLAST
Alternative sequencei293 – 36371LLSKG…HSRRP → CMYPISPGAKPAATWPPADT RTPQLPIPQDALPPHLNTSS LLPKPQGTVSFLAPSYPVPR SFSPHLPPWWP in isoform 4. 1 PublicationVSP_024523Add
BLAST
Alternative sequencei364 – 669306Missing in isoform 4. 1 PublicationVSP_024525Add
BLAST
Alternative sequencei611 – 66959SFLLT…SAQAD → VCWGINGILWPSLPSWLKPT VL in isoform 3. 3 PublicationsVSP_024526Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054067 mRNA. Translation: BAB69689.1.
AF463492 mRNA. Translation: AAL69947.1. Sequence problems.
AB118749 mRNA. Translation: BAD93355.1. Sequence problems.
AB295039 mRNA. Translation: BAG07185.1. Sequence problems.
AK021653 mRNA. Translation: BAB13865.1. Sequence problems.
AK024095 mRNA. Translation: BAB14824.1. Sequence problems.
AK027725 mRNA. Translation: BAB55324.1. Sequence problems.
AK297828 mRNA. Translation: BAG60164.1.
AC007193 Genomic DNA. Translation: AAD22668.1.
CH471126 Genomic DNA. Translation: EAW57410.1.
BC026308 mRNA. Translation: AAH26308.1.
BC080551 mRNA. Translation: AAH80551.1.
CCDSiCCDS12681.2. [Q9Y2N7-1]
CCDS12682.1. [Q9Y2N7-2]
CCDS42580.2. [Q9Y2N7-7]
PIRiJC7771.
RefSeqiNP_071907.4. NM_022462.4. [Q9Y2N7-7]
NP_690007.1. NM_152794.3. [Q9Y2N7-2]
NP_690008.2. NM_152795.3. [Q9Y2N7-1]
UniGeneiHs.420830.

Genome annotation databases

EnsembliENST00000244303; ENSP00000244303; ENSG00000124440. [Q9Y2N7-7]
ENST00000300862; ENSP00000300862; ENSG00000124440. [Q9Y2N7-2]
ENST00000377670; ENSP00000366898; ENSG00000124440. [Q9Y2N7-1]
GeneIDi64344.
KEGGihsa:64344.
UCSCiuc002peh.3. human. [Q9Y2N7-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Hypoxia inducible factor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054067 mRNA. Translation: BAB69689.1.
AF463492 mRNA. Translation: AAL69947.1. Sequence problems.
AB118749 mRNA. Translation: BAD93355.1. Sequence problems.
AB295039 mRNA. Translation: BAG07185.1. Sequence problems.
AK021653 mRNA. Translation: BAB13865.1. Sequence problems.
AK024095 mRNA. Translation: BAB14824.1. Sequence problems.
AK027725 mRNA. Translation: BAB55324.1. Sequence problems.
AK297828 mRNA. Translation: BAG60164.1.
AC007193 Genomic DNA. Translation: AAD22668.1.
CH471126 Genomic DNA. Translation: EAW57410.1.
BC026308 mRNA. Translation: AAH26308.1.
BC080551 mRNA. Translation: AAH80551.1.
CCDSiCCDS12681.2. [Q9Y2N7-1]
CCDS12682.1. [Q9Y2N7-2]
CCDS42580.2. [Q9Y2N7-7]
PIRiJC7771.
RefSeqiNP_071907.4. NM_022462.4. [Q9Y2N7-7]
NP_690007.1. NM_152794.3. [Q9Y2N7-2]
NP_690008.2. NM_152795.3. [Q9Y2N7-1]
UniGeneiHs.420830.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WN5X-ray1.15A/B237-347[»]
ProteinModelPortaliQ9Y2N7.
SMRiQ9Y2N7. Positions 9-357.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi122143. 2 interactions.
STRINGi9606.ENSP00000366898.

PTM databases

iPTMnetiQ9Y2N7.
PhosphoSiteiQ9Y2N7.

Polymorphism and mutation databases

BioMutaiHIF3A.
DMDMi145558932.

Proteomic databases

PaxDbiQ9Y2N7.
PeptideAtlasiQ9Y2N7.
PRIDEiQ9Y2N7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244303; ENSP00000244303; ENSG00000124440. [Q9Y2N7-7]
ENST00000300862; ENSP00000300862; ENSG00000124440. [Q9Y2N7-2]
ENST00000377670; ENSP00000366898; ENSG00000124440. [Q9Y2N7-1]
GeneIDi64344.
KEGGihsa:64344.
UCSCiuc002peh.3. human. [Q9Y2N7-1]

Organism-specific databases

CTDi64344.
GeneCardsiHIF3A.
HGNCiHGNC:15825. HIF3A.
HPAiHPA041141.
MIMi609976. gene.
neXtProtiNX_Q9Y2N7.
PharmGKBiPA29285.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3558. Eukaryota.
ENOG410YK57. LUCA.
GeneTreeiENSGT00760000118788.
HOGENOMiHOG000234306.
HOVERGENiHBG060456.
InParanoidiQ9Y2N7.
KOiK09096.
OMAiPMAGARK.
OrthoDBiEOG091G0486.
PhylomeDBiQ9Y2N7.
TreeFamiTF317772.

Enzyme and pathway databases

ReactomeiR-HSA-1234158. Regulation of gene expression by Hypoxia-inducible Factor.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-452723. Transcriptional regulation of pluripotent stem cells.

Miscellaneous databases

GenomeRNAii64344.
PROiQ9Y2N7.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124440.
CleanExiHS_HIF3A.
ExpressionAtlasiQ9Y2N7. baseline and differential.
GenevisibleiQ9Y2N7. HS.

Family and domain databases

InterProiIPR011598. bHLH_dom.
IPR021537. HIF_alpha_subunit.
IPR001610. PAC.
IPR000014. PAS.
IPR013767. PAS_fold.
[Graphical view]
PfamiPF11413. HIF-1. 1 hit.
PF00989. PAS. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
SM00086. PAC. 1 hit.
SM00091. PAS. 2 hits.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
SSF55785. SSF55785. 2 hits.
TIGRFAMsiTIGR00229. sensory_box. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
PS50112. PAS. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHIF3A_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2N7
Secondary accession number(s): B0M185
, B4DNA2, I6L988, Q58A43, Q66K72, Q8WXA1, Q96K34, Q9H7Z9, Q9HAI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: April 17, 2007
Last modified: September 7, 2016
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.