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Protein

Zinc finger protein with KRAB and SCAN domains 5

Gene

ZKSCAN5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri346 – 36823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri717 – 73923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri745 – 76319C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri773 – 79523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri801 – 82323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • zinc ion binding Source: UniProtKB

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein with KRAB and SCAN domains 5
Alternative name(s):
Zinc finger protein 95 homolog
Short name:
Zfp-95
Gene namesi
Name:ZKSCAN5
Synonyms:KIAA1015, ZFP95
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:12867. ZKSCAN5.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162409785.

Polymorphism and mutation databases

BioMutaiZKSCAN5.
DMDMi11136143.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 839839Zinc finger protein with KRAB and SCAN domains 5PRO_0000047315Add
BLAST

Proteomic databases

PaxDbiQ9Y2L8.
PRIDEiQ9Y2L8.

PTM databases

iPTMnetiQ9Y2L8.
PhosphoSiteiQ9Y2L8.

Expressioni

Gene expression databases

BgeeiQ9Y2L8.
CleanExiHS_ZKSCAN5.
ExpressionAtlasiQ9Y2L8. baseline and differential.
GenevisibleiQ9Y2L8. HS.

Organism-specific databases

HPAiHPA003201.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SUV39H1O434632EBI-2876965,EBI-349968

Protein-protein interaction databases

BioGridi117182. 8 interactions.
IntActiQ9Y2L8. 4 interactions.
MINTiMINT-8247613.
STRINGi9606.ENSP00000322872.

