Reviewed, UniProtKB/Swiss-Prot Q9Y2M0 (MTMRF_HUMAN)

Names and origin

Protein names

Recommended name:
    Coiled-coil domain-containing protein MTMR15

Gene names

Name:	MTMR15
Synonyms:	KIAA1018

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1017 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Sequence similarities

Belongs to the MTMR15 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
Gene Ontology (GO)
None. [Check GOA]

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q9Y2M0-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q9Y2M0-2)

The sequence of this isoform differs from the canonical sequence as follows:
     527-533: AKALAGQ → FCWLLLQ
     534-1017: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1017	1017	Coiled-coil domain-containing protein MTMR15		PRO_0000311224
Regions
	Coiled coil	671 – 696	26	Potential
Natural variations
	Alternative sequence	527 – 533	7	AKALAGQ → FCWLLLQ in isoform 2.		VSP_029429
	Alternative sequence	534 – 1017	484	Missing in isoform 2.		VSP_029430
	Natural variant	233	1	G → E: dbSNP rs4779794.		VAR_037167
Experimental info
	Sequence conflict	9	1	D → DK in AAH47882. Ref.3
	Sequence conflict	487	1	V → A in BAA76862. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 13, 2007. Version 4. Checksum: 5E4E0A8A1A158F50	FASTA	1,017	114,225
	10 20 30 40 50 60 MMSEGKPPDK KRPRRSLSIS KNKKKASNSI ISCFNNAPPA KLACPVCSKM VPRYDLNRHL 70 80 90 100 110 120 DEMCANNDFV QVDPGQVGLI NSNVSMVDLT SVTLEDVTPK KSPPPKTNLT PGQSDSAKRE 130 140 150 160 170 180 VKQKISPYFK SNDVVCKNQD ELRNRSVKVI CLGSLASKLS RKYVKAKKSI DKDEEFAGSS 190 200 210 220 230 240 PQSSKSTVVK SLIDNSSEIE DEDQILENSS QKENVFKCDS LKEECIPEHM VRGSKIMEAE 250 260 270 280 290 300 SQKATRECEK SALTPGFSDN AIMLFSPDFT LRNTLKSTSE DSLVKQECIK EVVEKREACH 310 320 330 340 350 360 CEEVKMTVAS EAKIQLSDSE AKSHSSADDA SAWSNIQEAP LQDDSCLNND IPHSIPLEQG 370 380 390 400 410 420 SSCNGPGQTT GHPYYLRSFL VVLKTVLENE DDMLLFDEQE KGIVTKFYQL SATGQKLYVR 430 440 450 460 470 480 LFQRKLSWIK MTKLEYEEIA LDLTPVIEEL TNAGFLQTES ELQELSEVLE LLSAPELKSL 490 500 510 520 530 540 AKTFHLVNPN GQKQQLVDAF LKLAKQRSVC TWGKNKPGIG AVILKRAKAL AGQSVRICKG 550 560 570 580 590 600 PRAVFSRILL LFSLTDSMED EDAACGGQGQ LSTVLLVNLG RMEFPSYTIN RKTHIFQDRD 610 620 630 640 650 660 DLIRYAAATH MLSDISSAMA NGNWEEAKEL AQCAKRDWNR LKNHPSLRCH EDLPLFLRCF 670 680 690 700 710 720 TVGWIYTRIL SRFVEILQRL HMYEEAVREL ESLLSQRIYC PDSRGRWWDR LALNLHQHLK 730 740 750 760 770 780 RLEPTIKCIT EGLADPEVRT GHRLSLYQRA VRLRESPSCK KFKHLFQQLP EMAVQDVKHV 790 800 810 820 830 840 TITGRLCPQR GMCKSVFVME AGEAADPTTV LCSVEELALA HYRRSGFDQG IHGEGSTFST 850 860 870 880 890 900 LYGLLLWDII FMDGIPDVFR NACQAFPLDL CTDSFFTSRR PALEARLQLI HDAPEESLRA 910 920 930 940 950 960 WVAATWHEQE GRVASLVSWD RFTSLQQAQD LVSCLGGPVL SGVCRHLAAD FRHCRGGLPD 970 980 990 1000 1010 LVVWNSQSRH FKLVEVKGPN DRLSHKQMIW LAELQKLGAE VEVCHVVAVG AKSQSLS
	Isoform 2 [UniParc]. Checksum: 016E3FDB6C031F95		533	59,498
	10 20 30 40 50 60 MMSEGKPPDK KRPRRSLSIS KNKKKASNSI ISCFNNAPPA KLACPVCSKM VPRYDLNRHL 70 80 90 100 110 120 DEMCANNDFV QVDPGQVGLI NSNVSMVDLT SVTLEDVTPK KSPPPKTNLT PGQSDSAKRE 130 140 150 160 170 180 VKQKISPYFK SNDVVCKNQD ELRNRSVKVI CLGSLASKLS RKYVKAKKSI DKDEEFAGSS 190 200 210 220 230 240 PQSSKSTVVK SLIDNSSEIE DEDQILENSS QKENVFKCDS LKEECIPEHM VRGSKIMEAE 250 260 270 280 290 300 SQKATRECEK SALTPGFSDN AIMLFSPDFT LRNTLKSTSE DSLVKQECIK EVVEKREACH 310 320 330 340 350 360 CEEVKMTVAS EAKIQLSDSE AKSHSSADDA SAWSNIQEAP LQDDSCLNND IPHSIPLEQG 370 380 390 400 410 420 SSCNGPGQTT GHPYYLRSFL VVLKTVLENE DDMLLFDEQE KGIVTKFYQL SATGQKLYVR 430 440 450 460 470 480 LFQRKLSWIK MTKLEYEEIA LDLTPVIEEL TNAGFLQTES ELQELSEVLE LLSAPELKSL 490 500 510 520 530 AKTFHLVNPN GQKQQLVDAF LKLAKQRSVC TWGKNKPGIG AVILKRFCWL LLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 6:63-70(1999) [PubMed: 10231032] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[2]	Ohara O., Nagase T., Kikuno R. Submitted (JAN-2005) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT GLU-233. Tissue: Lung.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AB023235 mRNA. Translation: BAA76862.3. Different initiation. BC047882 mRNA. Translation: AAH47882.1. Different initiation.
RefSeq	NP_055782.2.
UniGene	Hs.584863
3D structure databases
ModBase	Search...
Genome annotation databases
Ensembl	ENSG00000198690. Homo sapiens. [Contig view]
GeneID	22909.
KEGG	hsa:22909.
Organism-specific databases
HGNC	HGNC:29170. MTMR15.
HUGE	Search...
GenAtlas	Search...
GeneCards	Search...
Phylogenomic databases
HOGENOM	Q9Y2M0.
HOVERGEN	Q9Y2M0.
Gene expression databases
ArrayExpress	Q9Y2M0.
CleanEx	HS_MTMR15.
Family and domain databases
InterPro	IPR014883. VRR_NUC. IPR006642. Znf_Rad18_put. [Graphical view]
Pfam	PF08774. VRR_NUC. 1 hit. [Graphical view]
SMART	SM00734. ZnF_Rad18. 1 hit. [Graphical view]
BLOCKS	Search...
ProtoNet	Search...
Other Resources
NextBio	43581.

Entry information

Entry name

MTMRF_HUMAN

Accession

Primary (citable) accession number: Q9Y2M0
Secondary accession number(s): Q86WU8

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 13, 2007
Last sequence update:	November 13, 2007
Last modified:	November 4, 2008
This is version 37 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)