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Protein

Protein SSUH2 homolog

Gene

SSUH2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125046-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSUH2 homolog
Alternative name(s):
Protein ssu-2 homolog
Gene namesi
Name:SSUH2
Synonyms:C3orf32
ORF Names:FLS485
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:24809. SSUH2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi51066.
OpenTargetsiENSG00000125046.
PharmGKBiPA142672393.

Polymorphism and mutation databases

BioMutaiSSUH2.
DMDMi74721317.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600821 – 353Protein SSUH2 homologAdd BLAST353

Proteomic databases

PaxDbiQ9Y2M2.
PRIDEiQ9Y2M2.

PTM databases

iPTMnetiQ9Y2M2.
PhosphoSitePlusiQ9Y2M2.

Expressioni

Tissue specificityi

Expressed in enterocytes of small and large intestinal mucosa (at protein level). Expressed in enterocytes, chromaffine and interstitial cells.1 Publication

Inductioni

Induced during epithelial differentiation.1 Publication

Gene expression databases

BgeeiENSG00000125046.
CleanExiHS_C3orf32.
ExpressionAtlasiQ9Y2M2. baseline and differential.
GenevisibleiQ9Y2M2. HS.

Organism-specific databases

HPAiHPA049777.

Interactioni

Protein-protein interaction databases

BioGridi119257. 1 interactor.
IntActiQ9Y2M2. 3 interactors.
MINTiMINT-7945155.
STRINGi9606.ENSP00000324551.

Structurei

3D structure databases

ProteinModelPortaliQ9Y2M2.
SMRiQ9Y2M2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi155 – 218Cys-richAdd BLAST64

Phylogenomic databases

eggNOGiKOG2813. Eukaryota.
ENOG410XR3K. LUCA.
GeneTreeiENSGT00440000038003.
HOGENOMiHOG000111363.
HOVERGENiHBG081008.
InParanoidiQ9Y2M2.
OMAiSSKCCYG.
OrthoDBiEOG091G0K6A.
PhylomeDBiQ9Y2M2.
TreeFamiTF320855.

Family and domain databases

InterProiIPR033271. SSUH2.
[Graphical view]
PANTHERiPTHR15852:SF7. PTHR15852:SF7. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9Y2M2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSPVGLLRA LPLPWPQFLA CTLRRLAGPR ESTGPSQKPP PLCSVPCRVP
60 70 80 90 100
AMTEEVAREA LLSFVDSKCC YSSTVAGDLV IQELKRQTLC RYRLETFSES
110 120 130 140 150
RISEWTFQPF TNHSVDGPQR GASPRLWDIK VQGPPMFQED TRKFQVPHSS
160 170 180 190 200
LVKECHKCHG RGRYKCSGCH GAGTVRCPSC CGAKRKAKQS RRCQLCAGSG
210 220 230 240 250
RRRCSTCSGR GNKTCATCKG EKKLLHFIQL VIMWKNSLFE FVSEHRLNCP
260 270 280 290 300
RELLAKAKGE NLFKDENSVV YPIVDFPLRD ISLASQRGIA EHSAALASRA
310 320 330 340 350
RVLQQRQTIE LIPLTEVHYW YQGKTYVYYI YGTDHQVYAV DYPERYCCGC

TIV
Length:353
Mass (Da):39,845
Last modified:November 1, 1999 - v1
Checksum:iF6435E4541F4BBE3
GO
Isoform 2 (identifier: Q9Y2M2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-47: MPSPVGLLRA...KPPPLCSVPC → MDRDLNEDDS...QRSWPSFLEH

Note: No experimental confirmation available.
Show »
Length:375
Mass (Da):42,732
Checksum:iD5B84353A89786CC
GO

Sequence cautioni

The sequence AAH52614 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti221E → G in BAH13229 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03365929P → L.Corresponds to variant rs2276800dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0463551 – 47MPSPV…CSVPC → MDRDLNEDDSVVDLSFEAES PLAPPTELLERLPSYDWLLQ GGRGQIFFPPLEAPGRPQEQ RSWPSFLEH in isoform 2. 1 PublicationAdd BLAST47

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024705 mRNA. Translation: BAA76932.1.
AK093066 mRNA. Translation: BAG52646.1.
AK300175 mRNA. Translation: BAH13229.1.
AC034187 Genomic DNA. No translation available.
AC068312 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63941.1.
BC052614 mRNA. Translation: AAH52614.1. Different initiation.
CCDSiCCDS2568.1. [Q9Y2M2-1]
CCDS58815.1. [Q9Y2M2-2]
PIRiT44500.
RefSeqiNP_001243677.1. NM_001256748.1. [Q9Y2M2-2]
NP_001243678.1. NM_001256749.1.
NP_057015.1. NM_015931.2. [Q9Y2M2-1]
XP_016862027.1. XM_017006538.1. [Q9Y2M2-1]
XP_016862028.1. XM_017006539.1. [Q9Y2M2-1]
XP_016862029.1. XM_017006540.1. [Q9Y2M2-1]
XP_016862030.1. XM_017006541.1. [Q9Y2M2-1]
XP_016862031.1. XM_017006542.1. [Q9Y2M2-1]
UniGeneiHs.736935.
Hs.740735.