Structurei

Secondary structure

1
839
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi349 – 3513Combined sources
Helixi358 – 36811Combined sources
Beta strandi373 – 3753Combined sources
Turni377 – 3793Combined sources
Beta strandi382 – 3865Combined sources
Helixi387 – 3904Combined sources
Helixi393 – 3964Combined sources
Beta strandi405 – 4073Combined sources
Helixi414 – 4207Combined sources
Turni421 – 4255Combined sources
Beta strandi433 – 4353Combined sources
Beta strandi438 – 4414Combined sources
Helixi442 – 45312Combined sources
Beta strandi548 – 5503Combined sources
Beta strandi552 – 5543Combined sources
Beta strandi557 – 5604Combined sources
Helixi561 – 57111Combined sources
Beta strandi636 – 6383Combined sources
Helixi645 – 65713Combined sources
Turni664 – 6663Combined sources
Beta strandi669 – 6724Combined sources
Helixi673 – 68311Combined sources
Beta strandi772 – 7743Combined sources
Beta strandi776 – 7783Combined sources
Beta strandi781 – 7844Combined sources
Helixi785 – 7928Combined sources
Turni793 – 7953Combined sources
Beta strandi800 – 8023Combined sources
Beta strandi804 – 8063Combined sources
Beta strandi809 – 8135Combined sources
Helixi814 – 82512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EM5NMR-A768-800[»]
2EMMNMR-A544-576[»]
2EMZNMR-A628-660[»]
2EN3NMR-A796-828[»]
2EOMNMR-A341-373[»]
2EONNMR-A397-429[»]
2EOONMR-A425-457[»]
2YSONMR-A656-688[»]
2YTGNMR-A369-401[»]
ProteinModelPortaliQ9Y2L8.
SMRiQ9Y2L8. Positions 44-133, 334-830.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9Y2L8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 13282SCAN boxPROSITE-ProRule annotationAdd
BLAST
Domaini218 – 29174KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation
Contains 1 SCAN box domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri346 – 36823C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri374 – 39623C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri402 – 42423C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri430 – 45223C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri549 – 57123C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri577 – 59923C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri605 – 62723C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri633 – 65523C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri661 – 68323C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri717 – 73923C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri745 – 76319C2H2-type 11; atypicalPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri773 – 79523C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri801 – 82323C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129892.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9Y2L8.
KOiK09229.
OMAiYRTHTAE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y2L8.
TreeFamiTF338146.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9Y2L8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIMTESREVI DLDPPAETSQ EQEDLFIVKV EEEDCTWMQE YNPPTFETFY
60 70 80 90 100
QRFRHFQYHE ASGPREALSQ LRVLCCEWLR PELHTKEQIL ELLVLEQFLT
110 120 130 140 150
ILPEEFQPWV REHHPESGEE AVAVIENIQR ELEERRQQIV ACPDVLPRKM
160 170 180 190 200
ATPGAVQESC SPHPLTVDTQ PEQAPQKPRL LEENALPVLQ VPSLPLKDSQ
210 220 230 240 250
ELTASLLSTG SQKLVKIEEV ADVAVSFILE EWGHLDQSQK SLYRDDRKEN
260 270 280 290 300
YGSITSMGYE SRDNMELIVK QISDDSESHW VAPEHTERSV PQDPDFAEVS
310 320 330 340 350
DLKGMVQRWQ VNPTVGKSRQ NPSQKRDLDA ITDISPKQST HGERGHRCSD
360 370 380 390 400
CGKFFLQASN FIQHRRIHTG EKPFKCGECG KSYNQRVHLT QHQRVHTGEK
410 420 430 440 450
PYKCQVCGKA FRVSSHLVQH HSVHSGERPY GCNECGKNFG RHSHLIEHLK
460 470 480 490 500
RHFREKSQRC SDKRSKNTKL SVKKKISEYS EADMELSGKT QRNVSQVQDF
510 520 530 540 550
GEGCEFQGKL DRKQGIPMKE ILGQPSSKRM NYSEVPYVHK KSSTGERPHK
560 570 580 590 600
CNECGKSFIQ SAHLIQHQRI HTGEKPFRCE ECGKSYNQRV HLTQHQRVHT
610 620 630 640 650
GEKPYTCPLC GKAFRVRSHL VQHQSVHSGE RPFKCNECGK GFGRRSHLAG
660 670 680 690 700
HLRLHSREKS HQCRECGEIF FQYVSLIEHQ VLHMGQKNEK NGICEEAYSW
710 720 730 740 750
NLTVIEDKKI ELQEQPYQCD ICGKAFGYSS DLIQHYRTHT AEKPYQCDIC
760 770 780 790 800
RENVGQCSHT KQHQKIYSST KSHQCHECGR GFTLKSHLNQ HQRIHTGEKP
810 820 830
FQCKECGMNF SWSCSLFKHL RSHERTDPIN TLSVEGSLL
Length:839
Mass (Da):96,903
Last modified:November 1, 1999 - v1
Checksum:iF2E082CF6610806D
GO

Sequence cautioni

The sequence BAA76859.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170025 mRNA. Translation: AAF24219.1.
AB023232 mRNA. Translation: BAA76859.2. Different initiation.
CH236956 Genomic DNA. Translation: EAL23873.1.
CH471091 Genomic DNA. Translation: EAW76654.1.
CH471091 Genomic DNA. Translation: EAW76655.1.
CH471091 Genomic DNA. Translation: EAW76656.1.
CH471091 Genomic DNA. Translation: EAW76657.1.
CCDSiCCDS5667.1.
RefSeqiNP_001305011.1. NM_001318082.1.
NP_001305012.1. NM_001318083.1.
NP_001305013.1. NM_001318084.1.
NP_055384.1. NM_014569.3.
NP_659570.1. NM_145102.3.
XP_006715976.1. XM_006715913.2.
UniGeneiHs.110839.