Genome annotation databases

EnsembliENST00000317371; ENSP00000324551; ENSG00000125046. [Q9Y2M2-1]
ENST00000341795; ENSP00000339150; ENSG00000125046. [Q9Y2M2-1]
ENST00000544814; ENSP00000439378; ENSG00000125046. [Q9Y2M2-2]
GeneIDi51066.
KEGGihsa:51066.
UCSCiuc003bqu.5. human. [Q9Y2M2-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024705 mRNA. Translation: BAA76932.1.
AK093066 mRNA. Translation: BAG52646.1.
AK300175 mRNA. Translation: BAH13229.1.
AC034187 Genomic DNA. No translation available.
AC068312 Genomic DNA. No translation available.
CH471055 Genomic DNA. Translation: EAW63941.1.
BC052614 mRNA. Translation: AAH52614.1. Different initiation.
CCDSiCCDS2568.1. [Q9Y2M2-1]
CCDS58815.1. [Q9Y2M2-2]
PIRiT44500.
RefSeqiNP_001243677.1. NM_001256748.1. [Q9Y2M2-2]
NP_001243678.1. NM_001256749.1.
NP_057015.1. NM_015931.2. [Q9Y2M2-1]
XP_016862027.1. XM_017006538.1. [Q9Y2M2-1]
XP_016862028.1. XM_017006539.1. [Q9Y2M2-1]
XP_016862029.1. XM_017006540.1. [Q9Y2M2-1]
XP_016862030.1. XM_017006541.1. [Q9Y2M2-1]
XP_016862031.1. XM_017006542.1. [Q9Y2M2-1]
UniGeneiHs.736935.
Hs.740735.

3D structure databases

ProteinModelPortaliQ9Y2M2.
SMRiQ9Y2M2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119257. 1 interactor.
IntActiQ9Y2M2. 3 interactors.
MINTiMINT-7945155.
STRINGi9606.ENSP00000324551.

PTM databases

iPTMnetiQ9Y2M2.
PhosphoSitePlusiQ9Y2M2.

Polymorphism and mutation databases

BioMutaiSSUH2.
DMDMi74721317.

Proteomic databases

PaxDbiQ9Y2M2.
PRIDEiQ9Y2M2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317371; ENSP00000324551; ENSG00000125046. [Q9Y2M2-1]
ENST00000341795; ENSP00000339150; ENSG00000125046. [Q9Y2M2-1]
ENST00000544814; ENSP00000439378; ENSG00000125046. [Q9Y2M2-2]
GeneIDi51066.
KEGGihsa:51066.
UCSCiuc003bqu.5. human. [Q9Y2M2-1]

Organism-specific databases

CTDi51066.
DisGeNETi51066.
GeneCardsiSSUH2.
HGNCiHGNC:24809. SSUH2.
HPAiHPA049777.
neXtProtiNX_Q9Y2M2.
OpenTargetsiENSG00000125046.
PharmGKBiPA142672393.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2813. Eukaryota.
ENOG410XR3K. LUCA.
GeneTreeiENSGT00440000038003.
HOGENOMiHOG000111363.
HOVERGENiHBG081008.
InParanoidiQ9Y2M2.
OMAiSSKCCYG.
OrthoDBiEOG091G0K6A.
PhylomeDBiQ9Y2M2.
TreeFamiTF320855.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000125046-MONOMER.

Miscellaneous databases

GenomeRNAii51066.
PROiQ9Y2M2.

Gene expression databases

BgeeiENSG00000125046.
CleanExiHS_C3orf32.
ExpressionAtlasiQ9Y2M2. baseline and differential.
GenevisibleiQ9Y2M2. HS.

Family and domain databases

InterProiIPR033271. SSUH2.
[Graphical view]
PANTHERiPTHR15852:SF7. PTHR15852:SF7. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiSSUH2_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2M2
Secondary accession number(s): A6NFA9
, B3KS84, B7Z6E3, F5H2S5, Q7Z7K4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 1, 1999
Last modified: November 30, 2016
This is version 108 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.