Genome annotation databases

EnsembliENST00000326775; ENSP00000322872; ENSG00000196652.
ENST00000394170; ENSP00000377725; ENSG00000196652.
ENST00000451158; ENSP00000392104; ENSG00000196652.
GeneIDi23660.
KEGGihsa:23660.
UCSCiuc003uqv.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF170025 mRNA. Translation: AAF24219.1.
AB023232 mRNA. Translation: BAA76859.2. Different initiation.
CH236956 Genomic DNA. Translation: EAL23873.1.
CH471091 Genomic DNA. Translation: EAW76654.1.
CH471091 Genomic DNA. Translation: EAW76655.1.
CH471091 Genomic DNA. Translation: EAW76656.1.
CH471091 Genomic DNA. Translation: EAW76657.1.
CCDSiCCDS5667.1.
RefSeqiNP_001305011.1. NM_001318082.1.
NP_001305012.1. NM_001318083.1.
NP_001305013.1. NM_001318084.1.
NP_055384.1. NM_014569.3.
NP_659570.1. NM_145102.3.
XP_006715976.1. XM_006715913.2.
UniGeneiHs.110839.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2EM5NMR-A768-800[»]
2EMMNMR-A544-576[»]
2EMZNMR-A628-660[»]
2EN3NMR-A796-828[»]
2EOMNMR-A341-373[»]
2EONNMR-A397-429[»]
2EOONMR-A425-457[»]
2YSONMR-A656-688[»]
2YTGNMR-A369-401[»]
ProteinModelPortaliQ9Y2L8.
SMRiQ9Y2L8. Positions 44-133, 334-830.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi117182. 8 interactions.
IntActiQ9Y2L8. 4 interactions.
MINTiMINT-8247613.
STRINGi9606.ENSP00000322872.

PTM databases

iPTMnetiQ9Y2L8.
PhosphoSiteiQ9Y2L8.

Polymorphism and mutation databases

BioMutaiZKSCAN5.
DMDMi11136143.

Proteomic databases

PaxDbiQ9Y2L8.
PRIDEiQ9Y2L8.

Protocols and materials databases

DNASUi23660.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326775; ENSP00000322872; ENSG00000196652.
ENST00000394170; ENSP00000377725; ENSG00000196652.
ENST00000451158; ENSP00000392104; ENSG00000196652.
GeneIDi23660.
KEGGihsa:23660.
UCSCiuc003uqv.4. human.

Organism-specific databases

CTDi23660.
GeneCardsiZKSCAN5.
HGNCiHGNC:12867. ZKSCAN5.
HPAiHPA003201.
MIMi611272. gene.
neXtProtiNX_Q9Y2L8.
PharmGKBiPA162409785.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129892.
HOGENOMiHOG000234619.
HOVERGENiHBG018163.
InParanoidiQ9Y2L8.
KOiK09229.
OMAiYRTHTAE.
OrthoDBiEOG7KSX7Q.
PhylomeDBiQ9Y2L8.
TreeFamiTF338146.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

ChiTaRSiZKSCAN5. human.
EvolutionaryTraceiQ9Y2L8.
GeneWikiiZKSCAN5.
GenomeRNAii23660.
NextBioi46509.
PROiQ9Y2L8.
SOURCEiSearch...

Gene expression databases

BgeeiQ9Y2L8.
CleanExiHS_ZKSCAN5.
ExpressionAtlasiQ9Y2L8. baseline and differential.
GenevisibleiQ9Y2L8. HS.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR001909. KRAB.
IPR008916. Retrov_capsid_C.
IPR003309. SCAN_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF02023. SCAN. 1 hit.
PF00096. zf-C2H2. 4 hits.
PF13912. zf-C2H2_6. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00431. SCAN. 1 hit.
SM00355. ZnF_C2H2. 12 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
SSF47353. SSF47353. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS50804. SCAN_BOX. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 12 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation, characterization, and mapping of a zinc finger gene, ZFP95, containing both a SCAN box and an alternatively spliced KRAB A domain."
    Dreyer S.D., Zheng Q., Zabel B., Winterpacht A., Lee B.
    Genomics 62:119-122(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
    Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  3. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "Solution structure of the C2H2 type zinc finger region of human zinc finger protein 95 homolog."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 369-828.

Entry informationi

Entry nameiZKSC5_HUMAN
AccessioniPrimary (citable) accession number: Q9Y2L8
Secondary accession number(s): A4D280, D6W5S9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: November 1, 1999
Last modified: May 11, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.